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Q6UXT9

- ABH15_HUMAN

UniProt

Q6UXT9 - ABH15_HUMAN

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Protein

Abhydrolase domain-containing protein 15

Gene
ABHD15, UNQ6510/PRO21435
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Charge relay system By similarity
Active sitei391 – 3911Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 15 (EC:3.1.1.-)
Gene namesi
Name:ABHD15
ORF Names:UNQ6510/PRO21435
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26971. ABHD15.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164714659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 468445Abhydrolase domain-containing protein 15PRO_0000345395Add
BLAST

Proteomic databases

MaxQBiQ6UXT9.
PaxDbiQ6UXT9.
PRIDEiQ6UXT9.

PTM databases

PhosphoSiteiQ6UXT9.

Expressioni

Gene expression databases

BgeeiQ6UXT9.
GenevestigatoriQ6UXT9.

Organism-specific databases

HPAiHPA014470.

Interactioni

Protein-protein interaction databases

IntActiQ6UXT9. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6UXT9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0429.
HOGENOMiHOG000033769.
InParanoidiQ6UXT9.
KOiK13707.
OMAiRSWLSGP.
OrthoDBiEOG7J70FM.
PhylomeDBiQ6UXT9.
TreeFamiTF332985.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXT9-1 [UniParc]FASTAAdd to Basket

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MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA    50
DGGGPADQFS DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW 100
FSGPHLQTLC HFVLPVAPGP ELAREYLQLA DDGLVALDWV VGPCVRGRRI 150
TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL ALERGYYPVI FHRRGHHGCP 200
LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS ALLLSYLGEC 250
GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE 300
DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV 350
PVLCICSADD PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL 400
PAWSHEVILE SFRALTEFFR TEERIKGLSR HRASFLGGRR RGGALQRREV 450
SSSSNLEEIF NWKRSYTR 468
Length:468
Mass (Da):51,771
Last modified:October 5, 2010 - v2
Checksum:iA910F5F4294B0CC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341T → A.2 Publications
Corresponds to variant rs542939 [ dbSNP | Ensembl ].
VAR_045821

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871H → Y in AAH12476. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358212 mRNA. Translation: AAQ88579.1.
AC104564 Genomic DNA. No translation available.
BC012476 mRNA. Translation: AAH12476.2.
CCDSiCCDS32602.1.
RefSeqiNP_937790.2. NM_198147.2.
UniGeneiHs.106510.

Genome annotation databases

EnsembliENST00000307201; ENSP00000302657; ENSG00000168792.
GeneIDi116236.
KEGGihsa:116236.
UCSCiuc002hed.2. human.

Polymorphism databases

DMDMi308153403.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358212 mRNA. Translation: AAQ88579.1 .
AC104564 Genomic DNA. No translation available.
BC012476 mRNA. Translation: AAH12476.2 .
CCDSi CCDS32602.1.
RefSeqi NP_937790.2. NM_198147.2.
UniGenei Hs.106510.

3D structure databases

ProteinModelPortali Q6UXT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6UXT9. 2 interactions.

PTM databases

PhosphoSitei Q6UXT9.

Polymorphism databases

DMDMi 308153403.

Proteomic databases

MaxQBi Q6UXT9.
PaxDbi Q6UXT9.
PRIDEi Q6UXT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307201 ; ENSP00000302657 ; ENSG00000168792 .
GeneIDi 116236.
KEGGi hsa:116236.
UCSCi uc002hed.2. human.

Organism-specific databases

CTDi 116236.
GeneCardsi GC17M027887.
H-InvDB HIX0013677.
HGNCi HGNC:26971. ABHD15.
HPAi HPA014470.
neXtProti NX_Q6UXT9.
PharmGKBi PA164714659.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0429.
HOGENOMi HOG000033769.
InParanoidi Q6UXT9.
KOi K13707.
OMAi RSWLSGP.
OrthoDBi EOG7J70FM.
PhylomeDBi Q6UXT9.
TreeFami TF332985.

Miscellaneous databases

GenomeRNAii 116236.
NextBioi 79845.
PROi Q6UXT9.

Gene expression databases

Bgeei Q6UXT9.
Genevestigatori Q6UXT9.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
[Graphical view ]
PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-334.
    Tissue: Testis.

Entry informationi

Entry nameiABH15_HUMAN
AccessioniPrimary (citable) accession number: Q6UXT9
Secondary accession number(s): Q96EC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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