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Q6UXB4

- CLC4G_HUMAN

UniProt

Q6UXB4 - CLC4G_HUMAN

Protein

C-type lectin domain family 4 member G

Gene

CLEC4G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. protein binding Source: IntAct

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 4 member G
    Gene namesi
    Name:CLEC4G
    ORF Names:UNQ431/PRO792
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:24591. CLEC4G.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293C-type lectin domain family 4 member GPRO_0000223691Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi264 ↔ 278PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6UXB4.
    PRIDEiQ6UXB4.

    PTM databases

    PhosphoSiteiQ6UXB4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UXB4.
    BgeeiQ6UXB4.
    CleanExiHS_CLEC4G.
    GenevestigatoriQ6UXB4.

    Organism-specific databases

    HPAiCAB003789.
    HPA014044.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF3IQ133473EBI-2114729,EBI-354047
    IFI35P802174EBI-2114729,EBI-2115067

    Protein-protein interaction databases

    BioGridi130876. 20 interactions.
    IntActiQ6UXB4. 20 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXB4.
    SMRiQ6UXB4. Positions 119-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 293241ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 287116C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili96 – 13641Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271869.
    HOGENOMiHOG000013222.
    HOVERGENiHBG081249.
    InParanoidiQ6UXB4.
    KOiK10061.
    OMAiMLRTGMW.
    OrthoDBiEOG79KPH7.
    PhylomeDBiQ6UXB4.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UXB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS    50
    ILLSKASTER AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA 100
    QLQTTRAELG EAQAKLMEQE SALRELRERV TQGLAEAGRG REDVRTELFR 150
    ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS VPKTTWAAAQ DHCADASAHL 200
    VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV DGVSLSFSHW 250
    NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC 293
    Length:293
    Mass (Da):32,562
    Last modified:July 5, 2004 - v1
    Checksum:i7AEA4ED8654CE577
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358431 mRNA. Translation: AAQ88797.1.
    BC093691 mRNA. Translation: AAH93691.1.
    BC093693 mRNA. Translation: AAH93693.1.
    CCDSiCCDS12185.1.
    RefSeqiNP_940894.1. NM_198492.3.
    UniGeneiHs.220649.

    Genome annotation databases

    EnsembliENST00000328853; ENSP00000327599; ENSG00000182566.
    GeneIDi339390.
    KEGGihsa:339390.
    UCSCiuc002mhp.4. human.

    Polymorphism databases

    DMDMi74738199.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    LSECtin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358431 mRNA. Translation: AAQ88797.1 .
    BC093691 mRNA. Translation: AAH93691.1 .
    BC093693 mRNA. Translation: AAH93693.1 .
    CCDSi CCDS12185.1.
    RefSeqi NP_940894.1. NM_198492.3.
    UniGenei Hs.220649.

    3D structure databases

    ProteinModelPortali Q6UXB4.
    SMRi Q6UXB4. Positions 119-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130876. 20 interactions.
    IntActi Q6UXB4. 20 interactions.

    PTM databases

    PhosphoSitei Q6UXB4.

    Polymorphism databases

    DMDMi 74738199.

    Proteomic databases

    PaxDbi Q6UXB4.
    PRIDEi Q6UXB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328853 ; ENSP00000327599 ; ENSG00000182566 .
    GeneIDi 339390.
    KEGGi hsa:339390.
    UCSCi uc002mhp.4. human.

    Organism-specific databases

    CTDi 339390.
    GeneCardsi GC19M007793.
    HGNCi HGNC:24591. CLEC4G.
    HPAi CAB003789.
    HPA014044.
    neXtProti NX_Q6UXB4.
    PharmGKBi PA142672104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271869.
    HOGENOMi HOG000013222.
    HOVERGENi HBG081249.
    InParanoidi Q6UXB4.
    KOi K10061.
    OMAi MLRTGMW.
    OrthoDBi EOG79KPH7.
    PhylomeDBi Q6UXB4.
    TreeFami TF333341.

    Miscellaneous databases

    GenomeRNAii 339390.
    NextBioi 97374.
    PROi Q6UXB4.

    Gene expression databases

    ArrayExpressi Q6UXB4.
    Bgeei Q6UXB4.
    CleanExi HS_CLEC4G.
    Genevestigatori Q6UXB4.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCLC4G_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3