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Protein

Immunoglobulin superfamily containing leucine-rich repeat protein 2

Gene

ISLR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for axon extension during neural development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein 2
Alternative name(s):
Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein
Gene namesi
Name:ISLR2
Synonyms:KIAA1465, LINX
ORF Names:UNQ1885/PRO4329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000167178.15
HGNCiHGNC:29286 ISLR2
MIMi614179 gene
neXtProtiNX_Q6UXK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 589ExtracellularSequence analysisAdd BLAST571
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
Topological domaini611 – 745CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167178
PharmGKBiPA143485505

Polymorphism and mutation databases

BioMutaiISLR2
DMDMi74758577

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031749819 – 745Immunoglobulin superfamily containing leucine-rich repeat protein 2Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi260 ↔ 355PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei719PhosphotyrosineBy similarity1
Modified residuei720PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6UXK2
PeptideAtlasiQ6UXK2
PRIDEiQ6UXK2
ProteomicsDBi67633

PTM databases

iPTMnetiQ6UXK2
PhosphoSitePlusiQ6UXK2

Expressioni

Gene expression databases

BgeeiENSG00000167178
CleanExiHS_ISLR2
ExpressionAtlasiQ6UXK2 baseline and differential
GenevisibleiQ6UXK2 HS

Organism-specific databases

HPAiHPA012930
HPA067333

Interactioni

Subunit structurei

Homomultimer. Interacts with NTRK1/TrkA (By similarity).By similarity

Protein-protein interaction databases

BioGridi121658, 1 interactor
IntActiQ6UXK2, 1 interactor
STRINGi9606.ENSP00000355402

Structurei

3D structure databases

ProteinModelPortaliQ6UXK2
SMRiQ6UXK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 51LRRNTAdd BLAST33
Repeati52 – 73LRR 1Add BLAST22
Repeati76 – 97LRR 2Add BLAST22
Repeati100 – 123LRR 3Add BLAST24
Repeati124 – 145LRR 4Add BLAST22
Repeati148 – 169LRR 5Add BLAST22
Domaini181 – 232LRRCTAdd BLAST52
Domaini233 – 371Ig-likeAdd BLAST139

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000149011
HOGENOMiHOG000113108
HOVERGENiHBG100863
InParanoidiQ6UXK2
OMAiPRLQWQL
OrthoDBiEOG091G03ZU
PhylomeDBiQ6UXK2
TreeFamiTF351112

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP
60 70 80 90 100
ANVTTLSLSA NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ
110 120 130 140 150
LKNLDLSHNF ISSFPWSDLR NLSALQLLKM NHNRLGSLPR DALGALPDLR
160 170 180 190 200
SLRINNNRLR TLAPGTFDAL SALSHLQLYH NPFHCGCGLV WLQAWAASTR
210 220 230 240 250
VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE PPLEAPGTPL
260 270 280 290 300
RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG
310 320 330 340 350
EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA
360 370 380 390 400
GVYTCRAHNE LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST
410 420 430 440 450
AKGRGNSVLP SKPEGKIKGQ GLAKVSILGE TETEPEEDTS EGEEAEDQIL
460 470 480 490 500
ADPAEEQRCG NGDPSRYVSN HAFNQSAELK PHVFELGVIA LDVAEREARV
510 520 530 540 550
QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA VQWSRVEEGV
560 570 580 590 600
NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL
610 620 630 640 650
LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS
660 670 680 690 700
YLESEKSYPA GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS
710 720 730 740
LVESQSKANQ EEFEAGSEYS DRLPLGAEAV NIAQEINGNY RQTAG
Length:745
Mass (Da):78,990
Last modified:July 5, 2004 - v1
Checksum:i7188FC3003EC2B7E
GO

Sequence cautioni

The sequence BAA95989 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → P in BAF83156 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049881137S → F. Corresponds to variant dbSNP:rs3889598Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040898 mRNA Translation: BAA95989.2 Different initiation.
AY358316 mRNA Translation: AAQ88682.1
AK290467 mRNA Translation: BAF83156.1
CCDSiCCDS10259.1
RefSeqiNP_001123608.1, NM_001130136.1
NP_001123609.1, NM_001130137.1
NP_001123610.1, NM_001130138.1
NP_065902.1, NM_020851.2
XP_011520142.1, XM_011521840.2
XP_011520143.1, XM_011521841.1
UniGeneiHs.254775

Genome annotation databases

EnsembliENST00000361742; ENSP00000355402; ENSG00000167178
ENST00000435464; ENSP00000411443; ENSG00000167178
ENST00000453268; ENSP00000411834; ENSG00000167178
ENST00000565159; ENSP00000455531; ENSG00000167178
ENST00000565540; ENSP00000458080; ENSG00000167178
GeneIDi57611
KEGGihsa:57611
UCSCiuc002axd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiISLR2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXK2
Secondary accession number(s): A8K352, Q9P263
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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