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Q6UX04

- CWC27_HUMAN

UniProt

Q6UX04 - CWC27_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

CWC27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: UniProtKB
    2. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
    Short name:
    PPIase CWC27
    Alternative name(s):
    Antigen NY-CO-10
    Serologically defined colon cancer antigen 10
    Gene namesi
    Name:CWC27
    Synonyms:SDCCAG10
    ORF Names:UNQ438/PRO871
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:10664. CWC27.

    Subcellular locationi

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35594.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 472471Peptidyl-prolyl cis-trans isomerase CWC27 homologPRO_0000313647Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    MaxQBiQ6UX04.
    PaxDbiQ6UX04.
    PRIDEiQ6UX04.

    PTM databases

    PhosphoSiteiQ6UX04.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UX04.
    BgeeiQ6UX04.
    CleanExiHS_SDCCAG10.
    GenevestigatoriQ6UX04.

    Organism-specific databases

    HPAiHPA020344.
    HPA024149.

    Interactioni

    Protein-protein interaction databases

    BioGridi115572. 11 interactions.
    IntActiQ6UX04. 5 interactions.
    MINTiMINT-4655166.
    STRINGi9606.ENSP00000370460.

    Structurei

    Secondary structure

    1
    472
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 196
    Beta strandi22 – 298
    Turni30 – 323
    Helixi34 – 4512
    Turni46 – 516
    Beta strandi56 – 583
    Turni59 – 613
    Beta strandi62 – 654
    Beta strandi70 – 734
    Beta strandi95 – 1017
    Beta strandi113 – 1186
    Helixi121 – 1233
    Turni124 – 1263
    Beta strandi129 – 1335
    Helixi135 – 1373
    Helixi138 – 1436
    Beta strandi155 – 1573
    Beta strandi160 – 1689

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HQ6X-ray1.75A8-173[»]
    ProteinModelPortaliQ6UX04.
    SMRiQ6UX04. Positions 8-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6UX04.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 166156PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili206 – 23025Sequence AnalysisAdd
    BLAST
    Coiled coili306 – 37772Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclophilin-type PPIase family.Curated
    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000161443.
    HOVERGENiHBG097993.
    InParanoidiQ6UX04.
    KOiK12737.
    OMAiANMQDED.
    OrthoDBiEOG7353XC.
    PhylomeDBiQ6UX04.
    TreeFamiTF105935.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UX04-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD    50
    NTIFHRVVPG FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA 100
    MANAGSHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLSEVDID 150
    DDERPHNPHK IKSCEVLFNP FDDIIPREIK RLKKEKPEEE VKKLKPKGTK 200
    NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPVVES 250
    EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA 300
    GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE 350
    APPDGAVAEY RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI 400
    AETPENDIPE TEVEDDEGWM SHVLQFEDKS RKVKDASMQD SDTFEIYDPR 450
    NPVNKRRREE SKKLMREKKE RR 472
    Length:472
    Mass (Da):53,847
    Last modified:July 5, 2004 - v1
    Checksum:iBB0102157083439D
    GO
    Isoform 2 (identifier: Q6UX04-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         385-391: TLALLNQ → DVTCTS
         392-472: Missing.

    Show »
    Length:390
    Mass (Da):43,989
    Checksum:i29010D816F06A71E
    GO

    Sequence cautioni

    The sequence AAC18041.1 differs from that shown. Reason: Frameshift at position 41.
    The sequence AAC18042.1 differs from that shown. Reason: Frameshift at position 136.
    The sequence AAH12117.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1122SQ → TH in AAC18041. (PubMed:9610721)Curated
    Sequence conflicti331 – 3311K → E in AAC18042. (PubMed:9610721)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561P → A.1 Publication
    Corresponds to variant rs7735338 [ dbSNP | Ensembl ].
    VAR_037686

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei385 – 3917TLALLNQ → DVTCTS in isoform 2. 1 PublicationVSP_030082
    Alternative sequencei392 – 47281Missing in isoform 2. 1 PublicationVSP_030083Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358569 mRNA. Translation: AAQ88932.1.
    CH471137 Genomic DNA. Translation: EAW51365.1.
    AF039692 mRNA. Translation: AAC18041.1. Frameshift.
    AF039693 mRNA. Translation: AAC18042.1. Frameshift.
    BC012117 mRNA. Translation: AAH12117.1. Different initiation.
    CCDSiCCDS3982.2. [Q6UX04-1]
    RefSeqiNP_005860.2. NM_005869.2. [Q6UX04-1]
    UniGeneiHs.371372.

    Genome annotation databases

    EnsembliENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
    GeneIDi10283.
    KEGGihsa:10283.
    UCSCiuc003jtm.3. human. [Q6UX04-1]
    uc010iwt.1. human. [Q6UX04-2]

    Polymorphism databases

    DMDMi74749411.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358569 mRNA. Translation: AAQ88932.1 .
    CH471137 Genomic DNA. Translation: EAW51365.1 .
    AF039692 mRNA. Translation: AAC18041.1 . Frameshift.
    AF039693 mRNA. Translation: AAC18042.1 . Frameshift.
    BC012117 mRNA. Translation: AAH12117.1 . Different initiation.
    CCDSi CCDS3982.2. [Q6UX04-1 ]
    RefSeqi NP_005860.2. NM_005869.2. [Q6UX04-1 ]
    UniGenei Hs.371372.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HQ6 X-ray 1.75 A 8-173 [» ]
    ProteinModelPortali Q6UX04.
    SMRi Q6UX04. Positions 8-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115572. 11 interactions.
    IntActi Q6UX04. 5 interactions.
    MINTi MINT-4655166.
    STRINGi 9606.ENSP00000370460.

    PTM databases

    PhosphoSitei Q6UX04.

    Polymorphism databases

    DMDMi 74749411.

    Proteomic databases

    MaxQBi Q6UX04.
    PaxDbi Q6UX04.
    PRIDEi Q6UX04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381070 ; ENSP00000370460 ; ENSG00000153015 . [Q6UX04-1 ]
    GeneIDi 10283.
    KEGGi hsa:10283.
    UCSCi uc003jtm.3. human. [Q6UX04-1 ]
    uc010iwt.1. human. [Q6UX04-2 ]

    Organism-specific databases

    CTDi 10283.
    GeneCardsi GC05P064064.
    HGNCi HGNC:10664. CWC27.
    HPAi HPA020344.
    HPA024149.
    neXtProti NX_Q6UX04.
    PharmGKBi PA35594.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000161443.
    HOVERGENi HBG097993.
    InParanoidi Q6UX04.
    KOi K12737.
    OMAi ANMQDED.
    OrthoDBi EOG7353XC.
    PhylomeDBi Q6UX04.
    TreeFami TF105935.

    Miscellaneous databases

    EvolutionaryTracei Q6UX04.
    GenomeRNAii 10283.
    NextBioi 38960.
    PROi Q6UX04.

    Gene expression databases

    ArrayExpressi Q6UX04.
    Bgeei Q6UX04.
    CleanExi HS_SDCCAG10.
    Genevestigatori Q6UX04.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human colon cancer antigens recognized by autologous antibodies."
      Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.
      Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-256.
      Tissue: Colon carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-201.
      Tissue: Plasma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCWC27_HUMAN
    AccessioniPrimary (citable) accession number: Q6UX04
    Secondary accession number(s): O60529, O60530, Q96EM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3