Q6UXD5 (SE6L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Seizure 6-like protein 2

Gene names

Name:	SEZ6L2
Synonyms:	PSK
ORF Names:	UNQ1903/PRO4349

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May contribute to specialized endoplasmic reticulum functions in neurons By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Detected on cell surface of lung-cancer. Ref.6
Induction	Increased expression in the majority of primary lung cancers and lung-cell lines tested. Ref.6
Post-translational modification	O-glycosylated with core 1 or possibly core 8 glycans.
Miscellaneous	May serve as a prognostic marker for lung cancers.
Sequence similarities	Belongs to the SEZ6 family. Contains 3 CUB domains. Contains 5 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Cellular component	Cell membrane Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Sushi Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXD5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXD5-2)

Also known as: psk-3;

The sequence of this isoform differs from the canonical sequence as follows:
     72-141: Missing.

Isoform 3 (identifier: Q6UXD5-3)

Also known as: psk-1;

The sequence of this isoform differs from the canonical sequence as follows:
     72-141: Missing.
     830-830: V → VAYEELLDNRKLEV

Isoform 4 (identifier: Q6UXD5-4)

Also known as: psk-2;

The sequence of this isoform differs from the canonical sequence as follows:
     72-141: Missing.
     651-910: Missing.

Isoform 5 (identifier: Q6UXD5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     27-70: Missing.
     830-830: V → VAYEELLDNRKLEV

Note: No experimental confirmation available.

