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Protein

Uncharacterized protein C6orf15

Gene

C6orf15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf15
Alternative name(s):
Protein STG
Gene namesi
Name:C6orf15
Synonyms:STG
ORF Names:UNQ1840/PRO3566
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13927. C6orf15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi29113.
OpenTargetsiENSG00000204542.
ENSG00000224105.
ENSG00000225543.
ENSG00000231624.
PharmGKBiPA134866404.

Polymorphism and mutation databases

BioMutaiC6orf15.
DMDMi148887353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001954127 – 325Uncharacterized protein C6orf15Add BLAST299

Proteomic databases

PaxDbiQ6UXA7.
PeptideAtlasiQ6UXA7.
PRIDEiQ6UXA7.

Expressioni

Tissue specificityi

Expressed in skin and tonsils.1 Publication

Gene expression databases

BgeeiENSG00000204542.
CleanExiHS_C6orf15.
ExpressionAtlasiQ6UXA7. baseline and differential.
GenevisibleiQ6UXA7. HS.

Organism-specific databases

HPAiHPA001436.

Interactioni

Subunit structurei

Binds to numerous extracellular matrix proteins.By similarity

Protein-protein interaction databases

BioGridi118879. 2 interactors.
IntActiQ6UXA7. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6UXA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 284Gly-richAdd BLAST66
Compositional biasi290 – 320Pro-richAdd BLAST31

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0F6. Eukaryota.
ENOG41116A4. LUCA.
GeneTreeiENSGT00390000010291.
HOGENOMiHOG000111554.
HOVERGENiHBG057901.
InParanoidiQ6UXA7.
OMAiNSEHAQP.
OrthoDBiEOG091G0ON6.
PhylomeDBiQ6UXA7.
TreeFamiTF338298.

Family and domain databases

InterProiIPR026135. C6orf15.
[Graphical view]
PANTHERiPTHR15817. PTHR15817. 1 hit.
PfamiPF15809. STG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP
60 70 80 90 100
SSTGPSNSEH PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP
110 120 130 140 150
SWGLPAMDSW PPEDPWQMMA AAAEDRLGEA LPEELSYLSS AAALAPGSGP
160 170 180 190 200
LPGESSPDAT GLSPKASLLH QDSESRRLPR SNSLGAGGKI LSQRPPWSLI
210 220 230 240 250
HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG INNQPPGTSW
260 270 280 290 300
GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV
310 320
LRPPGSSWNI PAGFPNPPSP RLQWG
Length:325
Mass (Da):34,195
Last modified:June 12, 2007 - v3
Checksum:i8ED611FD4F9364E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0543995V → M.1 PublicationCorresponds to variant rs2270191dbSNPEnsembl.1
Natural variantiVAR_02290740L → F.2 PublicationsCorresponds to variant rs2233974dbSNPEnsembl.1
Natural variantiVAR_02290843N → D.1 PublicationCorresponds to variant rs2233975dbSNPEnsembl.1
Natural variantiVAR_05080148G → R.Corresponds to variant rs2233976dbSNPEnsembl.1
Natural variantiVAR_02873281V → A.Corresponds to variant rs2233977dbSNPEnsembl.1
Natural variantiVAR_02290983A → P.3 PublicationsCorresponds to variant rs1265053dbSNPEnsembl.1
Natural variantiVAR_028733145A → P.Corresponds to variant rs2233978dbSNPEnsembl.1
Natural variantiVAR_022910165K → E.4 PublicationsCorresponds to variant rs1265054dbSNPEnsembl.1
Natural variantiVAR_050802232M → I.Corresponds to variant rs2233982dbSNPEnsembl.1
Natural variantiVAR_028734291G → D.Corresponds to variant rs2233984dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031481 mRNA. Translation: BAA88132.1.
AY358438 mRNA. Translation: AAQ88804.1.
AB088114 Genomic DNA. Translation: BAC54947.1.
AB202103 Genomic DNA. Translation: BAE78624.1.
AB103620 Genomic DNA. Translation: BAF31282.1.
AL662867 Genomic DNA. Translation: CAI17718.1.
AL662844 Genomic DNA. Translation: CAI18322.1.
AL773544 Genomic DNA. Translation: CAI18478.1.
CR759805 Genomic DNA. Translation: CAQ08045.1.
BX927139 Genomic DNA. Translation: CAQ10500.1.
CR753819 Genomic DNA. Translation: CAQ10589.1.
CH471081 Genomic DNA. Translation: EAX03356.1.
CCDSiCCDS4693.1.
RefSeqiNP_054789.2. NM_014070.2.
UniGeneiHs.272214.

