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Protein

Probable palmitoyltransferase ZDHHC24

Gene

ZDHHC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC24 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 24
Short name:
DHHC-24
Gene namesi
Name:ZDHHC24
ORF Names:UNQ2528/PRO6027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174165.7
HGNCiHGNC:27387 ZDHHC24
neXtProtiNX_Q6UX98

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174165
PharmGKBiPA142670531

Polymorphism and mutation databases

BioMutaiZDHHC24
DMDMi74758568

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337101 – 284Probable palmitoyltransferase ZDHHC24Add BLAST284

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6UX98
PeptideAtlasiQ6UX98
PRIDEiQ6UX98
ProteomicsDBi67578

PTM databases

iPTMnetiQ6UX98
PhosphoSitePlusiQ6UX98

Expressioni

Gene expression databases

BgeeiENSG00000174165
CleanExiHS_ZDHHC24
ExpressionAtlasiQ6UX98 baseline and differential
GenevisibleiQ6UX98 HS

Organism-specific databases

HPAiHPA016619

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129032, 3 interactors
IntActiQ6UX98, 4 interactors
STRINGi9606.ENSP00000309429

Structurei

3D structure databases

ProteinModelPortaliQ6UX98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 144DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 222Leu-richAdd BLAST83

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00850000132405
HOGENOMiHOG000155773
HOVERGENiHBG061265
InParanoidiQ6UX98
KOiK18932
OMAiRCVGFRN
OrthoDBiEOG091G0RWR
PhylomeDBiQ6UX98
TreeFamiTF319523

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6UX98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQPWAAGST DGAPAQLPLV LTALWAAAVG LELAYVLVLG PGPPPLGPLA
60 70 80 90 100
RALQLALAAF QLLNLLGNVG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ
110 120 130 140 150
SQVPPRSGHC SACRVCILRR DHHCRLLGRC VGFGNYRPFL CLLLHAAGVL
160 170 180 190 200
LHVSVLLGPA LSALLRAHTP LHMAALLLLP WLMLLTGRVS LAQFALAFVT
210 220 230 240 250
DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG PCHNLQAALG
260 270 280
PRWALVWLWP FLASPLPGDG ITFQTTADVG HTAS
Length:284
Mass (Da):30,176
Last modified:July 5, 2004 - v1
Checksum:i67976701B26B3C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358448 mRNA Translation: AAQ88813.1
BC005015 mRNA Translation: AAH05015.1
BC057833 mRNA Translation: AAH57833.2
CCDSiCCDS8143.1
RefSeqiNP_997223.1, NM_207340.2
UniGeneiHs.659933

Genome annotation databases

EnsembliENST00000310442; ENSP00000309429; ENSG00000174165
GeneIDi254359
KEGGihsa:254359
UCSCiuc001oin.2 human

Similar proteinsi

Entry informationi

Entry nameiZDH24_HUMAN
AccessioniPrimary (citable) accession number: Q6UX98
Secondary accession number(s): Q6PEW7, Q9BSJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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