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Protein

Probable palmitoyltransferase ZDHHC24

Gene

ZDHHC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC24 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 24
Short name:
DHHC-24
Gene namesi
Name:ZDHHC24
ORF Names:UNQ2528/PRO6027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27387. ZDHHC24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670531.

Polymorphism and mutation databases

BioMutaiZDHHC24.
DMDMi74758568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Probable palmitoyltransferase ZDHHC24PRO_0000233710Add
BLAST

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6UX98.
PeptideAtlasiQ6UX98.
PRIDEiQ6UX98.

PTM databases

iPTMnetiQ6UX98.
PhosphoSiteiQ6UX98.

Expressioni

Gene expression databases

BgeeiQ6UX98.
CleanExiHS_ZDHHC24.
ExpressionAtlasiQ6UX98. baseline and differential.
GenevisibleiQ6UX98. HS.

Organism-specific databases

HPAiHPA016619.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10254561,EBI-307352
TCF4P158843EBI-10254561,EBI-533224

Protein-protein interaction databases

BioGridi129032. 2 interactions.
IntActiQ6UX98. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6UX98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 14451DHHCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 22283Leu-richAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000155773.
HOVERGENiHBG061265.
InParanoidiQ6UX98.
KOiK18932.
OMAiACRICIL.
PhylomeDBiQ6UX98.
TreeFamiTF319523.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UX98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQPWAAGST DGAPAQLPLV LTALWAAAVG LELAYVLVLG PGPPPLGPLA
60 70 80 90 100
RALQLALAAF QLLNLLGNVG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ
110 120 130 140 150
SQVPPRSGHC SACRVCILRR DHHCRLLGRC VGFGNYRPFL CLLLHAAGVL
160 170 180 190 200
LHVSVLLGPA LSALLRAHTP LHMAALLLLP WLMLLTGRVS LAQFALAFVT
210 220 230 240 250
DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG PCHNLQAALG
260 270 280
PRWALVWLWP FLASPLPGDG ITFQTTADVG HTAS
Length:284
Mass (Da):30,176
Last modified:July 5, 2004 - v1
Checksum:i67976701B26B3C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358448 mRNA. Translation: AAQ88813.1.
BC005015 mRNA. Translation: AAH05015.1.
BC057833 mRNA. Translation: AAH57833.2.
CCDSiCCDS8143.1.
RefSeqiNP_997223.1. NM_207340.1.
UniGeneiHs.659933.

Genome annotation databases

EnsembliENST00000310442; ENSP00000309429; ENSG00000174165.
GeneIDi254359.
KEGGihsa:254359.
UCSCiuc001oin.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358448 mRNA. Translation: AAQ88813.1.
BC005015 mRNA. Translation: AAH05015.1.
BC057833 mRNA. Translation: AAH57833.2.
CCDSiCCDS8143.1.
RefSeqiNP_997223.1. NM_207340.1.
UniGeneiHs.659933.

3D structure databases

ProteinModelPortaliQ6UX98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129032. 2 interactions.
IntActiQ6UX98. 2 interactions.

PTM databases

iPTMnetiQ6UX98.
PhosphoSiteiQ6UX98.

Polymorphism and mutation databases

BioMutaiZDHHC24.
DMDMi74758568.

Proteomic databases

PaxDbiQ6UX98.
PeptideAtlasiQ6UX98.
PRIDEiQ6UX98.

Protocols and materials databases

DNASUi254359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310442; ENSP00000309429; ENSG00000174165.
GeneIDi254359.
KEGGihsa:254359.
UCSCiuc001oin.2. human.

Organism-specific databases

CTDi254359.
GeneCardsiZDHHC24.
HGNCiHGNC:27387. ZDHHC24.
HPAiHPA016619.
neXtProtiNX_Q6UX98.
PharmGKBiPA142670531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000155773.
HOVERGENiHBG061265.
InParanoidiQ6UX98.
KOiK18932.
OMAiACRICIL.
PhylomeDBiQ6UX98.
TreeFamiTF319523.

Miscellaneous databases

ChiTaRSiZDHHC24. human.
GenomeRNAii254359.
PROiQ6UX98.

Gene expression databases

BgeeiQ6UX98.
CleanExiHS_ZDHHC24.
ExpressionAtlasiQ6UX98. baseline and differential.
GenevisibleiQ6UX98. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Choriocarcinoma and Placenta.

Entry informationi

Entry nameiZDH24_HUMAN
AccessioniPrimary (citable) accession number: Q6UX98
Secondary accession number(s): Q6PEW7, Q9BSJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.