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Protein

Interleukin-20 receptor subunit beta

Gene

IL20RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ6UXL0.
SIGNORiQ6UXL0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit beta
Short name:
IL-20 receptor subunit beta
Short name:
IL-20R-beta
Short name:
IL-20RB
Alternative name(s):
Fibronectin type III domain containing 6
Short name:
FNDC6
IL-20R2
Gene namesi
Name:IL20RB
Synonyms:DIRS1
ORF Names:UNQ557/PRO1114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6004. IL20RB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 233ExtracellularSequence analysisAdd BLAST204
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 311CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53833.
OpenTargetsiENSG00000174564.
PharmGKBiPA29819.

Polymorphism and mutation databases

BioMutaiIL20RB.
DMDMi51701521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000001103830 – 311Interleukin-20 receptor subunit betaAdd BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi89 ↔ 971 Publication
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi202 ↔ 2231 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXL0.
PRIDEiQ6UXL0.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.1 Publication

Gene expression databases

BgeeiENSG00000174564.
CleanExiHS_IL20RB.
ExpressionAtlasiQ6UXL0. baseline and differential.
GenevisibleiQ6UXL0. HS.

Organism-specific databases

HPAiHPA019772.

Interactioni

Subunit structurei

Heterodimer with IL20RA and heterodimer with IL22RA1.5 Publications

Protein-protein interaction databases

BioGridi119805. 17 interactors.
STRINGi9606.ENSP00000328133.

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 46Combined sources5
Beta strandi49 – 53Combined sources5
Beta strandi60 – 62Combined sources3
Beta strandi65 – 72Combined sources8
Helixi73 – 78Combined sources6
Beta strandi84 – 98Combined sources15
Turni100 – 102Combined sources3
Beta strandi105 – 107Combined sources3
Beta strandi109 – 117Combined sources9
Helixi133 – 135Combined sources3
Beta strandi143 – 148Combined sources6
Beta strandi151 – 156Combined sources6
Beta strandi164 – 175Combined sources12
Beta strandi179 – 183Combined sources5
Beta strandi186 – 194Combined sources9
Beta strandi197 – 199Combined sources3
Beta strandi201 – 209Combined sources9
Helixi210 – 212Combined sources3
Beta strandi222 – 224Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80B/D30-231[»]
ProteinModelPortaliQ6UXL0.
SMRiQ6UXL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 136Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini144 – 228Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN8F. Eukaryota.
ENOG410YRNK. LUCA.
GeneTreeiENSGT00510000048354.
HOGENOMiHOG000294100.
HOVERGENiHBG052066.
InParanoidiQ6UXL0.
KOiK05137.
OMAiPFNRNST.
OrthoDBiEOG091G0CVQ.
PhylomeDBiQ6UXL0.
TreeFamiTF332537.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH
60 70 80 90 100
LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT
110 120 130 140 150
DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF
160 170 180 190 200
HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA
210 220 230 240 250
YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV
260 270 280 290 300
PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM
310
SPEELLRAWI S
Length:311
Mass (Da):35,076
Last modified:July 5, 2004 - v1
Checksum:iFF366D518116D9E3
GO
Isoform 2 (identifier: Q6UXL0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     179-194: HVKMVRSGGIPVHLET → RPFPWYWPCLPLLASC
     195-311: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,945
Checksum:i71BAF49274618999
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0549051 – 47Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_054906179 – 194HVKMV…VHLET → RPFPWYWPCLPLLASC in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_054907195 – 311Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC033292 mRNA. Translation: AAH33292.1.
BC063696 mRNA. Translation: AAH63696.2.
CCDSiCCDS3093.1. [Q6UXL0-1]
RefSeqiNP_653318.2. NM_144717.3. [Q6UXL0-1]
UniGeneiHs.61232.

Genome annotation databases

EnsembliENST00000329582; ENSP00000328133; ENSG00000174564. [Q6UXL0-1]
GeneIDi53833.
KEGGihsa:53833.
UCSCiuc003eri.3. human. [Q6UXL0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC033292 mRNA. Translation: AAH33292.1.
BC063696 mRNA. Translation: AAH63696.2.
CCDSiCCDS3093.1. [Q6UXL0-1]
RefSeqiNP_653318.2. NM_144717.3. [Q6UXL0-1]
UniGeneiHs.61232.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80B/D30-231[»]
ProteinModelPortaliQ6UXL0.
SMRiQ6UXL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119805. 17 interactors.
STRINGi9606.ENSP00000328133.

Polymorphism and mutation databases

BioMutaiIL20RB.
DMDMi51701521.

Proteomic databases

PaxDbiQ6UXL0.
PRIDEiQ6UXL0.

Protocols and materials databases

DNASUi53833.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329582; ENSP00000328133; ENSG00000174564. [Q6UXL0-1]
GeneIDi53833.
KEGGihsa:53833.
UCSCiuc003eri.3. human. [Q6UXL0-1]

Organism-specific databases

CTDi53833.
DisGeNETi53833.
GeneCardsiIL20RB.
HGNCiHGNC:6004. IL20RB.
HPAiHPA019772.
MIMi605621. gene.
neXtProtiNX_Q6UXL0.
OpenTargetsiENSG00000174564.
PharmGKBiPA29819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN8F. Eukaryota.
ENOG410YRNK. LUCA.
GeneTreeiENSGT00510000048354.
HOGENOMiHOG000294100.
HOVERGENiHBG052066.
InParanoidiQ6UXL0.
KOiK05137.
OMAiPFNRNST.
OrthoDBiEOG091G0CVQ.
PhylomeDBiQ6UXL0.
TreeFamiTF332537.

Enzyme and pathway databases

ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ6UXL0.
SIGNORiQ6UXL0.

Miscellaneous databases

GeneWikiiInterleukin_20_receptor,_beta_subunit.
GenomeRNAii53833.
PROiQ6UXL0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174564.
CleanExiHS_IL20RB.
ExpressionAtlasiQ6UXL0. baseline and differential.
GenevisibleiQ6UXL0. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI20RB_HUMAN
AccessioniPrimary (citable) accession number: Q6UXL0
Secondary accession number(s): B4DL40
, Q6P438, Q8IYY5, Q8TAJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.