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Protein

WD repeat-containing protein 82

Gene

WDR82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.3 Publications

Caution

The gene encoding this protein shares one overlapping exon with TMEM113.Curated

GO - Molecular functioni

GO - Biological processi

  • histone H3-K4 methylation Source: UniProtKB
  • histone H3-K4 trimethylation Source: GO_Central

Enzyme and pathway databases

SignaLinkiQ6UXN9

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 82
Alternative name(s):
Protein TMEM113
Swd2
Gene namesi
Name:WDR82
Synonyms:TMEM113, WDR82A
ORF Names:UNQ9342/PRO34047
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000164091.11
HGNCiHGNC:28826 WDR82
MIMi611059 gene
neXtProtiNX_Q6UXN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164091
PharmGKBiPA142670585

Polymorphism and mutation databases

BioMutaiWDR82
DMDMi74758580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002796851 – 313WD repeat-containing protein 82Add BLAST313

Proteomic databases

EPDiQ6UXN9
MaxQBiQ6UXN9
PaxDbiQ6UXN9
PeptideAtlasiQ6UXN9
PRIDEiQ6UXN9

PTM databases

iPTMnetiQ6UXN9
PhosphoSitePlusiQ6UXN9
SwissPalmiQ6UXN9

Expressioni

Gene expression databases

BgeeiENSG00000164091
CleanExiHS_WDR82
ExpressionAtlasiQ6UXN9 baseline and differential
GenevisibleiQ6UXN9 HS

Organism-specific databases

HPAiHPA040427

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.6 Publications

Protein-protein interaction databases

BioGridi123245, 58 interactors
CORUMiQ6UXN9
IntActiQ6UXN9, 26 interactors
MINTiQ6UXN9
STRINGi9606.ENSP00000296490

Structurei

3D structure databases

ProteinModelPortaliQ6UXN9
SMRiQ6UXN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 58WD 1Add BLAST40
Repeati105 – 144WD 2Add BLAST40
Repeati146 – 184WD 3Add BLAST39
Repeati192 – 231WD 4Add BLAST40
Repeati236 – 276WD 5Add BLAST41
Repeati280 – 313WD 6Add BLAST34

Sequence similaritiesi

Belongs to the WD repeat SWD2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1446 Eukaryota
ENOG410XT9X LUCA
GeneTreeiENSGT00530000063965
HOGENOMiHOG000176477
HOVERGENiHBG089149
InParanoidiQ6UXN9
KOiK14962
OMAiCVLNGDH
OrthoDBiEOG091G0BWK
PhylomeDBiQ6UXN9
TreeFamiTF313497

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037846 WDR82
PANTHERiPTHR19861:SF2 PTHR19861:SF2, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6UXN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC
60 70 80 90 100
QEGKPKRTLY SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI
110 120 130 140 150
RYFPGHSKRV VALSMSPVDD TFISGSLDKT IRLWDLRSPN CQGLMHLQGK
160 170 180 190 200
PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD KGPFATFKMQ YDRTCEWTGL
210 220 230 240 250
KFSNDGKLIL ISTNGSFIRL IDAFKGVVMH TFGGYANSKA VTLEASFTPD
260 270 280 290 300
SQFIMIGSED GKIHVWNGES GIKVAVLDGK HTGPITCLQF NPKFMTFASA
310
CSNMAFWLPT IDD
Length:313
Mass (Da):35,079
Last modified:July 5, 2004 - v1
Checksum:iFD3505A9B89863A0
GO

Sequence cautioni

The sequence BAB85039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358264 mRNA Translation: AAQ88631.1
AK074290 mRNA Translation: BAB85039.1 Different initiation.
AK291380 mRNA Translation: BAF84069.1
CH471055 Genomic DNA Translation: EAW65202.1
CCDSiCCDS2851.2
RefSeqiNP_079498.2, NM_025222.3
UniGeneiHs.194110

Genome annotation databases

EnsembliENST00000296490; ENSP00000296490; ENSG00000164091
GeneIDi80335
KEGGihsa:80335
UCSCiuc003ddl.3 human

Similar proteinsi

Entry informationi

Entry nameiWDR82_HUMAN
AccessioniPrimary (citable) accession number: Q6UXN9
Secondary accession number(s): A8K5R5, Q8TEB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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