UniProtKB - Q6UXG3 (CLM9_HUMAN)
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Protein
CMRF35-like molecule 9
Gene
CD300LG
Organism
Homo sapiens (Human)
Status
Functioni
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).By similarity
GO - Biological processi
- immune system process Source: UniProtKB-KW
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. |
Names & Taxonomyi
Protein namesi | Recommended name: CMRF35-like molecule 9Short name: CLM-9 Alternative name(s): CD300 antigen-like family member G Triggering receptor expressed on myeloid cells 4 Short name: TREM-4 CD_antigen: CD300g |
Gene namesi | Name:CD300LG Synonyms:CLM9, TREM4 ORF Names:UNQ422/PRO846 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000161649.12. |
HGNCi | HGNC:30455. CD300LG. |
MIMi | 610520. gene. |
neXtProti | NX_Q6UXG3. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 247 | ExtracellularSequence analysisAdd BLAST | 229 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 332 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146894. |
OpenTargetsi | ENSG00000161649. |
PharmGKBi | PA142672154. |
Polymorphism and mutation databases
BioMutai | CD300LG. |
DMDMi | 296434455. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000306112 | 19 – 332 | CMRF35-like molecule 9Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 107 | PROSITE-ProRule annotation | ||
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 137 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 143 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 144 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 155 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 161 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 170 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 171 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 177 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 187 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 195 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 196 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 199 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 201 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 202 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 207 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 208 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 213 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 214 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 222 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 223 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 224 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 228 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 229 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 237 | O-linked (GalNAc...) serineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated with sialylated oligosaccharides.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6UXG3. |
PeptideAtlasi | Q6UXG3. |
PRIDEi | Q6UXG3. |
PTM databases
iPTMneti | Q6UXG3. |
PhosphoSitePlusi | Q6UXG3. |
Expressioni
Tissue specificityi
Highly expressed in heart, skeletal muscle and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000161649. |
CleanExi | HS_CD300LG. |
ExpressionAtlasi | Q6UXG3. baseline and differential. |
Genevisiblei | Q6UXG3. HS. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
KRTAP10-9 | P60411 | 3 | EBI-10254587,EBI-10172052 |
Protein-protein interaction databases
BioGridi | 127023. 2 interactors. |
IntActi | Q6UXG3. 4 interactors. |
STRINGi | 9606.ENSP00000321005. |
Structurei
3D structure databases
ProteinModelPortali | Q6UXG3. |
SMRi | Q6UXG3. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 121 | Ig-like V-typeAdd BLAST | 103 |
Domaini
Ig-like V-type domain mediates binding to lymphocyte.By similarity
Sequence similaritiesi
Belongs to the CD300 family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J03P. Eukaryota. ENOG41114KV. LUCA. |
GeneTreei | ENSGT00470000042273. |
HOGENOMi | HOG000168404. |
HOVERGENi | HBG107721. |
InParanoidi | Q6UXG3. |
KOi | K16663. |
OMAi | AKAWQTQ. |
OrthoDBi | EOG091G0MYS. |
PhylomeDBi | Q6UXG3. |
TreeFami | TF334441. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. |
Pfami | View protein in Pfam PF07686. V-set. 1 hit. |
SMARTi | View protein in SMART SM00409. IG. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UXG3-1) [UniParc]FASTAAdd to basket
Also known as: CD300LG-gamma
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW
60 70 80 90 100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ
110 120 130 140 150
DAGEYWCGVE KRGPDESLLI SLFVFPGPCC PPSPSPTFQP LATTRLQPKA
160 170 180 190 200
KAQQTQPPGL TSPGLYPAAT TAKQGKTGAE APPLPGTSQY GHERTSQYTG
210 220 230 240 250
TSPHPATSPP AGSSRPPMQL DSTSAEDTSP ALSSGSSKPR VSIPMVRILA
260 270 280 290 300
PVLVLLSLLS AAGLIAFCSH LLLWRKEAQQ ATETQRNEKF CLSRLTAEEK
310 320 330
EAPSQAPEGD VISMPPLHTS EEELGFSKFV SA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | C → W in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 10 | C → W in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 45 | D → G in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 45 | D → G in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 64 | T → H in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 64 | T → H in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 79 | V → L in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 79 | V → L in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 113 | G → A in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 113 | G → A in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 291 | C → W in AAQ88730 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035261 | 221 | D → N1 PublicationCorresponds to variant dbSNP:rs17852267Ensembl. | 1 | |
Natural variantiVAR_035262 | 228 | T → A1 PublicationCorresponds to variant dbSNP:rs12453522Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028410 | 127 – 211 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_045362 | 127 – 161 | GPCCP…PPGLT → A in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_028411 | 296 – 332 | TAEEK…KFVSA → NHRTSELDPDEAFEISSLTF LSV in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_028412 | 296 – 332 | TAEEK…KFVSA → NSLMFSLSLPWL in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF427619 mRNA. Translation: AAN86134.1. AF427620 mRNA. Translation: AAN86135.1. AY358364 mRNA. Translation: AAQ88730.1. AK298112 mRNA. Translation: BAG60397.1. AK309938 mRNA. No translation available. AC007993 Genomic DNA. No translation available. AC015937 Genomic DNA. No translation available. BC025395 mRNA. Translation: AAH25395.1. |
CCDSi | CCDS11470.1. [Q6UXG3-1] CCDS54131.1. [Q6UXG3-4] CCDS54132.1. [Q6UXG3-5] CCDS54133.1. [Q6UXG3-2] |
RefSeqi | NP_001161794.1. NM_001168322.1. [Q6UXG3-4] NP_001161795.1. NM_001168323.1. [Q6UXG3-5] NP_001161796.1. NM_001168324.1. [Q6UXG3-2] NP_660316.2. NM_145273.3. [Q6UXG3-1] |
UniGenei | Hs.147313. |
Genome annotation databases
Ensembli | ENST00000293396; ENSP00000293396; ENSG00000161649. [Q6UXG3-2] ENST00000317310; ENSP00000321005; ENSG00000161649. [Q6UXG3-1] ENST00000377203; ENSP00000366408; ENSG00000161649. [Q6UXG3-5] ENST00000539718; ENSP00000442368; ENSG00000161649. [Q6UXG3-4] ENST00000586233; ENSP00000468800; ENSG00000161649. [Q6UXG3-3] |
GeneIDi | 146894. |
KEGGi | hsa:146894. |
UCSCi | uc002iel.3. human. [Q6UXG3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CLM9_HUMAN | |
Accessioni | Q6UXG3Primary (citable) accession number: Q6UXG3 Secondary accession number(s): B4DNY5 Q8TA95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 28, 2018 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |