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Q6UXB2 (VCC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
VEGF coregulated chemokine 1
Alternative name(s):
C-X-C motif chemokine 17
Dendritic cell and monocyte chemokine-like protein
Short name=DMC
Gene names
Name:CXCL17
Synonyms:VCC1
ORF Names:UNQ473/PRO842
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections. Ref.1 Ref.6 Ref.7

Subcellular location

Secreted.

Tissue specificity

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation. Ref.1 Ref.6

Developmental stage

Detected in fetal lung.

Induction

Found to be up-regulated in duodenal mucosa during acute cholera. Ref.7

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processAngiogenesis
Chemotaxis
Differentiation
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

chemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.5
Chain22 – 11998VEGF coregulated chemokine 1
PRO_0000311097

Amino acid modifications

Disulfide bond50 ↔ 75 Ref.6
Disulfide bond52 ↔ 77 Ref.6

Experimental info

Mutagenesis501C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. Ref.6
Mutagenesis521C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. Ref.6
Mutagenesis751C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. Ref.6
Mutagenesis771C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. Ref.6
Mutagenesis1031C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. Ref.6
Mutagenesis1101C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q6UXB2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F2D2FD686E47CC9B

FASTA11913,819
        10         20         30         40         50         60 
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP 

        70         80         90        100        110 
RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL 

« Hide

References

« Hide 'large scale' references
[1]"VCC-1, a novel chemokine, promotes tumor growth."
Weinstein E.J., Head R., Griggs D.W., Sun D., Evans R.J., Swearingen M.L., Westlin M.M., Mazzarella R.
Biochem. Biophys. Res. Commun. 350:74-81(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Colon cancer and Lung.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-37.
[6]"Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods."
Pisabarro M.T., Leung B., Kwong M., Corpuz R., Frantz G.D., Chiang N., Vandlen R., Diehl L.J., Skelton N., Kim H.S., Eaton D., Schmidt K.N.
J. Immunol. 176:2069-2073(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, CIRCULAR DICHROISM, 3D-STRUCTURE MODELING, DISULFIDE BONDS, MUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110.
[7]"Broad up-regulation of innate defense factors during acute cholera."
Flach C.F., Qadri F., Bhuiyan T.R., Alam N.H., Jennische E., Lonnroth I., Holmgren J.
Infect. Immun. 75:2343-2350(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.

Web resources

Wikipedia

CXCL17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
RefSeqNP_940879.1. NM_198477.1.
UniGeneHs.445586.

3D structure databases

ProteinModelPortalQ6UXB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000345317.

Polymorphism databases

DMDM74738198.

Proteomic databases

PaxDbQ6UXB2.
PRIDEQ6UXB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000601181; ENSP00000472467; ENSG00000189377.
GeneID284340.
KEGGhsa:284340.
UCSCuc002otu.3. human.

Organism-specific databases

CTD284340.
GeneCardsGC19M042932.
HGNCHGNC:19232. CXCL17.
MIM611387. gene.
neXtProtNX_Q6UXB2.
PharmGKBPA162383045.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78269.
HOGENOMHOG000154812.
HOVERGENHBG097374.
InParanoidQ6UXB2.
OMADWFLRAP.
OrthoDBEOG754HRT.
PhylomeDBQ6UXB2.
TreeFamTF342477.

Gene expression databases

BgeeQ6UXB2.
CleanExHS_CXCL17.
GenevestigatorQ6UXB2.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi284340.
NextBio94740.
PROQ6UXB2.
SOURCESearch...

Entry information

Entry nameVCC1_HUMAN
AccessionPrimary (citable) accession number: Q6UXB2
Secondary accession number(s): A8KAC0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM