CLEC9A

Functionⁱ

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.2 Publications

GO - Molecular functionⁱ

carbohydrate binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

Complete GO annotation...

Keywordsⁱ

Molecular function	Receptor
Biological process	Endocytosis
Ligand	Lectin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-type lectin domain family 9 member A
Gene namesⁱ	Name:CLEC9A ORF Names:UNQ9341/PRO34046
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26705. CLEC9A.

HGNCⁱ

HGNC:26705. CLEC9A.

Subcellular locationⁱ

Membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes."
  Huysamen C., Willment J.A., Dennehy K.M., Brown G.D.
  J. Biol. Chem. 283:16693-16701(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
; Single-pass type II membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes."
  Huysamen C., Willment J.A., Dennehy K.M., Brown G.D.
  J. Biol. Chem. 283:16693-16701(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 35	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	36 – 56	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	57 – 241	ExtracellularSequence analysisAdd BLAST	185

GO - Cellular componentⁱ

cell surface
Source: UniProtKB
Inferred from direct assayⁱ
- 18408006
integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	131	W → A: Abolishes binding to damaged cells; when associated with A-227. 1 Publication		1
Mutagenesisⁱ	227	W → A: Abolishes binding to damaged cells; when associated with A-131. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283420.
Open Targets More...OpenTargetsⁱ	ENSG00000197992.
PharmGKBⁱ	PA142672093.

Polymorphism and mutation databases

BioMutaⁱ	CLEC9A.
DMDMⁱ	73917794.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046637	1 – 241	C-type lectin domain family 9 member AAdd BLAST		241

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	113 ↔ 124	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	141 ↔ 232	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	211 ↔ 224	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	223	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q6UXN8.
PRIDEⁱ	Q6UXN8.

PTM databases

iPTMnetⁱ	Q6UXN8.
PhosphoSitePlusⁱ	Q6UXN8.

Expressionⁱ

Tissue specificityⁱ

In peripheral blood highly restricted on the surface of BDCA31⁺ dendritic cells and on a small subset of CD14⁺ and CD16^- monocytes.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000197992.
CleanExⁱ	HS_CLEC9A.

Interactionⁱ

Subunit structureⁱ

Homodimer.2 Publications

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000348074.

STRINGⁱ

9606.ENSP00000348074.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	118 – 120	Combined sources	3
Beta strandⁱ	123 – 127	Combined sources	5
Helixⁱ	134 – 143	Combined sources	10
Helixⁱ	154 – 164	Combined sources	11
Beta strandⁱ	167 – 169	Combined sources	3
Beta strandⁱ	172 – 179	Combined sources	8
Turnⁱ	181 – 183	Combined sources	3
Beta strandⁱ	186 – 188	Combined sources	3
Beta strandⁱ	210 – 215	Combined sources	6
Beta strandⁱ	218 – 226	Combined sources	9
Beta strandⁱ	228 – 235	Combined sources	8

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3VPP	X-ray	1.64	A/B	110-241	[»]
ProteinModelPortalⁱ	Q6UXN8.
SMRⁱ	Q6UXN8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	120 – 233	C-type lectinPROSITE-ProRule annotationAdd BLAST		114

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	5 – 10	ITAM-like		6

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4297. Eukaryota. ENOG410XPJ1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104266.
HOGENOMⁱ	HOG000048721.
HOVERGENⁱ	HBG056591.
InParanoidⁱ	Q6UXN8.
KEGG Orthology (KO) More...KOⁱ	K17515.
OMAⁱ	DYWVGLS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CXT.
PhylomeDBⁱ	Q6UXN8.
TreeFamⁱ	TF336674.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03593. CLECT_NK_receptors_like. 1 hit.
Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001304. C-type_lectin-like. IPR016186. C-type_lectin-like/link. IPR018378. C-type_lectin_CS. IPR016187. CTDL_fold. IPR033992. NKR-like_CTLD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059. Lectin_C. 1 hit.
SMARTⁱ	View protein in SMART SM00034. CLECT. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6UXN8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA 
        60         70         80         90        100
SIFLGVKLLQ VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM 
       110        120        130        140        150
QNSLSSAHNS SPCPNNWIQN RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ 
       160        170        180        190        200
IESKEEMDFI TGSLRKIKGS YDYWVGLSQD GHSGRWLWQD GSSPSPGLLP 
       210        220        230        240 
AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V

