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Protein

Vitrin

Gene

VIT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vitrin
Gene namesi
Name:VIT
ORF Names:UNQ647/PRO1277
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12697. VIT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37316.

Polymorphism and mutation databases

BioMutaiVIT.
DMDMi74739159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 678652VitrinPRO_0000248210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 62PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence analysis
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXI7.
PeptideAtlasiQ6UXI7.
PRIDEiQ6UXI7.

PTM databases

iPTMnetiQ6UXI7.
PhosphoSiteiQ6UXI7.

Expressioni

Gene expression databases

BgeeiENSG00000205221.
CleanExiHS_VIT.
ExpressionAtlasiQ6UXI7. baseline and differential.
GenevisibleiQ6UXI7. HS.

Organism-specific databases

HPAiHPA058503.
HPA065598.

Interactioni

Subunit structurei

Binds dermatan sulfate and chondroitin sulfate.By similarity

Protein-protein interaction databases

BioGridi111233. 2 interactions.
STRINGi9606.ENSP00000368544.

Structurei

3D structure databases

ProteinModelPortaliQ6UXI7.
SMRiQ6UXI7. Positions 44-135, 289-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 13394LCCLPROSITE-ProRule annotationAdd
BLAST
Domaini293 – 478186VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini495 – 668174VWFA 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi397 – 4004Poly-Val

Sequence similaritiesi

Contains 1 LCCL domain.PROSITE-ProRule annotation
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR88. Eukaryota.
ENOG410YE05. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000013195.
HOVERGENiHBG005372.
InParanoidiQ6UXI7.
OMAiNKAVCRT.
OrthoDBiEOG091G002N.
PhylomeDBiQ6UXI7.
TreeFamiTF318242.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR004043. LCCL.
IPR030763. Vitrin.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF107. PTHR11132:SF107. 2 hits.
PfamiPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEiPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA
60 70 80 90 100
GKIIDPEFIV KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG
110 120 130 140 150
KILVRKVAGQ SGYKGSYSNG VQSLSLPRWR ESFIVLESKP KKGVTYPSAL
160 170 180 190 200
TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ PVTLMQLLAV TVAVATPTTL
210 220 230 240 250
PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR PRADPGIQRQ
260 270 280 290 300
DPSGAAFQKP VGADVSLGLV PKEELSTQSL EPVSLGDPNC KIDLSFLIDG
310 320 330 340 350
STSIGKRRFR IQKQLLADVA QALDIGPAGP LMGVVQYGDN PATHFNLKTH
360 370 380 390 400
TNSRDLKTAI EKITQRGGLS NVGRAISFVT KNFFSKANGN RSGAPNVVVV
410 420 430 440 450
MVDGWPTDKV EEASRLARES GINIFFITIE GAAENEKQYV VEPNFANKAV
460 470 480 490 500
CRTNGFYSLH VQSWFGLHKT LQPLVKRVCD TDRLACSKTC LNSADIGFVI
510 520 530 540 550
DGSSSVGTGN FRTVLQFVTN LTKEFEISDT DTRIGAVQYT YEQRLEFGFD
560 570 580 590 600
KYSSKPDILN AIKRVGYWSG GTSTGAAINF ALEQLFKKSK PNKRKLMILI
610 620 630 640 650
TDGRSYDDVR IPAMAAHLKG VITYAIGVAW AAQEELEVIA THPARDHSFF
660 670
VDEFDNLHQY VPRIIQNICT EFNSQPRN
Length:678
Mass (Da):73,930
Last modified:May 24, 2005 - v1
Checksum:i9870E75A218C686C
GO
Isoform 2 (identifier: Q6UXI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-268: Missing.

Show »
Length:656
Mass (Da):71,707
Checksum:i4A673A979F7A87B1
GO
Isoform 3 (identifier: Q6UXI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-203: ETTKAYQRPP...VATPTTLPRP → KCSRVIESKP...GQAPLALAIF
     204-678: Missing.

Show »
Length:203
Mass (Da):21,788
Checksum:i363E8CF460076BBA
GO
Isoform 4 (identifier: Q6UXI7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-267: L → LGEMDSWKPGSVLLDE

Show »
Length:693
Mass (Da):75,575
Checksum:i2DE8B2421F2D496D
GO
Isoform 5 (identifier: Q6UXI7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-289: GLVPKEELSTQSLEPVSLGDPN → D

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):71,754
Checksum:i3A996745E2385B40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801A → T in AAL18263 (PubMed:10830112).Curated
Sequence conflicti93 – 931G → S in AAL18263 (PubMed:10830112).Curated
Sequence conflicti97 – 971N → D in AAL18263 (PubMed:10830112).Curated
Sequence conflicti375 – 3751A → T in AAL18263 (PubMed:10830112).Curated
Sequence conflicti419 – 4191E → V in AAL18263 (PubMed:10830112).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti555 – 5551K → R.1 Publication
Corresponds to variant rs2072526 [ dbSNP | Ensembl ].
VAR_068964
Natural varianti559 – 5591L → I.1 Publication
Corresponds to variant rs2072525 [ dbSNP | Ensembl ].
VAR_068965
Natural varianti658 – 6581H → Y.1 Publication
Corresponds to variant rs11901202 [ dbSNP | Ensembl ].
VAR_068966

