Q6UXL0 (I20RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-20 receptor subunit beta
Short name=IL-20 receptor subunit beta
Short name=IL-20R-beta
Short name=IL-20RB

Alternative name(s):
IL-20R2

Gene names

Name:	IL20RB
Synonyms:	DIRS1
ORF Names:	UNQ557/PRO1114

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
Subunit structure	Heterodimer with IL20RA and heterodimer with IL22RA1. Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin. Ref.6
Sequence similarities	Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	homeostasis of number of cells within a tissue Inferred from electronic annotation. Source: Compara immune response-inhibiting signal transduction Inferred from electronic annotation. Source: Compara inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara negative regulation of T cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-2 production Inferred from electronic annotation. Source: Compara negative regulation of type IV hypersensitivity Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-4 production Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Ref.5

Chain

30 – 311

282

Interleukin-20 receptor subunit beta

PRO_0000011038

Regions

Topological domain

30 – 233

204

Extracellular Potential

Transmembrane

234 – 254

21

Helical; Potential

Topological domain

255 – 311

57

Cytoplasmic Potential

Domain

36 – 137

102

Fibronectin type-III 1

Domain

144 – 228

85

Fibronectin type-III 2

Amino acid modifications

Glycosylation

40

1

N-linked (GlcNAc...) Potential

Glycosylation

134

1

N-linked (GlcNAc...) Potential

Disulfide bond

202 ↔ 223

By similarity

Secondary structure

1

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311

Helix Strand Turn

Details...

Beta strand

42 – 46

5

Beta strand

49 – 53

5

Beta strand

60 – 62

3

Beta strand

65 – 72

8

Helix

73 – 78

6

Beta strand

84 – 98

15

Turn

100 – 102

3

Beta strand

105 – 107

3

Beta strand

109 – 117

9

Helix

133 – 135

3

Beta strand

143 – 148

6

Beta strand

151 – 156

6

Beta strand

164 – 175

12

Beta strand

179 – 183

5

Beta strand

186 – 194

9

Beta strand

197 – 199

3

Beta strand

201 – 209

9

Helix

210 – 212

3

Beta strand

222 – 224

3

Sequences

	Sequence		Length	Mass (Da)
	Q6UXL0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FF366D518116D9E3	FASTA	311	35,076
	10 20 30 40 50 60 MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP 70 80 90 100 110 120 GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ 130 140 150 160 170 180 TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV 190 200 210 220 230 240 KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF 250 260 270 280 290 300 VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM 310 SPEELLRAWI S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus and Tongue.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-44.
[6]	"Interleukin 20: discovery, receptor identification, and role in epidermal function." Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. , Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A. Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
[7]	"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types." Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C. J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING.
[8]	"Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions." Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A. J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING.
[9]	"Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20." Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A. Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC063696 mRNA. Translation: AAH63696.2.

IPI

IPI00097434.

RefSeq

NP_653318.2. NM_144717.3.

UniGene

Hs.61232.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DOH	X-ray	2.80	B/D	30-231	[»]

ProteinModelPortal

Q6UXL0.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000328133.

PTM databases

PhosphoSite

Q6UXL0.

Polymorphism databases

DMDM

51701521.

Proteomic databases

PaxDb

Q6UXL0.

PRIDE

Q6UXL0.

Protocols and materials databases

DNASU

53833.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000329582; ENSP00000328133; ENSG00000174564.

GeneID

53833.

KEGG

hsa:53833.

UCSC

uc003eri.2. human.

Organism-specific databases

CTD

53833.

GeneCards

GC03P136665.

HGNC

HGNC:6004. IL20RB.

HPA

HPA019772.

MIM

605621. gene.

neXtProt

NX_Q6UXL0.

PharmGKB

PA29819.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG44187.

HOGENOM

HOG000294100.

HOVERGEN

HBG052066.

InParanoid

Q6UXL0.

KO

K05137.

OMA

PFNRNST.

OrthoDB

EOG4KPTCD.

PhylomeDB

Q6UXL0.

Gene expression databases

ArrayExpress

Q6UXL0.

Bgee

Q6UXL0.

CleanEx

HS_IL20RB.

Genevestigator

Q6UXL0.

GermOnline

ENSG00000174564. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]

Pfam

PF09294. Interfer-bind. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

53833.

NextBio

56166.

SOURCE

Search...

Entry information

Entry name

I20RB_HUMAN

Accession

Primary (citable) accession number: Q6UXL0
Secondary accession number(s): B4DL40, Q6P438, Q8TAJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.