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Protein

Leucine-rich repeat neuronal protein 1

Gene

LRRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 1
Alternative name(s):
Neuronal leucine-rich repeat protein 1
Short name:
NLRR-1
Gene namesi
Name:LRRN1
Synonyms:KIAA1497
ORF Names:Nbla10449, UNQ693/PRO1338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20980. LRRN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 631ExtracellularSequence analysisAdd BLAST606
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 716CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57633.
OpenTargetsiENSG00000175928.
PharmGKBiPA134935557.

Polymorphism and mutation databases

BioMutaiLRRN1.
DMDMi60390188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001484726 – 716Leucine-rich repeat neuronal protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi447 ↔ 499PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UXK5.
MaxQBiQ6UXK5.
PaxDbiQ6UXK5.
PeptideAtlasiQ6UXK5.
PRIDEiQ6UXK5.

PTM databases

iPTMnetiQ6UXK5.
PhosphoSitePlusiQ6UXK5.

Expressioni

Gene expression databases

BgeeiENSG00000175928.
CleanExiHS_LRRN1.
GenevisibleiQ6UXK5. HS.

Organism-specific databases

HPAiHPA011071.

Interactioni

Protein-protein interaction databases

BioGridi121675. 3 interactors.
IntActiQ6UXK5. 1 interactor.
STRINGi9606.ENSP00000314901.

Structurei

3D structure databases

ProteinModelPortaliQ6UXK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 72LRRNTAdd BLAST47
Repeati73 – 95LRR 1Add BLAST23
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati313 – 335LRR 10Add BLAST23
Repeati338 – 359LRR 11Add BLAST22
Domaini371 – 424LRRCTAdd BLAST54
Domaini424 – 515Ig-like C2-typeAdd BLAST92
Domaini525 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
InParanoidiQ6UXK5.
OMAiHDTFPNH.
OrthoDBiEOG091G066E.
PhylomeDBiQ6UXK5.
TreeFamiTF334360.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY
60 70 80 90 100
REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL
110 120 130 140 150
DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI
160 170 180 190 200
NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE
210 220 230 240 250
NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK
260 270 280 290 300
LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
310 320 330 340 350
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN
360 370 380 390 400
AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA
410 420 430 440 450
MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM
460 470 480 490 500
AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV
510 520 530 540 550
AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM
560 570 580 590 600
TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
610 620 630 640 650
IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV
660 670 680 690 700
YFAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA
710
DTKPTQVDTS RSYYMW
Length:716
Mass (Da):80,716
Last modified:July 5, 2004 - v1
Checksum:iA6B84D3C7464799C
GO

Sequence cautioni

The sequence BAA96021 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264N → S in AAH34947 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049896395L → V.Corresponds to variant rs35362954dbSNPEnsembl.1
Natural variantiVAR_049897702T → P.Corresponds to variant rs34611357dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074161 mRNA. Translation: BAE45733.1.
AB040930 mRNA. Translation: BAA96021.1. Different initiation.
AY358312 mRNA. Translation: AAQ88679.1.
BC034947 mRNA. Translation: AAH34947.1.
AK023273 mRNA. Translation: BAB14500.1. Different initiation.
CCDSiCCDS33685.1.
RefSeqiNP_001311117.1. NM_001324188.1.
NP_001311118.1. NM_001324189.1.
NP_065924.3. NM_020873.6.
UniGeneiHs.163244.
Hs.737660.

Genome annotation databases

EnsembliENST00000319331; ENSP00000314901; ENSG00000175928.
GeneIDi57633.
KEGGihsa:57633.
UCSCiuc003bpt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074161 mRNA. Translation: BAE45733.1.
AB040930 mRNA. Translation: BAA96021.1. Different initiation.
AY358312 mRNA. Translation: AAQ88679.1.
BC034947 mRNA. Translation: AAH34947.1.
AK023273 mRNA. Translation: BAB14500.1. Different initiation.
CCDSiCCDS33685.1.
RefSeqiNP_001311117.1. NM_001324188.1.
NP_001311118.1. NM_001324189.1.
NP_065924.3. NM_020873.6.
UniGeneiHs.163244.
Hs.737660.

3D structure databases

ProteinModelPortaliQ6UXK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121675. 3 interactors.
IntActiQ6UXK5. 1 interactor.
STRINGi9606.ENSP00000314901.

PTM databases

iPTMnetiQ6UXK5.
PhosphoSitePlusiQ6UXK5.

Polymorphism and mutation databases

BioMutaiLRRN1.
DMDMi60390188.

Proteomic databases

EPDiQ6UXK5.
MaxQBiQ6UXK5.
PaxDbiQ6UXK5.
PeptideAtlasiQ6UXK5.
PRIDEiQ6UXK5.

Protocols and materials databases

DNASUi57633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319331; ENSP00000314901; ENSG00000175928.
GeneIDi57633.
KEGGihsa:57633.
UCSCiuc003bpt.4. human.

Organism-specific databases

CTDi57633.
DisGeNETi57633.
GeneCardsiLRRN1.
HGNCiHGNC:20980. LRRN1.
HPAiHPA011071.
neXtProtiNX_Q6UXK5.
OpenTargetsiENSG00000175928.
PharmGKBiPA134935557.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
InParanoidiQ6UXK5.
OMAiHDTFPNH.
OrthoDBiEOG091G066E.
PhylomeDBiQ6UXK5.
TreeFamiTF334360.

Miscellaneous databases

GeneWikiiLRRN1.
GenomeRNAii57633.
PROiQ6UXK5.

Gene expression databases

BgeeiENSG00000175928.
CleanExiHS_LRRN1.
GenevisibleiQ6UXK5. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXK5
Secondary accession number(s): Q3LID5
, Q8IYV5, Q9H8V1, Q9P231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.