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Q6UXL0

- I20RB_HUMAN

UniProt

Q6UXL0 - I20RB_HUMAN

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Protein
Interleukin-20 receptor subunit beta
Gene
IL20RB, DIRS1, UNQ557/PRO1114
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

GO - Biological processi

  1. homeostasis of number of cells within a tissue Source: Ensembl
  2. immune response-inhibiting signal transduction Source: Ensembl
  3. inflammatory response to antigenic stimulus Source: Ensembl
  4. negative regulation of T cell proliferation Source: Ensembl
  5. negative regulation of interferon-gamma production Source: Ensembl
  6. negative regulation of interleukin-2 production Source: Ensembl
  7. negative regulation of type IV hypersensitivity Source: Ensembl
  8. positive regulation of interleukin-10 production Source: Ensembl
  9. positive regulation of interleukin-4 production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ6UXL0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit beta
Short name:
IL-20 receptor subunit beta
Short name:
IL-20R-beta
Short name:
IL-20RB
Alternative name(s):
Fibronectin type III domain containing 6
Short name:
FNDC6
IL-20R2
Gene namesi
Name:IL20RB
Synonyms:DIRS1
ORF Names:UNQ557/PRO1114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6004. IL20RB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 233204Extracellular Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 31157Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 Publication
Add
BLAST
Chaini30 – 311282Interleukin-20 receptor subunit beta
PRO_0000011038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi89 ↔ 971 Publication
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi202 ↔ 2231 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXL0.
PRIDEiQ6UXL0.

PTM databases

PhosphoSiteiQ6UXL0.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.1 Publication

Gene expression databases

ArrayExpressiQ6UXL0.
BgeeiQ6UXL0.
CleanExiHS_IL20RB.
GenevestigatoriQ6UXL0.

Organism-specific databases

HPAiHPA019772.

Interactioni

Subunit structurei

Heterodimer with IL20RA and heterodimer with IL22RA1.5 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000328133.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 465
Beta strandi49 – 535
Beta strandi60 – 623
Beta strandi65 – 728
Helixi73 – 786
Beta strandi84 – 9815
Turni100 – 1023
Beta strandi105 – 1073
Beta strandi109 – 1179
Helixi133 – 1353
Beta strandi143 – 1486
Beta strandi151 – 1566
Beta strandi164 – 17512
Beta strandi179 – 1835
Beta strandi186 – 1949
Beta strandi197 – 1993
Beta strandi201 – 2099
Helixi210 – 2123
Beta strandi222 – 2243

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80B/D30-231[»]
ProteinModelPortaliQ6UXL0.
SMRiQ6UXL0. Positions 34-226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 136100Fibronectin type-III 1
Add
BLAST
Domaini144 – 22885Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44187.
HOGENOMiHOG000294100.
HOVERGENiHBG052066.
InParanoidiQ6UXL0.
KOiK05137.
OMAiPFNRNST.
OrthoDBiEOG7VMP76.
PhylomeDBiQ6UXL0.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UXL0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH    50
LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT 100
DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF 150
HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA 200
YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV 250
PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM 300
SPEELLRAWI S 311
Length:311
Mass (Da):35,076
Last modified:July 5, 2004 - v1
Checksum:iFF366D518116D9E3
GO
Isoform 2 (identifier: Q6UXL0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     179-194: HVKMVRSGGIPVHLET → RPFPWYWPCLPLLASC
     195-311: Missing.

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):16,945
Checksum:i71BAF49274618999
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 2.
VSP_054905Add
BLAST
Alternative sequencei179 – 19416HVKMV…VHLET → RPFPWYWPCLPLLASC in isoform 2.
VSP_054906Add
BLAST
Alternative sequencei195 – 311117Missing in isoform 2.
VSP_054907Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC033292 mRNA. Translation: AAH33292.1.
BC063696 mRNA. Translation: AAH63696.2.
CCDSiCCDS3093.1. [Q6UXL0-1]
RefSeqiNP_653318.2. NM_144717.3. [Q6UXL0-1]
UniGeneiHs.61232.

Genome annotation databases

EnsembliENST00000309741; ENSP00000311979; ENSG00000174564.
ENST00000329582; ENSP00000328133; ENSG00000174564.
GeneIDi53833.
KEGGihsa:53833.
UCSCiuc003eri.2. human. [Q6UXL0-1]

Polymorphism databases

DMDMi51701521.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358305 mRNA. Translation: AAQ88672.1 .
AK296832 mRNA. Translation: BAG59402.1 .
AK316084 mRNA. Translation: BAH14455.1 .
AC011597 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79101.1 .
CH471052 Genomic DNA. Translation: EAW79104.1 .
BC033292 mRNA. Translation: AAH33292.1 .
BC063696 mRNA. Translation: AAH63696.2 .
CCDSi CCDS3093.1. [Q6UXL0-1 ]
RefSeqi NP_653318.2. NM_144717.3. [Q6UXL0-1 ]
UniGenei Hs.61232.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DOH X-ray 2.80 B/D 30-231 [» ]
ProteinModelPortali Q6UXL0.
SMRi Q6UXL0. Positions 34-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328133.

PTM databases

PhosphoSitei Q6UXL0.

Polymorphism databases

DMDMi 51701521.

Proteomic databases

PaxDbi Q6UXL0.
PRIDEi Q6UXL0.

Protocols and materials databases

DNASUi 53833.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309741 ; ENSP00000311979 ; ENSG00000174564 .
ENST00000329582 ; ENSP00000328133 ; ENSG00000174564 .
GeneIDi 53833.
KEGGi hsa:53833.
UCSCi uc003eri.2. human. [Q6UXL0-1 ]

Organism-specific databases

CTDi 53833.
GeneCardsi GC03P136665.
HGNCi HGNC:6004. IL20RB.
HPAi HPA019772.
MIMi 605621. gene.
neXtProti NX_Q6UXL0.
PharmGKBi PA29819.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44187.
HOGENOMi HOG000294100.
HOVERGENi HBG052066.
InParanoidi Q6UXL0.
KOi K05137.
OMAi PFNRNST.
OrthoDBi EOG7VMP76.
PhylomeDBi Q6UXL0.
TreeFami TF332537.

Enzyme and pathway databases

SignaLinki Q6UXL0.

Miscellaneous databases

GeneWikii Interleukin_20_receptor,_beta_subunit.
GenomeRNAii 53833.
NextBioi 56166.
PROi Q6UXL0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UXL0.
Bgeei Q6UXL0.
CleanExi HS_IL20RB.
Genevestigatori Q6UXL0.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thalamus and Tongue.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-44.
  7. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  8. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
    Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
    J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  9. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
    Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
    J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  10. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
    Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
    Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  11. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-231 IN COMPLEX WITH IL20RA AND IL20, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiI20RB_HUMAN
AccessioniPrimary (citable) accession number: Q6UXL0
Secondary accession number(s): B4DL40
, Q6P438, Q8IYY5, Q8TAJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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