Q6UXP3 (TM14E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 14E

Gene names

Name:	TMEM14E
ORF Names:	UNQ9344/PRO34067

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0136 (TMEM14) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Transmembrane protein 14E		PRO_0000348435
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	81 – 101	21	Helical; Potential
Natural variations
	Natural variant	82	1	L → P. Corresponds to variant rs13077912 [ dbSNP | Ensembl ].		VAR_046161

Sequences

	Sequence		Length	Mass (Da)
	Q6UXP3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B341C0F9501B65CE	FASTA	125	13,608
	10 20 30 40 50 60 MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG LDASQPSRNP 70 80 90 100 110 120 KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV SKLGSMYGEQ ILSVVAMSQL GLMKN

References

[1]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

[2]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358260 mRNA. Translation: AAQ88627.1. CH471052 Genomic DNA. Translation: EAW78784.1.
IPI	IPI00414798.
RefSeq	NP_001116700.1. NM_001123228.1.
UniGene	Hs.632562.
3D structure databases
ProteinModelPortal	Q6UXP3.
ModBase	Search...
Polymorphism databases
DMDM	74738233.
Proteomic databases
PaxDb	Q6UXP3.
PRIDE	Q6UXP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408960; ENSP00000386163; ENSG00000221962.
GeneID	645843.
KEGG	hsa:645843.
UCSC	uc010hvo.3. human.
Organism-specific databases
CTD	645843.
GeneCards	GC03M152057.
HGNC	HGNC:34386. TMEM14E.
HPA	HPA014550.
neXtProt	NX_Q6UXP3.
PharmGKB	PA162405891.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240787.
HOGENOM	HOG000211932.
HOVERGEN	HBG066645.
PhylomeDB	Q6UXP3.
Gene expression databases
Bgee	Q6UXP3.
CleanEx	HS_TMEM14E.
Genevestigator	Q6UXP3.
Family and domain databases
InterPro	IPR005349. UPF0136_TM. [Graphical view]
Pfam	PF03647. Tmemb_14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	118033.

Entry information

Entry name

TM14E_HUMAN

Accession

Primary (citable) accession number: Q6UXP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.