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Q6UXB2

- VCC1_HUMAN

UniProt

Q6UXB2 - VCC1_HUMAN

Protein

VEGF coregulated chemokine 1

Gene

CXCL17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.3 Publications

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Chemotaxis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    VEGF coregulated chemokine 1
    Alternative name(s):
    C-X-C motif chemokine 17
    Dendritic cell and monocyte chemokine-like protein
    Short name:
    DMC
    Gene namesi
    Name:CXCL17
    Synonyms:VCC1
    ORF Names:UNQ473/PRO842
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19232. CXCL17.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi50 – 501C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication
    Mutagenesisi52 – 521C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication
    Mutagenesisi75 – 751C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication
    Mutagenesisi77 – 771C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication
    Mutagenesisi103 – 1031C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication
    Mutagenesisi110 – 1101C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication

    Organism-specific databases

    PharmGKBiPA162383045.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 11998VEGF coregulated chemokine 1PRO_0000311097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 751 Publication
    Disulfide bondi52 ↔ 771 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ6UXB2.
    PRIDEiQ6UXB2.

    Expressioni

    Tissue specificityi

    Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

    Developmental stagei

    Detected in fetal lung.

    Inductioni

    Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

    Gene expression databases

    BgeeiQ6UXB2.
    CleanExiHS_CXCL17.
    GenevestigatoriQ6UXB2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000345317.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG78269.
    HOGENOMiHOG000154812.
    HOVERGENiHBG097374.
    InParanoidiQ6UXB2.
    OMAiMEYLDYV.
    OrthoDBiEOG754HRT.
    PhylomeDBiQ6UXB2.
    TreeFamiTF342477.

    Family and domain databases

    InterProiIPR029183. CXCL17.
    [Graphical view]
    PfamiPF15211. CXCL17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UXB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC    50
    ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS 100
    RACQQFLKQC QLRSFALPL 119
    Length:119
    Mass (Da):13,819
    Last modified:July 5, 2004 - v1
    Checksum:iF2D2FD686E47CC9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598464 mRNA. Translation: AAU04875.1.
    AY358433 mRNA. Translation: AAQ88799.1.
    AK292985 mRNA. Translation: BAF85674.1.
    BC093946 mRNA. Translation: AAH93946.1.
    BC112095 mRNA. Translation: AAI12096.1.
    CCDSiCCDS12608.1.
    RefSeqiNP_940879.1. NM_198477.1.
    UniGeneiHs.445586.

    Genome annotation databases

    EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
    GeneIDi284340.
    KEGGihsa:284340.
    UCSCiuc002otu.3. human.

    Polymorphism databases

    DMDMi74738198.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL17 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598464 mRNA. Translation: AAU04875.1 .
    AY358433 mRNA. Translation: AAQ88799.1 .
    AK292985 mRNA. Translation: BAF85674.1 .
    BC093946 mRNA. Translation: AAH93946.1 .
    BC112095 mRNA. Translation: AAI12096.1 .
    CCDSi CCDS12608.1.
    RefSeqi NP_940879.1. NM_198477.1.
    UniGenei Hs.445586.

    3D structure databases

    ProteinModelPortali Q6UXB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000345317.

    Polymorphism databases

    DMDMi 74738198.

    Proteomic databases

    PaxDbi Q6UXB2.
    PRIDEi Q6UXB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000601181 ; ENSP00000472467 ; ENSG00000189377 .
    GeneIDi 284340.
    KEGGi hsa:284340.
    UCSCi uc002otu.3. human.

    Organism-specific databases

    CTDi 284340.
    GeneCardsi GC19M042932.
    HGNCi HGNC:19232. CXCL17.
    MIMi 611387. gene.
    neXtProti NX_Q6UXB2.
    PharmGKBi PA162383045.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78269.
    HOGENOMi HOG000154812.
    HOVERGENi HBG097374.
    InParanoidi Q6UXB2.
    OMAi MEYLDYV.
    OrthoDBi EOG754HRT.
    PhylomeDBi Q6UXB2.
    TreeFami TF342477.

    Miscellaneous databases

    GenomeRNAii 284340.
    NextBioi 94740.
    PROi Q6UXB2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UXB2.
    CleanExi HS_CXCL17.
    Genevestigatori Q6UXB2.

    Family and domain databases

    InterProi IPR029183. CXCL17.
    [Graphical view ]
    Pfami PF15211. CXCL17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Colon cancer and Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-37.
    6. "Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods."
      Pisabarro M.T., Leung B., Kwong M., Corpuz R., Frantz G.D., Chiang N., Vandlen R., Diehl L.J., Skelton N., Kim H.S., Eaton D., Schmidt K.N.
      J. Immunol. 176:2069-2073(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, CIRCULAR DICHROISM, 3D-STRUCTURE MODELING, DISULFIDE BONDS, MUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110.
    7. "Broad up-regulation of innate defense factors during acute cholera."
      Flach C.F., Qadri F., Bhuiyan T.R., Alam N.H., Jennische E., Lonnroth I., Holmgren J.
      Infect. Immun. 75:2343-2350(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiVCC1_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXB2
    Secondary accession number(s): A8KAC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3