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Q6UX68 (XKR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
XK-related protein 5
Gene names
Name:XKR5
Synonyms:XRG5
ORF Names:UNQ2754/PRO6493
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the XK family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UX68-1)

Also known as: 5a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UX68-2)

Also known as: 5b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686XK-related protein 5
PRO_0000190782

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane297 – 31721Helical; Potential

Natural variations

Alternative sequence1 – 163163Missing in isoform 2.
VSP_015818

Experimental info

Sequence conflict2971I → V in AAT07092. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (5a) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EB196608BD44A43F

FASTA68674,982
        10         20         30         40         50         60 
MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD 

        70         80         90        100        110        120 
GHPGHCSLVM LHLLQLGVWK RHWDAALTSL QKELEAPHRG WLQLQEADLS ALRLLEALLQ 

       130        140        150        160        170        180 
TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF 

       190        200        210        220        230        240 
CQQLWRMGML GTRVLSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF 

       250        260        270        280        290        300 
NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV 

       310        320        330        340        350        360 
LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA TDLAGKRTES 

       370        380        390        400        410        420 
SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNVSKI 

       430        440        450        460        470        480 
NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS AQQELPSSSR DPSTLENSSA FEGVPKAEAD 

       490        500        510        520        530        540 
PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS 

       550        560        570        580        590        600 
TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP 

       610        620        630        640        650        660 
ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ LRTAHEPCLT 

       670        680 
STPKSESIQT DCSCREQMKQ EPSFFI 

« Hide

Isoform 2 (5b) [UniParc].

Checksum: 13A2FE0E941BA936
Show »

FASTA52356,594

References

« Hide 'large scale' references
[1]"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
Huang C.-H., Chen Y.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY534242 mRNA. Translation: AAT07091.1.
AY534243 mRNA. Translation: AAT07092.1.
AY358489 mRNA. Translation: AAQ88853.1.
RefSeqNP_997294.3. NM_207411.4.
UniGeneHs.558840.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335064.

PTM databases

PhosphoSiteQ6UX68.

Polymorphism databases

DMDM74738183.

Proteomic databases

PaxDbQ6UX68.
PRIDEQ6UX68.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID389610.
KEGGhsa:389610.
UCSCuc022aqv.1. human. [Q6UX68-1]

Organism-specific databases

CTD389610.
GeneCardsGC08M006666.
H-InvDBHIX0034318.
HGNCHGNC:20782. XKR5.
neXtProtNX_Q6UX68.
PharmGKBPA142670564.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG113919.
HOGENOMHOG000137924.
HOVERGENHBG055843.
InParanoidQ6UX68.
PhylomeDBQ6UX68.

Gene expression databases

CleanExHS_XKR5.
GenevestigatorQ6UX68.

Family and domain databases

InterProIPR018629. Transport_prot_XK.
[Graphical view]
PfamPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi389610.
NextBio102945.
PROQ6UX68.

Entry information

Entry nameXKR5_HUMAN
AccessionPrimary (citable) accession number: Q6UX68
Secondary accession number(s): Q5GH74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM