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Q6UXK2 (ISLR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein 2
Alternative name(s):
Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein
Gene names
Name:ISLR2
Synonyms:KIAA1465, LINX
ORF Names:UNQ1885/PRO4329
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for axon extension during neural development By similarity.

Subunit structure

Homomultimer. Interacts with NTRK1/TrkA By similarity.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 5 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAA95989.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 745727Immunoglobulin superfamily containing leucine-rich repeat protein 2
PRO_0000317498

Regions

Topological domain19 – 589571Extracellular Potential
Transmembrane590 – 61021Helical; Potential
Topological domain611 – 745135Cytoplasmic Potential
Domain19 – 5133LRRNT
Repeat52 – 7322LRR 1
Repeat76 – 9722LRR 2
Repeat100 – 12324LRR 3
Repeat124 – 14522LRR 4
Repeat148 – 16922LRR 5
Domain181 – 23252LRRCT
Domain233 – 371139Ig-like

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation5631N-linked (GlcNAc...) Potential
Disulfide bond260 ↔ 355 By similarity

Natural variations

Natural variant1371S → F.
Corresponds to variant rs3889598 [ dbSNP | Ensembl ].
VAR_049881

Experimental info

Sequence conflict191S → P in BAF83156. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q6UXK2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7188FC3003EC2B7E

FASTA74578,990
        10         20         30         40         50         60 
MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP ANVTTLSLSA 

        70         80         90        100        110        120 
NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ LKNLDLSHNF ISSFPWSDLR 

       130        140        150        160        170        180 
NLSALQLLKM NHNRLGSLPR DALGALPDLR SLRINNNRLR TLAPGTFDAL SALSHLQLYH 

       190        200        210        220        230        240 
NPFHCGCGLV WLQAWAASTR VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE 

       250        260        270        280        290        300 
PPLEAPGTPL RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG 

       310        320        330        340        350        360 
EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA GVYTCRAHNE 

       370        380        390        400        410        420 
LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST AKGRGNSVLP SKPEGKIKGQ 

       430        440        450        460        470        480 
GLAKVSILGE TETEPEEDTS EGEEAEDQIL ADPAEEQRCG NGDPSRYVSN HAFNQSAELK 

       490        500        510        520        530        540 
PHVFELGVIA LDVAEREARV QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA 

       550        560        570        580        590        600 
VQWSRVEEGV NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL 

       610        620        630        640        650        660 
LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS YLESEKSYPA 

       670        680        690        700        710        720 
GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS LVESQSKANQ EEFEAGSEYS 

       730        740 
DRLPLGAEAV NIAQEINGNY RQTAG 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040898 mRNA. Translation: BAA95989.2. Different initiation.
AY358316 mRNA. Translation: AAQ88682.1.
AK290467 mRNA. Translation: BAF83156.1.
RefSeqNP_001123608.1. NM_001130136.1.
NP_001123609.1. NM_001130137.1.
NP_001123610.1. NM_001130138.1.
NP_065902.1. NM_020851.2.
XP_005254626.1. XM_005254569.1.
XP_005254627.1. XM_005254570.1.
UniGeneHs.254775.

3D structure databases

ProteinModelPortalQ6UXK2.
SMRQ6UXK2. Positions 20-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6UXK2. 1 interaction.
MINTMINT-6598539.
STRING9606.ENSP00000354217.

PTM databases

PhosphoSiteQ6UXK2.

Polymorphism databases

DMDM74758577.

Proteomic databases

PaxDbQ6UXK2.
PRIDEQ6UXK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361742; ENSP00000355402; ENSG00000167178.
ENST00000419208; ENSP00000408872; ENSG00000167178.
ENST00000435464; ENSP00000411443; ENSG00000167178.
ENST00000445793; ENSP00000403244; ENSG00000167178.
ENST00000453268; ENSP00000411834; ENSG00000167178.
ENST00000565159; ENSP00000455531; ENSG00000167178.
ENST00000565540; ENSP00000458080; ENSG00000167178.
GeneID57611.
KEGGhsa:57611.
UCSCuc002axd.3. human.

Organism-specific databases

CTD57611.
GeneCardsGC15P074392.
HGNCHGNC:29286. ISLR2.
MIM614179. gene.
neXtProtNX_Q6UXK2.
PharmGKBPA143485505.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240332.
HOGENOMHOG000113108.
HOVERGENHBG100863.
InParanoidQ6UXK2.
OMAPRLQWQL.
OrthoDBEOG71K62H.
TreeFamTF351112.

Gene expression databases

ArrayExpressQ6UXK2.
BgeeQ6UXK2.
CleanExHS_ISLR2.
GenevestigatorQ6UXK2.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57611.
NextBio64263.
PROQ6UXK2.
SOURCESearch...

Entry information

Entry nameISLR2_HUMAN
AccessionPrimary (citable) accession number: Q6UXK2
Secondary accession number(s): A8K352, Q9P263
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM