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Q6UXT9 (ABH15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein 15

EC=3.1.1.-
Gene names
Name:ABHD15
ORF Names:UNQ6510/PRO21435
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 468445Abhydrolase domain-containing protein 15
PRO_0000345395

Sites

Active site3601Charge relay system By similarity
Active site3911Charge relay system By similarity

Natural variations

Natural variant3341T → A. Ref.1 Ref.3
Corresponds to variant rs542939 [ dbSNP | Ensembl ].
VAR_045821

Experimental info

Sequence conflict2871H → Y in AAH12476. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6UXT9 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: A910F5F4294B0CC3

FASTA46851,771
        10         20         30         40         50         60 
MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA DGGGPADQFS 

        70         80         90        100        110        120 
DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW FSGPHLQTLC HFVLPVAPGP 

       130        140        150        160        170        180 
ELAREYLQLA DDGLVALDWV VGPCVRGRRI TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL 

       190        200        210        220        230        240 
ALERGYYPVI FHRRGHHGCP LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS 

       250        260        270        280        290        300 
ALLLSYLGEC GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE 

       310        320        330        340        350        360 
DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV PVLCICSADD 

       370        380        390        400        410        420 
PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL PAWSHEVILE SFRALTEFFR 

       430        440        450        460 
TEERIKGLSR HRASFLGGRR RGGALQRREV SSSSNLEEIF NWKRSYTR 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358212 mRNA. Translation: AAQ88579.1.
AC104564 Genomic DNA. No translation available.
BC012476 mRNA. Translation: AAH12476.2.
RefSeqNP_937790.2. NM_198147.2.
UniGeneHs.106510.

3D structure databases

ProteinModelPortalQ6UXT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6UXT9. 2 interactions.

PTM databases

PhosphoSiteQ6UXT9.

Polymorphism databases

DMDM308153403.

Proteomic databases

PaxDbQ6UXT9.
PRIDEQ6UXT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307201; ENSP00000302657; ENSG00000168792.
GeneID116236.
KEGGhsa:116236.
UCSCuc002hed.2. human.

Organism-specific databases

CTD116236.
GeneCardsGC17M027887.
H-InvDBHIX0013677.
HGNCHGNC:26971. ABHD15.
HPAHPA014470.
neXtProtNX_Q6UXT9.
PharmGKBPA164714659.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0429.
HOGENOMHOG000033769.
InParanoidQ6UXT9.
KOK13707.
OMAETLFCHT.
OrthoDBEOG7J70FM.
PhylomeDBQ6UXT9.
TreeFamTF332985.

Gene expression databases

BgeeQ6UXT9.
GenevestigatorQ6UXT9.

Family and domain databases

InterProIPR012020. AB-Hydro_YheT.
[Graphical view]
PIRSFPIRSF005211. Ab_hydro_YheT. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi116236.
NextBio79845.
PROQ6UXT9.

Entry information

Entry nameABH15_HUMAN
AccessionPrimary (citable) accession number: Q6UXT9
Secondary accession number(s): Q96EC5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM