Q6UXB2A8KAC0CXL17_HUMANC-X-C motif chemokine 176-Cys CXCL17Dendritic cell and monocyte chemokine-like proteinDMCVEGF coregulated chemokine 14-Cys CXCL17CXCL17VCC1UNQ473/PRO842Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoVCC-1, a novel chemokine, promotes tumor growth.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONTISSUE SPECIFICITYThe secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The DNA sequence and biology of human chromosome 19.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Signal peptide prediction based on analysis of experimentally verified cleavage sites.PROTEIN SEQUENCE OF 22-37Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.PROTEIN SEQUENCE OF 23-61 AND 97-112IDENTIFICATION BY MASS SPECTROMETRYNovel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods.FUNCTIONTISSUE SPECIFICITYCIRCULAR DICHROISM3D-STRUCTURE MODELINGDISULFIDE BONDSMUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110Broad up-regulation of innate defense factors during acute cholera.FUNCTIONINDUCTIONCXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor.SUBCELLULAR LOCATIONFUNCTION (6-CYS CXCL17 AND 4-CYS CXCL17)GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.INTERACTION WITH GPR35Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).4-Cys CXCL17Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.Q6UXB2P13501false2Q6UXB2P48061false2Q6UXB2P02776false2SecretedDetected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.Detected in fetal lung.Found to be up-regulated in duodenal mucosa during acute cholera.Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.Belongs to the intercrine alpha (chemokine CxC) family.CXCL17 entryAngiogenesisChemotaxisCleavage on pair of basic residuesDevelopmental proteinDifferentiationDirect protein sequencingDisulfide bondReference proteomeSecretedSignalCSCSCSCSCSCSMKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License