Q6UXI9 (NPNT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nephronectin

Alternative name(s):
Preosteoblast EGF-like repeat protein with MAM domain
Protein EGFL6-like

Gene names

Name:	NPNT
Synonyms:	EGFL6L, POEM
ORF Names:	UNQ295/PRO334

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins By similarity.
Subunit structure	Homodimer and homotrimer By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity. Note: Trapped on the cell surface or in the extracellular matrix By similarity.
Tissue specificity	Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels. Ref.5
Developmental stage	Expressed in fetal kidney, cochlea, eye, heart and lung. Ref.5
Domain	The MAM domain is required for localization at the cell surface By similarity.
Sequence similarities	Belongs to the nephronectin family. Contains 5 EGF-like domains. Contains 1 MAM domain.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	branching involved in ureteric bud morphogenesis Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cell-cell adhesion mediated by integrin Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL cell-matrix adhesion Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL cellular response to tumor necrosis factor Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL extracellular matrix organization Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL positive regulation of cell-substrate adhesion Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL positive regulation of osteoblast differentiation Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro proteinaceous extracellular matrix Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro integrin binding Inferred from sequence or structural similarity Ref.5. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXI9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXI9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     387-416: IPRQPSNDLFEIFEIERGVSADDEAKDDPG → S
     535-564: VVFKGEKRRGHTGEIGLDDVSLKKGHCSEE → ESQ

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6UXI9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: Q → QDEHIPAPLDQGSEQPLFQPLDHQATSLPSR

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6UXI9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: Q → QDEHIPAPLDQGSEQPLFQPLDHQATSLPSR
     387-416: IPRQPSNDLFEIFEIERGVSADDEAKDDPG → S

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6UXI9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     387-416: IPRQPSNDLFEIFEIERGVSADDEAKDDPG → S

Note: No experimental confirmation available.

