ID   ABH15_HUMAN             Reviewed;         468 AA.
AC   Q6UXT9; Q96EC5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=Protein ABHD15 {ECO:0000305};
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 15 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 15 {ECO:0000312|HGNC:HGNC:26971};
DE   Flags: Precursor;
GN   Name=ABHD15 {ECO:0000312|HGNC:HGNC:26971}; ORFNames=UNQ6510/PRO21435;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-334.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-334.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May regulate adipocyte lipolysis and liver lipid
CC       accumulation. {ECO:0000250|UniProtKB:Q5F2F2}.
CC   -!- SUBUNIT: Interacts with PDE3B; this interaction regulates PDE3B's
CC       stability and expression and, thereby, impacts the antilipolytic action
CC       of insulin. {ECO:0000250|UniProtKB:Q5F2F2}.
CC   -!- INTERACTION:
CC       Q6UXT9; O76011: KRT34; NbExp=3; IntAct=EBI-2824666, EBI-1047093;
CC       Q6UXT9; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-2824666, EBI-11522433;
CC       Q6UXT9; P21673: SAT1; NbExp=3; IntAct=EBI-2824666, EBI-711613;
CC       Q6UXT9; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-2824666, EBI-11957238;
CC       Q6UXT9; Q15007: WTAP; NbExp=3; IntAct=EBI-2824666, EBI-751647;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC       family. {ECO:0000305}.
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DR   EMBL; AY358212; AAQ88579.1; -; mRNA.
DR   EMBL; AC104564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC012476; AAH12476.2; -; mRNA.
DR   CCDS; CCDS32602.1; -.
DR   RefSeq; NP_937790.2; NM_198147.2.
DR   AlphaFoldDB; Q6UXT9; -.
DR   BioGRID; 125492; 37.
DR   IntAct; Q6UXT9; 15.
DR   STRING; 9606.ENSP00000302657; -.
DR   ESTHER; human-ABHD15; abh_upf0017.
DR   iPTMnet; Q6UXT9; -.
DR   PhosphoSitePlus; Q6UXT9; -.
DR   BioMuta; ABHD15; -.
DR   DMDM; 308153403; -.
DR   EPD; Q6UXT9; -.
DR   jPOST; Q6UXT9; -.
DR   MassIVE; Q6UXT9; -.
DR   MaxQB; Q6UXT9; -.
DR   PaxDb; 9606-ENSP00000302657; -.
DR   PeptideAtlas; Q6UXT9; -.
DR   ProteomicsDB; 67657; -.
DR   Pumba; Q6UXT9; -.
DR   Antibodypedia; 2595; 59 antibodies from 20 providers.
DR   DNASU; 116236; -.
DR   Ensembl; ENST00000307201.5; ENSP00000302657.3; ENSG00000168792.5.
DR   GeneID; 116236; -.
DR   KEGG; hsa:116236; -.
DR   MANE-Select; ENST00000307201.5; ENSP00000302657.3; NM_198147.3; NP_937790.2.
DR   UCSC; uc002hed.3; human.
DR   AGR; HGNC:26971; -.
DR   CTD; 116236; -.
DR   DisGeNET; 116236; -.
DR   GeneCards; ABHD15; -.
DR   HGNC; HGNC:26971; ABHD15.
DR   HPA; ENSG00000168792; Tissue enhanced (liver).
DR   MIM; 619894; gene.
DR   neXtProt; NX_Q6UXT9; -.
DR   OpenTargets; ENSG00000168792; -.
DR   PharmGKB; PA164714659; -.
DR   VEuPathDB; HostDB:ENSG00000168792; -.
DR   eggNOG; KOG1838; Eukaryota.
DR   GeneTree; ENSGT00950000182902; -.
DR   HOGENOM; CLU_032487_3_0_1; -.
DR   InParanoid; Q6UXT9; -.
DR   OMA; LPWLYER; -.
DR   OrthoDB; 2944016at2759; -.
DR   PhylomeDB; Q6UXT9; -.
DR   TreeFam; TF332985; -.
DR   PathwayCommons; Q6UXT9; -.
DR   SignaLink; Q6UXT9; -.
DR   BioGRID-ORCS; 116236; 22 hits in 1155 CRISPR screens.
DR   ChiTaRS; ABHD15; human.
DR   GenomeRNAi; 116236; -.
DR   Pharos; Q6UXT9; Tdark.
DR   PRO; PR:Q6UXT9; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q6UXT9; Protein.
DR   Bgee; ENSG00000168792; Expressed in granulocyte and 122 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR   GO; GO:0034338; F:short-chain carboxylesterase activity; IBA:GO_Central.
DR   GO; GO:0060612; P:adipose tissue development; ISS:UniProtKB.
DR   GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   PANTHER; PTHR10794; ABHYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10794:SF39; PROTEIN ABHD15; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   Genevisible; Q6UXT9; HS.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..468
FT                   /note="Protein ABHD15"
FT                   /id="PRO_0000345395"
FT   REGION          33..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        360
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        391
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         434
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         334
FT                   /note="T -> A (in dbSNP:rs542939)"
FT                   /evidence="ECO:0000269|PubMed:12975309,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_045821"
FT   CONFLICT        287
FT                   /note="H -> Y (in Ref. 3; AAH12476)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   468 AA;  51771 MW;  A910F5F4294B0CC3 CRC64;
     MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA DGGGPADQFS
     DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW FSGPHLQTLC HFVLPVAPGP
     ELAREYLQLA DDGLVALDWV VGPCVRGRRI TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL
     ALERGYYPVI FHRRGHHGCP LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS
     ALLLSYLGEC GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE
     DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV PVLCICSADD
     PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL PAWSHEVILE SFRALTEFFR
     TEERIKGLSR HRASFLGGRR RGGALQRREV SSSSNLEEIF NWKRSYTR
//