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Q6UXB0 (F131A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM131A
Gene names
Name:FAM131A
Synonyms:C3orf40
ORF Names:UNQ715/PRO1378
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the FAM131 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UXB0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UXB0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MFLATLSFLL...TRLLHPPLSP → MLPKSRRALTIQEIAALARSSLH
Isoform 3 (identifier: Q6UXB0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MFLATLSFLL...TRLLHPPLSP → MPMISVLGKM...IAALARSSLH
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 335314Protein FAM131A
PRO_0000243932

Natural variations

Alternative sequence1 – 7777MFLAT…PPLSP → MLPKSRRALTIQEIAALARS SLH in isoform 2.
VSP_019501
Alternative sequence1 – 7777MFLAT…PPLSP → MPMISVLGKMFLWQREGPGG RWTCQTSRRVSSDPAWAVEW IELPRGLSLSSLGSARTLRG WSRSSRPSSVDSQDLPEVNV GDTVAMLPKSRRALTIQEIA ALARSSLH in isoform 3.
VSP_046653
Natural variant521C → R.
Corresponds to variant rs13434353 [ dbSNP | Ensembl ].
VAR_053919
Natural variant2601S → N in a breast cancer sample; somatic mutation. Ref.5
VAR_036118

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9F57A1FEB71163A8

FASTA33536,108
        10         20         30         40         50         60 
MFLATLSFLL PFAHPFGTVS CEYMLGSPLS SLAQVNLSPF SHPKVHMDPN YCHPSTSLHL 

        70         80         90        100        110        120 
CSLAWSFTRL LHPPLSPGIS QVVKDHVTKP TAMAQGRVAH LIEWKGWSKP SDSPAALESA 

       130        140        150        160        170        180 
FSSYSDLSEG EQEARFAAGV AEQFAIAEAK LRAWSSVDGE DSTDDSYDED FAGGMDTDMA 

       190        200        210        220        230        240 
GQLPLGPHLQ DLFTGHRFSR PVRQGSVEPE SDCSQTVSPD TLCSSLCSLE DGLLGSPARL 

       250        260        270        280        290        300 
ASQLLGDELL LAKLPPSRES AFRSLGPLEA QDSLYNSPLT ESCLSPAEEE PAPCKDCQPL 

       310        320        330 
CPPLTGSWER QRQASDLASS GVVSLDEDEA EPEEQ 

« Hide

Isoform 2 [UniParc].

Checksum: 709D2ED7E3E85BFA
Show »

FASTA28130,146
Isoform 3 [UniParc].

Checksum: 2A21A6FE9FADC40E
Show »

FASTA36639,503

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Duodenum and Testis.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-260.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358435 mRNA. Translation: AAQ88801.1.
AC078797 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78252.1.
CH471052 Genomic DNA. Translation: EAW78254.1.
CH471052 Genomic DNA. Translation: EAW78255.1.
CH471052 Genomic DNA. Translation: EAW78256.1.
CH471052 Genomic DNA. Translation: EAW78253.1.
BC026221 mRNA. Translation: AAH26221.1.
BC037299 mRNA. Translation: AAH37299.1.
RefSeqNP_001164564.1. NM_001171093.1.
NP_653236.3. NM_144635.4.
XP_005247170.1. XM_005247113.1.
XP_005247171.1. XM_005247114.1.
XP_005247172.1. XM_005247115.2.
UniGeneHs.591307.

3D structure databases

ProteinModelPortalQ6UXB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126280. 2 interactions.
IntActQ6UXB0. 1 interaction.
STRING9606.ENSP00000310135.

PTM databases

PhosphoSiteQ6UXB0.

Polymorphism databases

DMDM74738196.

Proteomic databases

PaxDbQ6UXB0.
PRIDEQ6UXB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310585; ENSP00000310135; ENSG00000175182. [Q6UXB0-1]
ENST00000340957; ENSP00000340974; ENSG00000175182. [Q6UXB0-2]
ENST00000383847; ENSP00000373360; ENSG00000175182. [Q6UXB0-3]
ENST00000450976; ENSP00000388551; ENSG00000175182. [Q6UXB0-2]
ENST00000453072; ENSP00000390588; ENSG00000175182. [Q6UXB0-2]
GeneID131408.
KEGGhsa:131408.
UCSCuc003foc.3. human. [Q6UXB0-2]
uc003fog.3. human. [Q6UXB0-1]

Organism-specific databases

CTD131408.
GeneCardsGC03P184053.
HGNCHGNC:28308. FAM131A.
HPAHPA042800.
neXtProtNX_Q6UXB0.
PharmGKBPA162386054.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38937.
HOGENOMHOG000013105.
HOVERGENHBG081012.
InParanoidQ6UXB0.
OMAMRQGSVE.
OrthoDBEOG7060RH.
PhylomeDBQ6UXB0.
TreeFamTF331537.

Gene expression databases

ArrayExpressQ6UXB0.
BgeeQ6UXB0.
CleanExHS_FAM131A.
GenevestigatorQ6UXB0.

Family and domain databases

InterProIPR026782. FAM131.
[Graphical view]
PANTHERPTHR15736. PTHR15736. 1 hit.
PfamPF15010. FAM131. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM131A. human.
GenomeRNAi131408.
NextBio82908.
PROQ6UXB0.

Entry information

Entry nameF131A_HUMAN
AccessionPrimary (citable) accession number: Q6UXB0
Secondary accession number(s): D3DNT6, G5E9B1, Q8TA84
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM