Q6UXM1 (LRIG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name=LIG-3

Gene names

Name:	LRIG3
Synonyms:	LIG3
ORF Names:	UNQ287/PRO326/PRO335

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1119 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 By similarity.
Subunit structure	Interacts with EGFR, ERBB2 and ERBB4 (in vitro) By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity. Note: Detected in cytoplasmic vesicles when coexpressed with ERBB4 By similarity.
Tissue specificity	Widely expressed. Ref.1
Sequence similarities	Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Sequence caution	The sequence BAC11295.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 1119	1095	Leucine-rich repeats and immunoglobulin-like domains protein 3		PRO_0000014831
Regions
	Transmembrane	810 – 830	21	Helical; Potential
	Domain	38 – 74	37	LRRNT
	Repeat	75 – 96	22	LRR 1
	Repeat	99 – 120	22	LRR 2
	Repeat	122 – 142	21	LRR 3
	Repeat	146 – 167	22	LRR 4
	Repeat	168 – 189	22	LRR 5
	Repeat	193 – 214	22	LRR 6
	Repeat	216 – 237	22	LRR 7
	Repeat	240 – 261	22	LRR 8
	Repeat	264 – 285	22	LRR 9
	Repeat	288 – 309	22	LRR 10
	Repeat	312 – 333	22	LRR 11
	Repeat	336 – 357	22	LRR 12
	Repeat	360 – 382	23	LRR 13
	Repeat	387 – 408	22	LRR 14
	Repeat	411 – 432	22	LRR 15
	Domain	444 – 495	52	LRRCT
	Domain	499 – 598	100	Ig-like C2-type 1
	Domain	603 – 692	90	Ig-like C2-type 2
	Domain	697 – 783	87	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	122	1	N-linked (GlcNAc...) Potential
	Glycosylation	156	1	N-linked (GlcNAc...) Potential
	Glycosylation	274	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	469	1	N-linked (GlcNAc...) Potential
	Glycosylation	515	1	N-linked (GlcNAc...) Potential
	Glycosylation	688	1	N-linked (GlcNAc...) Potential
	Glycosylation	729	1	N-linked (GlcNAc...) Potential
	Glycosylation	905	1	N-linked (GlcNAc...) Potential
	Glycosylation	987	1	N-linked (GlcNAc...) Potential
	Glycosylation	999	1	N-linked (GlcNAc...) Potential
	Glycosylation	1016	1	N-linked (GlcNAc...) Potential
	Disulfide bond	520 ↔ 581		By similarity
	Disulfide bond	624 ↔ 676		By similarity
	Disulfide bond	718 ↔ 767		By similarity
Natural variations
	Alternative sequence	1 – 79	79	MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2.		VSP_015097

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EB3B6A391F3C8713	FASTA	1,119	123,434
	10 20 30 40 50 60 MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC 70 80 90 100 110 120 SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS 130 140 150 160 170 180 ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT 190 200 210 220 230 240 SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA 250 260 270 280 290 300 LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 310 320 330 340 350 360 RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS 370 380 390 400 410 420 LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN 430 440 450 460 470 480 AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG 490 500 510 520 530 540 RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL 550 560 570 580 590 600 LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 610 620 630 640 650 660 MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV 670 680 690 700 710 720 FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA 730 740 750 760 770 780 GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV 790 800 810 820 830 840 RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC 850 860 870 880 890 900 SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 910 920 930 940 950 960 CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY 970 980 990 1000 1010 1020 EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL 1030 1040 1050 1060 1070 1080 DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG 1090 1100 1110 SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT
	Isoform 2 [UniParc]. Checksum: 757A89BC1E91C20B	FASTA	1,059	117,438
	10 20 30 40 50 60 MVDVLLLFSL CLLFHISRPD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS 70 80 90 100 110 120 ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT 130 140 150 160 170 180 SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA 190 200 210 220 230 240 LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 250 260 270 280 290 300 RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS 310 320 330 340 350 360 LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN 370 380 390 400 410 420 AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG 430 440 450 460 470 480 RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL 490 500 510 520 530 540 LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 550 560 570 580 590 600 MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV 610 620 630 640 650 660 FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA 670 680 690 700 710 720 GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV 730 740 750 760 770 780 RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC 790 800 810 820 830 840 SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 850 860 870 880 890 900 CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY 910 920 930 940 950 960 EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL 970 980 990 1000 1010 1020 DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG 1030 1040 1050 SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea." Guo D., Holmlund C., Henriksson R., Hedman H. Genomics 84:157-165(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-1119.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY505340 mRNA. Translation: AAR98629.1. AY358288 mRNA. Translation: AAQ88655.1. AY358295 mRNA. Translation: AAQ88662.1. AK074921 mRNA. Translation: BAC11295.1. Different initiation.
IPI	IPI00184265. IPI00640455.
RefSeq	NP_001129523.1. NM_001136051.2. NP_700356.2. NM_153377.4.
UniGene	Hs.253736.
3D structure databases
ProteinModelPortal	Q6UXM1.
ModBase	Search...
PTM databases
PhosphoSite	Q6UXM1.
Polymorphism databases
DMDM	73621176.
Proteomic databases
PaxDb	Q6UXM1.
PRIDE	Q6UXM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320743; ENSP00000326759; ENSG00000139263. ENST00000379141; ENSP00000368436; ENSG00000139263.
GeneID	121227.
KEGG	hsa:121227.
UCSC	uc001sqr.3. human. uc009zqh.3. human.
Organism-specific databases
CTD	121227.
GeneCards	GC12M059265.
HGNC	HGNC:30991. LRIG3.
HPA	HPA010773.
MIM	608870. gene.
neXtProt	NX_Q6UXM1.
PharmGKB	PA134864136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000113380.
HOVERGEN	HBG052353.
InParanoid	Q6UXM1.
OMA	SHHQFVT.
OrthoDB	EOG4K6G3K.
PhylomeDB	Q6UXM1.
Gene expression databases
ArrayExpress	Q6UXM1.
Bgee	Q6UXM1.
CleanEx	HS_LIG3. HS_LRIG3.
Genevestigator	Q6UXM1.
GermOnline	ENSG00000139263. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF07679. I-set. 3 hits. PF12799. LRR_4. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. PS51450. LRR. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	121227.
NextBio	80680.
SOURCE	Search...

Entry information

Entry name

LRIG3_HUMAN

Accession

Primary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.