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Protein

Plexin domain-containing protein 2

Gene

PLXDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in tumor angiogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 2
Alternative name(s):
Tumor endothelial marker 7-related protein
Gene namesi
Name:PLXDC2
Synonyms:TEM7R
ORF Names:UNQ2514/PRO6003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21013. PLXDC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 454424ExtracellularSequence analysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence analysisAdd
BLAST
Topological domaini476 – 52954CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932187.

Polymorphism and mutation databases

BioMutaiPLXDC2.
DMDMi74749416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 529499Plexin domain-containing protein 2PRO_0000234574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)1 Publication
Glycosylationi160 – 1601N-linked (GlcNAc...)1 Publication
Modified residuei506 – 5061PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6UX71.
MaxQBiQ6UX71.
PaxDbiQ6UX71.
PeptideAtlasiQ6UX71.
PRIDEiQ6UX71.

PTM databases

iPTMnetiQ6UX71.
PhosphoSiteiQ6UX71.

Expressioni

Tissue specificityi

Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.1 Publication

Gene expression databases

BgeeiQ6UX71.
CleanExiHS_PLXDC2.
GenevisibleiQ6UX71. HS.

Organism-specific databases

HPAiHPA017268.

Interactioni

Subunit structurei

Interacts with CTTN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Zbp1A2APF72EBI-6115410,EBI-6115394From a different organism.

Protein-protein interaction databases

BioGridi124338. 29 interactions.
DIPiDIP-46251N.
IntActiQ6UX71. 1 interaction.
STRINGi9606.ENSP00000366460.

Structurei

3D structure databases

ProteinModelPortaliQ6UX71.
SMRiQ6UX71. Positions 316-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini327 – 37246PSIAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi383 – 42745Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 1 PSI domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ6UX71.
OMAiAYSHRWK.
OrthoDBiEOG712TWH.
PhylomeDBiQ6UX71.
TreeFamiTF314400.

Family and domain databases

InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031154. PLXDC2.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF11. PTHR13055:SF11. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT
60 70 80 90 100
EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG
110 120 130 140 150
QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS
160 170 180 190 200
NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA
210 220 230 240 250
PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL
260 270 280 290 300
MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
310 320 330 340 350
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS
360 370 380 390 400
KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT
410 420 430 440 450
TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG
460 470 480 490 500
TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM
510 520
KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
Length:529
Mass (Da):59,583
Last modified:July 5, 2004 - v1
Checksum:iCCE911D6DF837B40
GO
Isoform 2 (identifier: Q6UX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-157: Missing.

Show »
Length:480
Mass (Da):53,912
Checksum:iF8DB0E2631BC7816
GO
Isoform 3 (identifier: Q6UX71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Show »
Length:151
Mass (Da):16,423
Checksum:iEAC2BCBFC94AB047
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti396 – 3961V → I.2 Publications
Corresponds to variant rs3817405 [ dbSNP | Ensembl ].
VAR_026292
Natural varianti458 – 4581I → V.2 Publications
Corresponds to variant rs2778979 [ dbSNP | Ensembl ].
VAR_026293

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 378378Missing in isoform 3. 1 PublicationVSP_018377Add
BLAST
Alternative sequencei109 – 15749Missing in isoform 2. 1 PublicationVSP_018378Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA. Translation: AAL11994.1.
AY358486 mRNA. Translation: AAQ88850.1.
AK027529 mRNA. Translation: BAB55178.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71083.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71084.1.
BC012885 mRNA. Translation: AAH12885.1.
CCDSiCCDS60497.1. [Q6UX71-2]
CCDS7132.1. [Q6UX71-1]
RefSeqiNP_001269665.1. NM_001282736.1. [Q6UX71-2]
NP_116201.7. NM_032812.8. [Q6UX71-1]
UniGeneiHs.658134.
Hs.733859.
Hs.99472.

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594. [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594. [Q6UX71-1]
GeneIDi84898.
KEGGihsa:84898.
UCSCiuc001iqg.3. human. [Q6UX71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA. Translation: AAL11994.1.
AY358486 mRNA. Translation: AAQ88850.1.
AK027529 mRNA. Translation: BAB55178.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71083.1.
AL353147, AC067743, AC069549 Genomic DNA. Translation: CAH71084.1.
BC012885 mRNA. Translation: AAH12885.1.
CCDSiCCDS60497.1. [Q6UX71-2]
CCDS7132.1. [Q6UX71-1]
RefSeqiNP_001269665.1. NM_001282736.1. [Q6UX71-2]
NP_116201.7. NM_032812.8. [Q6UX71-1]
UniGeneiHs.658134.
Hs.733859.
Hs.99472.

3D structure databases

ProteinModelPortaliQ6UX71.
SMRiQ6UX71. Positions 316-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124338. 29 interactions.
DIPiDIP-46251N.
IntActiQ6UX71. 1 interaction.
STRINGi9606.ENSP00000366460.

PTM databases

iPTMnetiQ6UX71.
PhosphoSiteiQ6UX71.

Polymorphism and mutation databases

BioMutaiPLXDC2.
DMDMi74749416.

Proteomic databases

EPDiQ6UX71.
MaxQBiQ6UX71.
PaxDbiQ6UX71.
PeptideAtlasiQ6UX71.
PRIDEiQ6UX71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594. [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594. [Q6UX71-1]
GeneIDi84898.
KEGGihsa:84898.
UCSCiuc001iqg.3. human. [Q6UX71-1]

Organism-specific databases

CTDi84898.
GeneCardsiPLXDC2.
HGNCiHGNC:21013. PLXDC2.
HPAiHPA017268.
MIMi606827. gene.
neXtProtiNX_Q6UX71.
PharmGKBiPA134932187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ6UX71.
OMAiAYSHRWK.
OrthoDBiEOG712TWH.
PhylomeDBiQ6UX71.
TreeFamiTF314400.

Miscellaneous databases

ChiTaRSiPLXDC2. human.
GeneWikiiPLXDC2.
GenomeRNAii84898.
NextBioi75252.
PROiQ6UX71.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UX71.
CleanExiHS_PLXDC2.
GenevisibleiQ6UX71. HS.

Family and domain databases

InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031154. PLXDC2.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF11. PTHR13055:SF11. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."
    Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS ILE-396 AND VAL-458.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ILE-396 AND VAL-458.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-103.
    Tissue: Plasma.
  7. "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R."
    Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S., Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 64:8507-8511(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTN.
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160.
    Tissue: Liver.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPXDC2_HUMAN
AccessioniPrimary (citable) accession number: Q6UX71
Secondary accession number(s): Q96E59, Q96PD9, Q96SU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.