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei164 – 20340ETTKA…TLPRP → KCSRVIESKPSESMNTRRVL GDSGEINILTGQAPLALAIF in isoform 3. 2 PublicationsVSP_020209Add
BLAST
Alternative sequencei204 – 678475Missing in isoform 3. 2 PublicationsVSP_020210Add
BLAST
Alternative sequencei247 – 26822Missing in isoform 2. 1 PublicationVSP_020211Add
BLAST
Alternative sequencei267 – 2671L → LGEMDSWKPGSVLLDE in isoform 4. 1 PublicationVSP_040124
Alternative sequencei268 – 28922GLVPK…LGDPN → D in isoform 5. 1 PublicationVSP_044597Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063833 mRNA. Translation: AAL18263.1.
AY358338 mRNA. Translation: AAQ88704.1.
AK056772 mRNA. Translation: BAB71279.1.
AK292149 mRNA. Translation: BAF84838.1.
AC007363 Genomic DNA. Translation: AAF19243.2.
CH471053 Genomic DNA. Translation: EAX00416.1.
BC061519 mRNA. Translation: AAH61519.1.
BC128260 mRNA. Translation: AAI28261.1.
CCDSiCCDS33180.1. [Q6UXI7-4]
CCDS54347.1. [Q6UXI7-1]
CCDS54348.1. [Q6UXI7-5]
CCDS54349.1. [Q6UXI7-2]
CCDS54350.1. [Q6UXI7-3]
RefSeqiNP_001171440.1. NM_001177969.1. [Q6UXI7-1]
NP_001171441.1. NM_001177970.1. [Q6UXI7-5]
NP_001171442.1. NM_001177971.1. [Q6UXI7-2]
NP_001171443.1. NM_001177972.1. [Q6UXI7-3]
NP_444506.2. NM_053276.3. [Q6UXI7-4]
UniGeneiHs.137415.

Genome annotation databases

EnsembliENST00000379241; ENSP00000368543; ENSG00000205221. [Q6UXI7-2]
ENST00000379242; ENSP00000368544; ENSG00000205221. [Q6UXI7-4]
ENST00000389975; ENSP00000374625; ENSG00000205221. [Q6UXI7-1]
ENST00000401530; ENSP00000385658; ENSG00000205221. [Q6UXI7-5]
ENST00000457137; ENSP00000393561; ENSG00000205221. [Q6UXI7-3]
GeneIDi5212.
KEGGihsa:5212.
UCSCiuc002rpk.4. human. [Q6UXI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063833 mRNA. Translation: AAL18263.1.
AY358338 mRNA. Translation: AAQ88704.1.
AK056772 mRNA. Translation: BAB71279.1.
AK292149 mRNA. Translation: BAF84838.1.
AC007363 Genomic DNA. Translation: AAF19243.2.
CH471053 Genomic DNA. Translation: EAX00416.1.
BC061519 mRNA. Translation: AAH61519.1.
BC128260 mRNA. Translation: AAI28261.1.
CCDSiCCDS33180.1. [Q6UXI7-4]
CCDS54347.1. [Q6UXI7-1]
CCDS54348.1. [Q6UXI7-5]
CCDS54349.1. [Q6UXI7-2]
CCDS54350.1. [Q6UXI7-3]
RefSeqiNP_001171440.1. NM_001177969.1. [Q6UXI7-1]
NP_001171441.1. NM_001177970.1. [Q6UXI7-5]
NP_001171442.1. NM_001177971.1. [Q6UXI7-2]
NP_001171443.1. NM_001177972.1. [Q6UXI7-3]
NP_444506.2. NM_053276.3. [Q6UXI7-4]
UniGeneiHs.137415.

3D structure databases

ProteinModelPortaliQ6UXI7.
SMRiQ6UXI7. Positions 44-135, 289-677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111233. 2 interactions.
STRINGi9606.ENSP00000368544.

PTM databases

iPTMnetiQ6UXI7.
PhosphoSiteiQ6UXI7.

Polymorphism and mutation databases

BioMutaiVIT.
DMDMi74739159.

Proteomic databases

PaxDbiQ6UXI7.
PeptideAtlasiQ6UXI7.
PRIDEiQ6UXI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379241; ENSP00000368543; ENSG00000205221. [Q6UXI7-2]
ENST00000379242; ENSP00000368544; ENSG00000205221. [Q6UXI7-4]
ENST00000389975; ENSP00000374625; ENSG00000205221. [Q6UXI7-1]
ENST00000401530; ENSP00000385658; ENSG00000205221. [Q6UXI7-5]
ENST00000457137; ENSP00000393561; ENSG00000205221. [Q6UXI7-3]
GeneIDi5212.
KEGGihsa:5212.
UCSCiuc002rpk.4. human. [Q6UXI7-1]

Organism-specific databases

CTDi5212.
GeneCardsiVIT.
HGNCiHGNC:12697. VIT.
HPAiHPA058503.
HPA065598.
neXtProtiNX_Q6UXI7.
PharmGKBiPA37316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR88. Eukaryota.
ENOG410YE05. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000013195.
HOVERGENiHBG005372.
InParanoidiQ6UXI7.
OMAiNKAVCRT.
OrthoDBiEOG091G002N.
PhylomeDBiQ6UXI7.
TreeFamiTF318242.

Miscellaneous databases

ChiTaRSiVIT. human.
GenomeRNAii5212.
PROiQ6UXI7.

Gene expression databases

BgeeiENSG00000205221.
CleanExiHS_VIT.
ExpressionAtlasiQ6UXI7. baseline and differential.
GenevisibleiQ6UXI7. HS.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR004043. LCCL.
IPR030763. Vitrin.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF107. PTHR11132:SF107. 2 hits.
PfamiPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEiPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVITRN_HUMAN
AccessioniPrimary (citable) accession number: Q6UXI7
Secondary accession number(s): A1A526
, A6NKI9, A8K7Y4, E9PF47, Q6P7T3, Q96DM8, Q96DT1, Q9UDN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.