Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UPF0764 protein C16orf89

Gene

C16orf89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0764 protein C16orf89
Gene namesi
ORF Names:UNQ904/PRO1925
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28687. C16orf89.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378486.

Polymorphism and mutation databases

BioMutaiC16orf89.
DMDMi172046150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 402382UPF0764 protein C16orf89PRO_0000326202Add
BLAST

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UX73.
PaxDbiQ6UX73.
PeptideAtlasiQ6UX73.
PRIDEiQ6UX73.

PTM databases

iPTMnetiQ6UX73.
PhosphoSiteiQ6UX73.

Expressioni

Tissue specificityi

Predominantly expressed in thyroid tissue.1 Publication

Gene expression databases

BgeeiQ6UX73.
CleanExiHS_C16orf89.
ExpressionAtlasiQ6UX73. baseline and differential.
GenevisibleiQ6UX73. HS.

Organism-specific databases

HPAiHPA013613.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126998. 1 interaction.
STRINGi9606.ENSP00000324672.

Structurei

3D structure databases

ProteinModelPortaliQ6UX73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0764 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF35. Eukaryota.
ENOG4112ACS. LUCA.
GeneTreeiENSGT00390000013433.
HOGENOMiHOG000111907.
HOVERGENiHBG063538.
InParanoidiQ6UX73.
OMAiGVQEKWA.
OrthoDBiEOG73NG3P.
PhylomeDBiQ6UX73.

Family and domain databases

InterProiIPR031751. DUF4735.
[Graphical view]
PfamiPF15882. DUF4735. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLGLLLLL LLTALPPLWS SSLPGLDTAE SKATIADLIL SALERATVFL
60 70 80 90 100
EQRLPEINLD GMVGVRVLEE QLKSVREKWA QEPLLQPLSL RVGMLGEKLE
110 120 130 140 150
AAIQRSLHYL KLSDPKYLRE FQLTLQPGFW KLPHAWIHTD ASLVYPTFGP
160 170 180 190 200
QDSFSEERSD VCLVQLLGTG TDSSEPCGLS DLCRSLMTKP GCSGYCLSHQ
210 220 230 240 250
LLFFLWARMR GCTQGPLQQS QDYINLFCAN MMDLNRRAEA IGYAYPTRDI
260 270 280 290 300
FMENIMFCGM GGFSDFYKLR WLEAILSWQK QQEGCFGEPD AEDEELSKAI
310 320 330 340 350
QYQQHFSRRV KRREKQFPDS RSVAQAGVQW RNLGSLQPLP PGFKQFSCLI
360 370 380 390 400
LPSSWDYRSV PPYLANFYIF LVETGFHHVA HAGLELLISR DPPTSGSQSV

GL
Length:402
Mass (Da):45,391
Last modified:March 18, 2008 - v2
Checksum:i3364A7D02B589AB1
GO
Isoform 2 (identifier: Q6UX73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-402: SRSVAQAGVQ...PTSGSQSVGL → GCSSHNTATA...PSTPPPPSSR

Note: Major isoform, represents 80% of transcripts.
Show »
Length:361
Mass (Da):40,613
Checksum:iD6F5FC5368CAD49D
GO

Sequence cautioni

The sequence AAH33681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ88847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11494.1 differs from that shown.Aberrant splicing.Curated
The sequence EAW85244.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771E → G in BAG62387 (PubMed:14702039).Curated
Sequence conflicti94 – 941M → V in BAG62387 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151G → A.1 Publication
Corresponds to variant rs17853191 [ dbSNP | Ensembl ].
VAR_057992
Natural varianti296 – 2961L → S.1 Publication
Corresponds to variant rs1127920 [ dbSNP | Ensembl ].
VAR_040004
Natural varianti363 – 3631Y → H.1 Publication
Corresponds to variant rs11642955 [ dbSNP | Ensembl ].
VAR_040005

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 40283SRSVA…QSVGL → GCSSHNTATAVAALGGFLYI LAEYPPANREPHPSTPPPPS SR in isoform 2. 2 PublicationsVSP_032600Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358483 mRNA. Translation: AAQ88847.1. Different initiation.
AK300708 mRNA. Translation: BAG62387.1.
AK075242 mRNA. Translation: BAC11494.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85244.1. Different initiation.
BC033681 mRNA. Translation: AAH33681.1. Different initiation.
CCDSiCCDS42116.2. [Q6UX73-1]
CCDS45404.2. [Q6UX73-2]
RefSeqiNP_001091984.2. NM_001098514.2. [Q6UX73-2]
NP_689672.4. NM_152459.4. [Q6UX73-1]
UniGeneiHs.11782.

Genome annotation databases

EnsembliENST00000315997; ENSP00000324672; ENSG00000153446. [Q6UX73-1]
ENST00000472572; ENSP00000420566; ENSG00000153446. [Q6UX73-2]
GeneIDi146556.
KEGGihsa:146556.
UCSCiuc002cyk.5. human. [Q6UX73-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358483 mRNA. Translation: AAQ88847.1. Different initiation.
AK300708 mRNA. Translation: BAG62387.1.
AK075242 mRNA. Translation: BAC11494.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85244.1. Different initiation.
BC033681 mRNA. Translation: AAH33681.1. Different initiation.
CCDSiCCDS42116.2. [Q6UX73-1]
CCDS45404.2. [Q6UX73-2]
RefSeqiNP_001091984.2. NM_001098514.2. [Q6UX73-2]
NP_689672.4. NM_152459.4. [Q6UX73-1]
UniGeneiHs.11782.

3D structure databases

ProteinModelPortaliQ6UX73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126998. 1 interaction.
STRINGi9606.ENSP00000324672.

PTM databases

iPTMnetiQ6UX73.
PhosphoSiteiQ6UX73.

Polymorphism and mutation databases

BioMutaiC16orf89.
DMDMi172046150.

Proteomic databases

EPDiQ6UX73.
PaxDbiQ6UX73.
PeptideAtlasiQ6UX73.
PRIDEiQ6UX73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315997; ENSP00000324672; ENSG00000153446. [Q6UX73-1]
ENST00000472572; ENSP00000420566; ENSG00000153446. [Q6UX73-2]
GeneIDi146556.
KEGGihsa:146556.
UCSCiuc002cyk.5. human. [Q6UX73-1]

Organism-specific databases

CTDi146556.
GeneCardsiC16orf89.
H-InvDBHIX0174299.
HIX0202310.
HGNCiHGNC:28687. C16orf89.
HPAiHPA013613.
neXtProtiNX_Q6UX73.
PharmGKBiPA162378486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF35. Eukaryota.
ENOG4112ACS. LUCA.
GeneTreeiENSGT00390000013433.
HOGENOMiHOG000111907.
HOVERGENiHBG063538.
InParanoidiQ6UX73.
OMAiGVQEKWA.
OrthoDBiEOG73NG3P.
PhylomeDBiQ6UX73.

Miscellaneous databases

GenomeRNAii146556.
PROiQ6UX73.

Gene expression databases

BgeeiQ6UX73.
CleanExiHS_C16orf89.
ExpressionAtlasiQ6UX73. baseline and differential.
GenevisibleiQ6UX73. HS.

Family and domain databases

InterProiIPR031751. DUF4735.
[Graphical view]
PfamiPF15882. DUF4735. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-363.
    Tissue: Thyroid.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ALA-215 AND SER-296.
    Tissue: Colon.
  6. "Initial characterization of C16orf89, a novel thyroid-specific gene."
    Afink G.B., Veenboer G., de Randamie J., Keijser R., Meischl C., Niessen H., Ris-Stalpers C.
    Thyroid 20:811-821(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, SUBUNIT, GLYCOSYLATION.

Entry informationi

Entry nameiCP089_HUMAN
AccessioniPrimary (citable) accession number: Q6UX73
Secondary accession number(s): B4DUM5, Q8N2I3, Q8N4T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 6, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.