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Protein

Inter-alpha-trypsin inhibitor heavy chain H6

Gene

ITIH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H6
Alternative name(s):
Inter-alpha-trypsin inhibitor heavy chain H5-like protein
Short name:
Inter-alpha inhibitor H5-like protein
Gene namesi
Name:ITIH6
Synonyms:ITIH5L
ORF Names:UNQ6369/PRO21074
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28907. ITIH6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102313.
PharmGKBiPA134930661.

Polymorphism and mutation databases

BioMutaiITIH6.
DMDMi74762375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000028568024 – 1313Inter-alpha-trypsin inhibitor heavy chain H6Add BLAST1290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Glycosylationi594N-linked (GlcNAc...)Sequence analysis1
Glycosylationi971N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1231N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UXX5.
PaxDbiQ6UXX5.
PeptideAtlasiQ6UXX5.
PRIDEiQ6UXX5.

PTM databases

iPTMnetiQ6UXX5.
PhosphoSitePlusiQ6UXX5.

Expressioni

Gene expression databases

BgeeiENSG00000102313.
CleanExiHS_ITIH5L.
GenevisibleiQ6UXX5. HS.

Organism-specific databases

HPAiHPA000506.

Interactioni

Protein-protein interaction databases

BioGridi131428. 1 interactor.
IntActiQ6UXX5. 1 interactor.
STRINGi9606.ENSP00000218436.

Structurei

3D structure databases

ProteinModelPortaliQ6UXX5.
SMRiQ6UXX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 150VITPROSITE-ProRule annotationAdd BLAST127
Domaini283 – 469VWFAPROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi636 – 639Poly-Ser4
Compositional biasi738 – 994Pro-richAdd BLAST257
Compositional biasi917 – 920Poly-Thr4
Compositional biasi999 – 1002Poly-Leu4
Compositional biasi1192 – 1195Poly-Ala4

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000113117.
HOVERGENiHBG094819.
InParanoidiQ6UXX5.
OMAiPCLRRHH.
OrthoDBiEOG091G01HF.
PhylomeDBiQ6UXX5.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWRYLICV SFLLTILLEL TYQGPPVPAS SSTKLLMTSY SMRSTVVSRY
60 70 80 90 100
AHTLVTSVLF NPHAEAHEAI FDLDLPHLAF ISNFTMTINN KVYIAEVKEK
110 120 130 140 150
HQAKKIYEEA HQQGKTAAHV GIRDRESEKF RISTSLAAGT EVTFSLAYEE
160 170 180 190 200
LLQRHQGQYQ LVVSLRPGQL VKRLSIEVTV SERTGISYVH IPPLRTGRLR
210 220 230 240 250
TNAHASEVDS PPSTRIERGE TCVRITYCPT LQDQSSISGS GIMADFLVQY
260 270 280 290 300
DVVMEDIIGD VQIYDDYFIH YFAPRGLPPM EKNVVFVIDV SSSMFGTKME
310 320 330 340 350
QTKTAMNVIL SDLQANDYFN IISFSDTVNV WKAGGSIQAT IQNVHSAKDY
360 370 380 390 400
LHCMEADGWT DVNSALLAAA SVLNHSNQEP GRGPSVGRIP LIIFLTDGEP
410 420 430 440 450
TAGVTTPSVI LSNVRQALGH RVSLFSLAFG DDADFTLLRR LSLENRGIAR
460 470 480 490 500
RIYEDTDAAL QLKGLYEEIS MPLLADVRLN YLGGLVGASP WAVFPNYFGG
510 520 530 540 550
SELVVAGQVQ PGKQELGIHL AARGPKDQLL VAHHSEGATN NSQKAFGCPG
560 570 580 590 600
EPAPNVAHFI RRLWAYVTIG ELLDAHFQAR DTTTRHLLAA KVLNLSLEYN
610 620 630 640 650
FVTPLTSLVM VQPKQASEET RRQTSTSAGP DTIMPSSSSR HGLGVSTAQP
660 670 680 690 700
ALVPKVISPK SRPVKPKFYL SSTTTASTKK MLSSKELEPL GESPHTLSMP
710 720 730 740 750
TYPKAKIPAQ QDSGTLAQPT LRTKPTILVP SNSGTLLPLK PGSLSHQNPD
760 770 780 790 800
ILPTNSRTQV PPVKPGIPAS PKADTVKCVT PLHSKPGAPS HPQLGALTSQ
810 820 830 840 850
APKGLPQSRP GVSTLQVPKY PLHTRPRVPA PKTRNNMPHL GPGILLSKTP
860 870 880 890 900
KILLSLKPSA PPHQISTSIS LSKPETPNPH MPQTPLPPRP DRPRPPLPES
910 920 930 940 950
LSTFPNTISS STGPSSTTTT SVLGEPLPMP FTPTLPPGRF WHQYDLLPGP
960 970 980 990 1000
QRTRQVLGPS RPGVPTMSLL NSSRPTPEGS PPNLPILLPS SILPEAISLL
1010 1020 1030 1040 1050
LLPEELELLS ESMVESKFVE SLNPPAFYTF LTPDEDGSPN WDGNSEEILG
1060 1070 1080 1090 1100
GAGGSMESQG SSVGLAKGTL PSIFTFSSSV DGDPHFVIQI PHSEEKICFT
1110 1120 1130 1140 1150
LNGHPGDLLQ LIEDPKAGLH VSGKLLGAPP RPGHKDQTRT YFQIITVTTD
1160 1170 1180 1190 1200
KPRAYTITIS RSSISLRGEG TLRLSWDQPA LLKRPQLELY VAAAARLTLR
1210 1220 1230 1240 1250
LGPYLEFLVL RHRYRHPSTL QLPHLGFYVA NGSGLSPSAR GLIGQFQHAD
1260 1270 1280 1290 1300
IRLVTGPMGP CLRRHHGPDV PVILGKRLLK DSPRLLPRWA SCWLVKRSHV
1310
ELLLGHPYLS YVL
Length:1,313
Mass (Da):143,187
Last modified:July 5, 2004 - v1
Checksum:i4C63CF26AF187734
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032042387G → R.Corresponds to variant rs34188213dbSNPEnsembl.1
Natural variantiVAR_032043561R → C.Corresponds to variant rs34004499dbSNPEnsembl.1
Natural variantiVAR_0320441041W → S.Corresponds to variant rs17316491dbSNPEnsembl.1
Natural variantiVAR_0320451170G → A.Corresponds to variant rs35355718dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358170 mRNA. Translation: AAQ88537.1.
Z98046, AL022575 Genomic DNA. Translation: CAI42344.1.
AL022575, Z98046 Genomic DNA. Translation: CAI42356.1.
CH471154 Genomic DNA. Translation: EAW93186.1.
CCDSiCCDS14361.1.
RefSeqiNP_940912.1. NM_198510.2.
UniGeneiHs.454272.

