Q6UXI7 (VITRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vitrin

Gene names

Name:	VIT
ORF Names:	UNQ647/PRO1277

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	678 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes matrix assembly and cell adhesiveness By similarity.
Subunit structure	Binds dermatan sulfate and chondroitin sulfate By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Sequence similarities	Contains 1 LCCL domain. Contains 2 VWFA domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXI7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXI7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-268: Missing.

Isoform 3 (identifier: Q6UXI7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     164-203: ETTKAYQRPP...VATPTTLPRP → KCSRVIESKP...GQAPLALAIF
     204-678: Missing.

Isoform 4 (identifier: Q6UXI7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     267-267: L → LGEMDSWKPGSVLLDE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 678	652	Vitrin		PRO_0000248210
Regions
	Domain	40 – 133	94	LCCL
	Domain	293 – 478	186	VWFA 1
	Domain	495 – 668	174	VWFA 2
	Compositional bias	397 – 400	4	Poly-Val
Amino acid modifications
	Glycosylation	390	1	N-linked (GlcNAc...) Potential
	Glycosylation	520	1	N-linked (GlcNAc...) Potential
	Disulfide bond	46 ↔ 62		By similarity
	Disulfide bond	66 ↔ 86		By similarity
Natural variations
	Alternative sequence	164 – 203	40	ETTKA…TLPRP → KCSRVIESKPSESMNTRRVL GDSGEINILTGQAPLALAIF in isoform 3.		VSP_020209
	Alternative sequence	204 – 678	475	Missing in isoform 3.		VSP_020210
	Alternative sequence	247 – 268	22	Missing in isoform 2.		VSP_020211
	Alternative sequence	267	1	L → LGEMDSWKPGSVLLDE in isoform 4.		VSP_040124
Experimental info
	Sequence conflict	80	1	A → T in AAL18263. Ref.1
	Sequence conflict	93	1	G → S in AAL18263. Ref.1
	Sequence conflict	97	1	N → D in AAL18263. Ref.1
	Sequence conflict	375	1	A → T in AAL18263. Ref.1
	Sequence conflict	419	1	E → V in AAL18263. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9870E75A218C686C	FASTA	678	73,930
	10 20 30 40 50 60 MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV 70 80 90 100 110 120 KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG 130 140 150 160 170 180 VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ 190 200 210 220 230 240 PVTLMQLLAV TVAVATPTTL PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR 250 260 270 280 290 300 PRADPGIQRQ DPSGAAFQKP VGADVSLGLV PKEELSTQSL EPVSLGDPNC KIDLSFLIDG 310 320 330 340 350 360 STSIGKRRFR IQKQLLADVA QALDIGPAGP LMGVVQYGDN PATHFNLKTH TNSRDLKTAI 370 380 390 400 410 420 EKITQRGGLS NVGRAISFVT KNFFSKANGN RSGAPNVVVV MVDGWPTDKV EEASRLARES 430 440 450 460 470 480 GINIFFITIE GAAENEKQYV VEPNFANKAV CRTNGFYSLH VQSWFGLHKT LQPLVKRVCD 490 500 510 520 530 540 TDRLACSKTC LNSADIGFVI DGSSSVGTGN FRTVLQFVTN LTKEFEISDT DTRIGAVQYT 550 560 570 580 590 600 YEQRLEFGFD KYSSKPDILN AIKRVGYWSG GTSTGAAINF ALEQLFKKSK PNKRKLMILI 610 620 630 640 650 660 TDGRSYDDVR IPAMAAHLKG VITYAIGVAW AAQEELEVIA THPARDHSFF VDEFDNLHQY 670 VPRIIQNICT EFNSQPRN
	Isoform 2 [UniParc]. Checksum: 4A673A979F7A87B1	FASTA	656	71,707
	10 20 30 40 50 60 MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV 70 80 90 100 110 120 KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG 130 140 150 160 170 180 VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ 190 200 210 220 230 240 PVTLMQLLAV TVAVATPTTL PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR 250 260 270 280 290 300 PRADPGLVPK EELSTQSLEP VSLGDPNCKI DLSFLIDGST SIGKRRFRIQ KQLLADVAQA 310 320 330 340 350 360 LDIGPAGPLM GVVQYGDNPA THFNLKTHTN SRDLKTAIEK ITQRGGLSNV GRAISFVTKN 370 380 390 400 410 420 FFSKANGNRS GAPNVVVVMV DGWPTDKVEE ASRLARESGI NIFFITIEGA AENEKQYVVE 430 440 450 460 470 480 PNFANKAVCR TNGFYSLHVQ SWFGLHKTLQ PLVKRVCDTD RLACSKTCLN SADIGFVIDG 490 500 510 520 530 540 SSSVGTGNFR TVLQFVTNLT KEFEISDTDT RIGAVQYTYE QRLEFGFDKY SSKPDILNAI 550 560 570 580 590 600 KRVGYWSGGT STGAAINFAL EQLFKKSKPN KRKLMILITD GRSYDDVRIP AMAAHLKGVI 610 620 630 640 650 TYAIGVAWAA QEELEVIATH PARDHSFFVD EFDNLHQYVP RIIQNICTEF NSQPRN
	Isoform 3 [UniParc]. Checksum: 363E8CF460076BBA	FASTA	203	21,788
	10 20 30 40 50 60 MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV 70 80 90 100 110 120 KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG 130 140 150 160 170 180 VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGKCSRVIE SKPSESMNTR 190 200 RVLGDSGEIN ILTGQAPLAL AIF
	Isoform 4 [UniParc]. Checksum: 2DE8B2421F2D496D	FASTA	693	75,575
	10 20 30 40 50 60 MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV 70 80 90 100 110 120 KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG 130 140 150 160 170 180 VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ 190 200 210 220 230 240 PVTLMQLLAV TVAVATPTTL PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR 250 260 270 280 290 300 PRADPGIQRQ DPSGAAFQKP VGADVSLGEM DSWKPGSVLL DEGLVPKEEL STQSLEPVSL 310 320 330 340 350 360 GDPNCKIDLS FLIDGSTSIG KRRFRIQKQL LADVAQALDI GPAGPLMGVV QYGDNPATHF 370 380 390 400 410 420 NLKTHTNSRD LKTAIEKITQ RGGLSNVGRA ISFVTKNFFS KANGNRSGAP NVVVVMVDGW 430 440 450 460 470 480 PTDKVEEASR LARESGINIF FITIEGAAEN EKQYVVEPNF ANKAVCRTNG FYSLHVQSWF 490 500 510 520 530 540 GLHKTLQPLV KRVCDTDRLA CSKTCLNSAD IGFVIDGSSS VGTGNFRTVL QFVTNLTKEF 550 560 570 580 590 600 EISDTDTRIG AVQYTYEQRL EFGFDKYSSK PDILNAIKRV GYWSGGTSTG AAINFALEQL 610 620 630 640 650 660 FKKSKPNKRK LMILITDGRS YDDVRIPAMA AHLKGVITYA IGVAWAAQEE LEVIATHPAR 670 680 690 DHSFFVDEFD NLHQYVPRII QNICTEFNSQ PRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily." Mayne R., Ren Z.-X., Liu J.G., Cook T., Carson M., Narayana S. Biochem. Soc. Trans. 27:832-835(1999) [PubMed: 10830112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skeletal muscle.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Placenta and Synovium.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF063833 mRNA. Translation: AAL18263.1. AY358338 mRNA. Translation: AAQ88704.1. AK056772 mRNA. Translation: BAB71279.1. AK292149 mRNA. Translation: BAF84838.1. AC007363 Genomic DNA. Translation: AAF19243.2. CH471053 Genomic DNA. Translation: EAX00416.1. BC061519 mRNA. Translation: AAH61519.1.
IPI	IPI00785025. IPI00785115. IPI00963930. IPI00964774.
RefSeq	NP_001171440.1. NM_001177969.1. NP_001171441.1. NM_001177970.1. NP_001171442.1. NM_001177971.1. NP_001171443.1. NM_001177972.1. NP_444506.2. NM_053276.3.
UniGene	Hs.137415.
3D structure databases
HSSP	HSSP built from PDB template 1JBI based on UniProtKB O43405.
ProteinModelPortal	Q6UXI7.
SMR	Q6UXI7. Positions 42-137, 291-482, 492-671.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UXI7.
Polymorphism databases
DMDM	74739159.
Proteomic databases
PRIDE	Q6UXI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000389975; ENSP00000374625; ENSG00000205221.
GeneID	5212.
KEGG	hsa:5212.
UCSC	uc002rpk.2. human. uc002rpm.1. human. uc010ezv.1. human.
Organism-specific databases
CTD	5212.
GeneCards	GC02P036835.
H-InvDB	HIX0018783.
HGNC	HGNC:12697. VIT.
neXtProt	NX_Q6UXI7.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074248.
HOVERGEN	HBG005372.
OMA	VPRIIQN.
Gene expression databases
ArrayExpress	Q6UXI7.
Bgee	Q6UXI7.
CleanEx	HS_VIT.
Genevestigator	Q6UXI7.
GermOnline	ENSG00000205221. Homo sapiens.
Family and domain databases
InterPro	IPR004043. LCCL. IPR002035. VWF_A. [Graphical view]
Gene3D	G3DSA:2.170.130.20. LCCL. 1 hit.
Pfam	PF03815. LCCL. 1 hit. PF00092. VWA. 2 hits. [Graphical view]
SMART	SM00603. LCCL. 1 hit. SM00327. VWA. 2 hits. [Graphical view]
SUPFAM	SSF69848. LCCL. 1 hit.
PROSITE	PS50820. LCCL. 1 hit. PS50234. VWFA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VITRN_HUMAN

Accession

Primary (citable) accession number: Q6UXI7
Secondary accession number(s): A6NKI9 , A8K7Y4, Q6P7T3, Q96DM8, Q96DT1, Q9UDN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.