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Protein

C-type lectin domain family 18 member B

Gene

CLEC18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds polysaccharides in a Ca2+-independent manner (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 18 member B
Alternative name(s):
Mannose receptor-like protein 1
Gene namesi
Name:CLEC18B
Synonyms:MRLP1
ORF Names:UNQ306/PRO347
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:33849. CLEC18B.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718007.

Polymorphism and mutation databases

BioMutaiCLEC18B.
DMDMi338817862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 455429C-type lectin domain family 18 member BPRO_0000324315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi236 ↔ 249By similarity
Disulfide bondi251 ↔ 260By similarity
Disulfide bondi327 ↔ 441By similarity
Disulfide bondi417 ↔ 433By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXF7.
PRIDEiQ6UXF7.
TopDownProteomicsiQ6UXF7-2. [Q6UXF7-2]

Expressioni

Gene expression databases

BgeeiQ6UXF7.
ExpressionAtlasiQ6UXF7. baseline and differential.
GenevisibleiQ6UXF7. HS.

Organism-specific databases

HPAiHPA048976.

Structurei

3D structure databases

ProteinModelPortaliQ6UXF7.
SMRiQ6UXF7. Positions 51-310, 316-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 182131SCPAdd
BLAST
Domaini228 – 26134EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini306 – 442137C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SCP domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
KOG4297. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111780.
InParanoidiQ6UXF7.
OMAiIGLTYKP.
OrthoDBiEOG7PZRX2.
PhylomeDBiQ6UXF7.
TreeFamiTF350472.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR014044. CAP_domain.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF12661. hEGF. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHPETSPGR GHLLAVLLAL LGTTWAEVWP PQLQEQAPMA GALNRKESFL
60 70 80 90 100
LLSLHNRLRS WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL
110 120 130 140 150
WRTLQVGWNM QLLPAGLASF VEVVSLWFAE GQRYSHAAGE CARNATCTHY
160 170 180 190 200
TQLVWATSSQ LGCGRHLCSA GQTAIEAFVC AYSPGGNWEV NGKTIIPYKK
210 220 230 240 250
GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG RLNISTCHCH
260 270 280 290 300
CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
310 320 330 340 350
TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL
360 370 380 390 400
GRLETTNEVI DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP
410 420 430 440 450
DNHGLVWLSA AMGFGNCVEL QASAAFNWND QRCKTRNRYI CQFAQEHISR

WGPGS
Length:455
Mass (Da):50,490
Last modified:June 28, 2011 - v2
Checksum:iBF3DE7C742C685CE
GO
Isoform 2 (identifier: Q6UXF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-152: Missing.
     261-261: Q → QGHLPNSNMPHSAMGTKPKTPGVPAIGSL
     293-455: TKVHFPFHTC...EHISRWGPGS → SESCPRAPKE...AVCLSFQLIQ

Show »
Length:277
Mass (Da):29,961
Checksum:i40555E816C69641E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti360 – 3601I → T in AAQ88739 (PubMed:12975309).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 15280Missing in isoform 2. 1 PublicationVSP_037307Add
BLAST
Alternative sequencei261 – 2611Q → QGHLPNSNMPHSAMGTKPKT PGVPAIGSL in isoform 2. 1 PublicationVSP_037308
Alternative sequencei293 – 455163TKVHF…WGPGS → SESCPRAPKEPAPLKTPLQW GISSQEPAVCLSFQLIQ in isoform 2. 1 PublicationVSP_037309Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358373 mRNA. Translation: AAQ88739.1.
AK293982 mRNA. Translation: BAG57351.1.
AC009053 Genomic DNA. No translation available.
CCDSiCCDS32484.1. [Q6UXF7-1]
RefSeqiNP_001011880.2. NM_001011880.2. [Q6UXF7-1]
UniGeneiHs.454670.
Hs.556045.
Hs.592064.

Genome annotation databases

EnsembliENST00000339953; ENSP00000341051; ENSG00000140839. [Q6UXF7-1]
GeneIDi497190.
KEGGihsa:497190.
UCSCiuc002fct.4. human. [Q6UXF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358373 mRNA. Translation: AAQ88739.1.
AK293982 mRNA. Translation: BAG57351.1.
AC009053 Genomic DNA. No translation available.
CCDSiCCDS32484.1. [Q6UXF7-1]
RefSeqiNP_001011880.2. NM_001011880.2. [Q6UXF7-1]
UniGeneiHs.454670.
Hs.556045.
Hs.592064.

3D structure databases

ProteinModelPortaliQ6UXF7.
SMRiQ6UXF7. Positions 51-310, 316-442.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiCLEC18B.
DMDMi338817862.

Proteomic databases

PaxDbiQ6UXF7.
PRIDEiQ6UXF7.
TopDownProteomicsiQ6UXF7-2. [Q6UXF7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339953; ENSP00000341051; ENSG00000140839. [Q6UXF7-1]
GeneIDi497190.
KEGGihsa:497190.
UCSCiuc002fct.4. human. [Q6UXF7-1]

Organism-specific databases

CTDi497190.
GeneCardsiCLEC18B.
H-InvDBHIX0038587.
HIX0173253.
HGNCiHGNC:33849. CLEC18B.
HPAiHPA048976.
MIMi616572. gene.
neXtProtiNX_Q6UXF7.
PharmGKBiPA164718007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
KOG4297. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111780.
InParanoidiQ6UXF7.
OMAiIGLTYKP.
OrthoDBiEOG7PZRX2.
PhylomeDBiQ6UXF7.
TreeFamiTF350472.

Miscellaneous databases

GenomeRNAii497190.
NextBioi111915.
PROiQ6UXF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UXF7.
ExpressionAtlasiQ6UXF7. baseline and differential.
GenevisibleiQ6UXF7. HS.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR014044. CAP_domain.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF12661. hEGF. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human CLEC18 gene cluster contains C-type lectins with differential glycan-binding specificity."
    Huang Y.L., Pai F.S., Tsou Y.T., Mon H.C., Hsu T.L., Wu C.Y., Chou T.Y., Yang W.B., Chen C.H., Wong C.H., Hsieh S.L.
    J. Biol. Chem. 290:21252-21263(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCL18B_HUMAN
AccessioniPrimary (citable) accession number: Q6UXF7
Secondary accession number(s): B4DF90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: May 11, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.