Length:241

Mass (Da):27,324

Last modified:July 5, 2004 - v1

Checksum:ⁱ6158B3AC44EEC9C3

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050112	107	A → G. Corresponds to variant dbSNP:rs11831360Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU339276 mRNA. Translation: ABZ04557.1. AY358265 mRNA. Translation: AAQ88632.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8611.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_997228.1. NM_207345.3.
UniGeneⁱ	Hs.531189.

Genome annotation databases

Ensemblⁱ	ENST00000355819; ENSP00000348074; ENSG00000197992.
GeneIDⁱ	283420.
KEGGⁱ	hsa:283420.
UCSC genome browser More...UCSCⁱ	uc001qxa.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU339276 mRNA. Translation: ABZ04557.1. AY358265 mRNA. Translation: AAQ88632.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8611.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_997228.1. NM_207345.3.
UniGeneⁱ	Hs.531189.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3VPP	X-ray	1.64	A/B	110-241	[»]
ProteinModelPortalⁱ	Q6UXN8.
SMRⁱ	Q6UXN8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000348074.

STRINGⁱ

9606.ENSP00000348074.

PTM databases

iPTMnetⁱ	Q6UXN8.
PhosphoSitePlusⁱ	Q6UXN8.

Polymorphism and mutation databases

BioMutaⁱ	CLEC9A.
DMDMⁱ	73917794.

Proteomic databases

PaxDbⁱ	Q6UXN8.
PRIDEⁱ	Q6UXN8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000355819; ENSP00000348074; ENSG00000197992.
GeneIDⁱ	283420.
KEGGⁱ	hsa:283420.
UCSC genome browser More...UCSCⁱ	uc001qxa.4. human.

Organism-specific databases

CTDⁱ	283420.
DisGeNET More...DisGeNETⁱ	283420.
GeneCardsⁱ	CLEC9A.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26705. CLEC9A.
MIMⁱ	612252. gene.
neXtProtⁱ	NX_Q6UXN8.
Open Targets More...OpenTargetsⁱ	ENSG00000197992.
PharmGKBⁱ	PA142672093.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4297. Eukaryota. ENOG410XPJ1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104266.
HOGENOMⁱ	HOG000048721.
HOVERGENⁱ	HBG056591.
InParanoidⁱ	Q6UXN8.
KEGG Orthology (KO) More...KOⁱ	K17515.
OMAⁱ	DYWVGLS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CXT.
PhylomeDBⁱ	Q6UXN8.
TreeFamⁱ	TF336674.

Miscellaneous databases

GenomeRNAiⁱ	283420.
Protein Ontology More...PROⁱ	PR:Q6UXN8.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197992.
CleanExⁱ	HS_CLEC9A.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03593. CLECT_NK_receptors_like. 1 hit.
Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001304. C-type_lectin-like. IPR016186. C-type_lectin-like/link. IPR018378. C-type_lectin_CS. IPR016187. CTDL_fold. IPR033992. NKR-like_CTLD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059. Lectin_C. 1 hit.
SMARTⁱ	View protein in SMART SM00034. CLECT. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLC9A_HUMAN
Accessionⁱ	Q6UXN8Primary (citable) accession number: Q6UXN8 Secondary accession number(s): B0ZBM2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	July 5, 2004
	Last modified:	May 10, 2017
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6UXN8 (CLC9A_HUMAN)

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C-type lectin domain family 9 member A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