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Protein

Inactive serine protease PAMR1

Gene

PAMR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regeneration of skeletal muscle.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog

Protein family/group databases

MEROPSiS01.998.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease PAMR1
Alternative name(s):
Peptidase domain-containing protein associated with muscle regeneration 1
Regeneration-associated muscle protease homolog
Gene namesi
Name:PAMR1
Synonyms:RAMP
ORF Names:FP938, UNQ699/PRO1344
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24554. PAMR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25891.
OpenTargetsiENSG00000149090.
PharmGKBiPA164724339.

Polymorphism and mutation databases

BioMutaiPAMR1.
DMDMi74738221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028760222 – 720Inactive serine protease PAMR1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi128 ↔ 150By similarity
Disulfide bondi177 ↔ 199By similarity
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi244 ↔ 260By similarity
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi280 ↔ 329By similarity
Disulfide bondi315 ↔ 342By similarity
Disulfide bondi414 ↔ 442By similarity
Disulfide bondi489 ↔ 505By similarity
Glycosylationi614N-linked (GlcNAc...)1 Publication1
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi661 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXH9.
PeptideAtlasiQ6UXH9.
PRIDEiQ6UXH9.

PTM databases

iPTMnetiQ6UXH9.
PhosphoSitePlusiQ6UXH9.

Expressioni

Inductioni

Strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line.1 Publication

Gene expression databases

BgeeiENSG00000149090.
ExpressionAtlasiQ6UXH9. baseline and differential.
GenevisibleiQ6UXH9. HS.

Organism-specific databases

HPAiHPA039823.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000278360.

Structurei

3D structure databases

ProteinModelPortaliQ6UXH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 236CUBPROSITE-ProRule annotationAdd BLAST109
Domaini235 – 272EGF-likePROSITE-ProRule annotationAdd BLAST38
Domaini278 – 344Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini387 – 444Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini445 – 720Peptidase S1PROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 94Cys-richAdd BLAST53

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
HOGENOMiHOG000168611.
InParanoidiQ6UXH9.
OMAiIPCCRNE.
OrthoDBiEOG091G0GHF.
PhylomeDBiQ6UXH9.
TreeFamiTF351669.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00041. CUB. 1 hit.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00008. EGF. 1 hit.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGCWTQLG LTFLQLLLIS SLPREYTVIN EACPGAEWNI MCRECCEYDQ
60 70 80 90 100
IECVCPGKRE VVGYTIPCCR NEENECDSCL IHPGCTIFEN CKSCRNGSWG
110 120 130 140 150
GTLDDFYVKG FYCAECRAGW YGGDCMRCGQ VLRAPKGQIL LESYPLNAHC
160 170 180 190 200
EWTIHAKPGF VIQLRFVMLS LEFDYMCQYD YVEVRDGDNR DGQIIKRVCG
210 220 230 240 250
NERPAPIQSI GSSLHVLFHS DGSKNFDGFH AIYEEITACS SSPCFHDGTC
260 270 280 290 300
VLDKAGSYKC ACLAGYTGQR CENLLEERNC SDPGGPVNGY QKITGGPGLI
310 320 330 340 350
NGRHAKIGTV VSFFCNNSYV LSGNEKRTCQ QNGEWSGKQP ICIKACREPK
360 370 380 390 400
ISDLVRRRVL PMQVQSRETP LHQLYSAAFS KQKLQSAPTK KPALPFGDLP
410 420 430 440 450
MGYQHLHTQL QYECISPFYR RLGSSRRTCL RTGKWSGRAP SCIPICGKIE
460 470 480 490 500
NITAPKTQGL RWPWQAAIYR RTSGVHDGSL HKGAWFLVCS GALVNERTVV
510 520 530 540 550
VAAHCVTDLG KVTMIKTADL KVVLGKFYRD DDRDEKTIQS LQISAIILHP
560 570 580 590 600
NYDPILLDAD IAILKLLDKA RISTRVQPIC LAASRDLSTS FQESHITVAG
610 620 630 640 650
WNVLADVRSP GFKNDTLRSG VVSVVDSLLC EEQHEDHGIP VSVTDNMFCA
660 670 680 690 700
SWEPTAPSDI CTAETGGIAA VSFPGRASPE PRWHLMGLVS WSYDKTCSHR
710 720
LSTAFTKVLP FKDWIERNMK
Length:720
Mass (Da):80,199
Last modified:July 5, 2004 - v1
Checksum:iDC898BC7241289D3
GO
Isoform 2 (identifier: Q6UXH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: L → LLEAGKSKIKASEDSLSV

Show »
Length:737
Mass (Da):81,943
Checksum:iFD3BACCFE47778FE
GO
Isoform 3 (identifier: Q6UXH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-238: RCGQVLRAPK...FHAIYEEITA → P

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):67,541
Checksum:iEFBDB755BCA816C4
GO

