Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Germ cell-specific gene 1-like protein

Gene

GSG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.By similarity

Protein family/group databases

TCDBi8.A.16.5.3 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-specific gene 1-like protein
Short name:
GSG1-like protein
Gene namesi
Name:GSG1L
ORF Names:UNQ5831/PRO19651
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169181.12
HGNCiHGNC:28283 GSG1L
neXtProtiNX_Q6UXU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 132ExtracellularSequence analysisAdd BLAST103
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 173CytoplasmicSequence analysisAdd BLAST20
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 217ExtracellularSequence analysisAdd BLAST23
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 331CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169181
PharmGKBiPA145148734

Polymorphism and mutation databases

BioMutaiGSG1L
DMDMi187471161

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294641 – 331Germ cell-specific gene 1-like proteinAdd BLAST331

Proteomic databases

PaxDbiQ6UXU4
PeptideAtlasiQ6UXU4
PRIDEiQ6UXU4
ProteomicsDBi67660
67661 [Q6UXU4-2]
67662 [Q6UXU4-3]
67663 [Q6UXU4-4]

PTM databases

iPTMnetiQ6UXU4
PhosphoSitePlusiQ6UXU4

Expressioni

Gene expression databases

BgeeiENSG00000169181
CleanExiHS_GSG1L
ExpressionAtlasiQ6UXU4 baseline and differential
GenevisibleiQ6UXU4 HS

Organism-specific databases

HPAiHPA014479

Interactioni

Subunit structurei

Component of the inner core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LXNQ9BS403EBI-10297401,EBI-1044504

Protein-protein interaction databases

BioGridi126983, 1 interactor
IntActiQ6UXU4, 1 interactor
STRINGi9606.ENSP00000394954

Structurei

3D structure databases

ProteinModelPortaliQ6UXU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 76Ala-richAdd BLAST20

Sequence similaritiesi

Belongs to the GSG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAK Eukaryota
ENOG410ZXFF LUCA
GeneTreeiENSGT00390000011933
HOGENOMiHOG000112826
HOVERGENiHBG069545
InParanoidiQ6UXU4
OMAiCQGTQRV
OrthoDBiEOG091G0FIO
PhylomeDBiQ6UXU4
TreeFamiTF331388

Family and domain databases

InterProiView protein in InterPro
IPR012478 GSG-1
PfamiView protein in Pfam
PF07803 GSG-1, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTSRRGRAL LAVALNLLAL LFATTAFLTT HWCQGTQRVP KPGCGQGGRA
60 70 80 90 100
NCPNSGANAT ANGTAAPAAA AAAATASGNG PPGGALYSWE TGDDRFLFRN
110 120 130 140 150
FHTGIWYSCE EELSGLGEKC RSFIDLAPAS EKGVLWLSVV SEVLYILLLV
160 170 180 190 200
VGFSLMCLEL FHSSNVIDGL KLNAFAAVFT VLSGLLGMVA HMMYTQVFQV
210 220 230 240 250
TVSLGPEDWR PHSWDYGWSF CLAWGSFTCC MAASVTTLNS YTKTVIEFRH
260 270 280 290 300
KRKVFEQGYR EEPTFIDPEA IKYFRERMEK RDGSEEDFHL DCRHERYPAR
310 320 330
HQPHMADSWP RSSAQEAPEL NRQCWVLGHW V
Length:331
Mass (Da):36,774
Last modified:April 29, 2008 - v2
Checksum:i7CAC097C9DF7FBCB
GO
Isoform 2 (identifier: Q6UXU4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-183: Missing.

Show »
Length:280
Mass (Da):31,250
Checksum:i0FEF923418CB3831
GO
Isoform 3 (identifier: Q6UXU4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     277-277: R → RWQIEAQRGRATCPRSHSW

Show »
Length:194
Mass (Da):22,738
Checksum:i3B0AB145D1FAB663
GO
Isoform 4 (identifier: Q6UXU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:176
Mass (Da):20,586
Checksum:i408A16130B3F252C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335161 – 155Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST155
Alternative sequenceiVSP_033004133 – 183Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_033517277R → RWQIEAQRGRATCPRSHSW in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358206 mRNA Translation: AAQ88573.1
AY302134 mRNA Translation: AAP57626.1
AC008732 Genomic DNA No translation available.
AC009030 Genomic DNA No translation available.
AC130449 Genomic DNA No translation available.
CH471145 Genomic DNA Translation: EAW55740.1
BC016460 mRNA Translation: AAH16460.1
CCDSiCCDS10631.1 [Q6UXU4-2]
CCDS45450.1 [Q6UXU4-1]
CCDS81960.1 [Q6UXU4-3]
RefSeqiNP_001103233.1, NM_001109763.1 [Q6UXU4-1]
NP_001310830.1, NM_001323901.1 [Q6UXU4-3]
NP_653276.1, NM_144675.2 [Q6UXU4-2]
UniGeneiHs.91910

Genome annotation databases

EnsembliENST00000380897; ENSP00000370282; ENSG00000169181 [Q6UXU4-2]
ENST00000395724; ENSP00000379074; ENSG00000169181 [Q6UXU4-3]
ENST00000447459; ENSP00000394954; ENSG00000169181 [Q6UXU4-1]
ENST00000569166; ENSP00000454880; ENSG00000169181 [Q6UXU4-4]
GeneIDi146395
KEGGihsa:146395
UCSCiuc002doy.3 human [Q6UXU4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGSG1L_HUMAN
AccessioniPrimary (citable) accession number: Q6UXU4
Secondary accession number(s): Q7Z6F8, Q8TB81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health