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Q6UXB2

- VCC1_HUMAN

UniProt

Q6UXB2 - VCC1_HUMAN

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Protein

VEGF coregulated chemokine 1

Gene

CXCL17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.3 Publications

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Chemotaxis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
VEGF coregulated chemokine 1
Alternative name(s):
C-X-C motif chemokine 17
Dendritic cell and monocyte chemokine-like protein
Short name:
DMC
Gene namesi
Name:CXCL17
Synonyms:VCC1
ORF Names:UNQ473/PRO842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19232. CXCL17.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi50 – 501C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication
Mutagenesisi52 – 521C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication
Mutagenesisi75 – 751C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication
Mutagenesisi77 – 771C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication
Mutagenesisi103 – 1031C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication
Mutagenesisi110 – 1101C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication

Organism-specific databases

PharmGKBiPA162383045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11998VEGF coregulated chemokine 1PRO_0000311097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 751 Publication
Disulfide bondi52 ↔ 771 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UXB2.
PRIDEiQ6UXB2.

Expressioni

Tissue specificityi

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

Developmental stagei

Detected in fetal lung.

Inductioni

Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

Gene expression databases

BgeeiQ6UXB2.
CleanExiHS_CXCL17.
ExpressionAtlasiQ6UXB2. baseline and differential.
GenevestigatoriQ6UXB2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345317.

Structurei

3D structure databases

ProteinModelPortaliQ6UXB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78269.
GeneTreeiENSGT00390000002861.
HOGENOMiHOG000154812.
HOVERGENiHBG097374.
InParanoidiQ6UXB2.
OMAiMEYLDYV.
OrthoDBiEOG754HRT.
PhylomeDBiQ6UXB2.
TreeFamiTF342477.

Family and domain databases

InterProiIPR029183. CXCL17.
[Graphical view]
PfamiPF15211. CXCL17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC
60 70 80 90 100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS
110
RACQQFLKQC QLRSFALPL
Length:119
Mass (Da):13,819
Last modified:July 5, 2004 - v1
Checksum:iF2D2FD686E47CC9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
CCDSiCCDS12608.1.
RefSeqiNP_940879.1. NM_198477.1.
UniGeneiHs.445586.

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
GeneIDi284340.
KEGGihsa:284340.
UCSCiuc002otu.3. human.

Polymorphism databases

DMDMi74738198.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL17 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598464 mRNA. Translation: AAU04875.1 .
AY358433 mRNA. Translation: AAQ88799.1 .
AK292985 mRNA. Translation: BAF85674.1 .
BC093946 mRNA. Translation: AAH93946.1 .
BC112095 mRNA. Translation: AAI12096.1 .
CCDSi CCDS12608.1.
RefSeqi NP_940879.1. NM_198477.1.
UniGenei Hs.445586.

3D structure databases

ProteinModelPortali Q6UXB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000345317.

Polymorphism databases

DMDMi 74738198.

Proteomic databases

PaxDbi Q6UXB2.
PRIDEi Q6UXB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000601181 ; ENSP00000472467 ; ENSG00000189377 .
GeneIDi 284340.
KEGGi hsa:284340.
UCSCi uc002otu.3. human.

Organism-specific databases

CTDi 284340.
GeneCardsi GC19M042932.
HGNCi HGNC:19232. CXCL17.
MIMi 611387. gene.
neXtProti NX_Q6UXB2.
PharmGKBi PA162383045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78269.
GeneTreei ENSGT00390000002861.
HOGENOMi HOG000154812.
HOVERGENi HBG097374.
InParanoidi Q6UXB2.
OMAi MEYLDYV.
OrthoDBi EOG754HRT.
PhylomeDBi Q6UXB2.
TreeFami TF342477.

Miscellaneous databases

GenomeRNAii 284340.
NextBioi 94740.
PROi Q6UXB2.
SOURCEi Search...

Gene expression databases

Bgeei Q6UXB2.
CleanExi HS_CXCL17.
ExpressionAtlasi Q6UXB2. baseline and differential.
Genevestigatori Q6UXB2.

Family and domain databases

InterProi IPR029183. CXCL17.
[Graphical view ]
Pfami PF15211. CXCL17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Colon cancer and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-37.
  6. "Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods."
    Pisabarro M.T., Leung B., Kwong M., Corpuz R., Frantz G.D., Chiang N., Vandlen R., Diehl L.J., Skelton N., Kim H.S., Eaton D., Schmidt K.N.
    J. Immunol. 176:2069-2073(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, CIRCULAR DICHROISM, 3D-STRUCTURE MODELING, DISULFIDE BONDS, MUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110.
  7. "Broad up-regulation of innate defense factors during acute cholera."
    Flach C.F., Qadri F., Bhuiyan T.R., Alam N.H., Jennische E., Lonnroth I., Holmgren J.
    Infect. Immun. 75:2343-2350(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiVCC1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB2
Secondary accession number(s): A8KAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3