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Protein

Ly6/PLAUR domain-containing protein 2

Gene

LYPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 2
Gene namesi
Name:LYPD2
Synonyms:LYPDC2
ORF Names:UNQ430/PRO788
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000197353.3
HGNCiHGNC:25215 LYPD2
neXtProtiNX_Q6UXB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197353
PharmGKBiPA134911921

Polymorphism and mutation databases

BioMutaiLYPD2
DMDMi74749418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022674723 – 103Ly6/PLAUR domain-containing protein 2Add BLAST81
PropeptideiPRO_0000226748104 – 125Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi103GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6UXB3
PeptideAtlasiQ6UXB3
PRIDEiQ6UXB3

Expressioni

Gene expression databases

BgeeiENSG00000197353
CleanExiHS_LYPD2
ExpressionAtlasiQ6UXB3 baseline and differential

Organism-specific databases

HPAiHPA028599

Interactioni

Protein-protein interaction databases

BioGridi126484, 9 interactors
STRINGi9606.ENSP00000352163

Structurei

3D structure databases

ProteinModelPortaliQ6UXB3
SMRiQ6UXB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 100UPAR/Ly6Add BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J08V Eukaryota
ENOG410Z9QV LUCA
GeneTreeiENSGT00510000047304
HOGENOMiHOG000035114
HOVERGENiHBG094857
InParanoidiQ6UXB3
OMAiSCCNTEL
OrthoDBiEOG091G0UOB
PhylomeDBiQ6UXB3
TreeFamiTF336080

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGTRLALLA LVLAACGELA PALRCYVCPE PTGVSDCVTI ATCTTNETMC
60 70 80 90 100
KTTLYSREIV YPFQGDSTVT KSCASKCKPS DVDGIGQTLP VSCCNTELCN
110 120
VDGAPALNSL HCGALTLLPL LSLRL
Length:125
Mass (Da):13,115
Last modified:July 5, 2004 - v1
Checksum:iF727D41D50F57756
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → A in BAF83020 (PubMed:14702039).Curated1
Sequence conflicti5 – 7RLA → QLV in AAI19020 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0527015R → Q. Corresponds to variant dbSNP:rs11778314Ensembl.1
Natural variantiVAR_0527027A → V. Corresponds to variant dbSNP:rs11775636Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358432 mRNA Translation: AAQ88798.1
AK290331 mRNA Translation: BAF83020.1
BC119019 mRNA Translation: AAI19020.1
BC119812 mRNA Translation: AAI19813.1
CCDSiCCDS6388.1
RefSeqiNP_991108.1, NM_205545.2
UniGeneiHs.441280

Genome annotation databases

EnsembliENST00000359228; ENSP00000352163; ENSG00000197353
GeneIDi137797
KEGGihsa:137797
UCSCiuc003ywz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLYPD2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB3
Secondary accession number(s): A8K2R6, Q0VD64, Q0VF31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health