Sequence cautioni

The sequence AAQ15224 differs from that shown. Reason: Frameshift at position 334.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257S → P in BAB55404 (PubMed:14702039).Curated1
Sequence conflicti396F → S in BAH14559 (PubMed:14702039).Curated1
Sequence conflicti542Q → R in CAB43317 (PubMed:17974005).Curated1
Sequence conflicti542Q → R in CAI46203 (PubMed:17974005).Curated1
Sequence conflicti542Q → R in CAE45808 (PubMed:17974005).Curated1
Sequence conflicti665T → A in CAE45808 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032335305A → T.Corresponds to variant rs16927482dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055371127 – 238RCGQV…EEITA → P in isoform 3. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_025568274L → LLEAGKSKIKASEDSLSV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358346 mRNA. Translation: AAQ88712.1.
AK027841 mRNA. Translation: BAB55404.1.
AK316188 mRNA. Translation: BAH14559.1.
AL050214 mRNA. Translation: CAB43317.1.
AL832391 mRNA. Translation: CAI46203.1.
BX640676 mRNA. Translation: CAE45808.1.
AC090625 Genomic DNA. No translation available.
AL354921 Genomic DNA. No translation available.
BC089434 mRNA. Translation: AAH89434.1.
AF370388 mRNA. Translation: AAQ15224.1. Frameshift.
CCDSiCCDS31460.1. [Q6UXH9-1]
CCDS60760.1. [Q6UXH9-3]
CCDS7898.1. [Q6UXH9-2]
PIRiT08805.
RefSeqiNP_001001991.1. NM_001001991.2. [Q6UXH9-1]
NP_001269604.1. NM_001282675.1.
NP_001269605.1. NM_001282676.1. [Q6UXH9-3]
NP_056245.2. NM_015430.3. [Q6UXH9-2]
UniGeneiHs.55044.

Genome annotation databases

EnsembliENST00000615849; ENSP00000479260; ENSG00000149090. [Q6UXH9-3]
ENST00000619888; ENSP00000483703; ENSG00000149090. [Q6UXH9-1]
ENST00000622144; ENSP00000482899; ENSG00000149090. [Q6UXH9-2]
GeneIDi25891.
KEGGihsa:25891.
UCSCiuc031xjw.2. human. [Q6UXH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358346 mRNA. Translation: AAQ88712.1.
AK027841 mRNA. Translation: BAB55404.1.
AK316188 mRNA. Translation: BAH14559.1.
AL050214 mRNA. Translation: CAB43317.1.
AL832391 mRNA. Translation: CAI46203.1.
BX640676 mRNA. Translation: CAE45808.1.
AC090625 Genomic DNA. No translation available.
AL354921 Genomic DNA. No translation available.
BC089434 mRNA. Translation: AAH89434.1.
AF370388 mRNA. Translation: AAQ15224.1. Frameshift.
CCDSiCCDS31460.1. [Q6UXH9-1]
CCDS60760.1. [Q6UXH9-3]
CCDS7898.1. [Q6UXH9-2]
PIRiT08805.
RefSeqiNP_001001991.1. NM_001001991.2. [Q6UXH9-1]
NP_001269604.1. NM_001282675.1.
NP_001269605.1. NM_001282676.1. [Q6UXH9-3]
NP_056245.2. NM_015430.3. [Q6UXH9-2]
UniGeneiHs.55044.

3D structure databases

ProteinModelPortaliQ6UXH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000278360.

Protein family/group databases

MEROPSiS01.998.

PTM databases

iPTMnetiQ6UXH9.
PhosphoSitePlusiQ6UXH9.

Polymorphism and mutation databases

BioMutaiPAMR1.
DMDMi74738221.

Proteomic databases

PaxDbiQ6UXH9.
PeptideAtlasiQ6UXH9.
PRIDEiQ6UXH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615849; ENSP00000479260; ENSG00000149090. [Q6UXH9-3]
ENST00000619888; ENSP00000483703; ENSG00000149090. [Q6UXH9-1]
ENST00000622144; ENSP00000482899; ENSG00000149090. [Q6UXH9-2]
GeneIDi25891.
KEGGihsa:25891.
UCSCiuc031xjw.2. human. [Q6UXH9-1]

Organism-specific databases

CTDi25891.
DisGeNETi25891.
GeneCardsiPAMR1.
HGNCiHGNC:24554. PAMR1.
HPAiHPA039823.
neXtProtiNX_Q6UXH9.
OpenTargetsiENSG00000149090.
PharmGKBiPA164724339.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
HOGENOMiHOG000168611.
InParanoidiQ6UXH9.
OMAiIPCCRNE.
OrthoDBiEOG091G0GHF.
PhylomeDBiQ6UXH9.
TreeFamiTF351669.

Miscellaneous databases

GenomeRNAii25891.
PROiQ6UXH9.

Gene expression databases

BgeeiENSG00000149090.
ExpressionAtlasiQ6UXH9. baseline and differential.
GenevisibleiQ6UXH9. HS.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00041. CUB. 1 hit.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00008. EGF. 1 hit.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAMR1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXH9
Secondary accession number(s): A8MQ58
, B7ZA73, Q5EBL7, Q5JPI4, Q6N062, Q71RE9, Q96JW2, Q9Y432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.