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Q6UXA7 (CF015_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C6orf15
Alternative name(s):
Protein STG
Gene names
Name:C6orf15
Synonyms:STG
ORF Names:UNQ1840/PRO3566
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Binds to numerous extracellular matrix proteins By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Expressed in skin and tonsils. Ref.6

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processextracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentinterstitial matrix

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: Ensembl

hyaluronic acid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 325299Uncharacterized protein C6orf15
PRO_0000019541

Regions

Compositional bias219 – 28466Gly-rich
Compositional bias290 – 32031Pro-rich

Natural variations

Natural variant51V → M. Ref.3
Corresponds to variant rs2270191 [ dbSNP | Ensembl ].
VAR_054399
Natural variant401L → F. Ref.2 Ref.4
Corresponds to variant rs2233974 [ dbSNP | Ensembl ].
VAR_022907
Natural variant431N → D. Ref.4
Corresponds to variant rs2233975 [ dbSNP | Ensembl ].
VAR_022908
Natural variant481G → R.
Corresponds to variant rs2233976 [ dbSNP | Ensembl ].
VAR_050801
Natural variant811V → A.
Corresponds to variant rs2233977 [ dbSNP | Ensembl ].
VAR_028732
Natural variant831A → P. Ref.2 Ref.4 Ref.6
Corresponds to variant rs1265053 [ dbSNP | Ensembl ].
VAR_022909
Natural variant1451A → P.
Corresponds to variant rs2233978 [ dbSNP | Ensembl ].
VAR_028733
Natural variant1651K → E. Ref.1 Ref.2 Ref.4 Ref.6
Corresponds to variant rs1265054 [ dbSNP | Ensembl ].
VAR_022910
Natural variant2321M → I.
Corresponds to variant rs2233982 [ dbSNP | Ensembl ].
VAR_050802
Natural variant2911G → D.
Corresponds to variant rs2233984 [ dbSNP | Ensembl ].
VAR_028734

Sequences

Sequence LengthMass (Da)Tools
Q6UXA7 [UniParc].

Last modified June 12, 2007. Version 3.
Checksum: 8ED611FD4F9364E3

FASTA32534,195
        10         20         30         40         50         60 
MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH 

        70         80         90        100        110        120 
PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA 

       130        140        150        160        170        180 
AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR 

       190        200        210        220        230        240 
SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG 

       250        260        270        280        290        300 
INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV 

       310        320 
LRPPGSSWNI PAGFPNPPSP RLQWG 

« Hide

References

« Hide 'large scale' references
[1]"Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene."
Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.
Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-165.
Tissue: Keratinocyte.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-40; PRO-83 AND GLU-165.
[3]"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. expand/collapse author list , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-5.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-40; ASP-43; PRO-83 AND GLU-165.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"STG does not associate with psoriasis in the Swedish population."
Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M.
Exp. Dermatol. 13:413-418(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, VARIANTS PRO-83 AND GLU-165.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031481 mRNA. Translation: BAA88132.1.
AY358438 mRNA. Translation: AAQ88804.1.
AB088114 Genomic DNA. Translation: BAC54947.1.
AB202103 Genomic DNA. Translation: BAE78624.1.
AB103620 Genomic DNA. Translation: BAF31282.1.
AL662867 Genomic DNA. Translation: CAI17718.1.
AL662844 Genomic DNA. Translation: CAI18322.1.
AL773544 Genomic DNA. Translation: CAI18478.1.
CR759805 Genomic DNA. Translation: CAQ08045.1.
BX927139 Genomic DNA. Translation: CAQ10500.1.
CR753819 Genomic DNA. Translation: CAQ10589.1.
CH471081 Genomic DNA. Translation: EAX03356.1.
RefSeqNP_054789.2. NM_014070.2.
UniGeneHs.272214.

3D structure databases

ProteinModelPortalQ6UXA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118879. 3 interactions.
STRING9606.ENSP00000399436.

Polymorphism databases

DMDM148887353.

Proteomic databases

PaxDbQ6UXA7.
PRIDEQ6UXA7.

Protocols and materials databases

DNASU29113.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259870; ENSP00000259870; ENSG00000204542.
ENST00000383532; ENSP00000373024; ENSG00000206461.
ENST00000412706; ENSP00000394931; ENSG00000231624.
ENST00000427005; ENSP00000398496; ENSG00000225543.
ENST00000440933; ENSP00000391756; ENSG00000224105.
ENST00000452899; ENSP00000399436; ENSG00000229432.
GeneID29113.
KEGGhsa:29113.
UCSCuc003nsk.1. human.

Organism-specific databases

CTD29113.
GeneCardsGC06M031079.
GC06Mj31071.
GC06Mk31072.
GC06Ml31123.
GC06Mm31157.
GC06Mn31071.
H-InvDBHIX0032751.
HIX0058159.
HGNCHGNC:13927. C6orf15.
HPAHPA001436.
MIM611401. gene.
neXtProtNX_Q6UXA7.
PharmGKBPA134866404.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26596.
HOGENOMHOG000111554.
HOVERGENHBG057901.
InParanoidQ6UXA7.
OMANGLARDP.
OrthoDBEOG7MKW70.
PhylomeDBQ6UXA7.
TreeFamTF338298.

Gene expression databases

BgeeQ6UXA7.
CleanExHS_C6orf15.
GenevestigatorQ6UXA7.

Family and domain databases

InterProIPR026135. C6orf15.
[Graphical view]
PANTHERPTHR15817. PTHR15817. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi29113.
NextBio52183.
SOURCESearch...

Entry information

Entry nameCF015_HUMAN
AccessionPrimary (citable) accession number: Q6UXA7
Secondary accession number(s): B0S7V8 expand/collapse secondary AC list , Q0EFA6, Q2L6G7, Q5SQ81, Q86Z05, Q9UIG3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM