##gff-version 3
Q6UXX9	UniProtKB	Signal peptide	1	21	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q6UXX9	UniProtKB	Chain	22	243	.	.	.	ID=PRO_0000234439;Note=R-spondin-2	
Q6UXX9	UniProtKB	Repeat	90	134	.	.	.	Note=FU	
Q6UXX9	UniProtKB	Domain	144	204	.	.	.	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Region	204	243	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q6UXX9	UniProtKB	Compositional bias	204	223	.	.	.	Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q6UXX9	UniProtKB	Glycosylation	160	160	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q6UXX9	UniProtKB	Disulfide bond	40	46	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	43	52	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	55	74	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	78	93	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	96	104	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	101	110	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	113	124	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	128	141	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	145	187	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	156	163	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Disulfide bond	196	203	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210	
Q6UXX9	UniProtKB	Alternative sequence	1	67	.	.	.	ID=VSP_018321;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
Q6UXX9	UniProtKB	Alternative sequence	32	95	.	.	.	ID=VSP_018322;Note=In isoform 3. ASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCAR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
Q6UXX9	UniProtKB	Alternative sequence	143	143	.	.	.	ID=VSP_018323;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
Q6UXX9	UniProtKB	Natural variant	69	69	.	.	.	ID=VAR_081036;Note=In HHRRD%3B loss of LGR5-%2C RNF43- and ZNRF3-binding%3B decreased ability to amplify WNT3A signaling. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29769720;Dbxref=dbSNP:rs758888137,PMID:29769720	
Q6UXX9	UniProtKB	Natural variant	70	243	.	.	.	ID=VAR_081037;Note=In TETAMS2%3B loss of LGR5-%2C RNF43- and ZNRF3-binding%3B complete loss of amplification of WNT3A signaling. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29769720;Dbxref=PMID:29769720	
Q6UXX9	UniProtKB	Natural variant	137	243	.	.	.	ID=VAR_081038;Note=In TETAMS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29769720;Dbxref=PMID:29769720	
Q6UXX9	UniProtKB	Natural variant	186	186	.	.	.	ID=VAR_026247;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs601558,PMID:12975309,PMID:14702039,PMID:15489334	
Q6UXX9	UniProtKB	Mutagenesis	105	105	.	.	.	Note=Loss of LGR5-binding%2C no effect on interaction with RNF43 and ZNRF3%2C no effect on WNT3A signaling%3B when associated with A-109. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29769720;Dbxref=PMID:29769720	
Q6UXX9	UniProtKB	Mutagenesis	109	109	.	.	.	Note=Loss of LGR5-binding%2C no effect on interaction with RNF43 and ZNRF3%2C no effect on WNT3A signaling%3B when associated with A-105. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29769720;Dbxref=PMID:29769720