true
2007-11-13
2024-01-24
125
CXL17_HUMAN
VCC-1, a novel chemokine, promotes tumor growth.
Weinstein E.J.
Head R.
Griggs D.W.
Sun D.
Evans R.J.
Swearingen M.L.
Westlin M.M.
Mazzarella R.
doi:10.1016/j.bbrc.2006.08.194
2006
Biochem. Biophys. Res. Commun.
350
74-81
NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
TISSUE SPECIFICITY
Colon cancer
Lung
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark H.F.
Gurney A.L.
Abaya E.
Baker K.
Baldwin D.T.
Brush J.
Chen J.
Chow B.
Chui C.
Crowley C.
Currell B.
Deuel B.
Dowd P.
Eaton D.
Foster J.S.
Grimaldi C.
Gu Q.
Hass P.E.
Heldens S.
Huang A.
Kim H.S.
Klimowski L.
Jin Y.
Johnson S.
Lee J.
Lewis L.
Liao D.
Mark M.R.
Robbie E.
Sanchez C.
Schoenfeld J.
Seshagiri S.
Simmons L.
Singh J.
Smith V.
Stinson J.
Vagts A.
Vandlen R.L.
Watanabe C.
Wieand D.
Woods K.
Xie M.-H.
Yansura D.G.
Yi S.
Yu G.
Yuan J.
Zhang M.
Zhang Z.
Goddard A.D.
Wood W.I.
Godowski P.J.
Gray A.M.
doi:10.1101/gr.1293003
2003
Genome Res.
13
2265-2270
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Trachea
The DNA sequence and biology of human chromosome 19.
Grimwood J.
Gordon L.A.
Olsen A.S.
Terry A.
Schmutz J.
Lamerdin J.E.
Hellsten U.
Goodstein D.
Couronne O.
Tran-Gyamfi M.
Aerts A.
Altherr M.
Ashworth L.
Bajorek E.
Black S.
Branscomb E.
Caenepeel S.
Carrano A.V.
Caoile C.
Chan Y.M.
Christensen M.
Cleland C.A.
Copeland A.
Dalin E.
Dehal P.
Denys M.
Detter J.C.
Escobar J.
Flowers D.
Fotopulos D.
Garcia C.
Georgescu A.M.
Glavina T.
Gomez M.
Gonzales E.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Ho I.
Huang W.
Israni S.
Jett J.
Kadner K.
Kimball H.
Kobayashi A.
Larionov V.
Leem S.-H.
Lopez F.
Lou Y.
Lowry S.
Malfatti S.
Martinez D.
McCready P.M.
Medina C.
Morgan J.
Nelson K.
Nolan M.
Ovcharenko I.
Pitluck S.
Pollard M.
Popkie A.P.
Predki P.
Quan G.
Ramirez L.
Rash S.
Retterer J.
Rodriguez A.
Rogers S.
Salamov A.
Salazar A.
She X.
Smith D.
Slezak T.
Solovyev V.
Thayer N.
Tice H.
Tsai M.
Ustaszewska A.
Vo N.
Wagner M.
Wheeler J.
Wu K.
Xie G.
Yang J.
Dubchak I.
Furey T.S.
DeJong P.
Dickson M.
Gordon D.
Eichler E.E.
Pennacchio L.A.
Richardson P.
Stubbs L.
Rokhsar D.S.
Myers R.M.
Rubin E.M.
Lucas S.M.
doi:10.1038/nature02399
2004
Nature
428
529-535
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Heart
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z.
Henzel W.J.
doi:10.1110/ps.04682504
2004
Protein Sci.
13
2819-2824
PROTEIN SEQUENCE OF 22-37
Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.
Azkargorta M.
Soria J.
Ojeda C.
Guzman F.
Acera A.
Iloro I.
Suarez T.
Elortza F.
doi:10.1021/acs.jproteome.5b00179
2015
J. Proteome Res.
14
2649-2658
PROTEIN SEQUENCE OF 23-61 AND 97-112
IDENTIFICATION BY MASS SPECTROMETRY
Tear
Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods.
Pisabarro M.T.
Leung B.
Kwong M.
Corpuz R.
Frantz G.D.
Chiang N.
Vandlen R.
Diehl L.J.
Skelton N.
Kim H.S.
Eaton D.
Schmidt K.N.
doi:10.4049/jimmunol.176.4.2069
2006
J. Immunol.
176
2069-2073
FUNCTION
TISSUE SPECIFICITY
CIRCULAR DICHROISM
3D-STRUCTURE MODELING
DISULFIDE BONDS
MUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110
Broad up-regulation of innate defense factors during acute cholera.
Flach C.F.
Qadri F.
Bhuiyan T.R.
Alam N.H.
Jennische E.
Lonnroth I.
Holmgren J.
doi:10.1128/iai.01900-06
2007
Infect. Immun.
75
2343-2350
FUNCTION
INDUCTION
CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor.
Lee W.Y.
Wang C.J.
Lin T.Y.
Hsiao C.L.
Luo C.W.
doi:10.1152/ajpendo.00083.2012
2013
Am. J. Physiol.
304
E32-E40
SUBCELLULAR LOCATION
FUNCTION (6-CYS CXCL17 AND 4-CYS CXCL17)
GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.
Maravillas-Montero J.L.
Burkhardt A.M.
Hevezi P.A.
Carnevale C.D.
Smit M.J.
Zlotnik A.
doi:10.4049/jimmunol.1401704
2015
J. Immunol.
194
29-33
INTERACTION WITH GPR35
Wikipedia; CXCL17 entry
17
17
102 antibodies from 18 providers
human
CXCL17
Group enriched (esophagus, lung, salivary gland, stomach)
gene
Eukaryota
22 hits in 1142 CRISPR screens
Tbio
Protein
Expressed in nasal cavity epithelium and 141 other cell types or tissues
baseline and differential
HS
CXCL17
C-X-C MOTIF CHEMOKINE 17
C-X-C MOTIF CHEMOKINE 17
CXCL17
C-X-C motif chemokine 17
6-Cys CXCL17
Dendritic cell and monocyte chemokine-like protein
DMC
VEGF coregulated chemokine 1
4-Cys CXCL17
CXCL17
VCC1
UNQ473/PRO842
Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
Detected in fetal lung.
Found to be up-regulated in duodenal mucosa during acute cholera.
Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.
Belongs to the intercrine alpha (chemokine CxC) family.
1
21
C-X-C motif chemokine 17
11504
22
119
4-Cys CXCL17
6627
64
Disordered
81
100
Basic residues
84
Cleavage
63
75
103
77
110
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110.
S
50
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110.
S
52
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110.
S
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110.
S
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110.
S
Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103.
S
false
2
false
2
false
2
CCL5
CXCL12
PF4
2004-07-05
1
true
13819
1484d7e0f47b0965a988a459ceeaf34f
MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL
true
true
true
true
true
true
true
true
true
true
true
true
true