Q6UX72 (B3GN9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
Short name=BGnT-9
Short name=Beta-1,3-Gn-T9
Short name=Beta-1,3-N-acetylglucosaminyltransferase 9
Short name=Beta3Gn-T9
EC=2.4.1.-

Gene names

Name:	B3GNT9
ORF Names:	UNQ1922/PRO4397

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 31 family.
Sequence caution	The sequence BC012191 differs from that shown. Reason: Frameshift at position 81.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	galactosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9		PRO_0000352762
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 27	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	28 – 402	375	Lumenal Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6UX72 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E4FFEBDFD5F8F2FB	FASTA	402	43,751
	10 20 30 40 50 60 MRRRLRLRRD ALLTLLLGAS LGLLLYAQRD GAAPTASAPR GRGRAAPRPT PGPRAFQLPD 70 80 90 100 110 120 AGAAPPAYEG DTPAPPTPTG PFDFARYLRA KDQRRFPLLI NQPHKCRGDG APGGRPDLLI 130 140 150 160 170 180 AVKSVAEDFE RRQAVRQTWG AEGRVQGALV RRVFLLGVPR GAGSGGADEV GEGARTHWRA 190 200 210 220 230 240 LLRAESLAYA DILLWAFDDT FFNLTLKEIH FLAWASAFCP DVRFVFKGDA DVFVNVGNLL 250 260 270 280 290 300 EFLAPRDPAQ DLLAGDVIVH ARPIRTRASK YYIPEAVYGL PAYPAYAGGG GFVLSGATLH 310 320 330 340 350 360 RLAGACAQVE LFPIDDVFLG MCLQRLRLTP EPHPAFRTFG IPQPSAAPHL STFDPCFYRE 370 380 390 400 LVVVHGLSAA DIWLMWRLLH GPHGPACAHP QPVAAGPFQW DS

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358485 mRNA. Translation: AAQ88849.1. CH471092 Genomic DNA. Translation: EAW83079.1. BC012191 mRNA. No translation available.
IPI	IPI00061520.
RefSeq	NP_171608.2. NM_033309.2.
UniGene	Hs.729030.
3D structure databases
ProteinModelPortal	Q6UX72.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UX72. 2 interactions.
Protein family/group databases
CAZy	GT31. Glycosyltransferase Family 31.
Polymorphism databases
DMDM	74738184.
Proteomic databases
PRIDE	Q6UX72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000449549; ENSP00000400157; ENSG00000237172.
GeneID	84752.
KEGG	hsa:84752.
UCSC	uc002erf.1. human.
Organism-specific databases
CTD	84752.
GeneCards	GC16M067182.
H-InvDB	HIX0013133.
HGNC	HGNC:28714. B3GNT9.
neXtProt	NX_Q6UX72.
PharmGKB	PA164716431.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076821.
HOGENOM	HBG714704.
HOVERGEN	HBG050653.
OMA	FRTFGIP.
OrthoDB	EOG4BK54F.
PhylomeDB	Q6UX72.
Gene expression databases
ArrayExpress	Q6UX72.
Bgee	Q6UX72.
CleanEx	HS_B3GNT9.
Genevestigator	Q6UX72.
Family and domain databases
InterPro	IPR002659. Glyco_trans_31. [Graphical view]
PANTHER	PTHR11214. Glyco_trans_31. 1 hit.
Pfam	PF01762. Galactosyl_T. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	74896.

Entry information

Entry name

B3GN9_HUMAN

Accession

Primary (citable) accession number: Q6UX72
Secondary accession number(s): Q96EK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.