Isoform 6 (identifier: Q6UXI9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: P → PFYVLRQRIARIRCQLKA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 565	546	Nephronectin		PRO_0000295684
Regions
	Domain	52 – 87	36	EGF-like 1
	Domain	89 – 128	40	EGF-like 2; calcium-binding Potential
	Domain	132 – 168	37	EGF-like 3
	Domain	169 – 213	45	EGF-like 4; calcium-binding Potential
	Domain	214 – 254	41	EGF-like 5; calcium-binding Potential
	Domain	420 – 563	144	MAM
	Motif	382 – 384	3	Integrin interaction
	Compositional bias	296 – 365	70	Pro-rich
Amino acid modifications
	Disulfide bond	56 ↔ 69		By similarity
	Disulfide bond	60 ↔ 75		By similarity
	Disulfide bond	77 ↔ 86		By similarity
	Disulfide bond	93 ↔ 104		By similarity
	Disulfide bond	100 ↔ 113		By similarity
	Disulfide bond	115 ↔ 127		By similarity
	Disulfide bond	173 ↔ 186		By similarity
	Disulfide bond	180 ↔ 195		By similarity
	Disulfide bond	197 ↔ 212		By similarity
	Disulfide bond	218 ↔ 231		By similarity
	Disulfide bond	225 ↔ 240		By similarity
	Disulfide bond	242 ↔ 253		By similarity
Natural variations
	Alternative sequence	58	1	P → PFYVLRQRIARIRCQLKA in isoform 6.		VSP_046131
	Alternative sequence	88	1	Q → QDEHIPAPLDQGSEQPLFQP LDHQATSLPSR in isoform 3 and isoform 4.		VSP_045813
	Alternative sequence	387 – 416	30	IPRQP…KDDPG → S in isoform 2, isoform 4 and isoform 5.		VSP_026987
	Alternative sequence	535 – 564	30	VVFKG…HCSEE → ESQ in isoform 2.		VSP_026988
	Natural variant	159	1	Q → H. Ref.1 Corresponds to variant rs35132891 [ dbSNP | Ensembl ].		VAR_033314
	Natural variant	234	1	I → V. Ref.1 Ref.2 Ref.4 Corresponds to variant rs4340795 [ dbSNP | Ensembl ].		VAR_033315
	Natural variant	473	1	G → S. Corresponds to variant rs35613262 [ dbSNP | Ensembl ].		VAR_033316
	Natural variant	476	1	M → T. Corresponds to variant rs35488797 [ dbSNP | Ensembl ].		VAR_033317
Experimental info
	Sequence conflict	20	1	E → K in BAG63765. Ref.2
	Sequence conflict	340	1	T → A in BAG65139. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: D4AB4C41B7D5A819	FASTA	565	61,907
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC 70 80 90 100 110 120 QPRCKHGECI GPNKCKCHPG YAGKTCNQDL NECGLKPRPC KHRCMNTYGS YKCYCLNGYM 130 140 150 160 170 180 LMPDGSCSSA LTCSMANCQY GCDVVKGQIR CQCPSPGLQL APDGRTCVDV DECATGRASC 190 200 210 220 230 240 PRFRQCVNTF GSYICKCHKG FDLMYIGGKY QCHDIDECSL GQYQCSSFAR CYNIRGSYKC 250 260 270 280 290 300 KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP KGNGTILKGD TGNNNWIPDV GSTWWPPKTP 310 320 330 340 350 360 YIPPIITNRP TSKPTTRPTP KPTPIPTPPP PPPLPTELRT PLPPTTPERP TTGLTTIAPA 370 380 390 400 410 420 ASTPPGGITV DNRVQTDPQK PRGDVFIPRQ PSNDLFEIFE IERGVSADDE AKDDPGVLVH 430 440 450 460 470 480 SCNFDHGLCG WIREKDNDLH WEPIRDPAGG QYLTVSAAKA PGGKAARLVL PLGRLMHSGD 490 500 510 520 530 540 LCLSFRHKVT GLHSGTLQVF VRKHGAHGAA LWGRNGGHGW RQTQITLRGA DIKSVVFKGE 550 560 KRRGHTGEIG LDDVSLKKGH CSEER
	Isoform 2 [UniParc]. Checksum: E3D7FB3650B7BA29	FASTA	509	55,702
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC 70 80 90 100 110 120 QPRCKHGECI GPNKCKCHPG YAGKTCNQDL NECGLKPRPC KHRCMNTYGS YKCYCLNGYM 130 140 150 160 170 180 LMPDGSCSSA LTCSMANCQY GCDVVKGQIR CQCPSPGLQL APDGRTCVDV DECATGRASC 190 200 210 220 230 240 PRFRQCVNTF GSYICKCHKG FDLMYIGGKY QCHDIDECSL GQYQCSSFAR CYNIRGSYKC 250 260 270 280 290 300 KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP KGNGTILKGD TGNNNWIPDV GSTWWPPKTP 310 320 330 340 350 360 YIPPIITNRP TSKPTTRPTP KPTPIPTPPP PPPLPTELRT PLPPTTPERP TTGLTTIAPA 370 380 390 400 410 420 ASTPPGGITV DNRVQTDPQK PRGDVFSVLV HSCNFDHGLC GWIREKDNDL HWEPIRDPAG 430 440 450 460 470 480 GQYLTVSAAK APGGKAARLV LPLGRLMHSG DLCLSFRHKV TGLHSGTLQV FVRKHGAHGA 490 500 ALWGRNGGHG WRQTQITLRG ADIKSESQR
