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Protein

Methyltransferase-like protein 7B

Gene

METTL7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 7B (EC:2.1.1.-)
Gene namesi
Name:METTL7B
ORF Names:UNQ594/PRO1180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28276. METTL7B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485533.

Polymorphism and mutation databases

BioMutaiMETTL7B.
DMDMi115502257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 244221Methyltransferase-like protein 7BPRO_0000251922Add
BLAST

Proteomic databases

EPDiQ6UX53.
MaxQBiQ6UX53.
PaxDbiQ6UX53.
PRIDEiQ6UX53.

PTM databases

iPTMnetiQ6UX53.
PhosphoSiteiQ6UX53.
SwissPalmiQ6UX53.

Expressioni

Gene expression databases

BgeeiQ6UX53.
CleanExiHS_METTL7B.
ExpressionAtlasiQ6UX53. baseline and differential.
GenevisibleiQ6UX53. HS.

Organism-specific databases

HPAiHPA038644.

Interactioni

Protein-protein interaction databases

BioGridi128204. 5 interactions.
IntActiQ6UX53. 1 interaction.
STRINGi9606.ENSP00000377796.

Structurei

3D structure databases

ProteinModelPortaliQ6UX53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IQG6. Eukaryota.
ENOG4111H81. LUCA.
GeneTreeiENSGT00530000063658.
HOGENOMiHOG000236770.
HOVERGENiHBG054283.
InParanoidiQ6UX53.
OrthoDBiEOG73RBCN.
PhylomeDBiQ6UX53.
TreeFamiTF331790.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UX53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDILVPLLQL LVLLLTLPLH LMALLGCWQP LCKSYFPYLM AVLTPKSNRK
60 70 80 90 100
MESKKRELFS QIKGLTGASG KVALLELGCG TGANFQFYPP GCRVTCLDPN
110 120 130 140 150
PHFEKFLTKS MAENRHLQYE RFVVAPGEDM RQLADGSMDV VVCTLVLCSV
160 170 180 190 200
QSPRKVLQEV RRVLRPGGVL FFWEHVAEPY GSWAFMWQQV FEPTWKHIGD
210 220 230 240
GCCLTRETWK DLENAQFSEI QMERQPPPLK WLPVGPHIMG KAVK
Length:244
Mass (Da):27,775
Last modified:October 3, 2006 - v2
Checksum:iEB43D3787C7AFA8B
GO

Sequence cautioni

The sequence AAQ88872.1 differs from that shown. Reason: Erroneous termination at position 245. Translated as stop.Curated
The sequence BAF82801.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358508 mRNA. Translation: AAQ88872.1. Different termination.
AK290112 mRNA. Translation: BAF82801.1. Different initiation.
CCDSiCCDS8887.2.
RefSeqiNP_689850.2. NM_152637.2.
UniGeneiHs.51483.

Genome annotation databases

EnsembliENST00000394252; ENSP00000377796; ENSG00000170439.
GeneIDi196410.
KEGGihsa:196410.
UCSCiuc010spr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358508 mRNA. Translation: AAQ88872.1. Different termination.
AK290112 mRNA. Translation: BAF82801.1. Different initiation.
CCDSiCCDS8887.2.
RefSeqiNP_689850.2. NM_152637.2.
UniGeneiHs.51483.

3D structure databases

ProteinModelPortaliQ6UX53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128204. 5 interactions.
IntActiQ6UX53. 1 interaction.
STRINGi9606.ENSP00000377796.

PTM databases

iPTMnetiQ6UX53.
PhosphoSiteiQ6UX53.
SwissPalmiQ6UX53.

Polymorphism and mutation databases

BioMutaiMETTL7B.
DMDMi115502257.

Proteomic databases

EPDiQ6UX53.
MaxQBiQ6UX53.
PaxDbiQ6UX53.
PRIDEiQ6UX53.

Protocols and materials databases

DNASUi196410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394252; ENSP00000377796; ENSG00000170439.
GeneIDi196410.
KEGGihsa:196410.
UCSCiuc010spr.3. human.

Organism-specific databases

CTDi196410.
GeneCardsiMETTL7B.
HGNCiHGNC:28276. METTL7B.
HPAiHPA038644.
neXtProtiNX_Q6UX53.
PharmGKBiPA143485533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQG6. Eukaryota.
ENOG4111H81. LUCA.
GeneTreeiENSGT00530000063658.
HOGENOMiHOG000236770.
HOVERGENiHBG054283.
InParanoidiQ6UX53.
OrthoDBiEOG73RBCN.
PhylomeDBiQ6UX53.
TreeFamiTF331790.

Miscellaneous databases

GenomeRNAii196410.
PROiQ6UX53.

Gene expression databases

BgeeiQ6UX53.
CleanExiHS_METTL7B.
ExpressionAtlasiQ6UX53. baseline and differential.
GenevisibleiQ6UX53. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMET7B_HUMAN
AccessioniPrimary (citable) accession number: Q6UX53
Secondary accession number(s): A8K247, Q8WUI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.