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Q6UX68

- XKR5_HUMAN

UniProt

Q6UX68 - XKR5_HUMAN

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Protein

XK-related protein 5

Gene
XKR5, XRG5, UNQ2754/PRO6493
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 5
Gene namesi
Name:XKR5
Synonyms:XRG5
ORF Names:UNQ2754/PRO6493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:20782. XKR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST
Transmembranei297 – 31721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686XK-related protein 5PRO_0000190782Add
BLAST

Proteomic databases

PaxDbiQ6UX68.
PRIDEiQ6UX68.

PTM databases

PhosphoSiteiQ6UX68.

Expressioni

Gene expression databases

CleanExiHS_XKR5.
GenevestigatoriQ6UX68.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335064.

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG113919.
HOGENOMiHOG000137924.
HOVERGENiHBG055843.
InParanoidiQ6UX68.
PhylomeDBiQ6UX68.

Family and domain databases

InterProiIPR018629. Transport_prot_XK.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UX68-1) [UniParc]FASTAAdd to Basket

Also known as: 5a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ    50
ALSYLWFRAD GHPGHCSLVM LHLLQLGVWK RHWDAALTSL QKELEAPHRG 100
WLQLQEADLS ALRLLEALLQ TGPHLLLQTY VFLASDFTDI VPGVSTLFSW 150
SSLSWALVSY TRFMGFMKPG HLAMPWAALF CQQLWRMGML GTRVLSLVLF 200
YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF NLLVGAVYIL 250
CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV 300
LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA 350
TDLAGKRTES SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL 400
SHHHWLWVKL ALKTGNVSKI NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS 450
AQQELPSSSR DPSTLENSSA FEGVPKAEAD PLETSSYVSF ASDQQDEAPT 500
QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS TLYFSATAEV 550
ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP 600
ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ 650
LRTAHEPCLT STPKSESIQT DCSCREQMKQ EPSFFI 686
Length:686
Mass (Da):74,982
Last modified:July 5, 2004 - v1
Checksum:iEB196608BD44A43F
GO
Isoform 2 (identifier: Q6UX68-2) [UniParc]FASTAAdd to Basket

Also known as: 5b

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Show »
Length:523
Mass (Da):56,594
Checksum:i13A2FE0E941BA936
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 163163Missing in isoform 2. VSP_015818Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971I → V in AAT07092. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY534242 mRNA. Translation: AAT07091.1.
AY534243 mRNA. Translation: AAT07092.1.
AY358489 mRNA. Translation: AAQ88853.1.
RefSeqiNP_001276902.1. NM_001289973.1. [Q6UX68-2]
NP_997294.3. NM_207411.4.
UniGeneiHs.558840.

Genome annotation databases

GeneIDi389610.
KEGGihsa:389610.
UCSCiuc022aqv.1. human. [Q6UX68-1]

Polymorphism databases

DMDMi74738183.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY534242 mRNA. Translation: AAT07091.1 .
AY534243 mRNA. Translation: AAT07092.1 .
AY358489 mRNA. Translation: AAQ88853.1 .
RefSeqi NP_001276902.1. NM_001289973.1. [Q6UX68-2 ]
NP_997294.3. NM_207411.4.
UniGenei Hs.558840.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335064.

PTM databases

PhosphoSitei Q6UX68.

Polymorphism databases

DMDMi 74738183.

Proteomic databases

PaxDbi Q6UX68.
PRIDEi Q6UX68.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 389610.
KEGGi hsa:389610.
UCSCi uc022aqv.1. human. [Q6UX68-1 ]

Organism-specific databases

CTDi 389610.
GeneCardsi GC08M006666.
H-InvDB HIX0034318.
HGNCi HGNC:20782. XKR5.
neXtProti NX_Q6UX68.
PharmGKBi PA142670564.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG113919.
HOGENOMi HOG000137924.
HOVERGENi HBG055843.
InParanoidi Q6UX68.
PhylomeDBi Q6UX68.

Miscellaneous databases

GenomeRNAii 389610.
NextBioi 102945.
PROi Q6UX68.

Gene expression databases

CleanExi HS_XKR5.
Genevestigatori Q6UX68.

Family and domain databases

InterProi IPR018629. Transport_prot_XK.
[Graphical view ]
Pfami PF09815. XK-related. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
    Huang C.-H., Chen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiXKR5_HUMAN
AccessioniPrimary (citable) accession number: Q6UX68
Secondary accession number(s): Q5GH74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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