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Protein

Butyrophilin-like protein 3

Gene

BTNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin-like protein 3
Alternative name(s):
Butyrophilin-like receptor
Gene namesi
Name:BTNL3
Synonyms:BTNLR, COLF4100
ORF Names:UNQ744/PRO1472
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1143. BTNL3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 237220ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Topological domaini259 – 466208CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25464.

Polymorphism and mutation databases

BioMutaiBTNL3.
DMDMi296434411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 466449Butyrophilin-like protein 3PRO_0000014540Add
BLAST

Proteomic databases

PaxDbiQ6UXE8.
PeptideAtlasiQ6UXE8.
PRIDEiQ6UXE8.

Expressioni

Tissue specificityi

Expressed in small intestine, colon, testis, spleen, and leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000168903.
CleanExiHS_BTNL3.
GenevisibleiQ6UXE8. HS.

Interactioni

Protein-protein interaction databases

BioGridi116122. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6UXE8.
SMRiQ6UXE8. Positions 17-198, 279-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 21881Ig-like V-typeAdd
BLAST
Domaini270 – 463194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYU2. Eukaryota.
ENOG411140Z. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ6UXE8.
KOiK06712.
OMAiFICPVSW.
OrthoDBiEOG091G0CXQ.
PhylomeDBiQ6UXE8.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVLILVLS FYELVSGQWQ VTGPGKFVQA LVGEDAVFSC SLFPETSAEA
60 70 80 90 100
MEVRFFRNQF HAVVHLYRDG EDWESKQMPQ YRGRTEFVKD SIAGGRVSLR
110 120 130 140 150
LKNITPSDIG LYGCWFSSQI YDEEATWELR VAALGSLPLI SIVGYVDGGI
160 170 180 190 200
QLLCLSSGWF PQPTAKWKGP QGQDLSSDSR ANADGYSLYD VEISIIVQEN
210 220 230 240 250
AGSILCSIHL AEQSHEVESK VLIGETFFQP SPWRLASILL GLLCGALCGV
260 270 280 290 300
VMGMIIVFFK SKGKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
310 320 330 340 350
LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQGFQAGK HYWEVDVGQN
360 370 380 390 400
VGWYVGVCRD DVDRGKNNVT LSPNNGYWVL RLTTEHLYFT FNPHFISLPP
410 420 430 440 450
STPPTRVGVF LDYEGGTISF FNTNDQSLIY TLLTCQFEGL LRPYIQHAMY
460
DEEKGTPIFI CPVSWG
Length:466
Mass (Da):52,251
Last modified:May 18, 2010 - v2
Checksum:i00E451EDC19316DE
GO
Isoform 2 (identifier: Q6UXE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-227: Missing.
     269-269: L → LGMCHVLSLPHMVLPGPSLIHSLSLWTTLAAGWTGST

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):48,374
Checksum:i4CB10A0B7C7EC248
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401K → R in AAQ88751 (PubMed:12975309).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 22770Missing in isoform 2. 1 PublicationVSP_012716Add
BLAST
Alternative sequencei269 – 2691L → LGMCHVLSLPHMVLPGPSLI HSLSLWTTLAAGWTGST in isoform 2. 1 PublicationVSP_012717

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020625 mRNA. Translation: BAA76664.1.
AY358385 mRNA. Translation: AAQ88751.1.
AC091874 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53730.1.
BC100800 mRNA. Translation: AAI00801.1.
BC100801 mRNA. Translation: AAI00802.1.
BC100802 mRNA. Translation: AAI00803.1.
CCDSiCCDS47358.1. [Q6UXE8-1]
RefSeqiNP_932079.1. NM_197975.2. [Q6UXE8-1]
UniGeneiHs.225949.

Genome annotation databases

EnsembliENST00000342868; ENSP00000341787; ENSG00000168903. [Q6UXE8-1]
GeneIDi10917.
KEGGihsa:10917.
UCSCiuc003mmr.3. human. [Q6UXE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020625 mRNA. Translation: BAA76664.1.
AY358385 mRNA. Translation: AAQ88751.1.
AC091874 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53730.1.
BC100800 mRNA. Translation: AAI00801.1.
BC100801 mRNA. Translation: AAI00802.1.
BC100802 mRNA. Translation: AAI00803.1.
CCDSiCCDS47358.1. [Q6UXE8-1]
RefSeqiNP_932079.1. NM_197975.2. [Q6UXE8-1]
UniGeneiHs.225949.

3D structure databases

ProteinModelPortaliQ6UXE8.
SMRiQ6UXE8. Positions 17-198, 279-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116122. 8 interactions.

Polymorphism and mutation databases

BioMutaiBTNL3.
DMDMi296434411.

Proteomic databases

PaxDbiQ6UXE8.
PeptideAtlasiQ6UXE8.
PRIDEiQ6UXE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342868; ENSP00000341787; ENSG00000168903. [Q6UXE8-1]
GeneIDi10917.
KEGGihsa:10917.
UCSCiuc003mmr.3. human. [Q6UXE8-1]

Organism-specific databases

CTDi10917.
GeneCardsiBTNL3.
H-InvDBHIX0005503.
HGNCiHGNC:1143. BTNL3.
MIMi606192. gene.
neXtProtiNX_Q6UXE8.
PharmGKBiPA25464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYU2. Eukaryota.
ENOG411140Z. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ6UXE8.
KOiK06712.
OMAiFICPVSW.
OrthoDBiEOG091G0CXQ.
PhylomeDBiQ6UXE8.
TreeFamiTF331083.

Miscellaneous databases

GenomeRNAii10917.
PROiQ6UXE8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168903.
CleanExiHS_BTNL3.
GenevisibleiQ6UXE8. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTNL3_HUMAN
AccessioniPrimary (citable) accession number: Q6UXE8
Secondary accession number(s): Q496L7, Q9Y2C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.