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Protein

Amelotin

Gene

AMTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amelotin
Gene namesi
Name:AMTN
ORF Names:UNQ689/PRO1329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:33188. AMTN.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • basal lamina Source: HGNC
  • cell-cell junction Source: HGNC
  • proteinaceous extracellular matrix Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376390.

Polymorphism and mutation databases

BioMutaiAMTN.
DMDMi55976710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 209193AmelotinPRO_0000022613Add
BLAST

Post-translational modificationi

Phosphorylated by FAM20C in vitro.1 Publication
O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UX39.
PRIDEiQ6UX39.

PTM databases

iPTMnetiQ6UX39.

Expressioni

Gene expression databases

BgeeiQ6UX39.
CleanExiHS_AMTN.
ExpressionAtlasiQ6UX39. baseline and differential.

Organism-specific databases

HPAiHPA036136.
HPA036137.

Interactioni

Protein-protein interaction databases

BioGridi134946. 9 interactions.
STRINGi9606.ENSP00000341013.

Structurei

3D structure databases

ProteinModelPortaliQ6UX39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amelotin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZHR. Eukaryota.
ENOG41118MN. LUCA.
GeneTreeiENSGT00390000006715.
HOGENOMiHOG000033930.
HOVERGENiHBG080837.
InParanoidiQ6UX39.
OMAiIPLTQML.
OrthoDBiEOG77HDGM.
PhylomeDBiQ6UX39.
TreeFamiTF337677.

Family and domain databases

InterProiIPR031501. Amelotin.
[Graphical view]
PfamiPF15757. Amelotin. 1 hit.
[Graphical view]
ProDomiPD400414. PD400414. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSTILLFCL LGSTRSLPQL KPALGLPPTK LAPDQGTLPN QQQSNQVFPS
60 70 80 90 100
LSLIPLTQML TLGPDLHLLN PAAGMTPGTQ THPLTLGGLN VQQQLHPHVL
110 120 130 140 150
PIFVTQLGAQ GTILSSEELP QIFTSLIIHS LFPGGILPTS QAGANPDVQD
160 170 180 190 200
GSLPAGGAGV NPATQGTPAG RLPTPSGTDD DFAVTTPAGI QRSTHAIEEA

TTESANGIQ
Length:209
Mass (Da):21,588
Last modified:July 5, 2004 - v1
Checksum:i5DD8991674DB8457
GO
Isoform 2 (identifier: Q6UX39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):21,459
Checksum:iB1CE2E87F84854B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451N → S.
Corresponds to variant rs7660807 [ dbSNP | Ensembl ].
VAR_050661
Natural varianti50 – 501S → P.
Corresponds to variant rs34803339 [ dbSNP | Ensembl ].
VAR_050662
Natural varianti78 – 781G → S in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs151041998 [ dbSNP | Ensembl ].
VAR_035791

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 191Missing in isoform 2. 1 PublicationVSP_023919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358528 mRNA. Translation: AAQ88892.1.
BC121812 mRNA. Translation: AAI21813.1.
BC121817 mRNA. Translation: AAI21818.1.
CCDSiCCDS3542.1. [Q6UX39-1]
CCDS68716.1. [Q6UX39-2]
RefSeqiNP_001273660.1. NM_001286731.1. [Q6UX39-2]
NP_997722.1. NM_212557.3. [Q6UX39-1]
UniGeneiHs.453069.

Genome annotation databases

EnsembliENST00000339336; ENSP00000341013; ENSG00000187689. [Q6UX39-1]
ENST00000504451; ENSP00000422452; ENSG00000187689. [Q6UX39-2]
GeneIDi401138.
KEGGihsa:401138.
UCSCiuc003hfk.3. human. [Q6UX39-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358528 mRNA. Translation: AAQ88892.1.
BC121812 mRNA. Translation: AAI21813.1.
BC121817 mRNA. Translation: AAI21818.1.
CCDSiCCDS3542.1. [Q6UX39-1]
CCDS68716.1. [Q6UX39-2]
RefSeqiNP_001273660.1. NM_001286731.1. [Q6UX39-2]
NP_997722.1. NM_212557.3. [Q6UX39-1]
UniGeneiHs.453069.

3D structure databases

ProteinModelPortaliQ6UX39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134946. 9 interactions.
STRINGi9606.ENSP00000341013.

PTM databases

iPTMnetiQ6UX39.

Polymorphism and mutation databases

BioMutaiAMTN.
DMDMi55976710.

Proteomic databases

PaxDbiQ6UX39.
PRIDEiQ6UX39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339336; ENSP00000341013; ENSG00000187689. [Q6UX39-1]
ENST00000504451; ENSP00000422452; ENSG00000187689. [Q6UX39-2]
GeneIDi401138.
KEGGihsa:401138.
UCSCiuc003hfk.3. human. [Q6UX39-1]

Organism-specific databases

CTDi401138.
GeneCardsiAMTN.
HGNCiHGNC:33188. AMTN.
HPAiHPA036136.
HPA036137.
MIMi610912. gene.
neXtProtiNX_Q6UX39.
PharmGKBiPA162376390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZHR. Eukaryota.
ENOG41118MN. LUCA.
GeneTreeiENSGT00390000006715.
HOGENOMiHOG000033930.
HOVERGENiHBG080837.
InParanoidiQ6UX39.
OMAiIPLTQML.
OrthoDBiEOG77HDGM.
PhylomeDBiQ6UX39.
TreeFamiTF337677.

Miscellaneous databases

GenomeRNAii401138.
PROiQ6UX39.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UX39.
CleanExiHS_AMTN.
ExpressionAtlasiQ6UX39. baseline and differential.

Family and domain databases

InterProiIPR031501. Amelotin.
[Graphical view]
PfamiPF15757. Amelotin. 1 hit.
[Graphical view]
ProDomiPD400414. PD400414. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-31.
  4. "The enamel protein amelotin is a promoter of hydroxyapatite mineralization."
    Abbarin N., Miguel S.S., Holcroft J., Iwasaki K., Ganss B.
    J. Bone Miner. Res. 30:775-785(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "A secretory kinase complex regulates extracellular protein phosphorylation."
    Cui J., Xiao J., Tagliabracci V.S., Wen J., Rahdar M., Dixon J.E.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-78.

Entry informationi

Entry nameiAMTN_HUMAN
AccessioniPrimary (citable) accession number: Q6UX39
Secondary accession number(s): Q0P503, Q0P506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.