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Q6UXM1 (LRIG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3

Short name=LIG-3
Gene names
Name:LRIG3
Synonyms:LIG3
ORF Names:UNQ287/PRO326/PRO335
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 By similarity.

Subunit structure

Interacts with EGFR, ERBB2 and ERBB4 (in vitro) By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity. Note: Detected in cytoplasmic vesicles when coexpressed with ERBB4 By similarity.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 15 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAC11295.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UXM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UXM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 11191095Leucine-rich repeats and immunoglobulin-like domains protein 3
PRO_0000014831

Regions

Transmembrane810 – 83021Helical; Potential
Domain38 – 7437LRRNT
Repeat75 – 9622LRR 1
Repeat99 – 12022LRR 2
Repeat122 – 14221LRR 3
Repeat146 – 16722LRR 4
Repeat168 – 18922LRR 5
Repeat193 – 21422LRR 6
Repeat216 – 23722LRR 7
Repeat240 – 26122LRR 8
Repeat264 – 28522LRR 9
Repeat288 – 30922LRR 10
Repeat312 – 33322LRR 11
Repeat336 – 35722LRR 12
Repeat360 – 38223LRR 13
Repeat387 – 40822LRR 14
Repeat411 – 43222LRR 15
Domain444 – 49552LRRCT
Domain499 – 598100Ig-like C2-type 1
Domain603 – 69290Ig-like C2-type 2
Domain697 – 78387Ig-like C2-type 3

Amino acid modifications

Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation6881N-linked (GlcNAc...) Potential
Glycosylation7291N-linked (GlcNAc...) Potential
Glycosylation9051N-linked (GlcNAc...) Potential
Glycosylation9871N-linked (GlcNAc...) Potential
Glycosylation9991N-linked (GlcNAc...) Potential
Glycosylation10161N-linked (GlcNAc...) Potential
Disulfide bond520 ↔ 581 By similarity
Disulfide bond624 ↔ 676 By similarity
Disulfide bond718 ↔ 767 By similarity

Natural variations

Alternative sequence1 – 7979MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2.
VSP_015097

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EB3B6A391F3C8713

FASTA1,119123,434
        10         20         30         40         50         60 
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC 

        70         80         90        100        110        120 
SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS 

       130        140        150        160        170        180 
ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT 

       190        200        210        220        230        240 
SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA 

       250        260        270        280        290        300 
LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 

       310        320        330        340        350        360 
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS 

       370        380        390        400        410        420 
LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN 

       430        440        450        460        470        480 
AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG 

       490        500        510        520        530        540 
RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL 

       550        560        570        580        590        600 
LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 

       610        620        630        640        650        660 
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV 

       670        680        690        700        710        720 
FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA 

       730        740        750        760        770        780 
GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV 

       790        800        810        820        830        840 
RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC 

       850        860        870        880        890        900 
SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 

       910        920        930        940        950        960 
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY 

       970        980        990       1000       1010       1020 
EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL 

      1030       1040       1050       1060       1070       1080 
DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG 

      1090       1100       1110 
SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT 

« Hide

Isoform 2 [UniParc].

Checksum: 757A89BC1E91C20B
Show »

FASTA1,059117,438

References

« Hide 'large scale' references
[1]"The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea."
Guo D., Holmlund C., Henriksson R., Hedman H.
Genomics 84:157-165(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-1119.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY505340 mRNA. Translation: AAR98629.1.
AY358288 mRNA. Translation: AAQ88655.1.
AY358295 mRNA. Translation: AAQ88662.1.
AK074921 mRNA. Translation: BAC11295.1. Different initiation.
CCDSCCDS44933.1. [Q6UXM1-2]
CCDS8960.1. [Q6UXM1-1]
RefSeqNP_001129523.1. NM_001136051.2. [Q6UXM1-2]
NP_700356.2. NM_153377.4. [Q6UXM1-1]
UniGeneHs.253736.

3D structure databases

ProteinModelPortalQ6UXM1.
SMRQ6UXM1. Positions 45-826.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125712. 1 interaction.
IntActQ6UXM1. 1 interaction.

PTM databases

PhosphoSiteQ6UXM1.

Polymorphism databases

DMDM73621176.

Proteomic databases

MaxQBQ6UXM1.
PaxDbQ6UXM1.
PRIDEQ6UXM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320743; ENSP00000326759; ENSG00000139263. [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263. [Q6UXM1-2]
GeneID121227.
KEGGhsa:121227.
UCSCuc001sqr.4. human. [Q6UXM1-1]
uc009zqh.3. human. [Q6UXM1-2]

Organism-specific databases

CTD121227.
GeneCardsGC12M059265.
HGNCHGNC:30991. LRIG3.
HPAHPA010773.
MIM608870. gene.
neXtProtNX_Q6UXM1.
PharmGKBPA134864136.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000113380.
HOVERGENHBG052353.
InParanoidQ6UXM1.
OMAHQFVTSS.
OrthoDBEOG7DNNTD.
PhylomeDBQ6UXM1.
TreeFamTF325380.

Gene expression databases

ArrayExpressQ6UXM1.
BgeeQ6UXM1.
CleanExHS_LIG3.
HS_LRIG3.
GenevestigatorQ6UXM1.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF07679. I-set. 3 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi121227.
NextBio80680.
PROQ6UXM1.
SOURCESearch...

Entry information

Entry nameLRIG3_HUMAN
AccessionPrimary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM