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Q6UXP3 (TM14E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 14E
Gene names
Name:TMEM14E
ORF Names:UNQ9344/PRO34067
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the UPF0136 (TMEM14) family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125Transmembrane protein 14E
PRO_0000348435

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane81 – 10121Helical; Potential

Natural variations

Natural variant821L → P.
Corresponds to variant rs13077912 [ dbSNP | Ensembl ].
VAR_046161

Sequences

Sequence LengthMass (Da)Tools
Q6UXP3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B341C0F9501B65CE

FASTA12513,608
        10         20         30         40         50         60 
MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG LDASQPSRNP 

        70         80         90        100        110        120 
KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV SKLGSMYGEQ ILSVVAMSQL 


GLMKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358260 mRNA. Translation: AAQ88627.1.
CH471052 Genomic DNA. Translation: EAW78784.1.
RefSeqNP_001116700.1. NM_001123228.1.
UniGeneHs.632562.

3D structure databases

ProteinModelPortalQ6UXP3.
SMRQ6UXP3. Positions 4-61.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74738233.

Proteomic databases

PaxDbQ6UXP3.
PRIDEQ6UXP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408960; ENSP00000386163; ENSG00000221962.
GeneID645843.
KEGGhsa:645843.
UCSCuc010hvo.3. human.

Organism-specific databases

CTD645843.
GeneCardsGC03M152057.
HGNCHGNC:34386. TMEM14E.
HPAHPA014550.
neXtProtNX_Q6UXP3.
PharmGKBPA162405891.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240787.
HOGENOMHOG000211932.
HOVERGENHBG066645.
OrthoDBEOG7NKKP0.
PhylomeDBQ6UXP3.

Gene expression databases

BgeeQ6UXP3.
CleanExHS_TMEM14E.
GenevestigatorQ6UXP3.

Family and domain databases

InterProIPR005349. UPF0136_TM.
[Graphical view]
PANTHERPTHR12668. PTHR12668. 1 hit.
PfamPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio118033.
PROQ6UXP3.

Entry information

Entry nameTM14E_HUMAN
AccessionPrimary (citable) accession number: Q6UXP3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM