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Protein

C-type lectin domain family 4 member G

Gene

CLEC4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member G
Gene namesi
Name:CLEC4G
ORF Names:UNQ431/PRO792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:24591. CLEC4G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini53 – 293241ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293C-type lectin domain family 4 member GPRO_0000223691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi264 ↔ 278PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXB4.
PRIDEiQ6UXB4.

PTM databases

PhosphoSiteiQ6UXB4.

Expressioni

Gene expression databases

BgeeiQ6UXB4.
CleanExiHS_CLEC4G.
ExpressionAtlasiQ6UXB4. baseline and differential.
GenevestigatoriQ6UXB4.

Organism-specific databases

HPAiCAB003789.
HPA014044.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3IQ133473EBI-2114729,EBI-354047
IFI35P802174EBI-2114729,EBI-2115067

Protein-protein interaction databases

BioGridi130876. 20 interactions.
IntActiQ6UXB4. 20 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6UXB4.
SMRiQ6UXB4. Positions 119-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 287116C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili96 – 13641Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271869.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG081249.
InParanoidiQ6UXB4.
KOiK10061.
OMAiMLRTGMW.
OrthoDBiEOG79KPH7.
PhylomeDBiQ6UXB4.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UXB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS
60 70 80 90 100
ILLSKASTER AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA
110 120 130 140 150
QLQTTRAELG EAQAKLMEQE SALRELRERV TQGLAEAGRG REDVRTELFR
160 170 180 190 200
ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS VPKTTWAAAQ DHCADASAHL
210 220 230 240 250
VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV DGVSLSFSHW
260 270 280 290
NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC
Length:293
Mass (Da):32,562
Last modified:July 5, 2004 - v1
Checksum:i7AEA4ED8654CE577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358431 mRNA. Translation: AAQ88797.1.
BC093691 mRNA. Translation: AAH93691.1.
BC093693 mRNA. Translation: AAH93693.1.
CCDSiCCDS12185.1.
RefSeqiNP_940894.1. NM_198492.3.
UniGeneiHs.220649.

Genome annotation databases

EnsembliENST00000328853; ENSP00000327599; ENSG00000182566.
GeneIDi339390.
KEGGihsa:339390.
UCSCiuc002mhp.4. human.

Polymorphism databases

DMDMi74738199.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

LSECtin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358431 mRNA. Translation: AAQ88797.1.
BC093691 mRNA. Translation: AAH93691.1.
BC093693 mRNA. Translation: AAH93693.1.
CCDSiCCDS12185.1.
RefSeqiNP_940894.1. NM_198492.3.
UniGeneiHs.220649.

3D structure databases

ProteinModelPortaliQ6UXB4.
SMRiQ6UXB4. Positions 119-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130876. 20 interactions.
IntActiQ6UXB4. 20 interactions.

PTM databases

PhosphoSiteiQ6UXB4.

Polymorphism databases

DMDMi74738199.

Proteomic databases

PaxDbiQ6UXB4.
PRIDEiQ6UXB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328853; ENSP00000327599; ENSG00000182566.
GeneIDi339390.
KEGGihsa:339390.
UCSCiuc002mhp.4. human.

Organism-specific databases

CTDi339390.
GeneCardsiGC19M007793.
HGNCiHGNC:24591. CLEC4G.
HPAiCAB003789.
HPA014044.
neXtProtiNX_Q6UXB4.
PharmGKBiPA142672104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG271869.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG081249.
InParanoidiQ6UXB4.
KOiK10061.
OMAiMLRTGMW.
OrthoDBiEOG79KPH7.
PhylomeDBiQ6UXB4.
TreeFamiTF333341.

Miscellaneous databases

GenomeRNAii339390.
NextBioi97374.
PROiQ6UXB4.

Gene expression databases

BgeeiQ6UXB4.
CleanExiHS_CLEC4G.
ExpressionAtlasiQ6UXB4. baseline and differential.
GenevestigatoriQ6UXB4.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCLC4G_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.