	Isoform 3 [UniParc]. Checksum: 2A44A7A18BEE77FC	FASTA	595	65,213
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC 70 80 90 100 110 120 QPRCKHGECI GPNKCKCHPG YAGKTCNQDE HIPAPLDQGS EQPLFQPLDH QATSLPSRDL 130 140 150 160 170 180 NECGLKPRPC KHRCMNTYGS YKCYCLNGYM LMPDGSCSSA LTCSMANCQY GCDVVKGQIR 190 200 210 220 230 240 CQCPSPGLQL APDGRTCVDV DECATGRASC PRFRQCVNTF GSYICKCHKG FDLMYIGGKY 250 260 270 280 290 300 QCHDIDECSL GQYQCSSFAR CYNIRGSYKC KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP 310 320 330 340 350 360 KGNGTILKGD TGNNNWIPDV GSTWWPPKTP YIPPIITNRP TSKPTTRPTP KPTPIPTPPP 370 380 390 400 410 420 PPPLPTELRT PLPPTTPERP TTGLTTIAPA ASTPPGGITV DNRVQTDPQK PRGDVFIPRQ 430 440 450 460 470 480 PSNDLFEIFE IERGVSADDE AKDDPGVLVH SCNFDHGLCG WIREKDNDLH WEPIRDPAGG 490 500 510 520 530 540 QYLTVSAAKA PGGKAARLVL PLGRLMHSGD LCLSFRHKVT GLHSGTLQVF VRKHGAHGAA 550 560 570 580 590 LWGRNGGHGW RQTQITLRGA DIKSVVFKGE KRRGHTGEIG LDDVSLKKGH CSEER
	Isoform 4 [UniParc]. Checksum: B440DC01AB4FF573	FASTA	566	61,958
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC 70 80 90 100 110 120 QPRCKHGECI GPNKCKCHPG YAGKTCNQDE HIPAPLDQGS EQPLFQPLDH QATSLPSRDL 130 140 150 160 170 180 NECGLKPRPC KHRCMNTYGS YKCYCLNGYM LMPDGSCSSA LTCSMANCQY GCDVVKGQIR 190 200 210 220 230 240 CQCPSPGLQL APDGRTCVDV DECATGRASC PRFRQCVNTF GSYICKCHKG FDLMYIGGKY 250 260 270 280 290 300 QCHDIDECSL GQYQCSSFAR CYNIRGSYKC KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP 310 320 330 340 350 360 KGNGTILKGD TGNNNWIPDV GSTWWPPKTP YIPPIITNRP TSKPTTRPTP KPTPIPTPPP 370 380 390 400 410 420 PPPLPTELRT PLPPTTPERP TTGLTTIAPA ASTPPGGITV DNRVQTDPQK PRGDVFSVLV 430 440 450 460 470 480 HSCNFDHGLC GWIREKDNDL HWEPIRDPAG GQYLTVSAAK APGGKAARLV LPLGRLMHSG 490 500 510 520 530 540 DLCLSFRHKV TGLHSGTLQV FVRKHGAHGA ALWGRNGGHG WRQTQITLRG ADIKSVVFKG 550 560 EKRRGHTGEI GLDDVSLKKG HCSEER
	Isoform 5 [UniParc]. Checksum: 6DC363CBA70A8AA0	FASTA	536	58,651
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC 70 80 90 100 110 120 QPRCKHGECI GPNKCKCHPG YAGKTCNQDL NECGLKPRPC KHRCMNTYGS YKCYCLNGYM 130 140 150 160 170 180 LMPDGSCSSA LTCSMANCQY GCDVVKGQIR CQCPSPGLQL APDGRTCVDV DECATGRASC 190 200 210 220 230 240 PRFRQCVNTF GSYICKCHKG FDLMYIGGKY QCHDIDECSL GQYQCSSFAR CYNIRGSYKC 250 260 270 280 290 300 KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP KGNGTILKGD TGNNNWIPDV GSTWWPPKTP 310 320 330 340 350 360 YIPPIITNRP TSKPTTRPTP KPTPIPTPPP PPPLPTELRT PLPPTTPERP TTGLTTIAPA 370 380 390 400 410 420 ASTPPGGITV DNRVQTDPQK PRGDVFSVLV HSCNFDHGLC GWIREKDNDL HWEPIRDPAG 430 440 450 460 470 480 GQYLTVSAAK APGGKAARLV LPLGRLMHSG DLCLSFRHKV TGLHSGTLQV FVRKHGAHGA 490 500 510 520 530 ALWGRNGGHG WRQTQITLRG ADIKSVVFKG EKRRGHTGEI GLDDVSLKKG HCSEER
	Isoform 6 [UniParc]. Checksum: 256AD053250C578A	FASTA	582	64,023
	10 20 30 40 50 60 MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPFY 70 80 90 100 110 120 VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG KTCNQDLNEC GLKPRPCKHR 130 140 150 160 170 180 CMNTYGSYKC YCLNGYMLMP DGSCSSALTC SMANCQYGCD VVKGQIRCQC PSPGLQLAPD 190 200 210 220 230 240 GRTCVDVDEC ATGRASCPRF RQCVNTFGSY ICKCHKGFDL MYIGGKYQCH DIDECSLGQY 250 260 270 280 290 300 QCSSFARCYN IRGSYKCKCK EGYQGDGLTC VYIPKVMIEP SGPIHVPKGN GTILKGDTGN 310 320 330 340 350 360 NNWIPDVGST WWPPKTPYIP PIITNRPTSK PTTRPTPKPT PIPTPPPPPP LPTELRTPLP 370 380 390 400 410 420 PTTPERPTTG LTTIAPAAST PPGGITVDNR VQTDPQKPRG DVFIPRQPSN DLFEIFEIER 430 440 450 460 470 480 GVSADDEAKD DPGVLVHSCN FDHGLCGWIR EKDNDLHWEP IRDPAGGQYL TVSAAKAPGG 490 500 510 520 530 540 KAARLVLPLG RLMHSGDLCL SFRHKVTGLH SGTLQVFVRK HGAHGAALWG RNGGHGWRQT 550 560 570 580 QITLRGADIK SVVFKGEKRR GHTGEIGLDD VSLKKGHCSE ER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS HIS-159 AND VAL-234.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6), VARIANT VAL-234. Tissue: Hippocampus, Testis, Trachea and Uterus.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-234.
[5]	"Identification and characterization of a novel human nephronectin gene in silico." Huang J.T.-J., Lee V. Int. J. Mol. Med. 15:719-724(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358336 mRNA. Translation: AAQ88702.1. AK290029 mRNA. Translation: BAF82718.1. AK295772 mRNA. Translation: BAG58596.1. AK302477 mRNA. Translation: BAG63765.1. AK304279 mRNA. Translation: BAG65139.1. AK304721 mRNA. Translation: BAG65484.1. AC093782 Genomic DNA. No translation available. AC109361 Genomic DNA. No translation available. CH471057 Genomic DNA. Translation: EAX06196.1.
IPI	IPI00157556. IPI00748819. IPI00910097. IPI00910888. IPI00940626. IPI00967557.
RefSeq	NP_001028219.1. NM_001033047.2. NP_001171619.1. NM_001184690.1. NP_001171620.1. NM_001184691.1. NP_001171621.1. NM_001184692.1. NP_001171622.1. NM_001184693.1.
UniGene	Hs.518921.
3D structure databases
HSSP	HSSP built from PDB template 1UZK based on UniProtKB P35555.
ProteinModelPortal	Q6UXI9.
SMR	Q6UXI9. Positions 30-254, 422-562.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369323.
PTM databases
PhosphoSite	Q6UXI9.
Polymorphism databases
DMDM	311033424.
Proteomic databases
PaxDb	Q6UXI9.
PRIDE	Q6UXI9.
Protocols and materials databases
DNASU	255743.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305572; ENSP00000302557; ENSG00000168743. ENST00000379987; ENSP00000369323; ENSG00000168743. ENST00000427316; ENSP00000389252; ENSG00000168743. ENST00000453617; ENSP00000402884; ENSG00000168743. ENST00000506666; ENSP00000422474; ENSG00000168743. ENST00000514622; ENSP00000422044; ENSG00000168743.
GeneID	255743.
KEGG	hsa:255743.
UCSC	uc003hya.3. human.
Organism-specific databases
CTD	255743.
GeneCards	GC04P106816.
H-InvDB	HIX0004424.
HGNC	HGNC:27405. NPNT.
HPA	HPA003711.
MIM	610306. gene.
neXtProt	NX_Q6UXI9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254583.
HOGENOM	HOG000059638.
HOVERGEN	HBG108200.
InParanoid	Q6UXI9.
KO	K06824.
OrthoDB	EOG473PR5.
Gene expression databases
ArrayExpress	Q6UXI9.
Bgee	Q6UXI9.
CleanEx	HS_NPNT.
Genevestigator	Q6UXI9.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR000998. MAM_dom. [Graphical view]
Pfam	PF07645. EGF_CA. 3 hits. PF00629. MAM. 1 hit. [Graphical view]
SMART	SM00181. EGF. 3 hits. SM00179. EGF_CA. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 3 hits. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 3 hits. PS00740. MAM_1. False negative. PS50060. MAM_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NPNT. human.
GenomeRNAi	255743.
NextBio	92630.
SOURCE	Search...

Entry information

Entry name

NPNT_HUMAN

Accession

Primary (citable) accession number: Q6UXI9
Secondary accession number(s): A6NFT9 , A8K1W4, B4DIT4, B4DYK3, B4E2H7, B4E3H2, D6RCA1, E9PCK8, E9PCQ1, E9PE64, E9PF04

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.