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Q6UXB4 (CLC4G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type lectin domain family 4 member G
Gene names
Name:CLEC4G
ORF Names:UNQ431/PRO792
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Contains 1 C-type lectin domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293C-type lectin domain family 4 member G
PRO_0000223691

Regions

Topological domain1 – 3131Cytoplasmic Potential
Transmembrane32 – 5221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain53 – 293241Extracellular Potential
Domain172 – 287116C-type lectin
Coiled coil96 – 13641 Potential

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond264 ↔ 278 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6UXB4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7AEA4ED8654CE577

FASTA29332,562
        10         20         30         40         50         60 
MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS ILLSKASTER 

        70         80         90        100        110        120 
AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA QLQTTRAELG EAQAKLMEQE 

       130        140        150        160        170        180 
SALRELRERV TQGLAEAGRG REDVRTELFR ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS 

       190        200        210        220        230        240 
VPKTTWAAAQ DHCADASAHL VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV 

       250        260        270        280        290 
DGVSLSFSHW NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358431 mRNA. Translation: AAQ88797.1.
BC093691 mRNA. Translation: AAH93691.1.
BC093693 mRNA. Translation: AAH93693.1.
CCDSCCDS12185.1.
RefSeqNP_940894.1. NM_198492.3.
UniGeneHs.220649.

3D structure databases

ProteinModelPortalQ6UXB4.
SMRQ6UXB4. Positions 119-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130876. 20 interactions.
IntActQ6UXB4. 20 interactions.

PTM databases

PhosphoSiteQ6UXB4.

Polymorphism databases

DMDM74738199.

Proteomic databases

PaxDbQ6UXB4.
PRIDEQ6UXB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328853; ENSP00000327599; ENSG00000182566.
GeneID339390.
KEGGhsa:339390.
UCSCuc002mhp.4. human.

Organism-specific databases

CTD339390.
GeneCardsGC19M007793.
HGNCHGNC:24591. CLEC4G.
HPACAB003789.
HPA014044.
neXtProtNX_Q6UXB4.
PharmGKBPA142672104.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271869.
HOGENOMHOG000013222.
HOVERGENHBG081249.
InParanoidQ6UXB4.
KOK10061.
OMAMLRTGMW.
OrthoDBEOG79KPH7.
PhylomeDBQ6UXB4.
TreeFamTF333341.

Gene expression databases

ArrayExpressQ6UXB4.
BgeeQ6UXB4.
CleanExHS_CLEC4G.
GenevestigatorQ6UXB4.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339390.
NextBio97374.
PROQ6UXB4.

Entry information

Entry nameCLC4G_HUMAN
AccessionPrimary (citable) accession number: Q6UXB4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM