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Protein

C-X-C motif chemokine 17

Gene

CXCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).5 Publications
4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.1 Publication

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • angiogenesis Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • chemotaxis Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: UniProtKB
  • positive regulation of macrophage chemotaxis Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of vascular endothelial growth factor production Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Chemotaxis, Differentiation

Enzyme and pathway databases

BioCyciZFISH:G66-31947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 17
Short name:
6-Cys CXCL171 Publication
Alternative name(s):
Dendritic cell and monocyte chemokine-like protein
Short name:
DMC
VEGF coregulated chemokine 1
Cleaved into the following chain:
4-Cys CXCL171 Publication
Gene namesi
Name:CXCL17
Synonyms:VCC1
ORF Names:UNQ473/PRO842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19232. CXCL17.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi50C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi52C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi75C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi77C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication1
Mutagenesisi103C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication1
Mutagenesisi110C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication1

Organism-specific databases

DisGeNETi284340.
OpenTargetsiENSG00000189377.
PharmGKBiPA162383045.

Polymorphism and mutation databases

BioMutaiCXCL17.
DMDMi74738198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000031109722 – 119C-X-C motif chemokine 17Add BLAST98
ChainiPRO_000043848764 – 1194-Cys CXCL17CuratedAdd BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 1031 Publication
Disulfide bondi77 ↔ 1101 Publication

Post-translational modificationi

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ6UXB2.
PeptideAtlasiQ6UXB2.
PRIDEiQ6UXB2.

Expressioni

Tissue specificityi

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

Developmental stagei

Detected in fetal lung.

Inductioni

Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

Gene expression databases

BgeeiENSG00000189377.
CleanExiHS_CXCL17.
ExpressionAtlasiQ6UXB2. baseline and differential.
GenevisibleiQ6UXB2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000472467.

Structurei

3D structure databases

ProteinModelPortaliQ6UXB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ND. Eukaryota.
ENOG41118M3. LUCA.
GeneTreeiENSGT00390000002861.
HOGENOMiHOG000154812.
HOVERGENiHBG097374.
InParanoidiQ6UXB2.
OMAiGQASRRW.
OrthoDBiEOG091G0Y5M.
PhylomeDBiQ6UXB2.
TreeFamiTF342477.

Family and domain databases

InterProiIPR029183. CXCL17.
[Graphical view]
PfamiPF15211. CXCL17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC
60 70 80 90 100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS
110
RACQQFLKQC QLRSFALPL
Length:119
Mass (Da):13,819
Last modified:July 5, 2004 - v1
Checksum:iF2D2FD686E47CC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
AC011497 Genomic DNA. No translation available.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
CCDSiCCDS12608.1.
RefSeqiNP_940879.1. NM_198477.2.
UniGeneiHs.445586.

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
GeneIDi284340.
KEGGihsa:284340.
UCSCiuc002otu.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
AC011497 Genomic DNA. No translation available.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
CCDSiCCDS12608.1.
RefSeqiNP_940879.1. NM_198477.2.
UniGeneiHs.445586.

3D structure databases

ProteinModelPortaliQ6UXB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000472467.

Polymorphism and mutation databases

BioMutaiCXCL17.
DMDMi74738198.

Proteomic databases

PaxDbiQ6UXB2.
PeptideAtlasiQ6UXB2.
PRIDEiQ6UXB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
GeneIDi284340.
KEGGihsa:284340.
UCSCiuc002otu.4. human.

Organism-specific databases

CTDi284340.
DisGeNETi284340.
GeneCardsiCXCL17.
HGNCiHGNC:19232. CXCL17.
MIMi611387. gene.
neXtProtiNX_Q6UXB2.
OpenTargetsiENSG00000189377.
PharmGKBiPA162383045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ND. Eukaryota.
ENOG41118M3. LUCA.
GeneTreeiENSGT00390000002861.
HOGENOMiHOG000154812.
HOVERGENiHBG097374.
InParanoidiQ6UXB2.
OMAiGQASRRW.
OrthoDBiEOG091G0Y5M.
PhylomeDBiQ6UXB2.
TreeFamiTF342477.

Enzyme and pathway databases

BioCyciZFISH:G66-31947-MONOMER.

Miscellaneous databases

GenomeRNAii284340.
PROiQ6UXB2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189377.
CleanExiHS_CXCL17.
ExpressionAtlasiQ6UXB2. baseline and differential.
GenevisibleiQ6UXB2. HS.

Family and domain databases

InterProiIPR029183. CXCL17.
[Graphical view]
PfamiPF15211. CXCL17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXL17_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB2
Secondary accession number(s): A8KAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.