UniProtKB - Q6UXN8 (CLC9A_HUMAN)
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Protein
C-type lectin domain family 9 member A
Gene
CLEC9A
Organism
Homo sapiens (Human)
Status
Functioni
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.2 Publications
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of cytokine secretion Source: UniProtKB
- receptor-mediated endocytosis Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 9 member A |
Gene namesi | Name:CLEC9A ORF Names:UNQ9341/PRO34046 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197992.6. |
HGNCi | HGNC:26705. CLEC9A. |
MIMi | 612252. gene. |
neXtProti | NX_Q6UXN8. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 241 | ExtracellularSequence analysisAdd BLAST | 185 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 131 | W → A: Abolishes binding to damaged cells; when associated with A-227. 1 Publication | 1 | |
Mutagenesisi | 227 | W → A: Abolishes binding to damaged cells; when associated with A-131. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 283420. |
OpenTargetsi | ENSG00000197992. |
PharmGKBi | PA142672093. |
Polymorphism and mutation databases
BioMutai | CLEC9A. |
DMDMi | 73917794. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046637 | 1 – 241 | C-type lectin domain family 9 member AAdd BLAST | 241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 113 ↔ 124 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 141 ↔ 232 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 211 ↔ 224 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 223 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6UXN8. |
PRIDEi | Q6UXN8. |
PTM databases
iPTMneti | Q6UXN8. |
PhosphoSitePlusi | Q6UXN8. |
Expressioni
Tissue specificityi
In peripheral blood highly restricted on the surface of BDCA31+ dendritic cells and on a small subset of CD14+ and CD16- monocytes.2 Publications
Gene expression databases
Bgeei | ENSG00000197992. |
CleanExi | HS_CLEC9A. |
Interactioni
Subunit structurei
Homodimer.2 Publications
Protein-protein interaction databases
STRINGi | 9606.ENSP00000348074. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 118 – 120 | Combined sources | 3 | |
Beta strandi | 123 – 127 | Combined sources | 5 | |
Helixi | 134 – 143 | Combined sources | 10 | |
Helixi | 154 – 164 | Combined sources | 11 | |
Beta strandi | 167 – 169 | Combined sources | 3 | |
Beta strandi | 172 – 179 | Combined sources | 8 | |
Turni | 181 – 183 | Combined sources | 3 | |
Beta strandi | 186 – 188 | Combined sources | 3 | |
Beta strandi | 210 – 215 | Combined sources | 6 | |
Beta strandi | 218 – 226 | Combined sources | 9 | |
Beta strandi | 228 – 235 | Combined sources | 8 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3VPP | X-ray | 1.64 | A/B | 110-241 | [»] | |
ProteinModelPortali | Q6UXN8. | |||||
SMRi | Q6UXN8. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 233 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 114 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 10 | ITAM-like | 6 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297. Eukaryota. ENOG410XPJ1. LUCA. |
GeneTreei | ENSGT00700000104266. |
HOGENOMi | HOG000048721. |
HOVERGENi | HBG056591. |
InParanoidi | Q6UXN8. |
KOi | K17515. |
OMAi | DYWVGLS. |
OrthoDBi | EOG091G0CXT. |
PhylomeDBi | Q6UXN8. |
TreeFami | TF336674. |
Family and domain databases
CDDi | cd03593. CLECT_NK_receptors_like. 1 hit. |
Gene3Di | 3.10.100.10. 1 hit. |
InterProi | View protein in InterPro IPR001304. C-type_lectin-like. IPR016186. C-type_lectin-like/link_sf. IPR018378. C-type_lectin_CS. IPR016187. CTDL_fold. IPR033992. NKR-like_CTLD. |
Pfami | View protein in Pfam PF00059. Lectin_C. 1 hit. |
SMARTi | View protein in SMART SM00034. CLECT. 1 hit. |
SUPFAMi | SSF56436. SSF56436. 1 hit. |
PROSITEi | View protein in PROSITE PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6UXN8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA
60 70 80 90 100
SIFLGVKLLQ VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM
110 120 130 140 150
QNSLSSAHNS SPCPNNWIQN RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ
160 170 180 190 200
IESKEEMDFI TGSLRKIKGS YDYWVGLSQD GHSGRWLWQD GSSPSPGLLP
210 220 230 240
AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050112 | 107 | A → G. Corresponds to variant dbSNP:rs11831360Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU339276 mRNA. Translation: ABZ04557.1. AY358265 mRNA. Translation: AAQ88632.1. |
CCDSi | CCDS8611.1. |
RefSeqi | NP_997228.1. NM_207345.3. |
UniGenei | Hs.531189. |
Genome annotation databases
Ensembli | ENST00000355819; ENSP00000348074; ENSG00000197992. |
GeneIDi | 283420. |
KEGGi | hsa:283420. |
UCSCi | uc001qxa.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CLC9A_HUMAN | |
Accessioni | Q6UXN8Primary (citable) accession number: Q6UXN8 Secondary accession number(s): B0ZBM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 28, 2018 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |