Q6UXB4 (CLC4G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-type lectin domain family 4 member G

Gene names

Name:	CLEC4G
ORF Names:	UNQ431/PRO792

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Signal-anchor Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF3I	Q13347	3	EBI-2114729,EBI-354047
IFI35	P80217	4	EBI-2114729,EBI-2115067

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	C-type lectin domain family 4 member G		PRO_0000223691
Regions
	Topological domain	1 – 31	31	Cytoplasmic Potential
	Transmembrane	32 – 52	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	53 – 293	241	Extracellular Potential
	Domain	172 – 287	116	C-type lectin
	Coiled coil	96 – 136	41	Potential
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Disulfide bond	264 ↔ 278		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6UXB4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7AEA4ED8654CE577	FASTA	293	32,562
	10 20 30 40 50 60 MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS ILLSKASTER 70 80 90 100 110 120 AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA QLQTTRAELG EAQAKLMEQE 130 140 150 160 170 180 SALRELRERV TQGLAEAGRG REDVRTELFR ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS 190 200 210 220 230 240 VPKTTWAAAQ DHCADASAHL VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV 250 260 270 280 290 DGVSLSFSHW NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

LSECtin

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358431 mRNA. Translation: AAQ88797.1. BC093691 mRNA. Translation: AAH93691.1. BC093693 mRNA. Translation: AAH93693.1.
IPI	IPI00243602.
RefSeq	NP_940894.1. NM_198492.3.
UniGene	Hs.220649.
3D structure databases
ProteinModelPortal	Q6UXB4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UXB4. 20 interactions.
PTM databases
PhosphoSite	Q6UXB4.
Polymorphism databases
DMDM	74738199.
Proteomic databases
PaxDb	Q6UXB4.
PRIDE	Q6UXB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328853; ENSP00000327599; ENSG00000182566.
GeneID	339390.
KEGG	hsa:339390.
UCSC	uc002mhp.4. human.
Organism-specific databases
CTD	339390.
GeneCards	GC19M007793.
HGNC	HGNC:24591. CLEC4G.
HPA	CAB003789. HPA014044.
neXtProt	NX_Q6UXB4.
PharmGKB	PA142672104.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271869.
HOGENOM	HOG000013222.
HOVERGEN	HBG081249.
InParanoid	Q6UXB4.
KO	K10061.
OMA	ICEKRRS.
PhylomeDB	Q6UXB4.
Gene expression databases
ArrayExpress	Q6UXB4.
Bgee	Q6UXB4.
CleanEx	HS_CLEC4G.
Genevestigator	Q6UXB4.
GermOnline	ENSG00000182566. Homo sapiens.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. [Graphical view]
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339390.
NextBio	97374.

Entry information

Entry name

CLC4G_HUMAN

Accession

Primary (citable) accession number: Q6UXB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.