Q6UXT9 (ABH15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein 15
EC=3.1.1.-

Gene names

Name:	ABHD15
ORF Names:	UNQ6510/PRO21435

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 468	445	Abhydrolase domain-containing protein 15		PRO_0000345395
Sites
	Active site	360	1	Charge relay system By similarity
	Active site	391	1	Charge relay system By similarity
Natural variations
	Natural variant	334	1	T → A. Ref.1 Ref.3 Corresponds to variant rs542939 [ dbSNP | Ensembl ].		VAR_045821
Experimental info
	Sequence conflict	287	1	H → Y in AAH12476. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6UXT9 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: A910F5F4294B0CC3	FASTA	468	51,771
	10 20 30 40 50 60 MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA DGGGPADQFS 70 80 90 100 110 120 DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW FSGPHLQTLC HFVLPVAPGP 130 140 150 160 170 180 ELAREYLQLA DDGLVALDWV VGPCVRGRRI TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL 190 200 210 220 230 240 ALERGYYPVI FHRRGHHGCP LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS 250 260 270 280 290 300 ALLLSYLGEC GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE 310 320 330 340 350 360 DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV PVLCICSADD 370 380 390 400 410 420 PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL PAWSHEVILE SFRALTEFFR 430 440 450 460 TEERIKGLSR HRASFLGGRR RGGALQRREV SSSSNLEEIF NWKRSYTR

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358212 mRNA. Translation: AAQ88579.1. AC104564 Genomic DNA. No translation available. BC012476 mRNA. Translation: AAH12476.2.
IPI	IPI00304804.
RefSeq	NP_937790.2. NM_198147.2.
UniGene	Hs.106510.
3D structure databases
ProteinModelPortal	Q6UXT9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UXT9. 2 interactions.
PTM databases
PhosphoSite	Q6UXT9.
Polymorphism databases
DMDM	308153403.
Proteomic databases
PRIDE	Q6UXT9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307201; ENSP00000302657; ENSG00000168792.
GeneID	116236.
KEGG	hsa:116236.
UCSC	uc002hed.1. human.
Organism-specific databases
CTD	116236.
GeneCards	GC17M027887.
H-InvDB	HIX0013677.
HGNC	HGNC:26971. ABHD15.
HPA	HPA014470.
neXtProt	NX_Q6UXT9.
PharmGKB	PA164714659.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05746.
GeneTree	ENSGT00530000062981.
InParanoid	Q6UXT9.
OMA	HFVLPVG.
OrthoDB	EOG4V9TQQ.
PhylomeDB	Q6UXT9.
Gene expression databases
ArrayExpress	Q6UXT9.
Bgee	Q6UXT9.
Genevestigator	Q6UXT9.
Family and domain databases
InterPro	IPR012020. AB-Hydro_YheT. [Graphical view]
KO	K13707.
PIRSF	PIRSF005211. Ab_hydro_YheT. 1 hit.
ProtoNet	Search...
Other
NextBio	79845.

Entry information

Entry name

ABH15_HUMAN

Accession

Primary (citable) accession number: Q6UXT9
Secondary accession number(s): Q96EC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.