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Q6UXL0 (I20RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-20 receptor subunit beta

Short name=IL-20 receptor subunit beta
Short name=IL-20R-beta
Short name=IL-20RB
Alternative name(s):
IL-20R2
Gene names
Name:IL20RB
Synonyms:DIRS1
ORF Names:UNQ557/PRO1114
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Subunit structure

Heterodimer with IL20RA and heterodimer with IL22RA1. Ref.6 Ref.7 Ref.8 Ref.9

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin. Ref.6

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.5
Chain30 – 311282Interleukin-20 receptor subunit beta
PRO_0000011038

Regions

Topological domain30 – 233204Extracellular Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 31157Cytoplasmic Potential
Domain37 – 136100Fibronectin type-III 1
Domain144 – 22885Fibronectin type-III 2

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Disulfide bond202 ↔ 223 By similarity

Secondary structure

..................................... 311
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q6UXL0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FF366D518116D9E3

FASTA31135,076
        10         20         30         40         50         60 
MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP 

        70         80         90        100        110        120 
GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ 

       130        140        150        160        170        180 
TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV 

       190        200        210        220        230        240 
KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF 

       250        260        270        280        290        300 
VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM 

       310 
SPEELLRAWI S 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus and Tongue.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-44.
[6]"Interleukin 20: discovery, receptor identification, and role in epidermal function."
Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. expand/collapse author list , Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A.
Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
[7]"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING.
[8]"Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING.
[9]"Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358305 mRNA. Translation: AAQ88672.1.
AK296832 mRNA. Translation: BAG59402.1.
AK316084 mRNA. Translation: BAH14455.1.
CH471052 Genomic DNA. Translation: EAW79104.1.
BC063696 mRNA. Translation: AAH63696.2.
RefSeqNP_653318.2. NM_144717.3.
UniGeneHs.61232.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80B/D30-231[»]
ProteinModelPortalQ6UXL0.
SMRQ6UXL0. Positions 34-226.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000328133.

PTM databases

PhosphoSiteQ6UXL0.

Polymorphism databases

DMDM51701521.

Proteomic databases

PaxDbQ6UXL0.
PRIDEQ6UXL0.

Protocols and materials databases

DNASU53833.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329582; ENSP00000328133; ENSG00000174564.
GeneID53833.
KEGGhsa:53833.
UCSCuc003eri.2. human.

Organism-specific databases

CTD53833.
GeneCardsGC03P136665.
HGNCHGNC:6004. IL20RB.
HPAHPA019772.
MIM605621. gene.
neXtProtNX_Q6UXL0.
PharmGKBPA29819.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44187.
HOGENOMHOG000294100.
HOVERGENHBG052066.
InParanoidQ6UXL0.
KOK05137.
OMAPFNRNST.
OrthoDBEOG7VMP76.
PhylomeDBQ6UXL0.
TreeFamTF332537.

Enzyme and pathway databases

SignaLinkQ6UXL0.

Gene expression databases

ArrayExpressQ6UXL0.
BgeeQ6UXL0.
CleanExHS_IL20RB.
GenevestigatorQ6UXL0.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_20_receptor,_beta_subunit.
GenomeRNAi53833.
NextBio56166.
PROQ6UXL0.
SOURCESearch...

Entry information

Entry nameI20RB_HUMAN
AccessionPrimary (citable) accession number: Q6UXL0
Secondary accession number(s): B4DL40, Q6P438, Q8TAJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM