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Q6UXF1 (TM108_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 108
Gene names
Name:TMEM108
Synonyms:KIAA1690
ORF Names:UNQ1875/PRO4318
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UXF1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UXF1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     485-487: VLL → DPI
     488-575: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 575549Transmembrane protein 108
PRO_0000243913

Regions

Topological domain27 – 468442Extracellular Potential
Transmembrane469 – 48921Helical; Potential
Topological domain490 – 57586Cytoplasmic Potential
Compositional bias68 – 187120Pro-rich

Amino acid modifications

Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence485 – 4873VLL → DPI in isoform 2.
VSP_019494
Alternative sequence488 – 57588Missing in isoform 2.
VSP_019495
Natural variant841P → L. Ref.1 Ref.4
Corresponds to variant rs34111099 [ dbSNP | Ensembl ].
VAR_051427

Experimental info

Sequence conflict1081H → Y in AAQ88747. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: ED25B263837BBF33

FASTA57559,948
        10         20         30         40         50         60 
MKRSLQALYC QLLSFLLILA LTEALAFAIQ EPSPRESLQV LPSGTPPGTM VTAPHSSTRH 

        70         80         90        100        110        120 
TSVVMLTPNP DGPPSQAAAP MATPTPRAEG HPPTHTISTI AATVTAPHSE SSLSTGPAPA 

       130        140        150        160        170        180 
AMATTSSKPE GRPRGQAAPT ILLTKPPGAT SRPTTAPPRT TTRRPPRPPG SSRKGAGNSS 

       190        200        210        220        230        240 
RPVPPAPGGH SRSKEGQRGR NPSSTPLGQK RPLGKIFQIY KGNFTGSVEP EPSTLTPRTP 

       250        260        270        280        290        300 
LWGYSSSPQP QTVAATTVPS NTSWAPTTTS LGPAKDKPGL RRAAQGGGST FTSQGGTPDA 

       310        320        330        340        350        360 
TAASGAPVSP QAAPVPSQRP HHGDPQDGPS HSDSWLTVTP GTSRPLSTSS GVFTAATGPT 

       370        380        390        400        410        420 
PAAFDTSVSA PSQGIPQGAS TTPQAPTHPS RVSESTISGA KEETVATLTM TDRVPSPLST 

       430        440        450        460        470        480 
VVSTATGNFL NRLVPAGTWK PGTAGNISHV AEGDKPQHRA TICLSKMDIA WVILAISVPI 

       490        500        510        520        530        540 
SSCSVLLTVC CMKRKKKTAN PENNLSYWNN TITMDYFNRH AVELPREIQS LETSEDQLSE 

       550        560        570 
PRSPANGDYR DTGMVLVNPF CQETLFVGND QVSEI 

« Hide

Isoform 2 [UniParc].

Checksum: 270809B328B9B7C1
Show »

FASTA48749,836

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-84.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-575 (ISOFORM 2), VARIANT LEU-84.
Tissue: Brain.
[5]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-575 (ISOFORM 1).
Tissue: Amygdala.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358381 mRNA. Translation: AAQ88747.1.
CH471052 Genomic DNA. Translation: EAW79182.1.
CH471052 Genomic DNA. Translation: EAW79183.1.
CH471052 Genomic DNA. Translation: EAW79184.1.
BC000568 mRNA. Translation: AAH00568.1.
AB051477 mRNA. Translation: BAB21781.1.
AL136578 mRNA. Translation: CAB66513.3.
CCDSCCDS33858.1. [Q6UXF1-1]
RefSeqNP_001129941.1. NM_001136469.2. [Q6UXF1-1]
NP_001269794.1. NM_001282865.1.
NP_076432.1. NM_023943.3. [Q6UXF1-1]
XP_005247782.1. XM_005247725.2. [Q6UXF1-1]
XP_005247783.1. XM_005247726.1. [Q6UXF1-1]
UniGeneHs.191616.

3D structure databases

ProteinModelPortalQ6UXF1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122447. 3 interactions.
IntActQ6UXF1. 3 interactions.
MINTMINT-8247361.
STRING9606.ENSP00000324651.

PTM databases

PhosphoSiteQ6UXF1.

Polymorphism databases

DMDM109895211.

Proteomic databases

PaxDbQ6UXF1.
PRIDEQ6UXF1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321871; ENSP00000324651; ENSG00000144868. [Q6UXF1-1]
ENST00000393130; ENSP00000376838; ENSG00000144868. [Q6UXF1-1]
GeneID66000.
KEGGhsa:66000.
UCSCuc003eph.3. human. [Q6UXF1-1]

Organism-specific databases

CTD66000.
GeneCardsGC03P132757.
HGNCHGNC:28451. TMEM108.
neXtProtNX_Q6UXF1.
PharmGKBPA142670759.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87591.
HOGENOMHOG000154603.
HOVERGENHBG094052.
InParanoidQ6UXF1.
OMATWKPGTA.
OrthoDBEOG7GQXXT.
PhylomeDBQ6UXF1.
TreeFamTF336337.

Gene expression databases

ArrayExpressQ6UXF1.
BgeeQ6UXF1.
CleanExHS_TMEM108.
GenevestigatorQ6UXF1.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTmem108. human.
GenomeRNAi66000.
NextBio67505.
PROQ6UXF1.

Entry information

Entry nameTM108_HUMAN
AccessionPrimary (citable) accession number: Q6UXF1
Secondary accession number(s): D3DNC9 expand/collapse secondary AC list , Q9BQH1, Q9BW81, Q9C0H3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM