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Protein

VEGF coregulated chemokine 1

Gene

CXCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.3 Publications

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Chemotaxis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
VEGF coregulated chemokine 1
Alternative name(s):
C-X-C motif chemokine 17
Dendritic cell and monocyte chemokine-like protein
Short name:
DMC
Gene namesi
Name:CXCL17
Synonyms:VCC1
ORF Names:UNQ473/PRO842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19232. CXCL17.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi50 – 501C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication
Mutagenesisi52 – 521C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication
Mutagenesisi75 – 751C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication
Mutagenesisi77 – 771C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication
Mutagenesisi103 – 1031C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication
Mutagenesisi110 – 1101C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication

Organism-specific databases

PharmGKBiPA162383045.

Polymorphism and mutation databases

BioMutaiCXCL17.
DMDMi74738198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11998VEGF coregulated chemokine 1PRO_0000311097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 751 Publication
Disulfide bondi52 ↔ 771 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UXB2.
PRIDEiQ6UXB2.

Expressioni

Tissue specificityi

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

Developmental stagei

Detected in fetal lung.

Inductioni

Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

Gene expression databases

BgeeiQ6UXB2.
CleanExiHS_CXCL17.
ExpressionAtlasiQ6UXB2. baseline and differential.
GenevestigatoriQ6UXB2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345317.

Structurei

3D structure databases

ProteinModelPortaliQ6UXB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78269.
GeneTreeiENSGT00390000002861.
HOGENOMiHOG000154812.
HOVERGENiHBG097374.
InParanoidiQ6UXB2.
OMAiDWFLRAP.
OrthoDBiEOG754HRT.
PhylomeDBiQ6UXB2.
TreeFamiTF342477.

Family and domain databases

InterProiIPR029183. CXCL17.
[Graphical view]
PfamiPF15211. CXCL17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC
60 70 80 90 100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS
110
RACQQFLKQC QLRSFALPL
Length:119
Mass (Da):13,819
Last modified:July 5, 2004 - v1
Checksum:iF2D2FD686E47CC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
CCDSiCCDS12608.1.
RefSeqiNP_940879.1. NM_198477.1.
UniGeneiHs.445586.

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
GeneIDi284340.
KEGGihsa:284340.
UCSCiuc002otu.3. human.

Polymorphism and mutation databases

BioMutaiCXCL17.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA. Translation: AAU04875.1.
AY358433 mRNA. Translation: AAQ88799.1.
AK292985 mRNA. Translation: BAF85674.1.
BC093946 mRNA. Translation: AAH93946.1.
BC112095 mRNA. Translation: AAI12096.1.
CCDSiCCDS12608.1.
RefSeqiNP_940879.1. NM_198477.1.
UniGeneiHs.445586.

3D structure databases

ProteinModelPortaliQ6UXB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345317.

Polymorphism and mutation databases

BioMutaiCXCL17.
DMDMi74738198.

Proteomic databases

PaxDbiQ6UXB2.
PRIDEiQ6UXB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377.
GeneIDi284340.
KEGGihsa:284340.
UCSCiuc002otu.3. human.

Organism-specific databases

CTDi284340.
GeneCardsiGC19M042932.
HGNCiHGNC:19232. CXCL17.
MIMi611387. gene.
neXtProtiNX_Q6UXB2.
PharmGKBiPA162383045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78269.
GeneTreeiENSGT00390000002861.
HOGENOMiHOG000154812.
HOVERGENiHBG097374.
InParanoidiQ6UXB2.
OMAiDWFLRAP.
OrthoDBiEOG754HRT.
PhylomeDBiQ6UXB2.
TreeFamiTF342477.

Miscellaneous databases

GenomeRNAii284340.
NextBioi94740.
PROiQ6UXB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UXB2.
CleanExiHS_CXCL17.
ExpressionAtlasiQ6UXB2. baseline and differential.
GenevestigatoriQ6UXB2.

Family and domain databases

InterProiIPR029183. CXCL17.
[Graphical view]
PfamiPF15211. CXCL17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Colon cancer and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-37.
  6. "Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods."
    Pisabarro M.T., Leung B., Kwong M., Corpuz R., Frantz G.D., Chiang N., Vandlen R., Diehl L.J., Skelton N., Kim H.S., Eaton D., Schmidt K.N.
    J. Immunol. 176:2069-2073(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, CIRCULAR DICHROISM, 3D-STRUCTURE MODELING, DISULFIDE BONDS, MUTAGENESIS OF CYS-50; CYS-52; CYS-75; CYS-77; CYS-103 AND CYS-110.
  7. "Broad up-regulation of innate defense factors during acute cholera."
    Flach C.F., Qadri F., Bhuiyan T.R., Alam N.H., Jennische E., Lonnroth I., Holmgren J.
    Infect. Immun. 75:2343-2350(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiVCC1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB2
Secondary accession number(s): A8KAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.