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Q6UXL0

- I20RB_HUMAN

UniProt

Q6UXL0 - I20RB_HUMAN

Protein

Interleukin-20 receptor subunit beta

Gene

IL20RB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

    GO - Biological processi

    1. homeostasis of number of cells within a tissue Source: Ensembl
    2. immune response-inhibiting signal transduction Source: Ensembl
    3. inflammatory response to antigenic stimulus Source: Ensembl
    4. negative regulation of interferon-gamma production Source: Ensembl
    5. negative regulation of interleukin-2 production Source: Ensembl
    6. negative regulation of T cell proliferation Source: Ensembl
    7. negative regulation of type IV hypersensitivity Source: Ensembl
    8. positive regulation of interleukin-10 production Source: Ensembl
    9. positive regulation of interleukin-4 production Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ6UXL0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-20 receptor subunit beta
    Short name:
    IL-20 receptor subunit beta
    Short name:
    IL-20R-beta
    Short name:
    IL-20RB
    Alternative name(s):
    Fibronectin type III domain containing 6
    Short name:
    FNDC6
    IL-20R2
    Gene namesi
    Name:IL20RB
    Synonyms:DIRS1
    ORF Names:UNQ557/PRO1114
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6004. IL20RB.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29819.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 311282Interleukin-20 receptor subunit betaPRO_0000011038Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 971 Publication
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi202 ↔ 2231 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6UXL0.
    PRIDEiQ6UXL0.

    PTM databases

    PhosphoSiteiQ6UXL0.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.1 Publication

    Gene expression databases

    ArrayExpressiQ6UXL0.
    BgeeiQ6UXL0.
    CleanExiHS_IL20RB.
    GenevestigatoriQ6UXL0.

    Organism-specific databases

    HPAiHPA019772.

    Interactioni

    Subunit structurei

    Heterodimer with IL20RA and heterodimer with IL22RA1.5 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328133.

    Structurei

    Secondary structure

    1
    311
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi42 – 465
    Beta strandi49 – 535
    Beta strandi60 – 623
    Beta strandi65 – 728
    Helixi73 – 786
    Beta strandi84 – 9815
    Turni100 – 1023
    Beta strandi105 – 1073
    Beta strandi109 – 1179
    Helixi133 – 1353
    Beta strandi143 – 1486
    Beta strandi151 – 1566
    Beta strandi164 – 17512
    Beta strandi179 – 1835
    Beta strandi186 – 1949
    Beta strandi197 – 1993
    Beta strandi201 – 2099
    Helixi210 – 2123
    Beta strandi222 – 2243

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DOHX-ray2.80B/D30-231[»]
    ProteinModelPortaliQ6UXL0.
    SMRiQ6UXL0. Positions 34-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 233204ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini255 – 31157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 136100Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 22885Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44187.
    HOGENOMiHOG000294100.
    HOVERGENiHBG052066.
    InParanoidiQ6UXL0.
    KOiK05137.
    OMAiPFNRNST.
    OrthoDBiEOG7VMP76.
    PhylomeDBiQ6UXL0.
    TreeFamiTF332537.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UXL0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH    50
    LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT 100
    DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF 150
    HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA 200
    YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV 250
    PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM 300
    SPEELLRAWI S 311
    Length:311
    Mass (Da):35,076
    Last modified:July 5, 2004 - v1
    Checksum:iFF366D518116D9E3
    GO
    Isoform 2 (identifier: Q6UXL0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.
         179-194: HVKMVRSGGIPVHLET → RPFPWYWPCLPLLASC
         195-311: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:147
    Mass (Da):16,945
    Checksum:i71BAF49274618999
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4747Missing in isoform 2. 1 PublicationVSP_054905Add
    BLAST
    Alternative sequencei179 – 19416HVKMV…VHLET → RPFPWYWPCLPLLASC in isoform 2. 1 PublicationVSP_054906Add
    BLAST
    Alternative sequencei195 – 311117Missing in isoform 2. 1 PublicationVSP_054907Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358305 mRNA. Translation: AAQ88672.1.
    AK296832 mRNA. Translation: BAG59402.1.
    AK316084 mRNA. Translation: BAH14455.1.
    AC011597 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79101.1.
    CH471052 Genomic DNA. Translation: EAW79104.1.
    BC033292 mRNA. Translation: AAH33292.1.
    BC063696 mRNA. Translation: AAH63696.2.
    CCDSiCCDS3093.1. [Q6UXL0-1]
    RefSeqiNP_653318.2. NM_144717.3. [Q6UXL0-1]
    UniGeneiHs.61232.

    Genome annotation databases

    EnsembliENST00000309741; ENSP00000311979; ENSG00000174564. [Q6UXL0-3]
    ENST00000329582; ENSP00000328133; ENSG00000174564. [Q6UXL0-1]
    GeneIDi53833.
    KEGGihsa:53833.
    UCSCiuc003eri.2. human. [Q6UXL0-1]

    Polymorphism databases

    DMDMi51701521.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358305 mRNA. Translation: AAQ88672.1 .
    AK296832 mRNA. Translation: BAG59402.1 .
    AK316084 mRNA. Translation: BAH14455.1 .
    AC011597 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79101.1 .
    CH471052 Genomic DNA. Translation: EAW79104.1 .
    BC033292 mRNA. Translation: AAH33292.1 .
    BC063696 mRNA. Translation: AAH63696.2 .
    CCDSi CCDS3093.1. [Q6UXL0-1 ]
    RefSeqi NP_653318.2. NM_144717.3. [Q6UXL0-1 ]
    UniGenei Hs.61232.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DOH X-ray 2.80 B/D 30-231 [» ]
    ProteinModelPortali Q6UXL0.
    SMRi Q6UXL0. Positions 34-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328133.

    PTM databases

    PhosphoSitei Q6UXL0.

    Polymorphism databases

    DMDMi 51701521.

    Proteomic databases

    PaxDbi Q6UXL0.
    PRIDEi Q6UXL0.

    Protocols and materials databases

    DNASUi 53833.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309741 ; ENSP00000311979 ; ENSG00000174564 . [Q6UXL0-3 ]
    ENST00000329582 ; ENSP00000328133 ; ENSG00000174564 . [Q6UXL0-1 ]
    GeneIDi 53833.
    KEGGi hsa:53833.
    UCSCi uc003eri.2. human. [Q6UXL0-1 ]

    Organism-specific databases

    CTDi 53833.
    GeneCardsi GC03P136665.
    HGNCi HGNC:6004. IL20RB.
    HPAi HPA019772.
    MIMi 605621. gene.
    neXtProti NX_Q6UXL0.
    PharmGKBi PA29819.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44187.
    HOGENOMi HOG000294100.
    HOVERGENi HBG052066.
    InParanoidi Q6UXL0.
    KOi K05137.
    OMAi PFNRNST.
    OrthoDBi EOG7VMP76.
    PhylomeDBi Q6UXL0.
    TreeFami TF332537.

    Enzyme and pathway databases

    SignaLinki Q6UXL0.

    Miscellaneous databases

    GeneWikii Interleukin_20_receptor,_beta_subunit.
    GenomeRNAii 53833.
    NextBioi 56166.
    PROi Q6UXL0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UXL0.
    Bgeei Q6UXL0.
    CleanExi HS_IL20RB.
    Genevestigatori Q6UXL0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thalamus and Tongue.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-44.
    7. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
    8. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
      Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
      J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING.
    9. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
      Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
      J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING.
    10. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
      Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
      Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING.
    11. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
      Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
      Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-231 IN COMPLEX WITH IL20RA AND IL20, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiI20RB_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXL0
    Secondary accession number(s): B4DL40
    , Q6P438, Q8IYY5, Q8TAJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3