ID CF015_HUMAN Reviewed; 325 AA. AC Q6UXA7; B0S7V8; Q0EFA6; Q2L6G7; Q5SQ81; Q86Z05; Q9UIG3; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 12-JUN-2007, sequence version 3. DT 27-MAR-2024, entry version 140. DE RecName: Full=Uncharacterized protein C6orf15; DE AltName: Full=Protein STG; DE Flags: Precursor; GN Name=C6orf15; Synonyms=STG; ORFNames=UNQ1840/PRO3566; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLU-165. RC TISSUE=Keratinocyte; RX PubMed=10545595; DOI=10.1093/hmg/8.12.2165; RA Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., RA Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., RA Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.; RT "Association analysis using refined microsatellite markers localizes a RT susceptibility locus for psoriasis vulgaris within a 111kb segment RT telomeric to the HLA-C gene."; RL Hum. Mol. Genet. 8:2165-2170(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-40; PRO-83 AND RP GLU-165. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-5. RX PubMed=16702430; DOI=10.1534/genetics.106.057034; RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A., RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., RA Inoko H., Bahram S.; RT "Rapid evolution of major histocompatibility complex class I genes in RT primates generates new disease alleles in humans via hitchhiking RT diversity."; RL Genetics 173:1555-1570(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PHE-40; ASP-43; RP PRO-83 AND GLU-165. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP TISSUE SPECIFICITY, AND VARIANTS PRO-83 AND GLU-165. RX PubMed=15217361; DOI=10.1111/j.0906-6705.2004.00170.x; RA Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M.; RT "STG does not associate with psoriasis in the Swedish population."; RL Exp. Dermatol. 13:413-418(2004). CC -!- SUBUNIT: Binds to numerous extracellular matrix proteins. CC {ECO:0000250}. CC -!- INTERACTION: CC Q6UXA7; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11990870, EBI-11962084; CC Q6UXA7; O75360: PROP1; NbExp=3; IntAct=EBI-11990870, EBI-9027467; CC Q6UXA7; Q9UHD9: UBQLN2; NbExp=8; IntAct=EBI-11990870, EBI-947187; CC Q6UXA7; O95231: VENTX; NbExp=3; IntAct=EBI-11990870, EBI-10191303; CC Q6UXA7; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-11990870, EBI-1051237; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in skin and tonsils. CC {ECO:0000269|PubMed:15217361}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB031481; BAA88132.1; -; mRNA. DR EMBL; AY358438; AAQ88804.1; -; mRNA. DR EMBL; AB088114; BAC54947.1; -; Genomic_DNA. DR EMBL; AB202103; BAE78624.1; -; Genomic_DNA. DR EMBL; AB103620; BAF31282.1; -; Genomic_DNA. DR EMBL; AL662867; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL773544; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759805; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927139; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03356.1; -; Genomic_DNA. DR CCDS; CCDS4693.1; -. DR RefSeq; NP_054789.2; NM_014070.2. DR AlphaFoldDB; Q6UXA7; -. DR BioGRID; 118879; 25. DR IntAct; Q6UXA7; 5. DR STRING; 9606.ENSP00000259870; -. DR GlyGen; Q6UXA7; 1 site, 1 O-linked glycan (1 site). DR BioMuta; C6orf15; -. DR DMDM; 148887353; -. DR MassIVE; Q6UXA7; -. DR PaxDb; 9606-ENSP00000259870; -. DR PeptideAtlas; Q6UXA7; -. DR ProteomicsDB; 67579; -. DR Antibodypedia; 653; 26 antibodies from 13 providers. DR DNASU; 29113; -. DR Ensembl; ENST00000259870.4; ENSP00000259870.3; ENSG00000204542.3. DR Ensembl; ENST00000383532.4; ENSP00000373024.4; ENSG00000206461.4. DR Ensembl; ENST00000412706.2; ENSP00000394931.2; ENSG00000231624.2. DR Ensembl; ENST00000427005.2; ENSP00000398496.2; ENSG00000225543.2. DR Ensembl; ENST00000440933.2; ENSP00000391756.2; ENSG00000224105.2. DR Ensembl; ENST00000452899.2; ENSP00000399436.2; ENSG00000229432.2. DR GeneID; 29113; -. DR KEGG; hsa:29113; -. DR MANE-Select; ENST00000259870.4; ENSP00000259870.3; NM_014070.3; NP_054789.2. DR UCSC; uc003nsk.2; human. DR AGR; HGNC:13927; -. DR DisGeNET; 29113; -. DR GeneCards; C6orf15; -. DR HGNC; HGNC:13927; C6orf15. DR HPA; ENSG00000204542; Group enriched (cervix, lymphoid tissue, skin). DR MIM; 611401; gene. DR neXtProt; NX_Q6UXA7; -. DR OpenTargets; ENSG00000204542; -. DR PharmGKB; PA134866404; -. DR VEuPathDB; HostDB:ENSG00000204542; -. DR eggNOG; ENOG502SDN4; Eukaryota. DR GeneTree; ENSGT00390000010291; -. DR HOGENOM; CLU_919928_0_0_1; -. DR InParanoid; Q6UXA7; -. DR OMA; WPSEDPW; -. DR OrthoDB; 4634629at2759; -. DR PhylomeDB; Q6UXA7; -. DR TreeFam; TF338298; -. DR PathwayCommons; Q6UXA7; -. DR SignaLink; Q6UXA7; -. DR BioGRID-ORCS; 29113; 41 hits in 1135 CRISPR screens. DR GenomeRNAi; 29113; -. DR Pharos; Q6UXA7; Tdark. DR PRO; PR:Q6UXA7; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q6UXA7; Protein. DR Bgee; ENSG00000204542; Expressed in skin of leg and 22 other cell types or tissues. DR ExpressionAtlas; Q6UXA7; baseline and differential. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central. DR InterPro; IPR026135; C6orf15. DR PANTHER; PTHR15817:SF2; SIMILAR TO RIKEN CDNA 2300002M23; 1. DR PANTHER; PTHR15817; STG PROTEIN; 1. DR Pfam; PF15809; STG; 1. DR Genevisible; Q6UXA7; HS. PE 1: Evidence at protein level; KW Extracellular matrix; Reference proteome; Secreted; Signal. FT SIGNAL 1..26 FT /evidence="ECO:0000255" FT CHAIN 27..325 FT /note="Uncharacterized protein C6orf15" FT /id="PRO_0000019541" FT REGION 41..110 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 147..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 41..64 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 5 FT /note="V -> M (in dbSNP:rs2270191)" FT /evidence="ECO:0000269|PubMed:16702430" FT /id="VAR_054399" FT VARIANT 40 FT /note="L -> F (in dbSNP:rs2233974)" FT /evidence="ECO:0000269|PubMed:12975309, FT ECO:0000269|PubMed:14574404" FT /id="VAR_022907" FT VARIANT 43 FT /note="N -> D (in dbSNP:rs2233975)" FT /evidence="ECO:0000269|PubMed:14574404" FT /id="VAR_022908" FT VARIANT 48 FT /note="G -> R (in dbSNP:rs2233976)" FT /id="VAR_050801" FT VARIANT 81 FT /note="V -> A (in dbSNP:rs2233977)" FT /id="VAR_028732" FT VARIANT 83 FT /note="A -> P (in dbSNP:rs1265053)" FT /evidence="ECO:0000269|PubMed:12975309, FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15217361" FT /id="VAR_022909" FT VARIANT 145 FT /note="A -> P (in dbSNP:rs2233978)" FT /id="VAR_028733" FT VARIANT 165 FT /note="K -> E (in dbSNP:rs1265054)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15217361" FT /id="VAR_022910" FT VARIANT 232 FT /note="M -> I (in dbSNP:rs2233982)" FT /id="VAR_050802" FT VARIANT 291 FT /note="G -> D (in dbSNP:rs2233984)" FT /id="VAR_028734" SQ SEQUENCE 325 AA; 34195 MW; 8ED611FD4F9364E3 CRC64; MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV LRPPGSSWNI PAGFPNPPSP RLQWG //