ID   F131A_HUMAN             Reviewed;         366 AA.
AC   Q6UXB0; D3DNT6; G5E9B1; Q8TA84;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 2.
DT   24-JAN-2024, entry version 128.
DE   RecName: Full=Protein FAM131A;
GN   Name=FAM131A; Synonyms=C3orf40; ORFNames=UNQ715/PRO1378;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 74-366 (ISOFORM 3).
RC   TISSUE=Duodenum, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] ASN-291.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=3;
CC         IsoId=Q6UXB0-3; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q6UXB0-1; Sequence=VSP_059988;
CC       Name=2;
CC         IsoId=Q6UXB0-2; Sequence=VSP_059989;
CC   -!- SIMILARITY: Belongs to the FAM131 family. {ECO:0000305}.
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DR   EMBL; AY358435; AAQ88801.1; -; mRNA.
DR   EMBL; AC078797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW78252.1; -; Genomic_DNA.
DR   EMBL; CH471052; EAW78254.1; -; Genomic_DNA.
DR   EMBL; CH471052; EAW78255.1; -; Genomic_DNA.
DR   EMBL; CH471052; EAW78256.1; -; Genomic_DNA.
DR   EMBL; CH471052; EAW78253.1; -; Genomic_DNA.
DR   EMBL; BC026221; AAH26221.1; -; mRNA.
DR   EMBL; BC037299; AAH37299.1; -; mRNA.
DR   CCDS; CCDS3262.2; -. [Q6UXB0-3]
DR   CCDS; CCDS54689.1; -. [Q6UXB0-2]
DR   RefSeq; NP_001164564.1; NM_001171093.1. [Q6UXB0-2]
DR   RefSeq; NP_653236.3; NM_144635.4. [Q6UXB0-3]
DR   RefSeq; XP_005247170.1; XM_005247113.2.
DR   RefSeq; XP_005247171.1; XM_005247114.3. [Q6UXB0-2]
DR   RefSeq; XP_011510715.1; XM_011512413.2.
DR   AlphaFoldDB; Q6UXB0; -.
DR   BioGRID; 126280; 5.
DR   IntAct; Q6UXB0; 2.
DR   STRING; 9606.ENSP00000373360; -.
DR   iPTMnet; Q6UXB0; -.
DR   BioMuta; FAM131A; -.
DR   DMDM; 74738196; -.
DR   MassIVE; Q6UXB0; -.
DR   MaxQB; Q6UXB0; -.
DR   PaxDb; 9606-ENSP00000373360; -.
DR   PeptideAtlas; Q6UXB0; -.
DR   ProteomicsDB; 33886; -.
DR   ProteomicsDB; 67580; -. [Q6UXB0-1]
DR   ProteomicsDB; 67581; -. [Q6UXB0-2]
DR   Antibodypedia; 52588; 62 antibodies from 12 providers.
DR   DNASU; 131408; -.
DR   Ensembl; ENST00000310585.4; ENSP00000310135.4; ENSG00000175182.15. [Q6UXB0-1]
DR   Ensembl; ENST00000340957.9; ENSP00000340974.5; ENSG00000175182.15. [Q6UXB0-2]
DR   Ensembl; ENST00000383847.7; ENSP00000373360.2; ENSG00000175182.15. [Q6UXB0-3]
DR   Ensembl; ENST00000450976.5; ENSP00000388551.1; ENSG00000175182.15. [Q6UXB0-2]
DR   Ensembl; ENST00000453072.5; ENSP00000390588.1; ENSG00000175182.15. [Q6UXB0-2]
DR   GeneID; 131408; -.
DR   KEGG; hsa:131408; -.
DR   MANE-Select; ENST00000383847.7; ENSP00000373360.2; NM_144635.5; NP_653236.3.
DR   UCSC; uc003foc.4; human. [Q6UXB0-3]
DR   AGR; HGNC:28308; -.
DR   CTD; 131408; -.
DR   DisGeNET; 131408; -.
DR   GeneCards; FAM131A; -.
DR   HGNC; HGNC:28308; FAM131A.
DR   HPA; ENSG00000175182; Tissue enhanced (brain).
DR   neXtProt; NX_Q6UXB0; -.
DR   OpenTargets; ENSG00000175182; -.
DR   PharmGKB; PA162386054; -.
DR   VEuPathDB; HostDB:ENSG00000175182; -.
DR   eggNOG; ENOG502QR3P; Eukaryota.
DR   GeneTree; ENSGT00950000183106; -.
DR   HOGENOM; CLU_074265_0_0_1; -.
DR   InParanoid; Q6UXB0; -.
DR   OMA; ACISQVV; -.
DR   OrthoDB; 5316233at2759; -.
DR   PhylomeDB; Q6UXB0; -.
DR   TreeFam; TF331537; -.
DR   PathwayCommons; Q6UXB0; -.
DR   SignaLink; Q6UXB0; -.
DR   BioGRID-ORCS; 131408; 8 hits in 1154 CRISPR screens.
DR   ChiTaRS; FAM131A; human.
DR   GenomeRNAi; 131408; -.
DR   Pharos; Q6UXB0; Tdark.
DR   PRO; PR:Q6UXB0; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6UXB0; Protein.
DR   Bgee; ENSG00000175182; Expressed in prefrontal cortex and 202 other cell types or tissues.
DR   ExpressionAtlas; Q6UXB0; baseline and differential.
DR   InterPro; IPR026782; FAM131.
DR   PANTHER; PTHR15736:SF4; PROTEIN FAM131A; 1.
DR   PANTHER; PTHR15736; PROTEIN FAM131B-RELATED; 1.
DR   Pfam; PF15010; FAM131; 1.
DR   Genevisible; Q6UXB0; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..366
FT                   /note="Protein FAM131A"
FT                   /id="PRO_0000243932"
FT   REGION          342..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..108
FT                   /note="MPMISVLGKMFLWQREGPGGRWTCQTSRRVSSDPAWAVEWIELPRGLSLSSL
FT                   GSARTLRGWSRSSRPSSVDSQDLPEVNVGDTVAMLPKSRRALTIQEIAALARSSLH ->
FT                   MFLATLSFLLPFAHPFGTVSCEYMLGSPLSSLAQVNLSPFSHPKVHMDPNYCHPSTSLH
FT                   LCSLAWSFTRLLHPPLSP (in isoform 1)"
FT                   /id="VSP_059988"
FT   VAR_SEQ         1..85
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_059989"
FT   VARIANT         291
FT                   /note="S -> N (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036118"
SQ   SEQUENCE   366 AA;  39503 MW;  2A21A6FE9FADC40E CRC64;
     MPMISVLGKM FLWQREGPGG RWTCQTSRRV SSDPAWAVEW IELPRGLSLS SLGSARTLRG
     WSRSSRPSSV DSQDLPEVNV GDTVAMLPKS RRALTIQEIA ALARSSLHGI SQVVKDHVTK
     PTAMAQGRVA HLIEWKGWSK PSDSPAALES AFSSYSDLSE GEQEARFAAG VAEQFAIAEA
     KLRAWSSVDG EDSTDDSYDE DFAGGMDTDM AGQLPLGPHL QDLFTGHRFS RPVRQGSVEP
     ESDCSQTVSP DTLCSSLCSL EDGLLGSPAR LASQLLGDEL LLAKLPPSRE SAFRSLGPLE
     AQDSLYNSPL TESCLSPAEE EPAPCKDCQP LCPPLTGSWE RQRQASDLAS SGVVSLDEDE
     AEPEEQ
//