Isoform 6 (identifier: Q6UXD5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     171-284: Missing.
     829-829: K → KVAYEELLDNRKLE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27
	Chain	28 – 910	883	Seizure 6-like protein 2		PRO_0000333888
Regions
	Topological domain	28 – 844	817	Extracellular Potential
	Transmembrane	845 – 865	21	Helical; Potential
	Topological domain	866 – 910	45	Cytoplasmic Potential
	Domain	173 – 286	114	CUB 1
	Domain	288 – 347	60	Sushi 1
	Domain	349 – 459	111	CUB 2
	Domain	462 – 525	64	Sushi 2
	Domain	527 – 638	112	CUB 3
	Domain	642 – 701	60	Sushi 3
	Domain	703 – 766	64	Sushi 4
	Domain	769 – 830	62	Sushi 5
	Region	41 – 48	8	O-glycosylated at one site
	Compositional bias	70 – 146	77	Pro-rich
	Compositional bias	153 – 168	16	Thr-rich
Amino acid modifications
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	247	1	N-linked (GlcNAc...) Potential
	Glycosylation	332	1	N-linked (GlcNAc...) Potential
	Glycosylation	355	1	N-linked (GlcNAc...) Potential
	Glycosylation	373	1	N-linked (GlcNAc...) Potential
	Glycosylation	473	1	N-linked (GlcNAc...) Potential
	Glycosylation	517	1	N-linked (GlcNAc...) Potential
	Glycosylation	641	1	N-linked (GlcNAc...) Potential
	Disulfide bond	173 ↔ 202		By similarity
	Disulfide bond	290 ↔ 330		By similarity
	Disulfide bond	316 ↔ 345		By similarity
	Disulfide bond	349 ↔ 376		By similarity
	Disulfide bond	464 ↔ 508		By similarity
	Disulfide bond	491 ↔ 523		By similarity
	Disulfide bond	527 ↔ 553		By similarity
	Disulfide bond	644 ↔ 686		By similarity
	Disulfide bond	672 ↔ 699		By similarity
	Disulfide bond	705 ↔ 747		By similarity
	Disulfide bond	733 ↔ 764		By similarity
	Disulfide bond	771 ↔ 813		By similarity
	Disulfide bond	799 ↔ 828		By similarity
Natural variations
	Alternative sequence	27 – 70	44	Missing in isoform 5.		VSP_044739
	Alternative sequence	72 – 141	70	Missing in isoform 2, isoform 3 and isoform 4.		VSP_033595
	Alternative sequence	171 – 284	114	Missing in isoform 6.		VSP_045702
	Alternative sequence	651 – 910	260	Missing in isoform 4.		VSP_033597
	Alternative sequence	829	1	K → KVAYEELLDNRKLE in isoform 6.		VSP_045703
	Alternative sequence	830	1	V → VAYEELLDNRKLEV in isoform 3 and isoform 5.		VSP_033596
	Natural variant	74	1	R → P. Ref.2 Ref.3 Ref.5 Corresponds to variant rs11649499 [ dbSNP | Ensembl ].		VAR_065205
Experimental info
	Sequence conflict	228	1	E → G in BAH11566. Ref.3
	Sequence conflict	398	1	D → G in BAH11566. Ref.3
	Sequence conflict	494	1	G → R in BAH11566. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 31, 2011. Version 2. Checksum: 26CC6E04170A5AE4	FASTA	910	97,560
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 70 80 90 100 110 120 RRGPEMGYLP GSDRDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP 130 140 150 160 170 180 ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG 190 200 210 220 230 240 EGYVESPDLG SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL 250 260 270 280 290 300 APRLLANSSM LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD 310 320 330 340 350 360 VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR 370 380 390 400 410 420 IVSPEPGGAV GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS 430 440 450 460 470 480 DMDDVPERGL ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE 490 500 510 520 530 540 YRPGALATFS CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS 550 560 570 580 590 600 PDWPQSYSPG QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ 610 620 630 640 650 660 PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG 670 680 690 700 710 720 DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD 730 740 750 760 770 780 AGFPVGSHVQ YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG 790 800 810 820 830 840 YQTLYKHHYQ AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL 850 860 870 880 890 900 EGGNLALAIL LPLGLVIVLG SGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA 910 GDTREYEVSI
	Isoform 2 (psk-3) [UniParc]. Checksum: A160F0B6FCF0E65A	FASTA	840	90,882
