ID I20RB_HUMAN Reviewed; 311 AA. AC Q6UXL0; B4DL40; Q6P438; Q8IYY5; Q8TAJ7; DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 160. DE RecName: Full=Interleukin-20 receptor subunit beta; DE Short=IL-20 receptor subunit beta; DE Short=IL-20R-beta; DE Short=IL-20RB; DE AltName: Full=Fibronectin type III domain containing 6; DE Short=FNDC6; DE AltName: Full=IL-20R2; DE Flags: Precursor; GN Name=IL20RB; Synonyms=DIRS1; ORFNames=UNQ557/PRO1114; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Thalamus, and Tongue; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP PROTEIN SEQUENCE OF 30-44. RX PubMed=15340161; DOI=10.1110/ps.04682504; RA Zhang Z., Henzel W.J.; RT "Signal peptide prediction based on analysis of experimentally verified RT cleavage sites."; RL Protein Sci. 13:2819-2824(2004). RN [7] RP SUBUNIT, LIGAND-BINDING, AND TISSUE SPECIFICITY. RX PubMed=11163236; DOI=10.1016/s0092-8674(01)00187-8; RA Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., RA Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., RA Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., RA Sexson S., Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., RA Kuechle M.K., Dale B.A., Chandrasekher Y.A.; RT "Interleukin 20: discovery, receptor identification, and role in epidermal RT function."; RL Cell 104:9-19(2001). RN [8] RP SUBUNIT, AND LIGAND-BINDING. RX PubMed=11564763; DOI=10.4049/jimmunol.167.7.3545; RA Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.; RT "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes RT of two types."; RL J. Immunol. 167:3545-3549(2001). RN [9] RP SUBUNIT, AND LIGAND-BINDING. RX PubMed=12351624; DOI=10.1074/jbc.m205114200; RA Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., RA Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., RA Chandrasekher Y.A.; RT "Interleukins 19, 20, and 24 signal through two distinct receptor RT complexes. Differences in receptor-ligand interactions mediate unique RT biological functions."; RL J. Biol. Chem. 277:47517-47523(2002). RN [10] RP SUBUNIT, AND LIGAND-BINDING. RX PubMed=14580208; DOI=10.1021/bi0354583; RA Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., RA Zdanov A.; RT "Characterization of the recombinant extracellular domains of human RT interleukin-20 receptors and their complexes with interleukin-19 and RT interleukin-20."; RL Biochemistry 42:12617-12624(2003). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-231 IN COMPLEX WITH IL20RA AND RP IL20, SUBUNIT, AND DISULFIDE BONDS. RX PubMed=22802649; DOI=10.1073/pnas.1117551109; RA Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.; RT "Structural basis for receptor sharing and activation by interleukin-20 RT receptor-2 (IL-20R2) binding cytokines."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012). CC -!- FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and CC IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. CC -!- SUBUNIT: Heterodimer with IL20RA and heterodimer with IL22RA1. CC {ECO:0000269|PubMed:11163236, ECO:0000269|PubMed:11564763, CC ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:14580208, CC ECO:0000269|PubMed:22802649}. CC -!- INTERACTION: CC Q6UXL0; PRO_0000015379 [Q9UHD0]: IL19; NbExp=4; IntAct=EBI-14022792, EBI-14023330; CC Q6UXL0; PRO_0000015381 [Q9NYY1]: IL20; NbExp=5; IntAct=EBI-14022792, EBI-14022785; CC Q6UXL0; P21145: MAL; NbExp=3; IntAct=EBI-14022792, EBI-3932027; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6UXL0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6UXL0-3; Sequence=VSP_054905, VSP_054906, VSP_054907; CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in skin and CC testis. Highly expressed in psoriatic skin. CC {ECO:0000269|PubMed:11163236}. CC -!- SIMILARITY: Belongs to the type II cytokine receptor family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY358305; AAQ88672.1; -; mRNA. DR EMBL; AK296832; BAG59402.1; -; mRNA. DR EMBL; AK316084; BAH14455.1; -; mRNA. DR EMBL; AC011597; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471052; EAW79101.1; -; Genomic_DNA. DR EMBL; CH471052; EAW79104.1; -; Genomic_DNA. DR EMBL; BC033292; AAH33292.1; -; mRNA. DR EMBL; BC063696; AAH63696.2; -; mRNA. DR CCDS; CCDS3093.1; -. [Q6UXL0-1] DR RefSeq; NP_653318.2; NM_144717.3. [Q6UXL0-1] DR PDB; 4DOH; X-ray; 2.80 A; B/D=30-231. DR PDB; 6DF3; X-ray; 2.15 A; H=35-224. DR PDBsum; 4DOH; -. DR PDBsum; 6DF3; -. DR AlphaFoldDB; Q6UXL0; -. DR SMR; Q6UXL0; -. DR BioGRID; 119805; 37. DR IntAct; Q6UXL0; 14. DR STRING; 9606.ENSP00000328133; -. DR GlyCosmos; Q6UXL0; 2 sites, No reported glycans. DR GlyGen; Q6UXL0; 2 sites. DR iPTMnet; Q6UXL0; -. DR PhosphoSitePlus; Q6UXL0; -. DR BioMuta; IL20RB; -. DR DMDM; 51701521; -. DR EPD; Q6UXL0; -. DR MassIVE; Q6UXL0; -. DR PaxDb; 9606-ENSP00000328133; -. DR PeptideAtlas; Q6UXL0; -. DR