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Protein

ALK and LTK ligand 2

Gene

ALKAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.2 Publications

GO - Molecular functioni

  • receptor signaling protein tyrosine kinase activator activity Source: UniProtKB
  • receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of ERK5 cascade Source: UniProtKB
  • positive regulation of neuron projection development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
ALK and LTK ligand 2Imported
Alternative name(s):
Augmentor alpha1 Publication
Short name:
AUG-alpha1 Publication
Protein FAM150B
Gene namesi
Name:ALKAL2Imported
Synonyms:FAM150B
ORF Names:UNQ542/PRO1097
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000189292.15.
HGNCiHGNC:27683. ALKAL2.
neXtProtiNX_Q6UX46.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189292.
PharmGKBiPA162386448.

Polymorphism and mutation databases

BioMutaiFAM150B.
DMDMi229462850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000031719325 – 152ALK and LTK ligand 2Add BLAST128

Proteomic databases

PaxDbiQ6UX46.
PeptideAtlasiQ6UX46.
PRIDEiQ6UX46.

Expressioni

Tissue specificityi

Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.1 Publication

Gene expression databases

BgeeiENSG00000189292.
CleanExiHS_FAM150B.
ExpressionAtlasiQ6UX46. baseline and differential.
GenevisibleiQ6UX46. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALKQ9UM735EBI-11691780,EBI-357361

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ6UX46. 1 interactor.
STRINGi9606.ENSP00000384604.

Structurei

3D structure databases

ProteinModelPortaliQ6UX46.
SMRiQ6UX46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALKAL family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX76. Eukaryota.
ENOG410Y5NM. LUCA.
GeneTreeiENSGT00390000004054.
HOGENOMiHOG000082506.
HOVERGENiHBG107867.
InParanoidiQ6UX46.
OMAiYHSGESK.
OrthoDBiEOG091G0WD7.
PhylomeDBiQ6UX46.
TreeFamiTF333390.

Family and domain databases

InterProiView protein in InterPro
IPR029364. FAM150A/B.
PANTHERiPTHR28676. PTHR28676. 1 hit.
PfamiView protein in Pfam
PF15129. FAM150. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPGHPLLL GLLLVLGAAG RGRGGAEPRE PADGQALLRL VVELVQELRK
60 70 80 90 100
HHSAEHKGLQ LLGRDCALGR AEAAGLGPSP EQRVEIVPRD LRMKDKFLKH
110 120 130 140 150
LTGPLYFSPK CSKHFHRLYH NTRDCTIPAY YKRCARLLTR LAVSPVCMED

KQ
Length:152
Mass (Da):16,915
Last modified:May 5, 2009 - v2
Checksum:i547047F0FFA23D01
GO
Isoform 2 (identifier: Q6UX46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-76: Missing.
     152-152: Missing.

Show »
Length:91
Mass (Da):10,542
Checksum:i0EE995ED103A46C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03701717 – 76Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_037018152Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358517 mRNA. Translation: AAQ88881.1.
AC079779 Genomic DNA. No translation available.
CCDSiCCDS46218.1. [Q6UX46-1]
RefSeqiNP_001002919.2. NM_001002919.2. [Q6UX46-1]
XP_005264746.1. XM_005264689.4. [Q6UX46-1]
UniGeneiHs.355207.

Genome annotation databases

EnsembliENST00000403610; ENSP00000384604; ENSG00000189292. [Q6UX46-1]
ENST00000619265; ENSP00000478180; ENSG00000189292. [Q6UX46-2]
GeneIDi285016.
KEGGihsa:285016.
UCSCiuc002qwi.5. human. [Q6UX46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALKL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UX46
Secondary accession number(s): B5MC76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families