Q6UXB1 (IGFL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin growth factor-like family member 3

Gene names

Name:	IGFL3
ORF Names:	UNQ483/PRO982

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential ligand of the IGFLR1 cell membrane receptor. Ref.5
Subcellular location	Secreted Probable.
Tissue specificity	Detected in the cerebellum. Ref.1
Sequence similarities	Belongs to the IGFL family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.4
	Chain	25 – 125	101	Insulin growth factor-like family member 3		PRO_0000044634
Natural variations
	Natural variant	66	1	T → S. Corresponds to variant rs10406448 [ dbSNP | Ensembl ].		VAR_034012

Sequences

	Sequence		Length	Mass (Da)
	Q6UXB1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 57CE1D166779090D	FASTA	125	14,198
	10 20 30 40 50 60 MRPRCCILAL VCWITVFLLQ CSKGTTDAPV GSGLWLCQPT PRCGNKIYNP SEQCCYDDAI 70 80 90 100 110 120 LSLKETRRCG STCTFWPCFE LCCPESFGPQ QKFLVKLRVL GMKSQCHLSP ISRSCTRNRR HVLYP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily." Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B., Hazell S., Polizotto R., Funk W.D., Tang Y.T. Genomics 88:513-520(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[5]	"Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1." Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J., Ouyang W., Gonzalez L.C. J. Biol. Chem. 286:18969-18981(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY672113 mRNA. Translation: AAT77787.1. AY358434 mRNA. Translation: AAQ88800.1. AC007785 Genomic DNA. No translation available.
IPI	IPI00397724.
RefSeq	NP_997276.1. NM_207393.1.
UniGene	Hs.365496.
3D structure databases
ProteinModelPortal	Q6UXB1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UXB1. 1 interaction.
STRING	9606.ENSP00000344860.
Polymorphism databases
DMDM	74738197.
Proteomic databases
PaxDb	Q6UXB1.
PRIDE	Q6UXB1.
Protocols and materials databases
DNASU	388555.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341415; ENSP00000344860; ENSG00000188624.
GeneID	388555.
KEGG	hsa:388555.
UCSC	uc002pea.1. human.
Organism-specific databases
CTD	388555.
GeneCards	GC19M046627.
HGNC	HGNC:32930. IGFL3.
MIM	610546. gene.
neXtProt	NX_Q6UXB1.
PharmGKB	PA147357949.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG75788.
HOGENOM	HOG000113010.
HOVERGEN	HBG081785.
InParanoid	Q6UXB1.
OMA	CYDDAIL.
OrthoDB	EOG4DZ1WX.
PhylomeDB	Q6UXB1.
Gene expression databases
Bgee	Q6UXB1.
CleanEx	HS_IGFL3.
Genevestigator	Q6UXB1.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	388555.
NextBio	102144.
SOURCE	Search...

Entry information

Entry name

IGFL3_HUMAN

Accession

Primary (citable) accession number: Q6UXB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.