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Q6UXN9

- WDR82_HUMAN

UniProt

Q6UXN9 - WDR82_HUMAN

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Protein

WD repeat-containing protein 82

Gene
WDR82, TMEM113, WDR82A, UNQ9342/PRO34047
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. histone H3-K4 methylation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6UXN9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 82
Alternative name(s):
Protein TMEM113
Swd2
Gene namesi
Name:WDR82
Synonyms:TMEM113, WDR82A
ORF Names:UNQ9342/PRO34047
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28826. WDR82.

Subcellular locationi

Nucleus
Note: Associates with chromatin.3 Publications

GO - Cellular componenti

  1. chromatin Source: UniProtKB
  2. histone methyltransferase complex Source: UniProtKB
  3. PTW/PP1 phosphatase complex Source: UniProtKB
  4. Set1C/COMPASS complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313WD repeat-containing protein 82PRO_0000279685Add
BLAST

Proteomic databases

MaxQBiQ6UXN9.
PaxDbiQ6UXN9.
PeptideAtlasiQ6UXN9.
PRIDEiQ6UXN9.

PTM databases

PhosphoSiteiQ6UXN9.

Expressioni

Gene expression databases

ArrayExpressiQ6UXN9.
BgeeiQ6UXN9.
CleanExiHS_WDR82.
GenevestigatoriQ6UXN9.

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.6 Publications

Protein-protein interaction databases

BioGridi123245. 44 interactions.
IntActiQ6UXN9. 19 interactions.
MINTiMINT-4779947.
STRINGi9606.ENSP00000296490.

Structurei

3D structure databases

ProteinModelPortaliQ6UXN9.
SMRiQ6UXN9. Positions 8-300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 5840WD 1Add
BLAST
Repeati105 – 14440WD 2Add
BLAST
Repeati146 – 18439WD 3Add
BLAST
Repeati192 – 23140WD 4Add
BLAST
Repeati236 – 27641WD 5Add
BLAST
Repeati280 – 31334WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SWD2 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000176477.
HOVERGENiHBG089149.
InParanoidiQ6UXN9.
KOiK14962.
OMAiKECDWTG.
OrthoDBiEOG79GT6W.
PhylomeDBiQ6UXN9.
TreeFamiTF313497.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UXN9-1 [UniParc]FASTAAdd to Basket

« Hide

MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC    50
QEGKPKRTLY SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI 100
RYFPGHSKRV VALSMSPVDD TFISGSLDKT IRLWDLRSPN CQGLMHLQGK 150
PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD KGPFATFKMQ YDRTCEWTGL 200
KFSNDGKLIL ISTNGSFIRL IDAFKGVVMH TFGGYANSKA VTLEASFTPD 250
SQFIMIGSED GKIHVWNGES GIKVAVLDGK HTGPITCLQF NPKFMTFASA 300
CSNMAFWLPT IDD 313
Length:313
Mass (Da):35,079
Last modified:July 5, 2004 - v1
Checksum:iFD3505A9B89863A0
GO

Sequence cautioni

The sequence BAB85039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358264 mRNA. Translation: AAQ88631.1.
AK074290 mRNA. Translation: BAB85039.1. Different initiation.
AK291380 mRNA. Translation: BAF84069.1.
CH471055 Genomic DNA. Translation: EAW65202.1.
CCDSiCCDS2851.2.
RefSeqiNP_079498.2. NM_025222.3.
UniGeneiHs.194110.

Genome annotation databases

EnsembliENST00000296490; ENSP00000296490; ENSG00000164091.
GeneIDi80335.
KEGGihsa:80335.
UCSCiuc003ddk.2. human.

Polymorphism databases

DMDMi74758580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358264 mRNA. Translation: AAQ88631.1 .
AK074290 mRNA. Translation: BAB85039.1 . Different initiation.
AK291380 mRNA. Translation: BAF84069.1 .
CH471055 Genomic DNA. Translation: EAW65202.1 .
CCDSi CCDS2851.2.
RefSeqi NP_079498.2. NM_025222.3.
UniGenei Hs.194110.

3D structure databases

ProteinModelPortali Q6UXN9.
SMRi Q6UXN9. Positions 8-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123245. 44 interactions.
IntActi Q6UXN9. 19 interactions.
MINTi MINT-4779947.
STRINGi 9606.ENSP00000296490.

PTM databases

PhosphoSitei Q6UXN9.

Polymorphism databases

DMDMi 74758580.

Proteomic databases

MaxQBi Q6UXN9.
PaxDbi Q6UXN9.
PeptideAtlasi Q6UXN9.
PRIDEi Q6UXN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296490 ; ENSP00000296490 ; ENSG00000164091 .
GeneIDi 80335.
KEGGi hsa:80335.
UCSCi uc003ddk.2. human.

Organism-specific databases

CTDi 80335.
GeneCardsi GC03M052265.
HGNCi HGNC:28826. WDR82.
MIMi 611059. gene.
neXtProti NX_Q6UXN9.
PharmGKBi PA142670585.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000176477.
HOVERGENi HBG089149.
InParanoidi Q6UXN9.
KOi K14962.
OMAi KECDWTG.
OrthoDBi EOG79GT6W.
PhylomeDBi Q6UXN9.
TreeFami TF313497.

Enzyme and pathway databases

SignaLinki Q6UXN9.

Miscellaneous databases

ChiTaRSi WDR82. human.
GenomeRNAii 80335.
NextBioi 70900.
PROi Q6UXN9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UXN9.
Bgeei Q6UXN9.
CleanExi HS_WDR82.
Genevestigatori Q6UXN9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Hepatoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."
    Lee J.-H., Skalnik D.G.
    J. Biol. Chem. 280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE SET1 COMPLEX.
  5. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."
    Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.
    Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CUL4B.
  6. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
    Lee J.-H., Tate C.M., You J.-S., Skalnik D.G.
    J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN SET1 COMPLEX.
  7. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
    Lee J.H., Skalnik D.G.
    Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH SETD1A; SETD1B; POLR2A AND POLR2B.
  8. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
    Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A.
    Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH RBBP5.
  9. "Identification and characterization of a novel human PP1 phosphatase complex."
    Lee J.H., You J., Dobrota E., Skalnik D.G.
    J. Biol. Chem. 285:24466-24476(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PTW/PP1 PHOSPHATASE COMPLEX, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP1CA AND PPP1R10/PNUTS.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR82_HUMAN
AccessioniPrimary (citable) accession number: Q6UXN9
Secondary accession number(s): A8K5R5, Q8TEB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The gene encoding this protein shares one overlapping exon with TMEM113.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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