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Q6UXA7

- CF015_HUMAN

UniProt

Q6UXA7 - CF015_HUMAN

Protein

Uncharacterized protein C6orf15

Gene

C6orf15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. hyaluronic acid binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C6orf15
    Alternative name(s):
    Protein STG
    Gene namesi
    Name:C6orf15
    Synonyms:STG
    ORF Names:UNQ1840/PRO3566
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13927. C6orf15.

    Subcellular locationi

    GO - Cellular componenti

    1. interstitial matrix Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866404.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 325299Uncharacterized protein C6orf15PRO_0000019541Add
    BLAST

    Proteomic databases

    PaxDbiQ6UXA7.
    PRIDEiQ6UXA7.

    Expressioni

    Tissue specificityi

    Expressed in skin and tonsils.1 Publication

    Gene expression databases

    BgeeiQ6UXA7.
    CleanExiHS_C6orf15.
    GenevestigatoriQ6UXA7.

    Organism-specific databases

    HPAiHPA001436.

    Interactioni

    Subunit structurei

    Binds to numerous extracellular matrix proteins.By similarity

    Protein-protein interaction databases

    BioGridi118879. 3 interactions.
    STRINGi9606.ENSP00000399436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 28466Gly-richAdd
    BLAST
    Compositional biasi290 – 32031Pro-richAdd
    BLAST

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26596.
    HOGENOMiHOG000111554.
    HOVERGENiHBG057901.
    InParanoidiQ6UXA7.
    OMAiILFEVIF.
    OrthoDBiEOG7MKW70.
    PhylomeDBiQ6UXA7.
    TreeFamiTF338298.

    Family and domain databases

    InterProiIPR026135. C6orf15.
    [Graphical view]
    PANTHERiPTHR15817. PTHR15817. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UXA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP    50
    SSTGPSNSEH PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP 100
    SWGLPAMDSW PPEDPWQMMA AAAEDRLGEA LPEELSYLSS AAALAPGSGP 150
    LPGESSPDAT GLSPKASLLH QDSESRRLPR SNSLGAGGKI LSQRPPWSLI 200
    HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG INNQPPGTSW 250
    GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV 300
    LRPPGSSWNI PAGFPNPPSP RLQWG 325
    Length:325
    Mass (Da):34,195
    Last modified:June 12, 2007 - v3
    Checksum:i8ED611FD4F9364E3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51V → M.1 Publication
    Corresponds to variant rs2270191 [ dbSNP | Ensembl ].
    VAR_054399
    Natural varianti40 – 401L → F.2 Publications
    Corresponds to variant rs2233974 [ dbSNP | Ensembl ].
    VAR_022907
    Natural varianti43 – 431N → D.1 Publication
    Corresponds to variant rs2233975 [ dbSNP | Ensembl ].
    VAR_022908
    Natural varianti48 – 481G → R.
    Corresponds to variant rs2233976 [ dbSNP | Ensembl ].
    VAR_050801
    Natural varianti81 – 811V → A.
    Corresponds to variant rs2233977 [ dbSNP | Ensembl ].
    VAR_028732
    Natural varianti83 – 831A → P.3 Publications
    Corresponds to variant rs1265053 [ dbSNP | Ensembl ].
    VAR_022909
    Natural varianti145 – 1451A → P.
    Corresponds to variant rs2233978 [ dbSNP | Ensembl ].
    VAR_028733
    Natural varianti165 – 1651K → E.4 Publications
    Corresponds to variant rs1265054 [ dbSNP | Ensembl ].
    VAR_022910
    Natural varianti232 – 2321M → I.
    Corresponds to variant rs2233982 [ dbSNP | Ensembl ].
    VAR_050802
    Natural varianti291 – 2911G → D.
    Corresponds to variant rs2233984 [ dbSNP | Ensembl ].
    VAR_028734

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031481 mRNA. Translation: BAA88132.1.
    AY358438 mRNA. Translation: AAQ88804.1.
    AB088114 Genomic DNA. Translation: BAC54947.1.
    AB202103 Genomic DNA. Translation: BAE78624.1.
    AB103620 Genomic DNA. Translation: BAF31282.1.
    AL662867 Genomic DNA. Translation: CAI17718.1.
    AL662844 Genomic DNA. Translation: CAI18322.1.
    AL773544 Genomic DNA. Translation: CAI18478.1.
    CR759805 Genomic DNA. Translation: CAQ08045.1.
    BX927139 Genomic DNA. Translation: CAQ10500.1.
    CR753819 Genomic DNA. Translation: CAQ10589.1.
    CH471081 Genomic DNA. Translation: EAX03356.1.
    CCDSiCCDS4693.1.
    RefSeqiNP_054789.2. NM_014070.2.
    UniGeneiHs.272214.

