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Protein

Plexin domain-containing protein 2

Gene

PLXDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in tumor angiogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 2
Alternative name(s):
Tumor endothelial marker 7-related protein
Gene namesi
Name:PLXDC2
Synonyms:TEM7R
ORF Names:UNQ2514/PRO6003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21013. PLXDC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 454ExtracellularSequence analysisAdd BLAST424
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 529CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84898.
OpenTargetsiENSG00000120594.
PharmGKBiPA134932187.

Polymorphism and mutation databases

BioMutaiPLXDC2.
DMDMi74749416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000023457431 – 529Plexin domain-containing protein 2Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...)1 Publication1
Glycosylationi160N-linked (GlcNAc...)1 Publication1
Modified residuei506PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6UX71.
MaxQBiQ6UX71.
PaxDbiQ6UX71.
PeptideAtlasiQ6UX71.
PRIDEiQ6UX71.

PTM databases

iPTMnetiQ6UX71.
PhosphoSitePlusiQ6UX71.

Expressioni

Tissue specificityi

Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.1 Publication

Gene expression databases

BgeeiENSG00000120594.
CleanExiHS_PLXDC2.
GenevisibleiQ6UX71. HS.

Organism-specific databases

HPAiHPA017268.
HPA070793.

Interactioni

Subunit structurei

Interacts with CTTN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Zbp1A2APF72EBI-6115410,EBI-6115394From a different organism.

Protein-protein interaction databases

BioGridi124338. 29 interactors.
DIPiDIP-46251N.
IntActiQ6UX71. 2 interactors.
STRINGi9606.ENSP00000366460.

Structurei

3D structure databases

ProteinModelPortaliQ6UX71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 372PSIAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi383 – 427Thr-richAdd BLAST45

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 1 PSI domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ6UX71.
OMAiAYSHRWK.
OrthoDBiEOG091G0827.
PhylomeDBiQ6UX71.
TreeFamiTF314400.

Family and domain databases

InterProiIPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031154. PLXDC2.
IPR016201. PSI.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF11. PTHR13055:SF11. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT
60 70 80 90 100
EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG
110 120 130 140 150
QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS
160 170 180 190 200
NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA
210 220 230 240 250
PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL
260 270 280 290 300
MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
310 320 330 340 350
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS
360 370 380 390 400
KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT
410 420 430 440 450
TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG
460 470 480 490 500
TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM
510 520
KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
Length:529
Mass (Da):59,583
Last modified:July 5, 2004 - v1
Checksum:iCCE911D6DF837B40
GO
Isoform 2 (identifier: Q6UX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-157: Missing.

Show »
Length:480
Mass (Da):53,912
Checksum:iF8DB0E2631BC7816
GO
Isoform 3 (identifier: Q6UX71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Show »
Length:151
Mass (Da):16,423
Checksum:iEAC2BCBFC94AB047
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026292396V → I.2 PublicationsCorresponds to variant rs3817405dbSNPEnsembl.1
Natural variantiVAR_026293458I → V.2 PublicationsCorresponds to variant rs2778979dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183771 – 378Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_018378109 – 157Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA. Translation: AAL11994.1.
AY358486 mRNA. Translation: AAQ88850.1.
AK027529 mRNA. Translation: BAB55178.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71083.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71084.1.
BC012885 mRNA. Translation: AAH12885.1.
CCDSiCCDS60497.1. [Q6UX71-2]
CCDS7132.1. [Q6UX71-1]
RefSeqiNP_001269665.1. NM_001282736.1. [Q6UX71-2]
NP_116201.7. NM_032812.8. [Q6UX71-1]
UniGeneiHs.658134.
Hs.733859.
Hs.99472.

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594. [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594. [Q6UX71-1]
GeneIDi84898.
KEGGihsa:84898.
UCSCiuc001iqg.3. human. [Q6UX71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA. Translation: AAL11994.1.
AY358486 mRNA. Translation: AAQ88850.1.
AK027529 mRNA. Translation: BAB55178.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71083.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71084.1.
BC012885 mRNA. Translation: AAH12885.1.
CCDSiCCDS60497.1. [Q6UX71-2]
CCDS7132.1. [Q6UX71-1]
RefSeqiNP_001269665.1. NM_001282736.1. [Q6UX71-2]
NP_116201.7. NM_032812.8. [Q6UX71-1]
UniGeneiHs.658134.
Hs.733859.
Hs.99472.

3D structure databases

ProteinModelPortaliQ6UX71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124338. 29 interactors.
DIPiDIP-46251N.
IntActiQ6UX71. 2 interactors.
STRINGi9606.ENSP00000366460.

PTM databases

iPTMnetiQ6UX71.
PhosphoSitePlusiQ6UX71.

Polymorphism and mutation databases

BioMutaiPLXDC2.
DMDMi74749416.

Proteomic databases

EPDiQ6UX71.
MaxQBiQ6UX71.
PaxDbiQ6UX71.
PeptideAtlasiQ6UX71.
PRIDEiQ6UX71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594. [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594. [Q6UX71-1]
GeneIDi84898.
KEGGihsa:84898.
UCSCiuc001iqg.3. human. [Q6UX71-1]

Organism-specific databases

CTDi84898.
DisGeNETi84898.
GeneCardsiPLXDC2.
HGNCiHGNC:21013. PLXDC2.
HPAiHPA017268.
HPA070793.
MIMi606827. gene.
neXtProtiNX_Q6UX71.
OpenTargetsiENSG00000120594.
PharmGKBiPA134932187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ6UX71.
OMAiAYSHRWK.
OrthoDBiEOG091G0827.
PhylomeDBiQ6UX71.
TreeFamiTF314400.

Miscellaneous databases

ChiTaRSiPLXDC2. human.
GeneWikiiPLXDC2.
GenomeRNAii84898.
PROiQ6UX71.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120594.
CleanExiHS_PLXDC2.
GenevisibleiQ6UX71. HS.

Family and domain databases

InterProiIPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031154. PLXDC2.
IPR016201. PSI.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF11. PTHR13055:SF11. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPXDC2_HUMAN
AccessioniPrimary (citable) accession number: Q6UX71
Secondary accession number(s): Q96E59, Q96PD9, Q96SU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.