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Protein

Transmembrane protein 14E

Gene

TMEM14E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14E
Gene namesi
Name:TMEM14E
ORF Names:UNQ9344/PRO34067
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34386. TMEM14E.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405891.

Polymorphism and mutation databases

BioMutaiTMEM14E.
DMDMi74738233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Transmembrane protein 14EPRO_0000348435Add
BLAST

Proteomic databases

PaxDbiQ6UXP3.
PRIDEiQ6UXP3.

Expressioni

Gene expression databases

BgeeiQ6UXP3.
CleanExiHS_TMEM14E.

Organism-specific databases

HPAiHPA014550.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386163.

Structurei

3D structure databases

ProteinModelPortaliQ6UXP3.
SMRiQ6UXP3. Positions 4-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240787.
HOGENOMiHOG000211932.
HOVERGENiHBG066645.
InParanoidiQ6UXP3.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ6UXP3.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UXP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG
60 70 80 90 100
LDASQPSRNP KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV
110 120
SKLGSMYGEQ ILSVVAMSQL GLMKN
Length:125
Mass (Da):13,608
Last modified:July 5, 2004 - v1
Checksum:iB341C0F9501B65CE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821L → P.
Corresponds to variant rs13077912 [ dbSNP | Ensembl ].
VAR_046161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358260 mRNA. Translation: AAQ88627.1.
CH471052 Genomic DNA. Translation: EAW78784.1.
CCDSiCCDS43161.1.
RefSeqiNP_001116700.1. NM_001123228.1.
UniGeneiHs.632562.

Genome annotation databases

EnsembliENST00000408960; ENSP00000386163; ENSG00000221962.
GeneIDi645843.
KEGGihsa:645843.
UCSCiuc010hvo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358260 mRNA. Translation: AAQ88627.1.
CH471052 Genomic DNA. Translation: EAW78784.1.
CCDSiCCDS43161.1.
RefSeqiNP_001116700.1. NM_001123228.1.
UniGeneiHs.632562.

3D structure databases

ProteinModelPortaliQ6UXP3.
SMRiQ6UXP3. Positions 4-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386163.

Polymorphism and mutation databases

BioMutaiTMEM14E.
DMDMi74738233.

Proteomic databases

PaxDbiQ6UXP3.
PRIDEiQ6UXP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408960; ENSP00000386163; ENSG00000221962.
GeneIDi645843.
KEGGihsa:645843.
UCSCiuc010hvo.3. human.

Organism-specific databases

CTDi645843.
GeneCardsiGC03M152057.
HGNCiHGNC:34386. TMEM14E.
HPAiHPA014550.
neXtProtiNX_Q6UXP3.
PharmGKBiPA162405891.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG240787.
HOGENOMiHOG000211932.
HOVERGENiHBG066645.
InParanoidiQ6UXP3.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ6UXP3.

Miscellaneous databases

GenomeRNAii645843.
NextBioi118033.
PROiQ6UXP3.

Gene expression databases

BgeeiQ6UXP3.
CleanExiHS_TMEM14E.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM14E_HUMAN
AccessioniPrimary (citable) accession number: Q6UXP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.