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Q6UXT9

- ABH15_HUMAN

UniProt

Q6UXT9 - ABH15_HUMAN

Protein

Abhydrolase domain-containing protein 15

Gene

ABHD15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei360 – 3601Charge relay systemBy similarity
    Active sitei391 – 3911Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 15 (EC:3.1.1.-)
    Gene namesi
    Name:ABHD15
    ORF Names:UNQ6510/PRO21435
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26971. ABHD15.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164714659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 468445Abhydrolase domain-containing protein 15PRO_0000345395Add
    BLAST

    Proteomic databases

    MaxQBiQ6UXT9.
    PaxDbiQ6UXT9.
    PRIDEiQ6UXT9.

    PTM databases

    PhosphoSiteiQ6UXT9.

    Expressioni

    Gene expression databases

    BgeeiQ6UXT9.
    GenevestigatoriQ6UXT9.

    Organism-specific databases

    HPAiHPA014470.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6UXT9. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0429.
    HOGENOMiHOG000033769.
    InParanoidiQ6UXT9.
    KOiK13707.
    OMAiRSWLSGP.
    OrthoDBiEOG7J70FM.
    PhylomeDBiQ6UXT9.
    TreeFamiTF332985.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    [Graphical view]
    PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UXT9-1 [UniParc]FASTAAdd to Basket

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    MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA    50
    DGGGPADQFS DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW 100
    FSGPHLQTLC HFVLPVAPGP ELAREYLQLA DDGLVALDWV VGPCVRGRRI 150
    TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL ALERGYYPVI FHRRGHHGCP 200
    LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS ALLLSYLGEC 250
    GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE 300
    DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV 350
    PVLCICSADD PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL 400
    PAWSHEVILE SFRALTEFFR TEERIKGLSR HRASFLGGRR RGGALQRREV 450
    SSSSNLEEIF NWKRSYTR 468
    Length:468
    Mass (Da):51,771
    Last modified:October 5, 2010 - v2
    Checksum:iA910F5F4294B0CC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti287 – 2871H → Y in AAH12476. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti334 – 3341T → A.2 Publications
    Corresponds to variant rs542939 [ dbSNP | Ensembl ].
    VAR_045821

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358212 mRNA. Translation: AAQ88579.1.
    AC104564 Genomic DNA. No translation available.
    BC012476 mRNA. Translation: AAH12476.2.
    CCDSiCCDS32602.1.
    RefSeqiNP_937790.2. NM_198147.2.
    UniGeneiHs.106510.

    Genome annotation databases

    EnsembliENST00000307201; ENSP00000302657; ENSG00000168792.
    GeneIDi116236.
    KEGGihsa:116236.
    UCSCiuc002hed.2. human.

    Polymorphism databases

    DMDMi308153403.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358212 mRNA. Translation: AAQ88579.1 .
    AC104564 Genomic DNA. No translation available.
    BC012476 mRNA. Translation: AAH12476.2 .
    CCDSi CCDS32602.1.
    RefSeqi NP_937790.2. NM_198147.2.
    UniGenei Hs.106510.

    3D structure databases

    ProteinModelPortali Q6UXT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6UXT9. 2 interactions.

    PTM databases

    PhosphoSitei Q6UXT9.

    Polymorphism databases

    DMDMi 308153403.

    Proteomic databases

    MaxQBi Q6UXT9.
    PaxDbi Q6UXT9.
    PRIDEi Q6UXT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307201 ; ENSP00000302657 ; ENSG00000168792 .
    GeneIDi 116236.
    KEGGi hsa:116236.
    UCSCi uc002hed.2. human.

    Organism-specific databases

    CTDi 116236.
    GeneCardsi GC17M027887.
    H-InvDB HIX0013677.
    HGNCi HGNC:26971. ABHD15.
    HPAi HPA014470.
    neXtProti NX_Q6UXT9.
    PharmGKBi PA164714659.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0429.
    HOGENOMi HOG000033769.
    InParanoidi Q6UXT9.
    KOi K13707.
    OMAi RSWLSGP.
    OrthoDBi EOG7J70FM.
    PhylomeDBi Q6UXT9.
    TreeFami TF332985.

    Miscellaneous databases

    GenomeRNAii 116236.
    NextBioi 79845.
    PROi Q6UXT9.

    Gene expression databases

    Bgeei Q6UXT9.
    Genevestigatori Q6UXT9.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    [Graphical view ]
    PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
      Tissue: Testis.

    Entry informationi

    Entry nameiABH15_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXT9
    Secondary accession number(s): Q96EC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3