Antibodypedia; 17858; 313 antibodies from 28 providers. DR DNASU; 53833; -. DR Ensembl; ENST00000329582.9; ENSP00000328133.4; ENSG00000174564.13. [Q6UXL0-1] DR GeneID; 53833; -. DR KEGG; hsa:53833; -. DR MANE-Select; ENST00000329582.9; ENSP00000328133.4; NM_144717.4; NP_653318.2. DR UCSC; uc003eri.3; human. [Q6UXL0-1] DR AGR; HGNC:6004; -. DR CTD; 53833; -. DR DisGeNET; 53833; -. DR GeneCards; IL20RB; -. DR HGNC; HGNC:6004; IL20RB. DR HPA; ENSG00000174564; Group enriched (esophagus, skin, vagina). DR MIM; 605621; gene. DR neXtProt; NX_Q6UXL0; -. DR OpenTargets; ENSG00000174564; -. DR PharmGKB; PA29819; -. DR VEuPathDB; HostDB:ENSG00000174564; -. DR eggNOG; ENOG502S2V6; Eukaryota. DR GeneTree; ENSGT00510000048354; -. DR HOGENOM; CLU_074126_1_0_1; -. DR InParanoid; Q6UXL0; -. DR OMA; QGEYERY; -. DR OrthoDB; 5354301at2759; -. DR PhylomeDB; Q6UXL0; -. DR TreeFam; TF332537; -. DR PathwayCommons; Q6UXL0; -. DR Reactome; R-HSA-8854691; Interleukin-20 family signaling. DR SignaLink; Q6UXL0; -. DR SIGNOR; Q6UXL0; -. DR BioGRID-ORCS; 53833; 7 hits in 1157 CRISPR screens. DR GeneWiki; Interleukin_20_receptor,_beta_subunit; -. DR GenomeRNAi; 53833; -. DR Pharos; Q6UXL0; Tbio. DR PRO; PR:Q6UXL0; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q6UXL0; Protein. DR Bgee; ENSG00000174564; Expressed in upper arm skin and 112 other cell types or tissues. DR ExpressionAtlas; Q6UXL0; baseline and differential. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central. DR GO; GO:0042015; F:interleukin-20 binding; IBA:GO_Central. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl. DR GO; GO:0002765; P:immune response-inhibiting signal transduction; IEA:Ensembl. DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl. DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl. DR GO; GO:0001808; P:negative regulation of type IV hypersensitivity; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl. DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl. DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015373; Interferon/interleukin_rcp_dom. DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1. DR PANTHER; PTHR20859:SF48; INTERLEUKIN-20 RECEPTOR SUBUNIT BETA; 1. DR Pfam; PF09294; Interfer-bind; 1. DR Pfam; PF01108; Tissue_fac; 1. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR PROSITE; PS50853; FN3; 1. DR Genevisible; Q6UXL0; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; KW Repeat; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1..29 FT /evidence="ECO:0000269|PubMed:15340161" FT CHAIN 30..311 FT /note="Interleukin-20 receptor subunit beta" FT /id="PRO_0000011038" FT TOPO_DOM 30..233 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 234..254 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 255..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 37..136 FT /note="Fibronectin type-III 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 144..228 FT /note="Fibronectin type-III 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT CARBOHYD 40 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 134 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 89..97 FT /evidence="ECO:0000269|PubMed:22802649" FT DISULFID 202..223 FT /evidence="ECO:0000269|PubMed:22802649" FT VAR_SEQ 1..47 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_054905" FT VAR_SEQ 179..194 FT /note="HVKMVRSGGIPVHLET -> RPFPWYWPCLPLLASC (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_054906" FT VAR_SEQ 195..311 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_054907" FT STRAND 42..46 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 49..53 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 60..62 FT /evidence="ECO:0007829|PDB:4DOH" FT STRAND 65..71 FT /evidence="ECO:0007829|PDB:6DF3" FT HELIX 73..78 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 90..92 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 94..98 FT /evidence="ECO:0007829|PDB:6DF3" FT HELIX 100..102 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 105..117 FT /evidence="ECO:0007829|PDB:6DF3" FT HELIX 133..135 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 143..148 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 151..156 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 164..175 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 179..183 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 190..194 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 197..199 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 201..208 FT /evidence="ECO:0007829|PDB:6DF3" FT TURN 210..212 FT /evidence="ECO:0007829|PDB:6DF3" FT STRAND 222..224 FT /evidence="ECO:0007829|PDB:4DOH" SQ SEQUENCE 311 AA; 35076 MW; FF366D518116D9E3 CRC64; MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM SPEELLRAWI S //