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 70 80 90 100 110 120 RRGPEMGYLP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG EGYVESPDLG 130 140 150 160 170 180 SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL APRLLANSSM 190 200 210 220 230 240 LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD VSVTDLHPGG 250 260 270 280 290 300 TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR IVSPEPGGAV 310 320 330 340 350 360 GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS DMDDVPERGL 370 380 390 400 410 420 ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE YRPGALATFS 430 440 450 460 470 480 CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS PDWPQSYSPG 490 500 510 520 530 540 QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ PRRRLLSSGP 550 560 570 580 590 600 DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG DLIRGTVLTY 610 620 630 640 650 660 QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD AGFPVGSHVQ 670 680 690 700 710 720 YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG YQTLYKHHYQ 730 740 750 760 770 780 AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL EGGNLALAIL 790 800 810 820 830 840 LPLGLVIVLG SGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA GDTREYEVSI
	Isoform 3 (psk-1) [UniParc]. Checksum: 33B4B234056492CF	FASTA	853	92,455
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 70 80 90 100 110 120 RRGPEMGYLP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG EGYVESPDLG 130 140 150 160 170 180 SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL APRLLANSSM 190 200 210 220 230 240 LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD VSVTDLHPGG 250 260 270 280 290 300 TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR IVSPEPGGAV 310 320 330 340 350 360 GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS DMDDVPERGL 370 380 390 400 410 420 ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE YRPGALATFS 430 440 450 460 470 480 CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS PDWPQSYSPG 490 500 510 520 530 540 QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ PRRRLLSSGP 550 560 570 580 590 600 DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG DLIRGTVLTY 610 620 630 640 650 660 QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD AGFPVGSHVQ 670 680 690 700 710 720 YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG YQTLYKHHYQ 730 740 750 760 770 780 AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV AYEELLDNRK LEVTQTTDPS 790 800 810 820 830 840 RQLEGGNLAL AILLPLGLVI VLGSGVYIYY TKLQGKSLFG FSGSHSYSPI TVESDFSNPL 850 YEAGDTREYE VSI
	Isoform 4 (psk-2) [UniParc]. Checksum: 22DD0E71DBDB184D	FASTA	580	62,374
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 70 80 90 100 110 120 RRGPEMGYLP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG EGYVESPDLG 130 140 150 160 170 180 SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL APRLLANSSM 190 200 210 220 230 240 LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD VSVTDLHPGG 250 260 270 280 290 300 TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR IVSPEPGGAV 310 320 330 340 350 360 GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS DMDDVPERGL 370 380 390 400 410 420 ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE YRPGALATFS 430 440 450 460 470 480 CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS PDWPQSYSPG 490 500 510 520 530 540 QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ PRRRLLSSGP 550 560 570 580 DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP
	Isoform 5 [UniParc]. Checksum: B22F15363456EBCD	FASTA	879	94,469
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGSDR DPTLATPPAG QTLAVPSLPR ATEPGTGPLT 70 80 90 100 110 120 TAVTPNGVRG AGPTAPELLT PPPGTTAPPP PSPASPGPPL GPEGGEEETT TTIITTTTVT 130 140 150 160 170 180 TTVTSPVLCN NNISEGEGYV ESPDLGSPVS RTLGLLDCTY SIHVYPGYGI EIQVQTLNLS 190 200 210 220 230 240 QEEELLVLAG GGSPGLAPRL LANSSMLGEG QVLRSPTNRL LLHFQSPRVP RGGGFRIHYQ 250 260 270 280 290 300 AYLLSCGFPP RPAHGDVSVT DLHPGGTATF HCDSGYQLQG EETLICLNGT RPSWNGETPS 310 320 330 340 350 360 CMASCGGTIH NATLGRIVSP EPGGAVGPNL TCRWVIEAAE GRRLHLHFER VSLDEDNDRL 370 380 390 400 410 420 MVRSGGSPLS PVIYDSDMDD VPERGLISDA QSLYVELLSE TPANPLLLSL RFEAFEEDRC 430 440 450 460 470 480 FAPFLAHGNV TTTDPEYRPG ALATFSCLPG YALEPPGPPN AIECVDPTEP HWNDTEPACK 490 500 510 520 530 540 AMCGGELSEP AGVVLSPDWP QSYSPGQDCV WGVHVQEEKR ILLQVEILNV REGDMLTLFD 550 560 570 580 590 600 GDGPSARVLA QLRGPQPRRR LLSSGPDLTL QFQAPPGPPN PGLGQGFVLH FKEVPRNDTC 610 620 630 640 650 660 PELPPPEWGW RTASHGDLIR GTVLTYQCEP GYELLGSDIL TCQWDLSWSA APPACQKIMT 670 680 690 700 710 720 CADPGEIANG HRTASDAGFP VGSHVQYRCL PGYSLEGAAM LTCYSRDTGT PKWSDRVPKC 730 740 750 760 770 780 ALKYEPCLNP GVPENGYQTL YKHHYQAGES LRFFCYEGFE LIGEVTITCV PGHPSQWTSQ 790 800 810 820 830 840 PPLCKVAYEE LLDNRKLEVT QTTDPSRQLE GGNLALAILL PLGLVIVLGS GVYIYYTKLQ 850 860 870 GKSLFGFSGS HSYSPITVES DFSNPLYEAG DTREYEVSI
	Isoform 6 [UniParc]. Checksum: 04C650826BAF0268	FASTA	809	86,861
	10 20 30 40 50 60 MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 70 80 90 100 110 120 RRGPEMGYLP GSDRDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP 130 140 150 160 170 180 ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP AYLLSCGFPP 190 200 210 220 230 240 RPAHGDVSVT DLHPGGTATF HCDSGYQLQG EETLICLNGT RPSWNGETPS CMASCGGTIH 250 260 270 280 290 300 NATLGRIVSP EPGGAVGPNL TCRWVIEAAE GRRLHLHFER VSLDEDNDRL MVRSGGSPLS 310 320 330 340 350 360 PVIYDSDMDD VPERGLISDA QSLYVELLSE TPANPLLLSL RFEAFEEDRC FAPFLAHGNV 370 380 390 400 410 420 TTTDPEYRPG ALATFSCLPG YALEPPGPPN AIECVDPTEP HWNDTEPACK AMCGGELSEP 430 440 450 460 470 480 AGVVLSPDWP QSYSPGQDCV WGVHVQEEKR ILLQVEILNV REGDMLTLFD GDGPSARVLA 490 500 510 520 530 540 QLRGPQPRRR LLSSGPDLTL QFQAPPGPPN PGLGQGFVLH FKEVPRNDTC PELPPPEWGW 550 560 570 580 590 600 RTASHGDLIR GTVLTYQCEP GYELLGSDIL TCQWDLSWSA APPACQKIMT CADPGEIANG 610 620 630 640 650 660 HRTASDAGFP VGSHVQYRCL PGYSLEGAAM LTCYSRDTGT PKWSDRVPKC ALKYEPCLNP 670 680 690 700 710 720 GVPENGYQTL YKHHYQAGES LRFFCYEGFE LIGEVTITCV PGHPSQWTSQ PPLCKVAYEE 730 740 750 760 770 780 LLDNRKLEVT QTTDPSRQLE GGNLALAILL PLGLVIVLGS GVYIYYTKLQ GKSLFGFSGS 790 800 HSYSPITVES DFSNPLYEAG DTREYEVSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel seizure-related proteins from the human brain." Schrotz-King P., King A., Nyborg Nielsen P., Andersen J., Kuster B., Mann M. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-74.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT PRO-74. Tissue: Cerebellum.
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT PRO-74. Tissue: Brain.
[6]	"Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer." Ishikawa N., Daigo Y., Takano A., Taniwaki M., Kato T., Tanaka S., Yasui W., Takeshima Y., Inai K., Nishimura H., Tsuchiya E., Kohno N., Nakamura Y. Cancer Sci. 97:737-745(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, SUBCELLULAR LOCATION.
[7]	"Enrichment of glycopeptides for glycan structure and attachment site identification." Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G. Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS], SIGNAL SEQUENCE CLEAVAGE SITE, STRUCTURE OF CARBOHYDRATES, MASS SPECTROMETRY. Tissue: Cerebrospinal fluid.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ245820 mRNA. Translation: CAB57950.1. AJ245821 mRNA. Translation: CAB57951.1. AJ245822 mRNA. Translation: CAB57952.1. AY358404 mRNA. Translation: AAQ88770.1. AK293675 mRNA. Translation: BAH11566.1. AC120114 Genomic DNA. No translation available. BC000567 mRNA. Translation: AAH00567.1.
IPI	IPI00018276. IPI00306470. IPI00419722. IPI00645828. IPI00892924. IPI01013810.
RefSeq	NP_001107571.1. NM_001114099.2. NP_001107572.1. NM_001114100.2. NP_001230261.1. NM_001243332.1. NP_001230262.1. NM_001243333.1. NP_036542.1. NM_012410.3. NP_963869.2. NM_201575.3.
UniGene	Hs.6314.
3D structure databases
ProteinModelPortal	Q6UXD5.
SMR	Q6UXD5. Positions 348-459, 469-829.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UXD5. 5 interactions.
STRING	9606.ENSP00000312550.
PTM databases
PhosphoSite	Q6UXD5.
Polymorphism databases
DMDM	74749421.
Proteomic databases
PaxDb	Q6UXD5.
PRIDE	Q6UXD5.
Protocols and materials databases
DNASU	26470.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308713; ENSP00000312550; ENSG00000174938. ENST00000346932; ENSP00000319215; ENSG00000174938. ENST00000350527; ENSP00000310206; ENSG00000174938. ENST00000537485; ENSP00000439412; ENSG00000174938.
GeneID	26470.
KEGG	hsa:26470.
UCSC	uc002dup.4. human. uc002duq.4. human. uc002dur.4. human. uc002dus.4. human. uc010ved.2. human.
Organism-specific databases
CTD	26470.
GeneCards	GC16M029882.
HGNC	HGNC:30844. SEZ6L2.
neXtProt	NX_Q6UXD5.
PharmGKB	PA134924025.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148801.
HOVERGEN	HBG057885.
InParanoid	Q6UXD5.
OMA	GIEIQVQ.
PhylomeDB	Q6UXD5.
Enzyme and pathway databases
SignaLink	Q6UXD5.
Gene expression databases
ArrayExpress	Q6UXD5.
Bgee	Q6UXD5.
CleanEx	HS_SEZ6L2.
Genevestigator	Q6UXD5.
Family and domain databases
Gene3D	2.60.120.290. 3 hits.
InterPro	IPR000859. CUB_dom. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00431. CUB. 2 hits. PF00084. Sushi. 5 hits. [Graphical view]
SMART	SM00032. CCP. 5 hits. SM00042. CUB. 3 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 5 hits. SSF49854. CUB. 3 hits.
PROSITE	PS01180. CUB. 3 hits. PS50923. SUSHI. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26470.
NextBio	48715.

Entry information

Entry name

SE6L2_HUMAN

Accession

Primary (citable) accession number: Q6UXD5
Secondary accession number(s): B7Z1N0 , F5H293, H7BXQ6, Q9BW82, Q9UJ45, Q9UJ46, Q9UJ47

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 31, 2011
Last modified:	May 29, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.