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Protein

Ly6/PLAUR domain-containing protein 2

Gene

LYPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32908-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 2
Gene namesi
Name:LYPD2
Synonyms:LYPDC2
ORF Names:UNQ430/PRO788
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25215. LYPD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197353.
PharmGKBiPA134911921.

Polymorphism and mutation databases

BioMutaiLYPD2.
DMDMi74749418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022674723 – 103Ly6/PLAUR domain-containing protein 2Add BLAST81
PropeptideiPRO_0000226748104 – 125Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Lipidationi103GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6UXB3.
PeptideAtlasiQ6UXB3.
PRIDEiQ6UXB3.

Expressioni

Gene expression databases

BgeeiENSG00000197353.
CleanExiHS_LYPD2.
ExpressionAtlasiQ6UXB3. baseline and differential.

Organism-specific databases

HPAiHPA028599.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352163.

Structurei

3D structure databases

ProteinModelPortaliQ6UXB3.
SMRiQ6UXB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 100UPAR/Ly6Add BLAST76

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J08V. Eukaryota.
ENOG410Z9QV. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ6UXB3.
OMAiREIVYPF.
OrthoDBiEOG091G0UOB.
PhylomeDBiQ6UXB3.
TreeFamiTF336080.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGTRLALLA LVLAACGELA PALRCYVCPE PTGVSDCVTI ATCTTNETMC
60 70 80 90 100
KTTLYSREIV YPFQGDSTVT KSCASKCKPS DVDGIGQTLP VSCCNTELCN
110 120
VDGAPALNSL HCGALTLLPL LSLRL
Length:125
Mass (Da):13,115
Last modified:July 5, 2004 - v1
Checksum:iF727D41D50F57756
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → A in BAF83020 (PubMed:14702039).Curated1
Sequence conflicti5 – 7RLA → QLV in AAI19020 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0527015R → Q.Corresponds to variant rs11778314dbSNPEnsembl.1
Natural variantiVAR_0527027A → V.Corresponds to variant rs11775636dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358432 mRNA. Translation: AAQ88798.1.
AK290331 mRNA. Translation: BAF83020.1.
BC119019 mRNA. Translation: AAI19020.1.
BC119812 mRNA. Translation: AAI19813.1.
CCDSiCCDS6388.1.
RefSeqiNP_991108.1. NM_205545.2.
UniGeneiHs.441280.

Genome annotation databases

EnsembliENST00000359228; ENSP00000352163; ENSG00000197353.
GeneIDi137797.
KEGGihsa:137797.
UCSCiuc003ywz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358432 mRNA. Translation: AAQ88798.1.
AK290331 mRNA. Translation: BAF83020.1.
BC119019 mRNA. Translation: AAI19020.1.
BC119812 mRNA. Translation: AAI19813.1.
CCDSiCCDS6388.1.
RefSeqiNP_991108.1. NM_205545.2.
UniGeneiHs.441280.

3D structure databases

ProteinModelPortaliQ6UXB3.
SMRiQ6UXB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352163.

Polymorphism and mutation databases

BioMutaiLYPD2.
DMDMi74749418.

Proteomic databases

PaxDbiQ6UXB3.
PeptideAtlasiQ6UXB3.
PRIDEiQ6UXB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359228; ENSP00000352163; ENSG00000197353.
GeneIDi137797.
KEGGihsa:137797.
UCSCiuc003ywz.4. human.

Organism-specific databases

CTDi137797.
GeneCardsiLYPD2.
HGNCiHGNC:25215. LYPD2.
HPAiHPA028599.
neXtProtiNX_Q6UXB3.
OpenTargetsiENSG00000197353.
PharmGKBiPA134911921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J08V. Eukaryota.
ENOG410Z9QV. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ6UXB3.
OMAiREIVYPF.
OrthoDBiEOG091G0UOB.
PhylomeDBiQ6UXB3.
TreeFamiTF336080.

Enzyme and pathway databases

BioCyciZFISH:G66-32908-MONOMER.

Miscellaneous databases

GenomeRNAii137797.
PROiQ6UXB3.

Gene expression databases

BgeeiENSG00000197353.
CleanExiHS_LYPD2.
ExpressionAtlasiQ6UXB3. baseline and differential.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYPD2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB3
Secondary accession number(s): A8K2R6, Q0VD64, Q0VF31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.