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Q6UXL0

- I20RB_HUMAN

UniProt

Q6UXL0 - I20RB_HUMAN

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Protein

Interleukin-20 receptor subunit beta

Gene

IL20RB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

GO - Biological processi

  1. homeostasis of number of cells within a tissue Source: Ensembl
  2. immune response-inhibiting signal transduction Source: Ensembl
  3. inflammatory response to antigenic stimulus Source: Ensembl
  4. negative regulation of interferon-gamma production Source: Ensembl
  5. negative regulation of interleukin-2 production Source: Ensembl
  6. negative regulation of T cell proliferation Source: Ensembl
  7. negative regulation of type IV hypersensitivity Source: Ensembl
  8. positive regulation of interleukin-10 production Source: Ensembl
  9. positive regulation of interleukin-4 production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ6UXL0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit beta
Short name:
IL-20 receptor subunit beta
Short name:
IL-20R-beta
Short name:
IL-20RB
Alternative name(s):
Fibronectin type III domain containing 6
Short name:
FNDC6
IL-20R2
Gene namesi
Name:IL20RB
Synonyms:DIRS1
ORF Names:UNQ557/PRO1114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6004. IL20RB.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 233204ExtracellularSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 31157CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 311282Interleukin-20 receptor subunit betaPRO_0000011038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 971 Publication
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi202 ↔ 2231 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXL0.
PRIDEiQ6UXL0.

PTM databases

PhosphoSiteiQ6UXL0.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.1 Publication

Gene expression databases

BgeeiQ6UXL0.
CleanExiHS_IL20RB.
ExpressionAtlasiQ6UXL0. baseline and differential.
GenevestigatoriQ6UXL0.

Organism-specific databases

HPAiHPA019772.

Interactioni

Subunit structurei

Heterodimer with IL20RA and heterodimer with IL22RA1.5 Publications

Protein-protein interaction databases

BioGridi119805. 16 interactions.
STRINGi9606.ENSP00000328133.

Structurei

Secondary structure

1
311
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 465Combined sources
Beta strandi49 – 535Combined sources
Beta strandi60 – 623Combined sources
Beta strandi65 – 728Combined sources
Helixi73 – 786Combined sources
Beta strandi84 – 9815Combined sources
Turni100 – 1023Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi109 – 1179Combined sources
Helixi133 – 1353Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi151 – 1566Combined sources
Beta strandi164 – 17512Combined sources
Beta strandi179 – 1835Combined sources
Beta strandi186 – 1949Combined sources
Beta strandi197 – 1993Combined sources
Beta strandi201 – 2099Combined sources
Helixi210 – 2123Combined sources
Beta strandi222 – 2243Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80B/D30-231[»]
ProteinModelPortaliQ6UXL0.
SMRiQ6UXL0. Positions 34-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 136100Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 22885Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44187.
GeneTreeiENSGT00510000048354.
HOGENOMiHOG000294100.
HOVERGENiHBG052066.
InParanoidiQ6UXL0.
KOiK05137.
OMAiPFNRNST.
OrthoDBiEOG7VMP76.
PhylomeDBiQ6UXL0.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UXL0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH
60 70 80 90 100
LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT
110 120 130 140 150
DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF
160 170 180 190 200
HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA
210 220 230 240 250
YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV
260 270 280 290 300
PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM
310
SPEELLRAWI S
Length:311
Mass (Da):35,076
Last modified:July 5, 2004 - v1
Checksum:iFF366D518116D9E3
GO
Isoform 2 (identifier: Q6UXL0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     179-194: HVKMVRSGGIPVHLET → RPFPWYWPCLPLLASC
     195-311: Missing.

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):16,945
Checksum:i71BAF49274618999
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 2. 1 PublicationVSP_054905Add
BLAST
Alternative sequencei179 – 19416HVKMV…VHLET → RPFPWYWPCLPLLASC in isoform 2. 1 PublicationVSP_054906Add
BLAST
Alternative sequencei195 – 311117Missing in isoform 2. 1 PublicationVSP_054907Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC033292 mRNA. Translation: AAH33292.1.
BC063696 mRNA. Translation: AAH63696.2.
CCDSiCCDS3093.1. [Q6UXL0-1]
RefSeqiNP_653318.2. NM_144717.3. [Q6UXL0-1]
UniGeneiHs.61232.

Genome annotation databases

EnsembliENST00000309741; ENSP00000311979; ENSG00000174564. [Q6UXL0-3]
ENST00000329582; ENSP00000328133; ENSG00000174564. [Q6UXL0-1]
GeneIDi53833.
KEGGihsa:53833.
UCSCiuc003eri.2. human. [Q6UXL0-1]

Polymorphism databases

DMDMi51701521.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358305 mRNA. Translation: AAQ88672.1 .
AK296832 mRNA. Translation: BAG59402.1 .
AK316084 mRNA. Translation: BAH14455.1 .
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1 .
CH471052 Genomic DNA. Translation: EAW79104.1 .
BC033292 mRNA. Translation: AAH33292.1 .
BC063696 mRNA. Translation: AAH63696.2 .
CCDSi CCDS3093.1. [Q6UXL0-1 ]
RefSeqi NP_653318.2. NM_144717.3. [Q6UXL0-1 ]
UniGenei Hs.61232.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DOH X-ray 2.80 B/D 30-231 [» ]
ProteinModelPortali Q6UXL0.
SMRi Q6UXL0. Positions 34-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119805. 16 interactions.
STRINGi 9606.ENSP00000328133.

PTM databases

PhosphoSitei Q6UXL0.

Polymorphism databases

DMDMi 51701521.

Proteomic databases

PaxDbi Q6UXL0.
PRIDEi Q6UXL0.

Protocols and materials databases

DNASUi 53833.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309741 ; ENSP00000311979 ; ENSG00000174564 . [Q6UXL0-3 ]
ENST00000329582 ; ENSP00000328133 ; ENSG00000174564 . [Q6UXL0-1 ]
GeneIDi 53833.
KEGGi hsa:53833.
UCSCi uc003eri.2. human. [Q6UXL0-1 ]

Organism-specific databases

CTDi 53833.
GeneCardsi GC03P136665.
HGNCi HGNC:6004. IL20RB.
HPAi HPA019772.
MIMi 605621. gene.
neXtProti NX_Q6UXL0.
PharmGKBi PA29819.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44187.
GeneTreei ENSGT00510000048354.
HOGENOMi HOG000294100.
HOVERGENi HBG052066.
InParanoidi Q6UXL0.
KOi K05137.
OMAi PFNRNST.
OrthoDBi EOG7VMP76.
PhylomeDBi Q6UXL0.
TreeFami TF332537.

Enzyme and pathway databases

SignaLinki Q6UXL0.

Miscellaneous databases

GeneWikii Interleukin_20_receptor,_beta_subunit.
GenomeRNAii 53833.
NextBioi 56166.
PROi Q6UXL0.
SOURCEi Search...

Gene expression databases

Bgeei Q6UXL0.
CleanExi HS_IL20RB.
ExpressionAtlasi Q6UXL0. baseline and differential.
Genevestigatori Q6UXL0.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thalamus and Tongue.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-44.
  7. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  8. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
    Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
    J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  9. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
    Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
    J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  10. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
    Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
    Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  11. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-231 IN COMPLEX WITH IL20RA AND IL20, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiI20RB_HUMAN
AccessioniPrimary (citable) accession number: Q6UXL0
Secondary accession number(s): B4DL40
, Q6P438, Q8IYY5, Q8TAJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3