Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 107

Gene

TMEM107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 107
Gene namesi
Name:TMEM107
ORF Names:DC20, UNQ638/PRO1268
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28128. TMEM107.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • ciliary transition zone Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179029.
PharmGKBiPA142670758.

Polymorphism and mutation databases

BioMutaiTMEM107.
DMDMi74738174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545411 – 140Transmembrane protein 107Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UX40.
PeptideAtlasiQ6UX40.
PRIDEiQ6UX40.
TopDownProteomicsiQ6UX40-4. [Q6UX40-4]

Expressioni

Gene expression databases

BgeeiENSG00000179029.
CleanExiHS_TMEM107.
ExpressionAtlasiQ6UX40. baseline and differential.
GenevisibleiQ6UX40. HS.

Organism-specific databases

HPAiHPA052555.
HPA059653.

Interactioni

Protein-protein interaction databases

BioGridi124040. 4 interactors.
DIPiDIP-61993N.
STRINGi9606.ENSP00000314116.

Structurei

3D structure databases

ProteinModelPortaliQ6UX40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX7Q. Eukaryota.
ENOG4112136. LUCA.
GeneTreeiENSGT00390000014827.
HOGENOMiHOG000261639.
HOVERGENiHBG094051.
InParanoidiQ6UX40.
OMAiWWIFAFC.
OrthoDBiEOG091G0RVW.
PhylomeDBiQ6UX40.
TreeFamiTF328441.

Family and domain databases

InterProiIPR029248. TMEM107.
[Graphical view]
PfamiPF14995. TMEM107. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRVSGLVPS RFLTLLAHLV VVITLFWSRD SNIQACLPLT FTPEEYDKQD
60 70 80 90 100
IQLVAALSVT LGLFAVELAG FLSGVSMFNS TQSLISIGAH CSASVALSFF
110 120 130 140
IFERWECTTY WYIFVFCSAL PAVTEMALFV TVFGLKKKPF
Length:140
Mass (Da):15,503
Last modified:July 5, 2004 - v1
Checksum:iB2ED164C9F379EDD
GO
Isoform 2 (identifier: Q6UX40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: D → VRPTAALNPS...FNDVLNPAVY
     31-140: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):17,605
Checksum:iFA733A83F522F896
GO
Isoform 3 (identifier: Q6UX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → HPLPLCR
     111-118: WYIFVFCS → C

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):15,249
Checksum:iC78CFAD7B8CBD8C7
GO
Isoform 4 (identifier: Q6UX40-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → HPLPLCR

Show »
Length:146
Mass (Da):16,192
Checksum:iA166E2EB1727C957
GO

Sequence cautioni

The sequence AAK38512 differs from that shown. Reason: Frameshift at positions 63 and 82.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02121030D → VRPTAALNPSPFPSLSGPSP TLPPPSVLPSWVFLFPAAPR PALQPAPFSLLSAGWWPRSL SPWASLQWSWPVSSQESPCS TAPRASSVSFLPAHLSHTTH FYQDSLQPPDTIVSAVANPS SSKIFNDVLNPAVY in isoform 2. 1 Publication1
Alternative sequenceiVSP_02121131 – 140Missing in isoform 2. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_02121252Q → HPLPLCR in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_021213111 – 118WYIFVFCS → C in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311338 mRNA. Translation: AAK38512.1. Frameshift.
AY358525 mRNA. Translation: AAQ88889.1.
AK127891 mRNA. Translation: BAC87177.1.
AC129492 Genomic DNA. No translation available.
BC070231 mRNA. Translation: AAH70231.1.
BC127649 mRNA. Translation: AAI27650.1.
CCDSiCCDS11132.1. [Q6UX40-4]
CCDS45607.1. [Q6UX40-1]
RefSeqiNP_115730.2. NM_032354.3. [Q6UX40-4]
NP_898888.1. NM_183065.2. [Q6UX40-1]
UniGeneiHs.513933.

Genome annotation databases

EnsembliENST00000316425; ENSP00000314116; ENSG00000179029. [Q6UX40-4]
ENST00000437139; ENSP00000402732; ENSG00000179029. [Q6UX40-1]
ENST00000533070; ENSP00000436674; ENSG00000179029. [Q6UX40-3]
GeneIDi84314.
KEGGihsa:84314.
UCSCiuc002gkg.5. human. [Q6UX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311338 mRNA. Translation: AAK38512.1. Frameshift.
AY358525 mRNA. Translation: AAQ88889.1.
AK127891 mRNA. Translation: BAC87177.1.
AC129492 Genomic DNA. No translation available.
BC070231 mRNA. Translation: AAH70231.1.
BC127649 mRNA. Translation: AAI27650.1.
CCDSiCCDS11132.1. [Q6UX40-4]
CCDS45607.1. [Q6UX40-1]
RefSeqiNP_115730.2. NM_032354.3. [Q6UX40-4]
NP_898888.1. NM_183065.2. [Q6UX40-1]
UniGeneiHs.513933.

3D structure databases

ProteinModelPortaliQ6UX40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124040. 4 interactors.
DIPiDIP-61993N.
STRINGi9606.ENSP00000314116.

Polymorphism and mutation databases

BioMutaiTMEM107.
DMDMi74738174.

Proteomic databases

PaxDbiQ6UX40.
PeptideAtlasiQ6UX40.
PRIDEiQ6UX40.
TopDownProteomicsiQ6UX40-4. [Q6UX40-4]

Protocols and materials databases

DNASUi84314.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316425; ENSP00000314116; ENSG00000179029. [Q6UX40-4]
ENST00000437139; ENSP00000402732; ENSG00000179029. [Q6UX40-1]
ENST00000533070; ENSP00000436674; ENSG00000179029. [Q6UX40-3]
GeneIDi84314.
KEGGihsa:84314.
UCSCiuc002gkg.5. human. [Q6UX40-1]

Organism-specific databases

CTDi84314.
GeneCardsiTMEM107.
HGNCiHGNC:28128. TMEM107.
HPAiHPA052555.
HPA059653.
MIMi616183. gene.
neXtProtiNX_Q6UX40.
OpenTargetsiENSG00000179029.
PharmGKBiPA142670758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7Q. Eukaryota.
ENOG4112136. LUCA.
GeneTreeiENSGT00390000014827.
HOGENOMiHOG000261639.
HOVERGENiHBG094051.
InParanoidiQ6UX40.
OMAiWWIFAFC.
OrthoDBiEOG091G0RVW.
PhylomeDBiQ6UX40.
TreeFamiTF328441.

Miscellaneous databases

ChiTaRSiTMEM107. human.
GenomeRNAii84314.
PROiQ6UX40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179029.
CleanExiHS_TMEM107.
ExpressionAtlasiQ6UX40. baseline and differential.
GenevisibleiQ6UX40. HS.

Family and domain databases

InterProiIPR029248. TMEM107.
[Graphical view]
PfamiPF14995. TMEM107. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM107_HUMAN
AccessioniPrimary (citable) accession number: Q6UX40
Secondary accession number(s): A0PJV7
, Q6NSE3, Q6ZRX9, Q96T82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.