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Q6UXM1

- LRIG3_HUMAN

UniProt

Q6UXM1 - LRIG3_HUMAN

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Protein
Leucine-rich repeats and immunoglobulin-like domains protein 3
Gene
LRIG3, LIG3, UNQ287/PRO326/PRO335
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 By similarity.

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name:
LIG-3
Gene namesi
Name:LRIG3
Synonyms:LIG3
ORF Names:UNQ287/PRO326/PRO335
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30991. LRIG3.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity
Note: Detected in cytoplasmic vesicles when coexpressed with ERBB4 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei810 – 83021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. extracellular space Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 11191095Leucine-rich repeats and immunoglobulin-like domains protein 3
PRO_0000014831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi520 ↔ 581 By similarity
Disulfide bondi624 ↔ 676 By similarity
Glycosylationi688 – 6881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi718 ↔ 767 By similarity
Glycosylationi729 – 7291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi905 – 9051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi987 – 9871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi999 – 9991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1016 – 10161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UXM1.
PaxDbiQ6UXM1.
PRIDEiQ6UXM1.

PTM databases

PhosphoSiteiQ6UXM1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ6UXM1.
BgeeiQ6UXM1.
CleanExiHS_LIG3.
HS_LRIG3.
GenevestigatoriQ6UXM1.

Organism-specific databases

HPAiHPA010773.

Interactioni

Subunit structurei

Interacts with EGFR, ERBB2 and ERBB4 (in vitro) By similarity.

Protein-protein interaction databases

BioGridi125712. 1 interaction.
IntActiQ6UXM1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6UXM1.
SMRiQ6UXM1. Positions 45-826.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 7437LRRNT
Add
BLAST
Repeati75 – 9622LRR 1
Add
BLAST
Repeati99 – 12022LRR 2
Add
BLAST
Repeati122 – 14221LRR 3
Add
BLAST
Repeati146 – 16722LRR 4
Add
BLAST
Repeati168 – 18922LRR 5
Add
BLAST
Repeati193 – 21422LRR 6
Add
BLAST
Repeati216 – 23722LRR 7
Add
BLAST
Repeati240 – 26122LRR 8
Add
BLAST
Repeati264 – 28522LRR 9
Add
BLAST
Repeati288 – 30922LRR 10
Add
BLAST
Repeati312 – 33322LRR 11
Add
BLAST
Repeati336 – 35722LRR 12
Add
BLAST
Repeati360 – 38223LRR 13
Add
BLAST
Repeati387 – 40822LRR 14
Add
BLAST
Repeati411 – 43222LRR 15
Add
BLAST
Domaini444 – 49552LRRCT
Add
BLAST
Domaini499 – 598100Ig-like C2-type 1
Add
BLAST
Domaini603 – 69290Ig-like C2-type 2
Add
BLAST
Domaini697 – 78387Ig-like C2-type 3
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiQ6UXM1.
OMAiHQFVTSS.
OrthoDBiEOG7DNNTD.
PhylomeDBiQ6UXM1.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UXM1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT     50
CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL 100
REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL 150
DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN 200
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG 250
VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 300
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI 350
ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS 400
ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC 450
QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ 500
ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA 550
HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 600
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER 650
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL 700
RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ 750
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL 800
DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL 850
PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 900
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP 950
DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT 1000
SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL 1050
DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF 1100
KQTLENYRTP NFQSYDLDT 1119
Length:1,119
Mass (Da):123,434
Last modified:July 5, 2004 - v1
Checksum:iEB3B6A391F3C8713
GO
Isoform 2 (identifier: Q6UXM1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP

Note: No experimental confirmation available.

Show »
Length:1,059
Mass (Da):117,438
Checksum:i757A89BC1E91C20B
GO

Sequence cautioni

The sequence BAC11295.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2.
VSP_015097Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY505340 mRNA. Translation: AAR98629.1.
AY358288 mRNA. Translation: AAQ88655.1.
AY358295 mRNA. Translation: AAQ88662.1.
AK074921 mRNA. Translation: BAC11295.1. Different initiation.
CCDSiCCDS44933.1. [Q6UXM1-2]
CCDS8960.1. [Q6UXM1-1]
RefSeqiNP_001129523.1. NM_001136051.2. [Q6UXM1-2]
NP_700356.2. NM_153377.4. [Q6UXM1-1]
UniGeneiHs.253736.

Genome annotation databases

EnsembliENST00000320743; ENSP00000326759; ENSG00000139263. [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263. [Q6UXM1-2]
GeneIDi121227.
KEGGihsa:121227.
UCSCiuc001sqr.4. human. [Q6UXM1-1]
uc009zqh.3. human. [Q6UXM1-2]

Polymorphism databases

DMDMi73621176.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY505340 mRNA. Translation: AAR98629.1 .
AY358288 mRNA. Translation: AAQ88655.1 .
AY358295 mRNA. Translation: AAQ88662.1 .
AK074921 mRNA. Translation: BAC11295.1 . Different initiation.
CCDSi CCDS44933.1. [Q6UXM1-2 ]
CCDS8960.1. [Q6UXM1-1 ]
RefSeqi NP_001129523.1. NM_001136051.2. [Q6UXM1-2 ]
NP_700356.2. NM_153377.4. [Q6UXM1-1 ]
UniGenei Hs.253736.

3D structure databases

ProteinModelPortali Q6UXM1.
SMRi Q6UXM1. Positions 45-826.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125712. 1 interaction.
IntActi Q6UXM1. 1 interaction.

PTM databases

PhosphoSitei Q6UXM1.

Polymorphism databases

DMDMi 73621176.

Proteomic databases

MaxQBi Q6UXM1.
PaxDbi Q6UXM1.
PRIDEi Q6UXM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320743 ; ENSP00000326759 ; ENSG00000139263 . [Q6UXM1-1 ]
ENST00000379141 ; ENSP00000368436 ; ENSG00000139263 . [Q6UXM1-2 ]
GeneIDi 121227.
KEGGi hsa:121227.
UCSCi uc001sqr.4. human. [Q6UXM1-1 ]
uc009zqh.3. human. [Q6UXM1-2 ]

Organism-specific databases

CTDi 121227.
GeneCardsi GC12M059265.
HGNCi HGNC:30991. LRIG3.
HPAi HPA010773.
MIMi 608870. gene.
neXtProti NX_Q6UXM1.
PharmGKBi PA134864136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000113380.
HOVERGENi HBG052353.
InParanoidi Q6UXM1.
OMAi HQFVTSS.
OrthoDBi EOG7DNNTD.
PhylomeDBi Q6UXM1.
TreeFami TF325380.

Miscellaneous databases

GenomeRNAii 121227.
NextBioi 80680.
PROi Q6UXM1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UXM1.
Bgeei Q6UXM1.
CleanExi HS_LIG3.
HS_LRIG3.
Genevestigatori Q6UXM1.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea."
    Guo D., Holmlund C., Henriksson R., Hedman H.
    Genomics 84:157-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-1119.

Entry informationi

Entry nameiLRIG3_HUMAN
AccessioniPrimary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3