Genome annotation databases

EnsembliENST00000218436; ENSP00000218436; ENSG00000102313.
GeneIDi347365.
KEGGihsa:347365.
UCSCiuc004dtj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358170 mRNA. Translation: AAQ88537.1.
Z98046, AL022575 Genomic DNA. Translation: CAI42344.1.
AL022575, Z98046 Genomic DNA. Translation: CAI42356.1.
CH471154 Genomic DNA. Translation: EAW93186.1.
CCDSiCCDS14361.1.
RefSeqiNP_940912.1. NM_198510.2.
UniGeneiHs.454272.

3D structure databases

ProteinModelPortaliQ6UXX5.
SMRiQ6UXX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131428. 1 interactor.
IntActiQ6UXX5. 1 interactor.
STRINGi9606.ENSP00000218436.

PTM databases

iPTMnetiQ6UXX5.
PhosphoSitePlusiQ6UXX5.

Polymorphism and mutation databases

BioMutaiITIH6.
DMDMi74762375.

Proteomic databases

EPDiQ6UXX5.
PaxDbiQ6UXX5.
PeptideAtlasiQ6UXX5.
PRIDEiQ6UXX5.

Protocols and materials databases

DNASUi347365.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218436; ENSP00000218436; ENSG00000102313.
GeneIDi347365.
KEGGihsa:347365.
UCSCiuc004dtj.2. human.

Organism-specific databases

CTDi347365.
GeneCardsiITIH6.
HGNCiHGNC:28907. ITIH6.
HPAiHPA000506.
neXtProtiNX_Q6UXX5.
OpenTargetsiENSG00000102313.
PharmGKBiPA134930661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000113117.
HOVERGENiHBG094819.
InParanoidiQ6UXX5.
OMAiPCLRRHH.
OrthoDBiEOG091G01HF.
PhylomeDBiQ6UXX5.
TreeFamiTF328982.

Miscellaneous databases

GenomeRNAii347365.
PROiQ6UXX5.

Gene expression databases

BgeeiENSG00000102313.
CleanExiHS_ITIH5L.
GenevisibleiQ6UXX5. HS.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITIH6_HUMAN
AccessioniPrimary (citable) accession number: Q6UXX5
Secondary accession number(s): A6NN03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.