CD300LG

Functionⁱ

Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).By similarity

GO - Molecular functionⁱ

IgM binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

immune system process Source: UniProtKB-KW
immunoglobulin transcytosis in epithelial cells Source: Ensembl
regulation of immune response Source: Reactome

Complete GO annotation...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Reactomeⁱ

R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CMRF35-like molecule 9 Short name: CLM-9 Alternative name(s): CD300 antigen-like family member G Triggering receptor expressed on myeloid cells 4 Short name: TREM-4 CD_antigen: CD300g
Gene namesⁱ	Name:CD300LG Synonyms:CLM9, TREM4 ORF Names:UNQ422/PRO846
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30455. CD300LG.

HGNCⁱ

HGNC:30455. CD300LG.

Subcellular locationⁱ

Note:

Transcytoses across the cytoplasm.By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 247	ExtracellularSequence analysisAdd BLAST	229
Transmembraneⁱ	248 – 268	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	269 – 332	CytoplasmicSequence analysisAdd BLAST	64

GO - Cellular componentⁱ

apical plasma membrane Source: UniProtKB-SubCell
basolateral plasma membrane Source: UniProtKB-SubCell
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 23376485
integral component of membrane Source: UniProtKB-KW
multivesicular body membrane Source: UniProtKB-SubCell
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	146894.
Open Targets More...OpenTargetsⁱ	ENSG00000161649.
PharmGKBⁱ	PA142672154.

Polymorphism and mutation databases

BioMutaⁱ	CD300LG.
DMDMⁱ	296434455.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	1 PublicationAdd BLAST		18
ChainⁱPRO_0000306112	19 – 332	CMRF35-like molecule 9Add BLAST		314

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	37 ↔ 107	PROSITE-ProRule annotation
Glycosylationⁱ	96	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	137	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	143	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	144	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	155	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	161	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	170	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	171	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	177	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	187	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	195	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	196	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	199	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	201	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	202	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	207	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	208	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	213	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	214	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	222	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	223	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	224	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	228	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	229	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	237	O-linked (GalNAc...) serineSequence analysis	1

Post-translational modificationⁱ

O-glycosylated with sialylated oligosaccharides.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q6UXG3.
PeptideAtlas More...PeptideAtlasⁱ	Q6UXG3.
PRIDEⁱ	Q6UXG3.

PTM databases

iPTMnetⁱ	Q6UXG3.
PhosphoSitePlusⁱ	Q6UXG3.

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, skeletal muscle and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000161649.
CleanExⁱ	HS_CD300LG.
ExpressionAtlasⁱ	Q6UXG3. baseline and differential.
Genevisibleⁱ	Q6UXG3. HS.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KRTAP10-9	P60411	3	EBI-10254587,EBI-10172052

With

Entry

#Exp.

IntAct

Notes

KRTAP10-9

P60411

3

EBI-10254587,EBI-10172052

GO - Molecular functionⁱ

IgM binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	127023. 2 interactors.
IntActⁱ	Q6UXG3. 4 interactors.
STRINGⁱ	9606.ENSP00000321005.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6UXG3.
SMRⁱ	Q6UXG3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 121	Ig-like V-typeAdd BLAST		103

Domainⁱ

Ig-like V-type domain mediates binding to lymphocyte.By similarity

Sequence similaritiesⁱ

Belongs to the CD300 family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J03P. Eukaryota. ENOG41114KV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00470000042273.
HOGENOMⁱ	HOG000168404.
HOVERGENⁱ	HBG107721.
InParanoidⁱ	Q6UXG3.
KEGG Orthology (KO) More...KOⁱ	K16663.
OMAⁱ	AKAWQTQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MYS.
PhylomeDBⁱ	Q6UXG3.
TreeFamⁱ	TF334441.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686. V-set. 1 hit.
SMARTⁱ	View protein in SMART SM00409. IG. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit.

