Q6UXA7 (CF015_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C6orf15

Alternative name(s):
Protein STG

Gene names

Name:	C6orf15
Synonyms:	STG
ORF Names:	UNQ1840/PRO3566

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Binds to numerous extracellular matrix proteins By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Expressed in skin and tonsils. Ref.6

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular matrix organization Inferred from electronic annotation. Source: Compara
Cellular_component	interstitial matrix Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara hyaluronic acid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 325	299	Uncharacterized protein C6orf15		PRO_0000019541
Regions
	Compositional bias	219 – 284	66	Gly-rich
	Compositional bias	290 – 320	31	Pro-rich
Natural variations
	Natural variant	5	1	V → M. Ref.3 Corresponds to variant rs2270191 [ dbSNP | Ensembl ].		VAR_054399
	Natural variant	40	1	L → F. Ref.2 Ref.4 Corresponds to variant rs2233974 [ dbSNP | Ensembl ].		VAR_022907
	Natural variant	43	1	N → D. Ref.4 Corresponds to variant rs2233975 [ dbSNP | Ensembl ].		VAR_022908
	Natural variant	48	1	G → R. Corresponds to variant rs2233976 [ dbSNP | Ensembl ].		VAR_050801
	Natural variant	81	1	V → A. Corresponds to variant rs2233977 [ dbSNP | Ensembl ].		VAR_028732
	Natural variant	83	1	A → P. Ref.2 Ref.4 Ref.6 Corresponds to variant rs1265053 [ dbSNP | Ensembl ].		VAR_022909
	Natural variant	145	1	A → P. Corresponds to variant rs2233978 [ dbSNP | Ensembl ].		VAR_028733
	Natural variant	165	1	K → E. Ref.1 Ref.2 Ref.4 Ref.6 Corresponds to variant rs1265054 [ dbSNP | Ensembl ].		VAR_022910
	Natural variant	232	1	M → I. Corresponds to variant rs2233982 [ dbSNP | Ensembl ].		VAR_050802
	Natural variant	291	1	G → D. Corresponds to variant rs2233984 [ dbSNP | Ensembl ].		VAR_028734

Sequences

	Sequence		Length	Mass (Da)
	Q6UXA7 [UniParc]. Last modified June 12, 2007. Version 3. Checksum: 8ED611FD4F9364E3	FASTA	325	34,195
	10 20 30 40 50 60 MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH 70 80 90 100 110 120 PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA 130 140 150 160 170 180 AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR 190 200 210 220 230 240 SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG 250 260 270 280 290 300 INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV 310 320 LRPPGSSWNI PAGFPNPPSP RLQWG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene." Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H. Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-165. Tissue: Keratinocyte.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-40; PRO-83 AND GLU-165.
[3]	"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S. Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-5.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-40; ASP-43; PRO-83 AND GLU-165.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"STG does not associate with psoriasis in the Swedish population." Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M. Exp. Dermatol. 13:413-418(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, VARIANTS PRO-83 AND GLU-165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB031481 mRNA. Translation: BAA88132.1. AY358438 mRNA. Translation: AAQ88804.1. AB088114 Genomic DNA. Translation: BAC54947.1. AB202103 Genomic DNA. Translation: BAE78624.1. AB103620 Genomic DNA. Translation: BAF31282.1. AL662867 Genomic DNA. Translation: CAI17718.1. AL662844 Genomic DNA. Translation: CAI18322.1. AL773544 Genomic DNA. Translation: CAI18478.1. CR759805 Genomic DNA. Translation: CAQ08045.1. BX927139 Genomic DNA. Translation: CAQ10500.1. CR753819 Genomic DNA. Translation: CAQ10589.1. CH471081 Genomic DNA. Translation: EAX03356.1.
IPI	IPI00022381.
RefSeq	NP_054789.2. NM_014070.2.
UniGene	Hs.272214.
3D structure databases
ProteinModelPortal	Q6UXA7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000399436.
Polymorphism databases
DMDM	148887353.
Proteomic databases
PaxDb	Q6UXA7.
PRIDE	Q6UXA7.
Protocols and materials databases
DNASU	29113.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259870; ENSP00000259870; ENSG00000204542. ENST00000383532; ENSP00000373024; ENSG00000206461. ENST00000412706; ENSP00000394931; ENSG00000231624. ENST00000427005; ENSP00000398496; ENSG00000225543. ENST00000440933; ENSP00000391756; ENSG00000224105. ENST00000452899; ENSP00000399436; ENSG00000229432.
GeneID	29113.
KEGG	hsa:29113.
UCSC	uc003nsk.1. human.
Organism-specific databases
CTD	29113.
GeneCards	GC06M031079.
H-InvDB	HIX0032751. HIX0058159.
HGNC	HGNC:13927. C6orf15.
HPA	HPA001436.
MIM	611401. gene.
neXtProt	NX_Q6UXA7.
PharmGKB	PA134866404.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26596.
HOGENOM	HOG000111554.
HOVERGEN	HBG057901.
InParanoid	Q6UXA7.
OMA	GIWGINN.
OrthoDB	EOG43XV40.
PhylomeDB	Q6UXA7.
Gene expression databases
Bgee	Q6UXA7.
CleanEx	HS_C6orf15.
Genevestigator	Q6UXA7.
Family and domain databases
InterPro	IPR026135. C6orf15. [Graphical view]
PANTHER	PTHR15817. PTHR15817. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	29113.
NextBio	52183.
SOURCE	Search...

Entry information

Entry name

CF015_HUMAN

Accession

Primary (citable) accession number: Q6UXA7
Secondary accession number(s): B0S7V8 , Q0EFA6, Q2L6G7, Q5SQ81, Q86Z05, Q9UIG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	June 12, 2007
Last modified:	April 3, 2013
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.