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Q6UX68

- XKR5_HUMAN

UniProt

Q6UX68 - XKR5_HUMAN

Protein

XK-related protein 5

Gene

XKR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    XK-related protein 5
    Gene namesi
    Name:XKR5
    Synonyms:XRG5
    ORF Names:UNQ2754/PRO6493
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:20782. XKR5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686XK-related protein 5PRO_0000190782Add
    BLAST

    Proteomic databases

    PaxDbiQ6UX68.
    PRIDEiQ6UX68.

    PTM databases

    PhosphoSiteiQ6UX68.

    Expressioni

    Gene expression databases

    CleanExiHS_XKR5.
    GenevestigatoriQ6UX68.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335064.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XK family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG113919.
    HOGENOMiHOG000137924.
    HOVERGENiHBG055843.
    InParanoidiQ6UX68.
    PhylomeDBiQ6UX68.

    Family and domain databases

    InterProiIPR018629. Transport_prot_XK.
    [Graphical view]
    PfamiPF09815. XK-related. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UX68-1) [UniParc]FASTAAdd to Basket

    Also known as: 5a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ    50
    ALSYLWFRAD GHPGHCSLVM LHLLQLGVWK RHWDAALTSL QKELEAPHRG 100
    WLQLQEADLS ALRLLEALLQ TGPHLLLQTY VFLASDFTDI VPGVSTLFSW 150
    SSLSWALVSY TRFMGFMKPG HLAMPWAALF CQQLWRMGML GTRVLSLVLF 200
    YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF NLLVGAVYIL 250
    CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV 300
    LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA 350
    TDLAGKRTES SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL 400
    SHHHWLWVKL ALKTGNVSKI NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS 450
    AQQELPSSSR DPSTLENSSA FEGVPKAEAD PLETSSYVSF ASDQQDEAPT 500
    QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS TLYFSATAEV 550
    ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP 600
    ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ 650
    LRTAHEPCLT STPKSESIQT DCSCREQMKQ EPSFFI 686
    Length:686
    Mass (Da):74,982
    Last modified:July 5, 2004 - v1
    Checksum:iEB196608BD44A43F
    GO
    Isoform 2 (identifier: Q6UX68-2) [UniParc]FASTAAdd to Basket

    Also known as: 5b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-163: Missing.

    Show »
    Length:523
    Mass (Da):56,594
    Checksum:i13A2FE0E941BA936
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971I → V in AAT07092. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 163163Missing in isoform 2. 1 PublicationVSP_015818Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534242 mRNA. Translation: AAT07091.1.
    AY534243 mRNA. Translation: AAT07092.1.
    AY358489 mRNA. Translation: AAQ88853.1.
    RefSeqiNP_001276902.1. NM_001289973.1. [Q6UX68-2]
    NP_997294.3. NM_207411.4.
    UniGeneiHs.558840.

    Genome annotation databases

    GeneIDi389610.
    KEGGihsa:389610.
    UCSCiuc022aqv.1. human. [Q6UX68-1]

    Polymorphism databases

    DMDMi74738183.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534242 mRNA. Translation: AAT07091.1 .
    AY534243 mRNA. Translation: AAT07092.1 .
    AY358489 mRNA. Translation: AAQ88853.1 .
    RefSeqi NP_001276902.1. NM_001289973.1. [Q6UX68-2 ]
    NP_997294.3. NM_207411.4.
    UniGenei Hs.558840.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335064.

    PTM databases

    PhosphoSitei Q6UX68.

    Polymorphism databases

    DMDMi 74738183.

    Proteomic databases

    PaxDbi Q6UX68.
    PRIDEi Q6UX68.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 389610.
    KEGGi hsa:389610.
    UCSCi uc022aqv.1. human. [Q6UX68-1 ]

    Organism-specific databases

    CTDi 389610.
    GeneCardsi GC08M006666.
    H-InvDB HIX0034318.
    HGNCi HGNC:20782. XKR5.
    neXtProti NX_Q6UX68.
    PharmGKBi PA142670564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG113919.
    HOGENOMi HOG000137924.
    HOVERGENi HBG055843.
    InParanoidi Q6UX68.
    PhylomeDBi Q6UX68.

    Miscellaneous databases

    GenomeRNAii 389610.
    NextBioi 102945.
    PROi Q6UX68.

    Gene expression databases

    CleanExi HS_XKR5.
    Genevestigatori Q6UX68.

    Family and domain databases

    InterProi IPR018629. Transport_prot_XK.
    [Graphical view ]
    Pfami PF09815. XK-related. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
      Huang C.-H., Chen Y.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiXKR5_HUMAN
    AccessioniPrimary (citable) accession number: Q6UX68
    Secondary accession number(s): Q5GH74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3