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Q6UXK2

- ISLR2_HUMAN

UniProt

Q6UXK2 - ISLR2_HUMAN

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Protein

Immunoglobulin superfamily containing leucine-rich repeat protein 2

Gene
ISLR2, KIAA1465, LINX, UNQ1885/PRO4329
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for axon extension during neural development By similarity.

GO - Biological processi

  1. positive regulation of axon extension Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein 2
Alternative name(s):
Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein
Gene namesi
Name:ISLR2
Synonyms:KIAA1465, LINX
ORF Names:UNQ1885/PRO4329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:29286. ISLR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 589571Extracellular Reviewed predictionAdd
BLAST
Transmembranei590 – 61021Helical; Reviewed predictionAdd
BLAST
Topological domaini611 – 745135Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 745727Immunoglobulin superfamily containing leucine-rich repeat protein 2PRO_0000317498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi260 ↔ 355 By similarity
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi563 – 5631N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXK2.
PRIDEiQ6UXK2.

PTM databases

PhosphoSiteiQ6UXK2.

Expressioni

Gene expression databases

ArrayExpressiQ6UXK2.
BgeeiQ6UXK2.
CleanExiHS_ISLR2.
GenevestigatoriQ6UXK2.

Interactioni

Subunit structurei

Homomultimer. Interacts with NTRK1/TrkA By similarity.

Protein-protein interaction databases

IntActiQ6UXK2. 1 interaction.
MINTiMINT-6598539.
STRINGi9606.ENSP00000354217.

Structurei

3D structure databases

ProteinModelPortaliQ6UXK2.
SMRiQ6UXK2. Positions 20-372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 5133LRRNTAdd
BLAST
Repeati52 – 7322LRR 1Add
BLAST
Repeati76 – 9722LRR 2Add
BLAST
Repeati100 – 12324LRR 3Add
BLAST
Repeati124 – 14522LRR 4Add
BLAST
Repeati148 – 16922LRR 5Add
BLAST
Domaini181 – 23252LRRCTAdd
BLAST
Domaini233 – 371139Ig-likeAdd
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240332.
HOGENOMiHOG000113108.
HOVERGENiHBG100863.
InParanoidiQ6UXK2.
OMAiPRLQWQL.
OrthoDBiEOG71K62H.
PhylomeDBiQ6UXK2.
TreeFamiTF351112.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXK2-1 [UniParc]FASTAAdd to Basket

« Hide

MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP    50
ANVTTLSLSA NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ 100
LKNLDLSHNF ISSFPWSDLR NLSALQLLKM NHNRLGSLPR DALGALPDLR 150
SLRINNNRLR TLAPGTFDAL SALSHLQLYH NPFHCGCGLV WLQAWAASTR 200
VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE PPLEAPGTPL 250
RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG 300
EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA 350
GVYTCRAHNE LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST 400
AKGRGNSVLP SKPEGKIKGQ GLAKVSILGE TETEPEEDTS EGEEAEDQIL 450
ADPAEEQRCG NGDPSRYVSN HAFNQSAELK PHVFELGVIA LDVAEREARV 500
QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA VQWSRVEEGV 550
NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL 600
LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS 650
YLESEKSYPA GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS 700
LVESQSKANQ EEFEAGSEYS DRLPLGAEAV NIAQEINGNY RQTAG 745
Length:745
Mass (Da):78,990
Last modified:July 5, 2004 - v1
Checksum:i7188FC3003EC2B7E
GO

Sequence cautioni

The sequence BAA95989.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371S → F.
Corresponds to variant rs3889598 [ dbSNP | Ensembl ].
VAR_049881

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → P in BAF83156. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040898 mRNA. Translation: BAA95989.2. Different initiation.
AY358316 mRNA. Translation: AAQ88682.1.
AK290467 mRNA. Translation: BAF83156.1.
CCDSiCCDS10259.1.
RefSeqiNP_001123608.1. NM_001130136.1.
NP_001123609.1. NM_001130137.1.
NP_001123610.1. NM_001130138.1.
NP_065902.1. NM_020851.2.
UniGeneiHs.254775.

Genome annotation databases

EnsembliENST00000361742; ENSP00000355402; ENSG00000167178.
ENST00000419208; ENSP00000408872; ENSG00000167178.
ENST00000435464; ENSP00000411443; ENSG00000167178.
ENST00000445793; ENSP00000403244; ENSG00000167178.
ENST00000453268; ENSP00000411834; ENSG00000167178.
ENST00000565159; ENSP00000455531; ENSG00000167178.
ENST00000565540; ENSP00000458080; ENSG00000167178.
GeneIDi57611.
KEGGihsa:57611.
UCSCiuc002axd.3. human.

Polymorphism databases

DMDMi74758577.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040898 mRNA. Translation: BAA95989.2 . Different initiation.
AY358316 mRNA. Translation: AAQ88682.1 .
AK290467 mRNA. Translation: BAF83156.1 .
CCDSi CCDS10259.1.
RefSeqi NP_001123608.1. NM_001130136.1.
NP_001123609.1. NM_001130137.1.
NP_001123610.1. NM_001130138.1.
NP_065902.1. NM_020851.2.
UniGenei Hs.254775.

3D structure databases

ProteinModelPortali Q6UXK2.
SMRi Q6UXK2. Positions 20-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6UXK2. 1 interaction.
MINTi MINT-6598539.
STRINGi 9606.ENSP00000354217.

PTM databases

PhosphoSitei Q6UXK2.

Polymorphism databases

DMDMi 74758577.

Proteomic databases

PaxDbi Q6UXK2.
PRIDEi Q6UXK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361742 ; ENSP00000355402 ; ENSG00000167178 .
ENST00000419208 ; ENSP00000408872 ; ENSG00000167178 .
ENST00000435464 ; ENSP00000411443 ; ENSG00000167178 .
ENST00000445793 ; ENSP00000403244 ; ENSG00000167178 .
ENST00000453268 ; ENSP00000411834 ; ENSG00000167178 .
ENST00000565159 ; ENSP00000455531 ; ENSG00000167178 .
ENST00000565540 ; ENSP00000458080 ; ENSG00000167178 .
GeneIDi 57611.
KEGGi hsa:57611.
UCSCi uc002axd.3. human.

Organism-specific databases

CTDi 57611.
GeneCardsi GC15P074392.
HGNCi HGNC:29286. ISLR2.
MIMi 614179. gene.
neXtProti NX_Q6UXK2.
PharmGKBi PA143485505.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240332.
HOGENOMi HOG000113108.
HOVERGENi HBG100863.
InParanoidi Q6UXK2.
OMAi PRLQWQL.
OrthoDBi EOG71K62H.
PhylomeDBi Q6UXK2.
TreeFami TF351112.

Miscellaneous databases

GenomeRNAii 57611.
NextBioi 64263.
PROi Q6UXK2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UXK2.
Bgeei Q6UXK2.
CleanExi HS_ISLR2.
Genevestigatori Q6UXK2.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiISLR2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXK2
Secondary accession number(s): A8K352, Q9P263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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