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Protein

C-type lectin domain family 9 member A

Gene

CLEC9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cytokine secretion Source: UniProtKB
  • receptor-mediated endocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-30775-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 9 member A
Gene namesi
Name:CLEC9A
ORF Names:UNQ9341/PRO34046
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26705. CLEC9A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 241ExtracellularSequence analysisAdd BLAST185

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131W → A: Abolishes binding to damaged cells; when associated with A-227. 1 Publication1
Mutagenesisi227W → A: Abolishes binding to damaged cells; when associated with A-131. 1 Publication1

Organism-specific databases

DisGeNETi283420.
OpenTargetsiENSG00000197992.
PharmGKBiPA142672093.

Polymorphism and mutation databases

BioMutaiCLEC9A.
DMDMi73917794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466371 – 241C-type lectin domain family 9 member AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 124PROSITE-ProRule annotation1 Publication
Disulfide bondi141 ↔ 232PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 224PROSITE-ProRule annotation1 Publication
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXN8.
PRIDEiQ6UXN8.

PTM databases

iPTMnetiQ6UXN8.
PhosphoSitePlusiQ6UXN8.

Expressioni

Tissue specificityi

In peripheral blood highly restricted on the surface of BDCA31+ dendritic cells and on a small subset of CD14+ and CD16- monocytes.2 Publications

Gene expression databases

BgeeiENSG00000197992.
CleanExiHS_CLEC9A.

Organism-specific databases

HPAiCAB037055.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000348074.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi118 – 120Combined sources3
Beta strandi123 – 127Combined sources5
Helixi134 – 143Combined sources10
Helixi154 – 164Combined sources11
Beta strandi167 – 169Combined sources3
Beta strandi172 – 179Combined sources8
Turni181 – 183Combined sources3
Beta strandi186 – 188Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi218 – 226Combined sources9
Beta strandi228 – 235Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VPPX-ray1.64A/B110-241[»]
ProteinModelPortaliQ6UXN8.
SMRiQ6UXN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 233C-type lectinPROSITE-ProRule annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITAM-like6

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000048721.
HOVERGENiHBG056591.
InParanoidiQ6UXN8.
KOiK17515.
OMAiDYWVGLS.
OrthoDBiEOG091G0CXT.
PhylomeDBiQ6UXN8.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UXN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA
60 70 80 90 100
SIFLGVKLLQ VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM
110 120 130 140 150
QNSLSSAHNS SPCPNNWIQN RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ
160 170 180 190 200
IESKEEMDFI TGSLRKIKGS YDYWVGLSQD GHSGRWLWQD GSSPSPGLLP
210 220 230 240
AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V
Length:241
Mass (Da):27,324
Last modified:July 5, 2004 - v1
Checksum:i6158B3AC44EEC9C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050112107A → G.Corresponds to variant rs11831360dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU339276 mRNA. Translation: ABZ04557.1.
AY358265 mRNA. Translation: AAQ88632.1.
CCDSiCCDS8611.1.
RefSeqiNP_997228.1. NM_207345.3.
UniGeneiHs.531189.

Genome annotation databases

EnsembliENST00000355819; ENSP00000348074; ENSG00000197992.
GeneIDi283420.
KEGGihsa:283420.
UCSCiuc001qxa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU339276 mRNA. Translation: ABZ04557.1.
AY358265 mRNA. Translation: AAQ88632.1.
CCDSiCCDS8611.1.
RefSeqiNP_997228.1. NM_207345.3.
UniGeneiHs.531189.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VPPX-ray1.64A/B110-241[»]
ProteinModelPortaliQ6UXN8.
SMRiQ6UXN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348074.

PTM databases

iPTMnetiQ6UXN8.
PhosphoSitePlusiQ6UXN8.

Polymorphism and mutation databases

BioMutaiCLEC9A.
DMDMi73917794.

Proteomic databases

PaxDbiQ6UXN8.
PRIDEiQ6UXN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355819; ENSP00000348074; ENSG00000197992.
GeneIDi283420.
KEGGihsa:283420.
UCSCiuc001qxa.4. human.

Organism-specific databases

CTDi283420.
DisGeNETi283420.
GeneCardsiCLEC9A.
HGNCiHGNC:26705. CLEC9A.
HPAiCAB037055.
MIMi612252. gene.
neXtProtiNX_Q6UXN8.
OpenTargetsiENSG00000197992.
PharmGKBiPA142672093.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000048721.
HOVERGENiHBG056591.
InParanoidiQ6UXN8.
KOiK17515.
OMAiDYWVGLS.
OrthoDBiEOG091G0CXT.
PhylomeDBiQ6UXN8.
TreeFamiTF336674.

Enzyme and pathway databases

BioCyciZFISH:G66-30775-MONOMER.

Miscellaneous databases

GenomeRNAii283420.
PROiQ6UXN8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197992.
CleanExiHS_CLEC9A.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC9A_HUMAN
AccessioniPrimary (citable) accession number: Q6UXN8
Secondary accession number(s): B0ZBM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.