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Protein

XK-related protein 5

Gene

XKR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Protein family/group databases

TCDBi2.A.112.1.14 the kx blood-group antigen (kxa) family

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 5
Gene namesi
Name:XKR5
Synonyms:XRG5
ORF Names:UNQ2754/PRO6493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000275591.4
HGNCiHGNC:20782 XKR5
neXtProtiNX_Q6UX68

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000275591
PharmGKBiPA142670564

Polymorphism and mutation databases

BioMutaiXKR5
DMDMi74738183

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907821 – 686XK-related protein 5Add BLAST686

Proteomic databases

EPDiQ6UX68
PeptideAtlasiQ6UX68
PRIDEiQ6UX68

PTM databases

iPTMnetiQ6UX68
PhosphoSitePlusiQ6UX68

Expressioni

Gene expression databases

CleanExiHS_XKR5

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062854
HOGENOMiHOG000137924
HOVERGENiHBG055843
InParanoidiQ6UX68
OMAiAHWLVMT
PhylomeDBiQ6UX68

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX68-1) [UniParc]FASTAAdd to basket
Also known as: 5a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ
60 70 80 90 100
ALSYLWFRAD GHPGHCSLMM LHLLQLGVWK RHWDAALTSL QKELEAPHRG
110 120 130 140 150
WLQLQEADLS ALRLLEALLQ TGPHLLLQTY VFLASDFTDI VPGVSTLFSW
160 170 180 190 200
SSLSWALVSY TRFMGFMKPG HLAMPWAALF CQQLWRMGML GTRVLSLVLF
210 220 230 240 250
YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF NLLVGAVYIL
260 270 280 290 300
CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV
310 320 330 340 350
LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA
360 370 380 390 400
TDLAGKRTES SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL
410 420 430 440 450
SHHHWLWVKL ALKTGNVSKI NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS
460 470 480 490 500
AQQELPSSSR DPSTLENSSA FEGVPKAEAD PLETSSYVSF ASDQQDEAPT
510 520 530 540 550
QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS TLYFSATAEV
560 570 580 590 600
ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP
610 620 630 640 650
ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ
660 670 680
LRTAHEPCLT STPKSESIQT DCSCREQMKQ EPSFFI
Length:686
Mass (Da):75,014
Last modified:March 28, 2018 - v2
Checksum:iDD0B46DA37F27F57
GO
Isoform 2 (identifier: Q6UX68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-86: HWDAA → PQIHL
     87-686: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:86
Mass (Da):9,773
Checksum:i3F7A22A08C2D8924
GO

Sequence cautioni

The sequence AAT07092 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69M → V in AAT07091 (Ref. 1) 1
Sequence conflicti69M → V in AAQ88853 (PubMed:12975309).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05937182 – 86HWDAA → PQIHL in isoform 2. 5
Alternative sequenceiVSP_05937287 – 686Missing in isoform 2. Add BLAST600

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534242 mRNA Translation: AAT07091.1
AY534243 mRNA Translation: AAT07092.1 Sequence problems.
AY358489 mRNA Translation: AAQ88853.1
AF233439 Genomic DNA No translation available.
KF495715 Genomic DNA No translation available.
CH471153 Genomic DNA Translation: EAW80480.1
CCDSiCCDS47763.2 [Q6UX68-1]
RefSeqiNP_997294.3, NM_207411.4
UniGeneiHs.558840

Genome annotation databases

EnsembliENST00000618742; ENSP00000483879; ENSG00000275591 [Q6UX68-1]
ENST00000618990; ENSP00000485506; ENSG00000275591 [Q6UX68-3]
GeneIDi389610
KEGGihsa:389610

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiXKR5_HUMAN
AccessioniPrimary (citable) accession number: Q6UX68
Secondary accession number(s): A0A087X143, A0A096LPC1, Q5GH74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome