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Q6UXV4 (APOOL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein O-like
Alternative name(s):
Protein FAM121A
Gene names
Name:APOOL
Synonyms:CXorf33, FAM121A
ORF Names:UNQ8193/PRO23204
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the maintenance of mitochondrial cristae morphology. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Ref.5

Subunit structure

Interacts with several subunits of the MINOS/MitOS complex, namely IMMT/Mitofilin, MINOS1, and SAMM50. Ref.5

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.5.

Miscellaneous

Overexpression of APOOL results in mitochondrial fragmentation, reduced oxygen consumption, and altered cristae morphology. Down-regulation impairs mitochondrial function and also alters cristae morphology.

Sequence similarities

Belongs to the apolipoprotein O family.

Sequence caution

The sequence CAI42458.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2727Mitochondrion Potential
Chain28 – 268241Apolipoprotein O-like
PRO_0000042052

Regions

Topological domain28 – 11083Mitochondrial intermembrane Potential
Transmembrane111 – 12919Helical; Potential
Topological domain130 – 1378Mitochondrial matrix Potential
Transmembrane138 – 15518Helical; Potential
Topological domain156 – 268113Mitochondrial intermembrane Potential

Sequences

Sequence LengthMass (Da)Tools
Q6UXV4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2BA4B3AACFBDA298

FASTA26829,159
        10         20         30         40         50         60 
MAAIRMGKLT TMPAGLIYAS VSVHAAKQEE SKKQLVKPEQ LPIYTAPPLQ SKYVEEQPGH 

        70         80         90        100        110        120 
LQMGFASIRT ATGCYIGWCK GVYVFVKNGI MDTVQFGKDA YVYLKNPPRD FLPKMGVITV 

       130        140        150        160        170        180 
SGLAGLVSAR KGSKFKKITY PLGLATLGAT VCYPVQSVII AKVTAKKVYA TSQQIFGAVK 

       190        200        210        220        230        240 
SLWTKSSKEE SLPKPKEKTK LGSSSEIEVP AKTTHVLKHS VPLPTELSSE AKTKSESTSG 

       250        260 
ATQFMPDPKL MDHGQSHPED IDMYSTRS 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria."
Weber T.A., Koob S., Heide H., Wittig I., Head B., van der Bliek A., Brandt U., Mittelbronn M., Reichert A.S.
PLoS ONE 8:E63683-E63683(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, MISCELLANEOUS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358193 mRNA. Translation: AAQ88560.1.
Z83820 Genomic DNA. Translation: CAI42458.1. Different initiation.
BC107096 mRNA. Translation: AAI07097.1.
CCDSCCDS48138.1.
RefSeqNP_940852.3. NM_198450.5.
UniGeneHs.512181.
Hs.729014.

3D structure databases

ProteinModelPortalQ6UXV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126558. 2 interactions.
DIPDIP-47309N.
STRING9606.ENSP00000407202.

PTM databases

PhosphoSiteQ6UXV4.

Polymorphism databases

DMDM74749432.

Proteomic databases

MaxQBQ6UXV4.
PaxDbQ6UXV4.
PRIDEQ6UXV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373173; ENSP00000362268; ENSG00000155008.
GeneID139322.
KEGGhsa:139322.
UCSCuc004eem.3. human.

Organism-specific databases

CTD139322.
GeneCardsGC0XP084258.
HGNCHGNC:24009. APOOL.
HPAHPA000612.
neXtProtNX_Q6UXV4.
PharmGKBPA162376732.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240513.
HOGENOMHOG000034010.
HOVERGENHBG055885.
OMANTSEWEE.
OrthoDBEOG7CG70V.
PhylomeDBQ6UXV4.
TreeFamTF315313.

Gene expression databases

BgeeQ6UXV4.
CleanExHS_APOOL.
GenevestigatorQ6UXV4.

Family and domain databases

InterProIPR019166. Apolipoprotein_O.
[Graphical view]
PfamPF09769. ApoO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi139322.
NextBio83938.
PROQ6UXV4.

Entry information

Entry nameAPOOL_HUMAN
AccessionPrimary (citable) accession number: Q6UXV4
Secondary accession number(s): Q3KNU7, Q5H9D1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM