Q6UX71 (PXDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin domain-containing protein 2

Alternative name(s):
Tumor endothelial marker 7-related protein

Gene names

Name:	PLXDC2
Synonyms:	TEM7R
ORF Names:	UNQ2514/PRO6003

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in tumor angiogenesis. Ref.1
Subunit structure	Interacts with CTTN. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue. Ref.1
Sequence similarities	Belongs to the plexin family. Contains 1 PSI domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UX71-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UX71-2)

The sequence of this isoform differs from the canonical sequence as follows:
     109-157: Missing.

Isoform 3 (identifier: Q6UX71-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 529	499	Plexin domain-containing protein 2		PRO_0000234574
Regions
	Topological domain	31 – 454	424	Extracellular Potential
	Transmembrane	455 – 475	21	Helical; Potential
	Topological domain	476 – 529	54	Cytoplasmic Potential
	Domain	327 – 372	46	PSI
	Compositional bias	383 – 427	45	Thr-rich
Amino acid modifications
	Modified residue	506	1	Phosphoserine By similarity
	Glycosylation	103	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	160	1	N-linked (GlcNAc...) Ref.8
Natural variations
	Alternative sequence	1 – 378	378	Missing in isoform 3.		VSP_018377
	Alternative sequence	109 – 157	49	Missing in isoform 2.		VSP_018378
	Natural variant	396	1	V → I. Ref.1 Ref.3 Corresponds to variant rs3817405 [ dbSNP | Ensembl ].		VAR_026292
	Natural variant	458	1	I → V. Ref.1 Ref.3 Corresponds to variant rs2778979 [ dbSNP | Ensembl ].		VAR_026293

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CCE911D6DF837B40	FASTA	529	59,583
	10 20 30 40 50 60 MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT EEEVEVDSHA 70 80 90 100 110 120 YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG QDNNTQIEED TDHNYYISRI 130 140 150 160 170 180 YGPSDSASRD LWVNIDQMEK DKVKIHGILS NTHRQAARVN LSFDFPFYGH FLREITVATG 190 200 210 220 230 240 GFIYTGEVVH RMLTATQYIA PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL 250 260 270 280 290 300 GSFTFQATLL MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT 310 320 330 340 350 360 IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS KLQRCSSGFD 370 380 390 400 410 420 RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT TQFRVLTTTR RAVTSQFPTS 430 440 450 460 470 480 LPTEDDTKIA LHLKDNGAST DDSAAEKKGG TLHAGLIIGI LILVLIVATA ILVTVYMYHH 490 500 510 520 PTSAASIFFI ERRPSRWPAM KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
	Isoform 2 [UniParc]. Checksum: F8DB0E2631BC7816	FASTA	480	53,912
	10 20 30 40 50 60 MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT EEEVEVDSHA 70 80 90 100 110 120 YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG QDNNTQIERV NLSFDFPFYG 130 140 150 160 170 180 HFLREITVAT GGFIYTGEVV HRMLTATQYI APLMANFDPS VSRNSTVRYF DNGTALVVQW 190 200 210 220 230 240 DHVHLQDNYN LGSFTFQATL LMDGRIIFGY KEIPVLVTQI SSTNHPVKVG LSDAFVVVHR 250 260 270 280 290 300 IQQIPNVRRR TIYEYHRVEL QMSKITNISA VEMTPLPTCL QFNRCGPCVS SQIGFNCSWC 310 320 330 340 350 360 SKLQRCSSGF DRHRQDWVDS GCPEESKEKM CENTEPVETS SRTTTTVGAT TTQFRVLTTT 370 380 390 400 410 420 RRAVTSQFPT SLPTEDDTKI ALHLKDNGAS TDDSAAEKKG GTLHAGLIIG ILILVLIVAT 430 440 450 460 470 480 AILVTVYMYH HPTSAASIFF IERRPSRWPA MKFRRGSGHP AYAEVEPVGE KEGFIVSEQC
	Isoform 3 [UniParc]. Checksum: EAC2BCBFC94AB047	FASTA	151	16,423
	10 20 30 40 50 60 MCENTEPVET SSRTTTTVGA TTTQFRVLTT TRRAVTSQFP TSLPTEDDTK IALHLKDNGA 70 80 90 100 110 120 STDDSAAEKK GGTLHAGLII GILILVLIVA TAILVTVYMY HHPTSAASIF FIERRPSRWP 130 140 150 AMKFRRGSGH PAYAEVEPVG EKEGFIVSEQ C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cell surface tumor endothelial markers are conserved in mice and humans." Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B. Cancer Res. 61:6649-6655(2001) [PubMed: 11559528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS ILE-396 AND VAL-458.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ILE-396 AND VAL-458.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Ovary.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-103, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R." Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S., Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W., St Croix B. Cancer Res. 64:8507-8511(2004) [PubMed: 15574754] [Abstract] Cited for: INTERACTION WITH CTTN.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF378757 mRNA. Translation: AAL11994.1. AY358486 mRNA. Translation: AAQ88850.1. AK027529 mRNA. Translation: BAB55178.1. AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71083.1. AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71084.1. BC012885 mRNA. Translation: AAH12885.1.
IPI	IPI00044369. IPI00073777. IPI00640599.
RefSeq	NP_116201.7. NM_032812.7.
UniGene	Hs.658134.
3D structure databases
ProteinModelPortal	Q6UX71.
SMR	Q6UX71. Positions 313-357.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46251N.
STRING	Q6UX71.
PTM databases
PhosphoSite	Q6UX71.
Polymorphism databases
DMDM	74749416.
Proteomic databases
PeptideAtlas	Q6UX71.
PRIDE	Q6UX71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377252; ENSP00000366460; ENSG00000120594.
GeneID	84898.
KEGG	hsa:84898.
UCSC	uc001iqg.1. human. uc001iqh.1. human.
Organism-specific databases
CTD	84898.
GeneCards	GC10P020145.
H-InvDB	HIX0020374.
HGNC	HGNC:21013. PLXDC2.
HPA	HPA017268.
MIM	606827. gene.
neXtProt	NX_Q6UX71.
PharmGKB	PA134932187.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14135.
GeneTree	ENSGT00440000033408.
HOGENOM	HBG402962.
HOVERGEN	HBG079500.
InParanoid	Q6UX71.
OMA	HAYSHRW.
OrthoDB	EOG4CRM04.
PhylomeDB	Q6UX71.
Gene expression databases
ArrayExpress	Q6UX71.
Bgee	Q6UX71.
CleanEx	HS_PLXDC2.
Genevestigator	Q6UX71.
GermOnline	ENSG00000120594. Homo sapiens.
Family and domain databases
InterPro	IPR003659. Plexin-like. IPR002165. Plexin_repeat. [Graphical view]
Pfam	PF01437. PSI. 1 hit. [Graphical view]
SMART	SM00423. PSI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	75252.
SOURCE	Search...

Entry information

Entry name

PXDC2_HUMAN

Accession

Primary (citable) accession number: Q6UX71
Secondary accession number(s): Q96E59, Q96PD9, Q96SU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.