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Q6UXA7

- CF015_HUMAN

UniProt

Q6UXA7 - CF015_HUMAN

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Protein

Uncharacterized protein C6orf15

Gene

C6orf15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. hyaluronic acid binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf15
Alternative name(s):
Protein STG
Gene namesi
Name:C6orf15
Synonyms:STG
ORF Names:UNQ1840/PRO3566
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13927. C6orf15.

Subcellular locationi

GO - Cellular componenti

  1. interstitial matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 325299Uncharacterized protein C6orf15PRO_0000019541Add
BLAST

Proteomic databases

PaxDbiQ6UXA7.
PRIDEiQ6UXA7.

Expressioni

Tissue specificityi

Expressed in skin and tonsils.1 Publication

Gene expression databases

BgeeiQ6UXA7.
CleanExiHS_C6orf15.
ExpressionAtlasiQ6UXA7. baseline and differential.
GenevestigatoriQ6UXA7.

Organism-specific databases

HPAiHPA001436.

Interactioni

Subunit structurei

Binds to numerous extracellular matrix proteins.By similarity

Protein-protein interaction databases

BioGridi118879. 3 interactions.
STRINGi9606.ENSP00000399436.

Structurei

3D structure databases

ProteinModelPortaliQ6UXA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 28466Gly-richAdd
BLAST
Compositional biasi290 – 32031Pro-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26596.
GeneTreeiENSGT00390000010291.
HOGENOMiHOG000111554.
HOVERGENiHBG057901.
InParanoidiQ6UXA7.
OMAiILFEVIF.
OrthoDBiEOG7MKW70.
PhylomeDBiQ6UXA7.
TreeFamiTF338298.

Family and domain databases

InterProiIPR026135. C6orf15.
[Graphical view]
PANTHERiPTHR15817. PTHR15817. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP
60 70 80 90 100
SSTGPSNSEH PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP
110 120 130 140 150
SWGLPAMDSW PPEDPWQMMA AAAEDRLGEA LPEELSYLSS AAALAPGSGP
160 170 180 190 200
LPGESSPDAT GLSPKASLLH QDSESRRLPR SNSLGAGGKI LSQRPPWSLI
210 220 230 240 250
HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG INNQPPGTSW
260 270 280 290 300
GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV
310 320
LRPPGSSWNI PAGFPNPPSP RLQWG
Length:325
Mass (Da):34,195
Last modified:June 12, 2007 - v3
Checksum:i8ED611FD4F9364E3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51V → M.1 Publication
Corresponds to variant rs2270191 [ dbSNP | Ensembl ].
VAR_054399
Natural varianti40 – 401L → F.2 Publications
Corresponds to variant rs2233974 [ dbSNP | Ensembl ].
VAR_022907
Natural varianti43 – 431N → D.1 Publication
Corresponds to variant rs2233975 [ dbSNP | Ensembl ].
VAR_022908
Natural varianti48 – 481G → R.
Corresponds to variant rs2233976 [ dbSNP | Ensembl ].
VAR_050801
Natural varianti81 – 811V → A.
Corresponds to variant rs2233977 [ dbSNP | Ensembl ].
VAR_028732
Natural varianti83 – 831A → P.3 Publications
Corresponds to variant rs1265053 [ dbSNP | Ensembl ].
VAR_022909
Natural varianti145 – 1451A → P.
Corresponds to variant rs2233978 [ dbSNP | Ensembl ].
VAR_028733
Natural varianti165 – 1651K → E.4 Publications
Corresponds to variant rs1265054 [ dbSNP | Ensembl ].
VAR_022910
Natural varianti232 – 2321M → I.
Corresponds to variant rs2233982 [ dbSNP | Ensembl ].
VAR_050802
Natural varianti291 – 2911G → D.
Corresponds to variant rs2233984 [ dbSNP | Ensembl ].
VAR_028734

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031481 mRNA. Translation: BAA88132.1.
AY358438 mRNA. Translation: AAQ88804.1.
AB088114 Genomic DNA. Translation: BAC54947.1.
AB202103 Genomic DNA. Translation: BAE78624.1.
AB103620 Genomic DNA. Translation: BAF31282.1.
AL662867 Genomic DNA. Translation: CAI17718.1.
AL662844 Genomic DNA. Translation: CAI18322.1.
AL773544 Genomic DNA. Translation: CAI18478.1.
CR759805 Genomic DNA. Translation: CAQ08045.1.
BX927139 Genomic DNA. Translation: CAQ10500.1.
CR753819 Genomic DNA. Translation: CAQ10589.1.
CH471081 Genomic DNA. Translation: EAX03356.1.
CCDSiCCDS4693.1.
RefSeqiNP_054789.2. NM_014070.2.
UniGeneiHs.272214.

Genome annotation databases

EnsembliENST00000259870; ENSP00000259870; ENSG00000204542.
ENST00000383532; ENSP00000373024; ENSG00000206461.
ENST00000412706; ENSP00000394931; ENSG00000231624.
ENST00000427005; ENSP00000398496; ENSG00000225543.
ENST00000440933; ENSP00000391756; ENSG00000224105.
ENST00000452899; ENSP00000399436; ENSG00000229432.
GeneIDi29113.
KEGGihsa:29113.
UCSCiuc003nsk.1. human.

Polymorphism databases

DMDMi148887353.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031481 mRNA. Translation: BAA88132.1 .
AY358438 mRNA. Translation: AAQ88804.1 .
AB088114 Genomic DNA. Translation: BAC54947.1 .
AB202103 Genomic DNA. Translation: BAE78624.1 .
AB103620 Genomic DNA. Translation: BAF31282.1 .
AL662867 Genomic DNA. Translation: CAI17718.1 .
AL662844 Genomic DNA. Translation: CAI18322.1 .
AL773544 Genomic DNA. Translation: CAI18478.1 .
CR759805 Genomic DNA. Translation: CAQ08045.1 .
BX927139 Genomic DNA. Translation: CAQ10500.1 .
CR753819 Genomic DNA. Translation: CAQ10589.1 .
CH471081 Genomic DNA. Translation: EAX03356.1 .
CCDSi CCDS4693.1.
RefSeqi NP_054789.2. NM_014070.2.
UniGenei Hs.272214.

3D structure databases

ProteinModelPortali Q6UXA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118879. 3 interactions.
STRINGi 9606.ENSP00000399436.

Polymorphism databases

DMDMi 148887353.

Proteomic databases

PaxDbi Q6UXA7.
PRIDEi Q6UXA7.

Protocols and materials databases

DNASUi 29113.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259870 ; ENSP00000259870 ; ENSG00000204542 .
ENST00000383532 ; ENSP00000373024 ; ENSG00000206461 .
ENST00000412706 ; ENSP00000394931 ; ENSG00000231624 .
ENST00000427005 ; ENSP00000398496 ; ENSG00000225543 .
ENST00000440933 ; ENSP00000391756 ; ENSG00000224105 .
ENST00000452899 ; ENSP00000399436 ; ENSG00000229432 .
GeneIDi 29113.
KEGGi hsa:29113.
UCSCi uc003nsk.1. human.

Organism-specific databases

CTDi 29113.
GeneCardsi GC06M031079.
GC06Mj31071.
GC06Mk31072.
GC06Ml31123.
GC06Mm31157.
GC06Mn31071.
H-InvDB HIX0032751.
HIX0058159.
HGNCi HGNC:13927. C6orf15.
HPAi HPA001436.
MIMi 611401. gene.
neXtProti NX_Q6UXA7.
PharmGKBi PA134866404.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26596.
GeneTreei ENSGT00390000010291.
HOGENOMi HOG000111554.
HOVERGENi HBG057901.
InParanoidi Q6UXA7.
OMAi ILFEVIF.
OrthoDBi EOG7MKW70.
PhylomeDBi Q6UXA7.
TreeFami TF338298.

Miscellaneous databases

GenomeRNAii 29113.
NextBioi 52183.
SOURCEi Search...

Gene expression databases

Bgeei Q6UXA7.
CleanExi HS_C6orf15.
ExpressionAtlasi Q6UXA7. baseline and differential.
Genevestigatori Q6UXA7.

Family and domain databases

InterProi IPR026135. C6orf15.
[Graphical view ]
PANTHERi PTHR15817. PTHR15817. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene."
    Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.
    Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-165.
    Tissue: Keratinocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-40; PRO-83 AND GLU-165.
  3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-5.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-40; ASP-43; PRO-83 AND GLU-165.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "STG does not associate with psoriasis in the Swedish population."
    Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M.
    Exp. Dermatol. 13:413-418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, VARIANTS PRO-83 AND GLU-165.

Entry informationi

Entry nameiCF015_HUMAN
AccessioniPrimary (citable) accession number: Q6UXA7
Secondary accession number(s): B0S7V8
, Q0EFA6, Q2L6G7, Q5SQ81, Q86Z05, Q9UIG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3