Genome annotation databases

EnsembliENST00000259870; ENSP00000259870; ENSG00000204542.
ENST00000383532; ENSP00000373024; ENSG00000206461.
ENST00000412706; ENSP00000394931; ENSG00000231624.
ENST00000427005; ENSP00000398496; ENSG00000225543.
ENST00000440933; ENSP00000391756; ENSG00000224105.
ENST00000452899; ENSP00000399436; ENSG00000229432.
GeneIDi29113.
KEGGihsa:29113.
UCSCiuc003nsk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031481 mRNA. Translation: BAA88132.1.
AY358438 mRNA. Translation: AAQ88804.1.
AB088114 Genomic DNA. Translation: BAC54947.1.
AB202103 Genomic DNA. Translation: BAE78624.1.
AB103620 Genomic DNA. Translation: BAF31282.1.
AL662867 Genomic DNA. Translation: CAI17718.1.
AL662844 Genomic DNA. Translation: CAI18322.1.
AL773544 Genomic DNA. Translation: CAI18478.1.
CR759805 Genomic DNA. Translation: CAQ08045.1.
BX927139 Genomic DNA. Translation: CAQ10500.1.
CR753819 Genomic DNA. Translation: CAQ10589.1.
CH471081 Genomic DNA. Translation: EAX03356.1.
CCDSiCCDS4693.1.
RefSeqiNP_054789.2. NM_014070.2.
UniGeneiHs.272214.

3D structure databases

ProteinModelPortaliQ6UXA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118879. 2 interactors.
IntActiQ6UXA7. 1 interactor.

Polymorphism and mutation databases

BioMutaiC6orf15.
DMDMi148887353.

Proteomic databases

PaxDbiQ6UXA7.
PeptideAtlasiQ6UXA7.
PRIDEiQ6UXA7.

Protocols and materials databases

DNASUi29113.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259870; ENSP00000259870; ENSG00000204542.
ENST00000383532; ENSP00000373024; ENSG00000206461.
ENST00000412706; ENSP00000394931; ENSG00000231624.
ENST00000427005; ENSP00000398496; ENSG00000225543.
ENST00000440933; ENSP00000391756; ENSG00000224105.
ENST00000452899; ENSP00000399436; ENSG00000229432.
GeneIDi29113.
KEGGihsa:29113.
UCSCiuc003nsk.2. human.

Organism-specific databases

CTDi29113.
DisGeNETi29113.
GeneCardsiC6orf15.
H-InvDBHIX0032751.
HIX0058159.
HGNCiHGNC:13927. C6orf15.
HPAiHPA001436.
MIMi611401. gene.
neXtProtiNX_Q6UXA7.
OpenTargetsiENSG00000204542.
ENSG00000224105.
ENSG00000225543.
ENSG00000231624.
PharmGKBiPA134866404.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0F6. Eukaryota.
ENOG41116A4. LUCA.
GeneTreeiENSGT00390000010291.
HOGENOMiHOG000111554.
HOVERGENiHBG057901.
InParanoidiQ6UXA7.
OMAiNSEHAQP.
OrthoDBiEOG091G0ON6.
PhylomeDBiQ6UXA7.
TreeFamiTF338298.

Miscellaneous databases

GenomeRNAii29113.
PROiQ6UXA7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204542.
CleanExiHS_C6orf15.
ExpressionAtlasiQ6UXA7. baseline and differential.
GenevisibleiQ6UXA7. HS.

Family and domain databases

InterProiIPR026135. C6orf15.
[Graphical view]
PANTHERiPTHR15817. PTHR15817. 1 hit.
PfamiPF15809. STG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCF015_HUMAN
AccessioniPrimary (citable) accession number: Q6UXA7
Secondary accession number(s): B0S7V8
, Q0EFA6, Q2L6G7, Q5SQ81, Q86Z05, Q9UIG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.