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Protein

C-type lectin domain family 4 member G

Gene

CLEC4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca2+-dependent manner, in vitro.1 Publication
(Microbial infection) Acts as a receptor for Japanese encephalitis virus.1 Publication
(Microbial infection) Acts as a receptor for Ebolavirus.1 Publication
(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.1 Publication
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member G
Alternative name(s):
Liver and lymph node sinusoidal endothelial cell C-type lectin1 Publication
Short name:
LSECtin1 Publication
Gene namesi
Name:CLEC4G
ORF Names:UNQ431/PRO792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182566.12
HGNCiHGNC:24591 CLEC4G
MIMi616256 gene
neXtProtiNX_Q6UXB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini53 – 293ExtracellularSequence analysisAdd BLAST241

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi339390
OpenTargetsiENSG00000182566
PharmGKBiPA142672104

Polymorphism and mutation databases

BioMutaiCLEC4G
DMDMi74738199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236911 – 293C-type lectin domain family 4 member GAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi264 ↔ 278PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6UXB4
PeptideAtlasiQ6UXB4
PRIDEiQ6UXB4
ProteomicsDBi67585

PTM databases

iPTMnetiQ6UXB4
PhosphoSitePlusiQ6UXB4

Expressioni

Tissue specificityi

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000182566
CleanExiHS_CLEC4G
ExpressionAtlasiQ6UXB4 baseline and differential
GenevisibleiQ6UXB4 HS

Organism-specific databases

HPAiCAB003789
HPA014044

Interactioni

Subunit structurei

(Microbial infection) Interacts with Japanese encephalitis virus envelope protein E.1 Publication
(Microbial infection) Interacts with ebolavirus glycoprotein.1 Publication
(Microbial infection) Interacts with SARS coronavirus/SARS-CoV spike glycoprotein.1 Publication
(Microbial infection) Interacts with lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130876, 22 interactors
IntActiQ6UXB4, 21 interactors
STRINGi9606.ENSP00000327599

Structurei

3D structure databases

ProteinModelPortaliQ6UXB4
SMRiQ6UXB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 287C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 136Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000013222
HOVERGENiHBG081249
InParanoidiQ6UXB4
KOiK10061
OMAiMLRTGMW
OrthoDBiEOG091G0F1S
PhylomeDBiQ6UXB4
TreeFamiTF333341

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6UXB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS
60 70 80 90 100
ILLSKASTER AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA
110 120 130 140 150
QLQTTRAELG EAQAKLMEQE SALRELRERV TQGLAEAGRG REDVRTELFR
160 170 180 190 200
ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS VPKTTWAAAQ DHCADASAHL
210 220 230 240 250
VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV DGVSLSFSHW
260 270 280 290
NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC
Length:293
Mass (Da):32,562
Last modified:July 5, 2004 - v1
Checksum:i7AEA4ED8654CE577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358431 mRNA Translation: AAQ88797.1
BC093691 mRNA Translation: AAH93691.1
BC093693 mRNA Translation: AAH93693.1
CCDSiCCDS12185.1
RefSeqiNP_940894.1, NM_198492.3
UniGeneiHs.220649

Genome annotation databases

EnsembliENST00000328853; ENSP00000327599; ENSG00000182566
GeneIDi339390
KEGGihsa:339390
UCSCiuc002mhp.4 human

Similar proteinsi

Entry informationi

Entry nameiCLC4G_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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