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Q6UXP3

- TM14E_HUMAN

UniProt

Q6UXP3 - TM14E_HUMAN

Protein

Transmembrane protein 14E

Gene

TMEM14E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 14E
    Gene namesi
    Name:TMEM14E
    ORF Names:UNQ9344/PRO34067
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:34386. TMEM14E.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405891.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 125125Transmembrane protein 14EPRO_0000348435Add
    BLAST

    Proteomic databases

    PaxDbiQ6UXP3.
    PRIDEiQ6UXP3.

    Expressioni

    Gene expression databases

    BgeeiQ6UXP3.
    CleanExiHS_TMEM14E.
    GenevestigatoriQ6UXP3.

    Organism-specific databases

    HPAiHPA014550.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXP3.
    SMRiQ6UXP3. Positions 4-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0136 (TMEM14) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240787.
    HOGENOMiHOG000211932.
    HOVERGENiHBG066645.
    OMAiHEWEYEA.
    OrthoDBiEOG7NKKP0.
    PhylomeDBiQ6UXP3.

    Family and domain databases

    InterProiIPR005349. UPF0136_TM.
    [Graphical view]
    PANTHERiPTHR12668. PTHR12668. 1 hit.
    PfamiPF03647. Tmemb_14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UXP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG    50
    LDASQPSRNP KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV 100
    SKLGSMYGEQ ILSVVAMSQL GLMKN 125
    Length:125
    Mass (Da):13,608
    Last modified:July 5, 2004 - v1
    Checksum:iB341C0F9501B65CE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821L → P.
    Corresponds to variant rs13077912 [ dbSNP | Ensembl ].
    VAR_046161

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358260 mRNA. Translation: AAQ88627.1.
    CH471052 Genomic DNA. Translation: EAW78784.1.
    CCDSiCCDS43161.1.
    RefSeqiNP_001116700.1. NM_001123228.1.
    UniGeneiHs.632562.

    Genome annotation databases

    EnsembliENST00000408960; ENSP00000386163; ENSG00000221962.
    GeneIDi645843.
    KEGGihsa:645843.
    UCSCiuc010hvo.3. human.

    Polymorphism databases

    DMDMi74738233.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358260 mRNA. Translation: AAQ88627.1 .
    CH471052 Genomic DNA. Translation: EAW78784.1 .
    CCDSi CCDS43161.1.
    RefSeqi NP_001116700.1. NM_001123228.1.
    UniGenei Hs.632562.

    3D structure databases

    ProteinModelPortali Q6UXP3.
    SMRi Q6UXP3. Positions 4-61.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74738233.

    Proteomic databases

    PaxDbi Q6UXP3.
    PRIDEi Q6UXP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408960 ; ENSP00000386163 ; ENSG00000221962 .
    GeneIDi 645843.
    KEGGi hsa:645843.
    UCSCi uc010hvo.3. human.

    Organism-specific databases

    CTDi 645843.
    GeneCardsi GC03M152057.
    HGNCi HGNC:34386. TMEM14E.
    HPAi HPA014550.
    neXtProti NX_Q6UXP3.
    PharmGKBi PA162405891.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240787.
    HOGENOMi HOG000211932.
    HOVERGENi HBG066645.
    OMAi HEWEYEA.
    OrthoDBi EOG7NKKP0.
    PhylomeDBi Q6UXP3.

    Miscellaneous databases

    NextBioi 118033.
    PROi Q6UXP3.

    Gene expression databases

    Bgeei Q6UXP3.
    CleanExi HS_TMEM14E.
    Genevestigatori Q6UXP3.

    Family and domain databases

    InterProi IPR005349. UPF0136_TM.
    [Graphical view ]
    PANTHERi PTHR12668. PTHR12668. 1 hit.
    Pfami PF03647. Tmemb_14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTM14E_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3