Q6UX68 (XKR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 5

Gene names

Name:	XKR5
Synonyms:	XRG5
ORF Names:	UNQ2754/PRO6493

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UX68-1)

Also known as: 5a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UX68-2)

Also known as: 5b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 686	686	XK-related protein 5		PRO_0000190782
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Transmembrane	297 – 317	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 163	163	Missing in isoform 2.		VSP_015818
Experimental info
	Sequence conflict	297	1	I → V in AAT07092. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (5a) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EB196608BD44A43F	FASTA	686	74,982
	10 20 30 40 50 60 MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD 70 80 90 100 110 120 GHPGHCSLVM LHLLQLGVWK RHWDAALTSL QKELEAPHRG WLQLQEADLS ALRLLEALLQ 130 140 150 160 170 180 TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF 190 200 210 220 230 240 CQQLWRMGML GTRVLSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF 250 260 270 280 290 300 NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV 310 320 330 340 350 360 LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA TDLAGKRTES 370 380 390 400 410 420 SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNVSKI 430 440 450 460 470 480 NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS AQQELPSSSR DPSTLENSSA FEGVPKAEAD 490 500 510 520 530 540 PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS 550 560 570 580 590 600 TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP 610 620 630 640 650 660 ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ LRTAHEPCLT 670 680 STPKSESIQT DCSCREQMKQ EPSFFI
	Isoform 2 (5b) [UniParc]. Checksum: 13A2FE0E941BA936	FASTA	523	56,594
	10 20 30 40 50 60 MGFMKPGHLA MPWAALFCQQ LWRMGMLGTR VLSLVLFYKA YHFWVFVVAG AHWLVMTFWL 70 80 90 100 110 120 VAQQSDIIDS TCHWRLFNLL VGAVYILCYL SFWDSPSRNR MVTFYMVMLL ENIILLLLAT 130 140 150 160 170 180 DFLQGASWTS LQTIAGVLSG FLIGSVSLVI YYSLLHPKST DIWQGCLRKS CGIAGGDKTE 190 200 210 220 230 240 RRDSPRATDL AGKRTESSGS CQGASYEPTI LGKPPTPEQV PPEAGLGTQV AVEDSFLSHH 250 260 270 280 290 300 HWLWVKLALK TGNVSKINAA FGDNSPAYCP PAWGLSQQDY LQRKALSAQQ ELPSSSRDPS 310 320 330 340 350 360 TLENSSAFEG VPKAEADPLE TSSYVSFASD QQDEAPTQNP AATQGEGTPK EGADAVSGTQ 370 380 390 400 410 420 GKGTGGQQRG GEGQQSSTLY FSATAEVATS SQQEGSPATL QTAHSGRRLG KSSPAQPASP 430 440 450 460 470 480 HPVGLAPFPD TMADISPILG TGPCRGFCPS AGFPGRTLSI SELEEPLEPK RELSHHAAVG 490 500 510 520 VWVSLPQLRT AHEPCLTSTP KSESIQTDCS CREQMKQEPS FFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY534242 mRNA. Translation: AAT07091.1. AY534243 mRNA. Translation: AAT07092.1. AY358489 mRNA. Translation: AAQ88853.1.
IPI	IPI00410477. IPI00651718.
RefSeq	NP_997294.3. NM_207411.4.
UniGene	Hs.558840.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6UX68.
Polymorphism databases
DMDM	74738183.
Proteomic databases
PRIDE	Q6UX68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409172; ENSP00000386256; ENSG00000186530.
GeneID	389610.
KEGG	hsa:389610.
Organism-specific databases
CTD	389610.
GeneCards	GC08M006659.
H-InvDB	HIX0034318.
HGNC	HGNC:20782. XKR5.
neXtProt	NX_Q6UX68.
PharmGKB	PA142670564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17611.
GeneTree	ENSGT00530000062854.
HOGENOM	HBG283446.
HOVERGEN	HBG055843.
InParanoid	Q6UX68.
OrthoDB	EOG4BVRTJ.
Gene expression databases
CleanEx	HS_XKR5.
Genevestigator	Q6UX68.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	102945.

Entry information

Entry name

XKR5_HUMAN

Accession

Primary (citable) accession number: Q6UX68
Secondary accession number(s): Q5GH74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.