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6UXG3-1) [UniParc]FASTA Add to basket

Also known as: CD300LG-gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW 
        60         70         80         90        100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ 
       110        120        130        140        150
DAGEYWCGVE KRGPDESLLI SLFVFPGPCC PPSPSPTFQP LATTRLQPKA 
       160        170        180        190        200
KAQQTQPPGL TSPGLYPAAT TAKQGKTGAE APPLPGTSQY GHERTSQYTG 
       210        220        230        240        250
TSPHPATSPP AGSSRPPMQL DSTSAEDTSP ALSSGSSKPR VSIPMVRILA 
       260        270        280        290        300
PVLVLLSLLS AAGLIAFCSH LLLWRKEAQQ ATETQRNEKF CLSRLTAEEK 
       310        320        330 
EAPSQAPEGD VISMPPLHTS EEELGFSKFV SA

Length:332

Mass (Da):36,060

Last modified:May 18, 2010 - v2

Checksum:ⁱ2347FF0FA55515FB

GO

Isoform 2 (identifier: Q6UXG3-2) [UniParc]FASTA Add to basket

Also known as: TREM4-alpha, CD300LG-alpha 1

The sequence of this isoform differs from the canonical sequence as follows:
127-211: Missing.
296-332: TAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA → NHRTSELDPDEAFEISSLTFLSV

« Hide

        10         20         30         40         50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW 
        60         70         80         90        100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ 
       110        120        130        140        150
DAGEYWCGVE KRGPDESLLI SLFVFPGSSR PPMQLDSTSA EDTSPALSSG 
       160        170        180        190        200
SSKPRVSIPM VRILAPVLVL LSLLSAAGLI AFCSHLLLWR KEAQQATETQ 
       210        220        230 
RNEKFCLSRL NHRTSELDPD EAFEISSLTF LSV

Show »

Length:233

Mass (Da):26,091

Checksum:ⁱ8D227B31A9739898

GO

Isoform 3 (identifier: Q6UXG3-3) [UniParc]FASTA Add to basket

Also known as: TREM4-beta, CD300LG-alpha 2

The sequence of this isoform differs from the canonical sequence as follows:
127-211: Missing.
296-332: TAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA → NSLMFSLSLPWL

« Hide

        10         20         30         40         50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW 
        60         70         80         90        100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ 
       110        120        130        140        150
DAGEYWCGVE KRGPDESLLI SLFVFPGSSR PPMQLDSTSA EDTSPALSSG 
       160        170        180        190        200
SSKPRVSIPM VRILAPVLVL LSLLSAAGLI AFCSHLLLWR KEAQQATETQ 
       210        220 
RNEKFCLSRL NSLMFSLSLP WL

Show »

Length:222

Mass (Da):24,891

Checksum:ⁱ5E3DC88C1EDF86D4

GO

Isoform 4 (identifier: Q6UXG3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
296-332: TAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA → NSLMFSLSLPWL

« Hide

        10         20         30         40         50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW 
        60         70         80         90        100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ 
       110        120        130        140        150
DAGEYWCGVE KRGPDESLLI SLFVFPGPCC PPSPSPTFQP LATTRLQPKA 
       160        170        180        190        200
KAQQTQPPGL TSPGLYPAAT TAKQGKTGAE APPLPGTSQY GHERTSQYTG 
       210        220        230        240        250
TSPHPATSPP AGSSRPPMQL DSTSAEDTSP ALSSGSSKPR VSIPMVRILA 
       260        270        280        290        300
PVLVLLSLLS AAGLIAFCSH LLLWRKEAQQ ATETQRNEKF CLSRLNSLMF 

SLSLPWL

Note: No experimental confirmation available.

Show »

Length:307

Mass (Da):33,521

Checksum:ⁱ3E0ED9B3BC4E569D

GO

Isoform 5 (identifier: Q6UXG3-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
127-161: GPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGLT → A
296-332: TAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA → NSLMFSLSLPWL

« Hide

        10         20         30         40         50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW 
        60         70         80         90        100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ 
       110        120        130        140        150
DAGEYWCGVE KRGPDESLLI SLFVFPASPG LYPAATTAKQ GKTGAEAPPL 
       160        170        180        190        200
PGTSQYGHER TSQYTGTSPH PATSPPAGSS RPPMQLDSTS AEDTSPALSS 
       210        220        230        240        250
GSSKPRVSIP MVRILAPVLV LLSLLSAAGL IAFCSHLLLW RKEAQQATET 
       260        270 
QRNEKFCLSR LNSLMFSLSL PWL

Note: No experimental confirmation available.

Show »

Length:273

Mass (Da):29,965

Checksum:ⁱ8EBC7C234BADF339

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10	C → W in AAN86134 (Ref. 1) Curated	1
Sequence conflictⁱ	10	C → W in AAN86135 (Ref. 1) Curated	1
Sequence conflictⁱ	45	D → G in AAN86134 (Ref. 1) Curated	1
Sequence conflictⁱ	45	D → G in AAN86135 (Ref. 1) Curated	1
Sequence conflictⁱ	64	T → H in AAN86134 (Ref. 1) Curated	1
Sequence conflictⁱ	64	T → H in AAN86135 (Ref. 1) Curated	1
Sequence conflictⁱ	79	V → L in AAN86134 (Ref. 1) Curated	1
Sequence conflictⁱ	79	V → L in AAN86135 (Ref. 1) Curated	1
Sequence conflictⁱ	113	G → A in AAN86134 (Ref. 1) Curated	1
Sequence conflictⁱ	113	G → A in AAN86135 (Ref. 1) Curated	1
Sequence conflictⁱ	291	C → W in AAQ88730 (PubMed:12975309).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035261	221	D → N1 PublicationCorresponds to variant dbSNP:rs17852267Ensembl.		1
Natural variantⁱVAR_035262	228	T → A1 PublicationCorresponds to variant dbSNP:rs12453522Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_028410	127 – 211	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	85
Alternative sequenceⁱVSP_045362	127 – 161	GPCCP…PPGLT → A in isoform 5. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_028411	296 – 332	TAEEK…KFVSA → NHRTSELDPDEAFEISSLTF LSV in isoform 2. 1 PublicationAdd BLAST	37
Alternative sequenceⁱVSP_028412	296 – 332	TAEEK…KFVSA → NSLMFSLSLPWL in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST	37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF427619 mRNA. Translation: AAN86134.1. AF427620 mRNA. Translation: AAN86135.1. AY358364 mRNA. Translation: AAQ88730.1. AK298112 mRNA. Translation: BAG60397.1. AK309938 mRNA. No translation available. AC007993 Genomic DNA. No translation available. AC015937 Genomic DNA. No translation available. BC025395 mRNA. Translation: AAH25395.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11470.1. [Q6UXG3-1] CCDS54131.1. [Q6UXG3-4] CCDS54132.1. [Q6UXG3-5] CCDS54133.1. [Q6UXG3-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161794.1. NM_001168322.1. [Q6UXG3-4] NP_001161795.1. NM_001168323.1. [Q6UXG3-5] NP_001161796.1. NM_001168324.1. [Q6UXG3-2] NP_660316.2. NM_145273.3. [Q6UXG3-1]
UniGeneⁱ	Hs.147313.

Genome annotation databases

Ensemblⁱ	ENST00000293396; ENSP00000293396; ENSG00000161649. [Q6UXG3-2] ENST00000317310; ENSP00000321005; ENSG00000161649. [Q6UXG3-1] ENST00000377203; ENSP00000366408; ENSG00000161649. [Q6UXG3-5] ENST00000539718; ENSP00000442368; ENSG00000161649. [Q6UXG3-4] ENST00000586233; ENSP00000468800; ENSG00000161649. [Q6UXG3-3]
GeneIDⁱ	146894.
KEGGⁱ	hsa:146894.
UCSC genome browser More...UCSCⁱ	uc002iel.3. human. [Q6UXG3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF427619 mRNA. Translation: AAN86134.1. AF427620 mRNA. Translation: AAN86135.1. AY358364 mRNA. Translation: AAQ88730.1. AK298112 mRNA. Translation: BAG60397.1. AK309938 mRNA. No translation available. AC007993 Genomic DNA. No translation available. AC015937 Genomic DNA. No translation available. BC025395 mRNA. Translation: AAH25395.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11470.1. [Q6UXG3-1] CCDS54131.1. [Q6UXG3-4] CCDS54132.1. [Q6UXG3-5] CCDS54133.1. [Q6UXG3-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161794.1. NM_001168322.1. [Q6UXG3-4] NP_001161795.1. NM_001168323.1. [Q6UXG3-5] NP_001161796.1. NM_001168324.1. [Q6UXG3-2] NP_660316.2. NM_145273.3. [Q6UXG3-1]
UniGeneⁱ	Hs.147313.

3D structure databases

ProteinModelPortalⁱ	Q6UXG3.
SMRⁱ	Q6UXG3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127023. 2 interactors.
IntActⁱ	Q6UXG3. 4 interactors.
STRINGⁱ	9606.ENSP00000321005.

PTM databases

iPTMnetⁱ	Q6UXG3.
PhosphoSitePlusⁱ	Q6UXG3.

Polymorphism and mutation databases

BioMutaⁱ	CD300LG.
DMDMⁱ	296434455.

Proteomic databases

PaxDbⁱ	Q6UXG3.
PeptideAtlas More...PeptideAtlasⁱ	Q6UXG3.
PRIDEⁱ	Q6UXG3.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	146894.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000293396; ENSP00000293396; ENSG00000161649. [Q6UXG3-2] ENST00000317310; ENSP00000321005; ENSG00000161649. [Q6UXG3-1] ENST00000377203; ENSP00000366408; ENSG00000161649. [Q6UXG3-5] ENST00000539718; ENSP00000442368; ENSG00000161649. [Q6UXG3-4] ENST00000586233; ENSP00000468800; ENSG00000161649. [Q6UXG3-3]
GeneIDⁱ	146894.
KEGGⁱ	hsa:146894.
UCSC genome browser More...UCSCⁱ	uc002iel.3. human. [Q6UXG3-1]

Organism-specific databases

CTDⁱ	146894.
DisGeNET More...DisGeNETⁱ	146894.
GeneCardsⁱ	CD300LG.
H-InvDBⁱ	HIX0013869.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30455. CD300LG.
MIMⁱ	610520. gene.
neXtProtⁱ	NX_Q6UXG3.
Open Targets More...OpenTargetsⁱ	ENSG00000161649.
PharmGKBⁱ	PA142672154.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J03P. Eukaryota. ENOG41114KV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00470000042273.
HOGENOMⁱ	HOG000168404.
HOVERGENⁱ	HBG107721.
InParanoidⁱ	Q6UXG3.
KEGG Orthology (KO) More...KOⁱ	K16663.
OMAⁱ	AKAWQTQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MYS.
PhylomeDBⁱ	Q6UXG3.
TreeFamⁱ	TF334441.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Reactomeⁱ

R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAiⁱ	146894.
Protein Ontology More...PROⁱ	PR:Q6UXG3.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161649.
CleanExⁱ	HS_CD300LG.
ExpressionAtlasⁱ	Q6UXG3. baseline and differential.
Genevisibleⁱ	Q6UXG3. HS.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686. V-set. 1 hit.
SMARTⁱ	View protein in SMART SM00409. IG. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLM9_HUMAN
Accessionⁱ	Q6UXG3Primary (citable) accession number: Q6UXG3 Secondary accession number(s): B4DNY5 , F5H7P9, F8W9M3, Q8IX38, Q8IX39, Q8TA95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	May 18, 2010
	Last modified:	June 7, 2017
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6UXG3 (CLM9_HUMAN)

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CMRF35-like molecule 9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (5)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