    Genome annotation databases

    EnsembliENST00000259870; ENSP00000259870; ENSG00000204542.
    ENST00000383532; ENSP00000373024; ENSG00000206461.
    ENST00000412706; ENSP00000394931; ENSG00000231624.
    ENST00000427005; ENSP00000398496; ENSG00000225543.
    ENST00000440933; ENSP00000391756; ENSG00000224105.
    ENST00000452899; ENSP00000399436; ENSG00000229432.
    GeneIDi29113.
    KEGGihsa:29113.
    UCSCiuc003nsk.1. human.

    Polymorphism databases

    DMDMi148887353.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031481 mRNA. Translation: BAA88132.1 .
    AY358438 mRNA. Translation: AAQ88804.1 .
    AB088114 Genomic DNA. Translation: BAC54947.1 .
    AB202103 Genomic DNA. Translation: BAE78624.1 .
    AB103620 Genomic DNA. Translation: BAF31282.1 .
    AL662867 Genomic DNA. Translation: CAI17718.1 .
    AL662844 Genomic DNA. Translation: CAI18322.1 .
    AL773544 Genomic DNA. Translation: CAI18478.1 .
    CR759805 Genomic DNA. Translation: CAQ08045.1 .
    BX927139 Genomic DNA. Translation: CAQ10500.1 .
    CR753819 Genomic DNA. Translation: CAQ10589.1 .
    CH471081 Genomic DNA. Translation: EAX03356.1 .
    CCDSi CCDS4693.1.
    RefSeqi NP_054789.2. NM_014070.2.
    UniGenei Hs.272214.

    3D structure databases

    ProteinModelPortali Q6UXA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118879. 3 interactions.
    STRINGi 9606.ENSP00000399436.

    Polymorphism databases

    DMDMi 148887353.

    Proteomic databases

    PaxDbi Q6UXA7.
    PRIDEi Q6UXA7.

    Protocols and materials databases

    DNASUi 29113.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259870 ; ENSP00000259870 ; ENSG00000204542 .
    ENST00000383532 ; ENSP00000373024 ; ENSG00000206461 .
    ENST00000412706 ; ENSP00000394931 ; ENSG00000231624 .
    ENST00000427005 ; ENSP00000398496 ; ENSG00000225543 .
    ENST00000440933 ; ENSP00000391756 ; ENSG00000224105 .
    ENST00000452899 ; ENSP00000399436 ; ENSG00000229432 .
    GeneIDi 29113.
    KEGGi hsa:29113.
    UCSCi uc003nsk.1. human.

    Organism-specific databases

    CTDi 29113.
    GeneCardsi GC06M031079.
    GC06Mj31071.
    GC06Mk31072.
    GC06Ml31123.
    GC06Mm31157.
    GC06Mn31071.
    H-InvDB HIX0032751.
    HIX0058159.
    HGNCi HGNC:13927. C6orf15.
    HPAi HPA001436.
    MIMi 611401. gene.
    neXtProti NX_Q6UXA7.
    PharmGKBi PA134866404.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26596.
    HOGENOMi HOG000111554.
    HOVERGENi HBG057901.
    InParanoidi Q6UXA7.
    OMAi ILFEVIF.
    OrthoDBi EOG7MKW70.
    PhylomeDBi Q6UXA7.
    TreeFami TF338298.

    Miscellaneous databases

    GenomeRNAii 29113.
    NextBioi 52183.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UXA7.
    CleanExi HS_C6orf15.
    Genevestigatori Q6UXA7.

    Family and domain databases

    InterProi IPR026135. C6orf15.
    [Graphical view ]
    PANTHERi PTHR15817. PTHR15817. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene."
      Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.
      Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-165.
      Tissue: Keratinocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-40; PRO-83 AND GLU-165.
    3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
      Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
      , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
      Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-5.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-40; ASP-43; PRO-83 AND GLU-165.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "STG does not associate with psoriasis in the Swedish population."
      Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M.
      Exp. Dermatol. 13:413-418(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, VARIANTS PRO-83 AND GLU-165.

    Entry informationi

    Entry nameiCF015_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXA7
    Secondary accession number(s): B0S7V8
    , Q0EFA6, Q2L6G7, Q5SQ81, Q86Z05, Q9UIG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3