Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6UX40

- TM107_HUMAN

UniProt

Q6UX40 - TM107_HUMAN

Protein

Transmembrane protein 107

Gene

TMEM107

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types By similarity.By similarity

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. embryonic digit morphogenesis Source: Ensembl
    3. neural tube patterning Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 107
    Gene namesi
    Name:TMEM107
    ORF Names:DC20, UNQ638/PRO1268
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28128. TMEM107.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Transmembrane protein 107PRO_0000254541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6UX40.
    PRIDEiQ6UX40.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UX40.
    BgeeiQ6UX40.
    CleanExiHS_TMEM107.
    GenevestigatoriQ6UX40.

    Organism-specific databases

    HPAiHPA052555.

    Interactioni

    Protein-protein interaction databases

    BioGridi124040. 1 interaction.
    STRINGi9606.ENSP00000314116.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UX40.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44128.
    HOGENOMiHOG000261639.
    HOVERGENiHBG094051.
    InParanoidiQ6UX40.
    OMAiCARAGIN.
    PhylomeDBiQ6UX40.
    TreeFamiTF328441.

    Family and domain databases

    InterProiIPR029248. TMEM107.
    [Graphical view]
    PfamiPF14995. TMEM107. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UX40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRVSGLVPS RFLTLLAHLV VVITLFWSRD SNIQACLPLT FTPEEYDKQD    50
    IQLVAALSVT LGLFAVELAG FLSGVSMFNS TQSLISIGAH CSASVALSFF 100
    IFERWECTTY WYIFVFCSAL PAVTEMALFV TVFGLKKKPF 140
    Length:140
    Mass (Da):15,503
    Last modified:July 5, 2004 - v1
    Checksum:iB2ED164C9F379EDD
    GO
    Isoform 2 (identifier: Q6UX40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-30: D → VRPTAALNPS...FNDVLNPAVY
         31-140: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:163
    Mass (Da):17,605
    Checksum:iFA733A83F522F896
    GO
    Isoform 3 (identifier: Q6UX40-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Q → HPLPLCR
         111-118: WYIFVFCS → C

    Note: No experimental confirmation available.

    Show »
    Length:139
    Mass (Da):15,249
    Checksum:iC78CFAD7B8CBD8C7
    GO
    Isoform 4 (identifier: Q6UX40-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Q → HPLPLCR

    Show »
    Length:146
    Mass (Da):16,192
    Checksum:iA166E2EB1727C957
    GO

    Sequence cautioni

    The sequence AAK38512.1 differs from that shown. Reason: Frameshift at positions 63 and 82.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei30 – 301D → VRPTAALNPSPFPSLSGPSP TLPPPSVLPSWVFLFPAAPR PALQPAPFSLLSAGWWPRSL SPWASLQWSWPVSSQESPCS TAPRASSVSFLPAHLSHTTH FYQDSLQPPDTIVSAVANPS SSKIFNDVLNPAVY in isoform 2. 1 PublicationVSP_021210
    Alternative sequencei31 – 140110Missing in isoform 2. 1 PublicationVSP_021211Add
    BLAST
    Alternative sequencei52 – 521Q → HPLPLCR in isoform 3 and isoform 4. 2 PublicationsVSP_021212
    Alternative sequencei111 – 1188WYIFVFCS → C in isoform 3. 1 PublicationVSP_021213

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311338 mRNA. Translation: AAK38512.1. Frameshift.
    AY358525 mRNA. Translation: AAQ88889.1.
    AK127891 mRNA. Translation: BAC87177.1.
    AC129492 Genomic DNA. No translation available.
    BC070231 mRNA. Translation: AAH70231.1.
    BC127649 mRNA. Translation: AAI27650.1.
    CCDSiCCDS11132.1. [Q6UX40-4]
    CCDS45607.1. [Q6UX40-1]
    RefSeqiNP_115730.2. NM_032354.3. [Q6UX40-4]
    NP_898888.1. NM_183065.2. [Q6UX40-1]
    UniGeneiHs.513933.

    Genome annotation databases

    EnsembliENST00000316425; ENSP00000314116; ENSG00000179029. [Q6UX40-4]
    ENST00000437139; ENSP00000402732; ENSG00000179029. [Q6UX40-1]
    ENST00000533070; ENSP00000436674; ENSG00000179029. [Q6UX40-3]
    GeneIDi84314.
    KEGGihsa:84314.
    UCSCiuc002gkg.4. human. [Q6UX40-1]
    uc002gkh.4. human. [Q6UX40-4]
    uc002gki.4. human. [Q6UX40-3]

    Polymorphism databases

    DMDMi74738174.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311338 mRNA. Translation: AAK38512.1 . Frameshift.
    AY358525 mRNA. Translation: AAQ88889.1 .
    AK127891 mRNA. Translation: BAC87177.1 .
    AC129492 Genomic DNA. No translation available.
    BC070231 mRNA. Translation: AAH70231.1 .
    BC127649 mRNA. Translation: AAI27650.1 .
    CCDSi CCDS11132.1. [Q6UX40-4 ]
    CCDS45607.1. [Q6UX40-1 ]
    RefSeqi NP_115730.2. NM_032354.3. [Q6UX40-4 ]
    NP_898888.1. NM_183065.2. [Q6UX40-1 ]
    UniGenei Hs.513933.

    3D structure databases

    ProteinModelPortali Q6UX40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124040. 1 interaction.
    STRINGi 9606.ENSP00000314116.

    Polymorphism databases

    DMDMi 74738174.

    Proteomic databases

    PaxDbi Q6UX40.
    PRIDEi Q6UX40.

    Protocols and materials databases

    DNASUi 84314.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316425 ; ENSP00000314116 ; ENSG00000179029 . [Q6UX40-4 ]
    ENST00000437139 ; ENSP00000402732 ; ENSG00000179029 . [Q6UX40-1 ]
    ENST00000533070 ; ENSP00000436674 ; ENSG00000179029 . [Q6UX40-3 ]
    GeneIDi 84314.
    KEGGi hsa:84314.
    UCSCi uc002gkg.4. human. [Q6UX40-1 ]
    uc002gkh.4. human. [Q6UX40-4 ]
    uc002gki.4. human. [Q6UX40-3 ]

    Organism-specific databases

    CTDi 84314.
    GeneCardsi GC17M008113.
    HGNCi HGNC:28128. TMEM107.
    HPAi HPA052555.
    neXtProti NX_Q6UX40.
    PharmGKBi PA142670758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44128.
    HOGENOMi HOG000261639.
    HOVERGENi HBG094051.
    InParanoidi Q6UX40.
    OMAi CARAGIN.
    PhylomeDBi Q6UX40.
    TreeFami TF328441.

    Miscellaneous databases

    ChiTaRSi TMEM107. human.
    GenomeRNAii 84314.
    NextBioi 74018.
    PROi Q6UX40.

    Gene expression databases

    ArrayExpressi Q6UX40.
    Bgeei Q6UX40.
    CleanExi HS_TMEM107.
    Genevestigatori Q6UX40.

    Family and domain databases

    InterProi IPR029248. TMEM107.
    [Graphical view ]
    Pfami PF14995. TMEM107. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene from human dendritic cells."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Dendritic cell.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.

    Entry informationi

    Entry nameiTM107_HUMAN
    AccessioniPrimary (citable) accession number: Q6UX40
    Secondary accession number(s): A0PJV7
    , Q6NSE3, Q6ZRX9, Q96T82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM

    External Data

    Dasty 3