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Q6UXN9

- WDR82_HUMAN

UniProt

Q6UXN9 - WDR82_HUMAN

Protein

WD repeat-containing protein 82

Gene

WDR82

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.3 Publications

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. histone H3-K4 methylation Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiQ6UXN9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 82
    Alternative name(s):
    Protein TMEM113
    Swd2
    Gene namesi
    Name:WDR82
    Synonyms:TMEM113, WDR82A
    ORF Names:UNQ9342/PRO34047
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28826. WDR82.

    Subcellular locationi

    Nucleus 3 Publications
    Note: Associates with chromatin.

    GO - Cellular componenti

    1. chromatin Source: UniProtKB
    2. histone methyltransferase complex Source: UniProtKB
    3. PTW/PP1 phosphatase complex Source: UniProtKB
    4. Set1C/COMPASS complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670585.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313WD repeat-containing protein 82PRO_0000279685Add
    BLAST

    Proteomic databases

    MaxQBiQ6UXN9.
    PaxDbiQ6UXN9.
    PeptideAtlasiQ6UXN9.
    PRIDEiQ6UXN9.

    PTM databases

    PhosphoSiteiQ6UXN9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UXN9.
    BgeeiQ6UXN9.
    CleanExiHS_WDR82.
    GenevestigatoriQ6UXN9.

    Interactioni

    Subunit structurei

    Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.6 Publications

    Protein-protein interaction databases

    BioGridi123245. 44 interactions.
    IntActiQ6UXN9. 19 interactions.
    MINTiMINT-4779947.
    STRINGi9606.ENSP00000296490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXN9.
    SMRiQ6UXN9. Positions 8-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati19 – 5840WD 1Add
    BLAST
    Repeati105 – 14440WD 2Add
    BLAST
    Repeati146 – 18439WD 3Add
    BLAST
    Repeati192 – 23140WD 4Add
    BLAST
    Repeati236 – 27641WD 5Add
    BLAST
    Repeati280 – 31334WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat SWD2 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000176477.
    HOVERGENiHBG089149.
    InParanoidiQ6UXN9.
    KOiK14962.
    OMAiKECDWTG.
    OrthoDBiEOG79GT6W.
    PhylomeDBiQ6UXN9.
    TreeFamiTF313497.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UXN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC    50
    QEGKPKRTLY SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI 100
    RYFPGHSKRV VALSMSPVDD TFISGSLDKT IRLWDLRSPN CQGLMHLQGK 150
    PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD KGPFATFKMQ YDRTCEWTGL 200
    KFSNDGKLIL ISTNGSFIRL IDAFKGVVMH TFGGYANSKA VTLEASFTPD 250
    SQFIMIGSED GKIHVWNGES GIKVAVLDGK HTGPITCLQF NPKFMTFASA 300
    CSNMAFWLPT IDD 313
    Length:313
    Mass (Da):35,079
    Last modified:July 5, 2004 - v1
    Checksum:iFD3505A9B89863A0
    GO

    Sequence cautioni

    The sequence BAB85039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358264 mRNA. Translation: AAQ88631.1.
    AK074290 mRNA. Translation: BAB85039.1. Different initiation.
    AK291380 mRNA. Translation: BAF84069.1.
    CH471055 Genomic DNA. Translation: EAW65202.1.
    CCDSiCCDS2851.2.
    RefSeqiNP_079498.2. NM_025222.3.
    UniGeneiHs.194110.

    Genome annotation databases

    EnsembliENST00000296490; ENSP00000296490; ENSG00000164091.
    GeneIDi80335.
    KEGGihsa:80335.
    UCSCiuc003ddk.2. human.

    Polymorphism databases

    DMDMi74758580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358264 mRNA. Translation: AAQ88631.1 .
    AK074290 mRNA. Translation: BAB85039.1 . Different initiation.
    AK291380 mRNA. Translation: BAF84069.1 .
    CH471055 Genomic DNA. Translation: EAW65202.1 .
    CCDSi CCDS2851.2.
    RefSeqi NP_079498.2. NM_025222.3.
    UniGenei Hs.194110.

    3D structure databases

    ProteinModelPortali Q6UXN9.
    SMRi Q6UXN9. Positions 8-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123245. 44 interactions.
    IntActi Q6UXN9. 19 interactions.
    MINTi MINT-4779947.
    STRINGi 9606.ENSP00000296490.

    PTM databases

    PhosphoSitei Q6UXN9.

    Polymorphism databases

    DMDMi 74758580.

    Proteomic databases

    MaxQBi Q6UXN9.
    PaxDbi Q6UXN9.
    PeptideAtlasi Q6UXN9.
    PRIDEi Q6UXN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296490 ; ENSP00000296490 ; ENSG00000164091 .
    GeneIDi 80335.
    KEGGi hsa:80335.
    UCSCi uc003ddk.2. human.

    Organism-specific databases

    CTDi 80335.
    GeneCardsi GC03M052265.
    HGNCi HGNC:28826. WDR82.
    MIMi 611059. gene.
    neXtProti NX_Q6UXN9.
    PharmGKBi PA142670585.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000176477.
    HOVERGENi HBG089149.
    InParanoidi Q6UXN9.
    KOi K14962.
    OMAi KECDWTG.
    OrthoDBi EOG79GT6W.
    PhylomeDBi Q6UXN9.
    TreeFami TF313497.

    Enzyme and pathway databases

    SignaLinki Q6UXN9.

    Miscellaneous databases

    ChiTaRSi WDR82. human.
    GenomeRNAii 80335.
    NextBioi 70900.
    PROi Q6UXN9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UXN9.
    Bgeei Q6UXN9.
    CleanExi HS_WDR82.
    Genevestigatori Q6UXN9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Hepatoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."
      Lee J.-H., Skalnik D.G.
      J. Biol. Chem. 280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE SET1 COMPLEX.
    5. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."
      Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.
      Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CUL4B.
    6. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
      Lee J.-H., Tate C.M., You J.-S., Skalnik D.G.
      J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN SET1 COMPLEX.
    7. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
      Lee J.H., Skalnik D.G.
      Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH SETD1A; SETD1B; POLR2A AND POLR2B.
    8. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
      Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A.
      Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH RBBP5.
    9. "Identification and characterization of a novel human PP1 phosphatase complex."
      Lee J.H., You J., Dobrota E., Skalnik D.G.
      J. Biol. Chem. 285:24466-24476(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE PTW/PP1 PHOSPHATASE COMPLEX, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP1CA AND PPP1R10/PNUTS.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR82_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXN9
    Secondary accession number(s): A8K5R5, Q8TEB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The gene encoding this protein shares one overlapping exon with TMEM113.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3