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Protein

Dehydrogenase/reductase SDR family member 13

Gene

DHRS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateSequence analysis1
Active sitei197Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 49NAD or NADPBy similarity7

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 13 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 7C member 51 Publication
Gene namesi
Name:DHRS13
Synonyms:SDR7C51 Publication
ORF Names:UNQ419/PRO853
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28326. DHRS13.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi147015.
OpenTargetsiENSG00000167536.
PharmGKBiPA147358144.

Polymorphism and mutation databases

BioMutaiDHRS13.
DMDMi74738164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031192026 – 377Dehydrogenase/reductase SDR family member 13Add BLAST352

Proteomic databases

EPDiQ6UX07.
MaxQBiQ6UX07.
PaxDbiQ6UX07.
PeptideAtlasiQ6UX07.
PRIDEiQ6UX07.
TopDownProteomicsiQ6UX07-1. [Q6UX07-1]

PTM databases

iPTMnetiQ6UX07.
PhosphoSitePlusiQ6UX07.

Expressioni

Gene expression databases

BgeeiENSG00000167536.
CleanExiHS_DHRS13.
GenevisibleiQ6UX07. HS.

Organism-specific databases

HPAiHPA022991.

Interactioni

Protein-protein interaction databases

BioGridi127030. 5 interactors.
IntActiQ6UX07. 1 interactor.
STRINGi9606.ENSP00000368173.

Structurei

3D structure databases

ProteinModelPortaliQ6UX07.
SMRiQ6UX07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ6UX07.
KOiK11169.
OMAiAPPCGGI.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ6UX07.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK
60 70 80 90 100
MTALELARRG ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA
110 120 130 140 150
SVRAFATAFL SSEPRLDILI HNAGISSCGR TREAFNLLLR VNHIGPFLLT
160 170 180 190 200
HLLLPCLKAC APSRVVVVAS AAHCRGRLDF KRLDRPVVGW RQELRAYADT
210 220 230 240 250
KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP GWLRPLLRPL
260 270 280 290 300
AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
310 320 330 340 350
HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY
360 370
PSPQSSPDLS KMTHRIQAKV EPEIQLS
Length:377
Mass (Da):40,849
Last modified:July 5, 2004 - v1
Checksum:i742688974BBDA564
GO
Isoform 2 (identifier: Q6UX07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:327
Mass (Da):35,846
Checksum:i31BAE68CEC40DA29
GO
Isoform 3 (identifier: Q6UX07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-123: Missing.

Show »
Length:296
Mass (Da):32,249
Checksum:iC92DD29B03CACEFB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037348191R → Q.Corresponds to variant rs2277666dbSNPEnsembl.1
Natural variantiVAR_037349336L → Q.Corresponds to variant rs4795472dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296401 – 50Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_05752943 – 123Missing in isoform 3. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358566 mRNA. Translation: AAQ88929.1.
AK296017 mRNA. Translation: BAG58787.1.
AC024267 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51159.1.
CH471159 Genomic DNA. Translation: EAW51153.1.
BC015582 mRNA. Translation: AAH15582.1.
CCDSiCCDS11246.2. [Q6UX07-1]
RefSeqiNP_653284.2. NM_144683.3. [Q6UX07-1]
UniGeneiHs.631760.

Genome annotation databases

EnsembliENST00000378895; ENSP00000368173; ENSG00000167536. [Q6UX07-1]
ENST00000394901; ENSP00000378361; ENSG00000167536. [Q6UX07-2]
ENST00000426464; ENSP00000412826; ENSG00000167536. [Q6UX07-3]
GeneIDi147015.
KEGGihsa:147015.
UCSCiuc002hdd.5. human. [Q6UX07-1]
uc010wba.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358566 mRNA. Translation: AAQ88929.1.
AK296017 mRNA. Translation: BAG58787.1.
AC024267 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51159.1.
CH471159 Genomic DNA. Translation: EAW51153.1.
BC015582 mRNA. Translation: AAH15582.1.
CCDSiCCDS11246.2. [Q6UX07-1]
RefSeqiNP_653284.2. NM_144683.3. [Q6UX07-1]
UniGeneiHs.631760.

3D structure databases

ProteinModelPortaliQ6UX07.
SMRiQ6UX07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127030. 5 interactors.
IntActiQ6UX07. 1 interactor.
STRINGi9606.ENSP00000368173.

PTM databases

iPTMnetiQ6UX07.
PhosphoSitePlusiQ6UX07.

Polymorphism and mutation databases

BioMutaiDHRS13.
DMDMi74738164.

Proteomic databases

EPDiQ6UX07.
MaxQBiQ6UX07.
PaxDbiQ6UX07.
PeptideAtlasiQ6UX07.
PRIDEiQ6UX07.
TopDownProteomicsiQ6UX07-1. [Q6UX07-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378895; ENSP00000368173; ENSG00000167536. [Q6UX07-1]
ENST00000394901; ENSP00000378361; ENSG00000167536. [Q6UX07-2]
ENST00000426464; ENSP00000412826; ENSG00000167536. [Q6UX07-3]
GeneIDi147015.
KEGGihsa:147015.
UCSCiuc002hdd.5. human. [Q6UX07-1]
uc010wba.3. human.

Organism-specific databases

CTDi147015.
DisGeNETi147015.
GeneCardsiDHRS13.
HGNCiHGNC:28326. DHRS13.
HPAiHPA022991.
MIMi616157. gene.
neXtProtiNX_Q6UX07.
OpenTargetsiENSG00000167536.
PharmGKBiPA147358144.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ6UX07.
KOiK11169.
OMAiAPPCGGI.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ6UX07.
TreeFamiTF105429.

Miscellaneous databases

GenomeRNAii147015.
PROiQ6UX07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167536.
CleanExiHS_DHRS13.
GenevisibleiQ6UX07. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHR13_HUMAN
AccessioniPrimary (citable) accession number: Q6UX07
Secondary accession number(s): B4DJC5, Q96BH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.