Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6UXM1

- LRIG3_HUMAN

UniProt

Q6UXM1 - LRIG3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine-rich repeats and immunoglobulin-like domains protein 3

Gene

LRIG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).By similarity

GO - Biological processi

  1. otolith morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name:
LIG-3
Gene namesi
Name:LRIG3
Synonyms:LIG3
ORF Names:UNQ287/PRO326/PRO335
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30991. LRIG3.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein By similarity
Note: Detected in cytoplasmic vesicles when coexpressed with ERBB4.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. extracellular space Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 11191095Leucine-rich repeats and immunoglobulin-like domains protein 3PRO_0000014831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi520 ↔ 581PROSITE-ProRule annotation
Disulfide bondi624 ↔ 676PROSITE-ProRule annotation
Glycosylationi688 – 6881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi718 ↔ 767PROSITE-ProRule annotation
Glycosylationi729 – 7291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi905 – 9051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi987 – 9871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi999 – 9991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1016 – 10161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UXM1.
PaxDbiQ6UXM1.
PRIDEiQ6UXM1.

PTM databases

PhosphoSiteiQ6UXM1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ6UXM1.
CleanExiHS_LIG3.
HS_LRIG3.
ExpressionAtlasiQ6UXM1. baseline and differential.
GenevestigatoriQ6UXM1.

Organism-specific databases

HPAiHPA010773.

Interactioni

Subunit structurei

Interacts with EGFR, ERBB2 and ERBB4 (in vitro).By similarity

Protein-protein interaction databases

BioGridi125712. 9 interactions.
IntActiQ6UXM1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6UXM1.
SMRiQ6UXM1. Positions 45-826.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei810 – 83021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 7437LRRNTAdd
BLAST
Repeati75 – 9622LRR 1Add
BLAST
Repeati99 – 12022LRR 2Add
BLAST
Repeati122 – 14221LRR 3Add
BLAST
Repeati146 – 16722LRR 4Add
BLAST
Repeati168 – 18922LRR 5Add
BLAST
Repeati193 – 21422LRR 6Add
BLAST
Repeati216 – 23722LRR 7Add
BLAST
Repeati240 – 26122LRR 8Add
BLAST
Repeati264 – 28522LRR 9Add
BLAST
Repeati288 – 30922LRR 10Add
BLAST
Repeati312 – 33322LRR 11Add
BLAST
Repeati336 – 35722LRR 12Add
BLAST
Repeati360 – 38223LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Domaini444 – 49552LRRCTAdd
BLAST
Domaini499 – 598100Ig-like C2-type 1Add
BLAST
Domaini603 – 69290Ig-like C2-type 2Add
BLAST
Domaini697 – 78387Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiQ6UXM1.
OMAiHQFVTSS.
OrthoDBiEOG7DNNTD.
PhylomeDBiQ6UXM1.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UXM1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT
60 70 80 90 100
CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL
110 120 130 140 150
REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL
160 170 180 190 200
DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN
210 220 230 240 250
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG
260 270 280 290 300
VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN
310 320 330 340 350
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI
360 370 380 390 400
ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS
410 420 430 440 450
ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC
460 470 480 490 500
QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ
510 520 530 540 550
ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA
560 570 580 590 600
HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN
610 620 630 640 650
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER
660 670 680 690 700
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL
710 720 730 740 750
RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ
760 770 780 790 800
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL
810 820 830 840 850
DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL
860 870 880 890 900
PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT
910 920 930 940 950
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP
960 970 980 990 1000
DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT
1010 1020 1030 1040 1050
SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL
1060 1070 1080 1090 1100
DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF
1110
KQTLENYRTP NFQSYDLDT
Length:1,119
Mass (Da):123,434
Last modified:July 5, 2004 - v1
Checksum:iEB3B6A391F3C8713
GO
Isoform 2 (identifier: Q6UXM1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP

Note: No experimental confirmation available.

Show »
Length:1,059
Mass (Da):117,438
Checksum:i757A89BC1E91C20B
GO

Sequence cautioni

The sequence BAC11295.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2. 1 PublicationVSP_015097Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY505340 mRNA. Translation: AAR98629.1.
AY358288 mRNA. Translation: AAQ88655.1.
AY358295 mRNA. Translation: AAQ88662.1.
AK074921 mRNA. Translation: BAC11295.1. Different initiation.
CCDSiCCDS44933.1. [Q6UXM1-2]
CCDS8960.1. [Q6UXM1-1]
RefSeqiNP_001129523.1. NM_001136051.2. [Q6UXM1-2]
NP_700356.2. NM_153377.4. [Q6UXM1-1]
UniGeneiHs.253736.

Genome annotation databases

EnsembliENST00000320743; ENSP00000326759; ENSG00000139263. [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263. [Q6UXM1-2]
GeneIDi121227.
KEGGihsa:121227.
UCSCiuc001sqr.4. human. [Q6UXM1-1]
uc009zqh.3. human. [Q6UXM1-2]

Polymorphism databases

DMDMi73621176.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY505340 mRNA. Translation: AAR98629.1 .
AY358288 mRNA. Translation: AAQ88655.1 .
AY358295 mRNA. Translation: AAQ88662.1 .
AK074921 mRNA. Translation: BAC11295.1 . Different initiation.
CCDSi CCDS44933.1. [Q6UXM1-2 ]
CCDS8960.1. [Q6UXM1-1 ]
RefSeqi NP_001129523.1. NM_001136051.2. [Q6UXM1-2 ]
NP_700356.2. NM_153377.4. [Q6UXM1-1 ]
UniGenei Hs.253736.

3D structure databases

ProteinModelPortali Q6UXM1.
SMRi Q6UXM1. Positions 45-826.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125712. 9 interactions.
IntActi Q6UXM1. 1 interaction.

PTM databases

PhosphoSitei Q6UXM1.

Polymorphism databases

DMDMi 73621176.

Proteomic databases

MaxQBi Q6UXM1.
PaxDbi Q6UXM1.
PRIDEi Q6UXM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320743 ; ENSP00000326759 ; ENSG00000139263 . [Q6UXM1-1 ]
ENST00000379141 ; ENSP00000368436 ; ENSG00000139263 . [Q6UXM1-2 ]
GeneIDi 121227.
KEGGi hsa:121227.
UCSCi uc001sqr.4. human. [Q6UXM1-1 ]
uc009zqh.3. human. [Q6UXM1-2 ]

Organism-specific databases

CTDi 121227.
GeneCardsi GC12M059265.
HGNCi HGNC:30991. LRIG3.
HPAi HPA010773.
MIMi 608870. gene.
neXtProti NX_Q6UXM1.
PharmGKBi PA134864136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000113380.
HOVERGENi HBG052353.
InParanoidi Q6UXM1.
OMAi HQFVTSS.
OrthoDBi EOG7DNNTD.
PhylomeDBi Q6UXM1.
TreeFami TF325380.

Miscellaneous databases

GenomeRNAii 121227.
NextBioi 80680.
PROi Q6UXM1.
SOURCEi Search...

Gene expression databases

Bgeei Q6UXM1.
CleanExi HS_LIG3.
HS_LRIG3.
ExpressionAtlasi Q6UXM1. baseline and differential.
Genevestigatori Q6UXM1.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea."
    Guo D., Holmlund C., Henriksson R., Hedman H.
    Genomics 84:157-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-1119.

Entry informationi

Entry nameiLRIG3_HUMAN
AccessioniPrimary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3