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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

CWC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
  • protein folding Source: InterPro
  • protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BRENDAi5.2.1.8. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Alternative name(s):
Antigen NY-CO-10
Serologically defined colon cancer antigen 10
Gene namesi
Name:CWC27
Synonyms:SDCCAG10
ORF Names:UNQ438/PRO871
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10664. CWC27.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35594.

Polymorphism and mutation databases

BioMutaiCWC27.
DMDMi74749411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 472471Peptidyl-prolyl cis-trans isomerase CWC27 homologPRO_0000313647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi201 – 2011N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiQ6UX04.
PaxDbiQ6UX04.
PRIDEiQ6UX04.

PTM databases

PhosphoSiteiQ6UX04.

Expressioni

Gene expression databases

BgeeiQ6UX04.
CleanExiHS_SDCCAG10.
ExpressionAtlasiQ6UX04. baseline and differential.
GenevestigatoriQ6UX04.

Organism-specific databases

HPAiHPA020344.
HPA024149.

Interactioni

Protein-protein interaction databases

BioGridi115572. 12 interactions.
IntActiQ6UX04. 5 interactions.
MINTiMINT-4655166.
STRINGi9606.ENSP00000370460.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 196Combined sources
Beta strandi22 – 298Combined sources
Turni30 – 323Combined sources
Helixi34 – 4512Combined sources
Turni46 – 516Combined sources
Beta strandi56 – 583Combined sources
Turni59 – 613Combined sources
Beta strandi62 – 654Combined sources
Beta strandi70 – 734Combined sources
Beta strandi95 – 1017Combined sources
Beta strandi113 – 1186Combined sources
Helixi121 – 1233Combined sources
Turni124 – 1263Combined sources
Beta strandi129 – 1335Combined sources
Helixi135 – 1373Combined sources
Helixi138 – 1436Combined sources
Helixi151 – 1533Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi160 – 1689Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HQ6X-ray1.75A8-173[»]
4R3EX-ray2.00A1-178[»]
ProteinModelPortaliQ6UX04.
SMRiQ6UX04. Positions 6-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UX04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 166156PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili206 – 23025Sequence AnalysisAdd
BLAST
Coiled coili306 – 37772Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0652.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ6UX04.
KOiK12737.
OMAiFNMLKLE.
OrthoDBiEOG7353XC.
PhylomeDBiQ6UX04.
TreeFamiTF105935.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGSHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLSEVDID
160 170 180 190 200
DDERPHNPHK IKSCEVLFNP FDDIIPREIK RLKKEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPVVES
260 270 280 290 300
EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA
310 320 330 340 350
GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE
360 370 380 390 400
APPDGAVAEY RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI
410 420 430 440 450
AETPENDIPE TEVEDDEGWM SHVLQFEDKS RKVKDASMQD SDTFEIYDPR
460 470
NPVNKRRREE SKKLMREKKE RR
Length:472
Mass (Da):53,847
Last modified:July 5, 2004 - v1
Checksum:iBB0102157083439D
GO
Isoform 2 (identifier: Q6UX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-391: TLALLNQ → DVTCTS
     392-472: Missing.

Show »
Length:390
Mass (Da):43,989
Checksum:i29010D816F06A71E
GO

Sequence cautioni

The sequence AAC18041.1 differs from that shown. Reason: Frameshift at position 41. Curated
The sequence AAC18042.1 differs from that shown. Reason: Frameshift at position 136. Curated
The sequence AAH12117.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1122SQ → TH in AAC18041 (PubMed:9610721).Curated
Sequence conflicti331 – 3311K → E in AAC18042 (PubMed:9610721).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561P → A.1 Publication
Corresponds to variant rs7735338 [ dbSNP | Ensembl ].
VAR_037686

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei385 – 3917TLALLNQ → DVTCTS in isoform 2. 1 PublicationVSP_030082
Alternative sequencei392 – 47281Missing in isoform 2. 1 PublicationVSP_030083Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358569 mRNA. Translation: AAQ88932.1.
CH471137 Genomic DNA. Translation: EAW51365.1.
AF039692 mRNA. Translation: AAC18041.1. Frameshift.
AF039693 mRNA. Translation: AAC18042.1. Frameshift.
BC012117 mRNA. Translation: AAH12117.1. Different initiation.
CCDSiCCDS3982.2. [Q6UX04-1]
RefSeqiNP_001284573.1. NM_001297644.1.
NP_001284574.1. NM_001297645.1.
NP_005860.2. NM_005869.3. [Q6UX04-1]
UniGeneiHs.371372.

Genome annotation databases

EnsembliENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
GeneIDi10283.
KEGGihsa:10283.
UCSCiuc003jtm.3. human. [Q6UX04-1]
uc010iwt.1. human. [Q6UX04-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358569 mRNA. Translation: AAQ88932.1.
CH471137 Genomic DNA. Translation: EAW51365.1.
AF039692 mRNA. Translation: AAC18041.1. Frameshift.
AF039693 mRNA. Translation: AAC18042.1. Frameshift.
BC012117 mRNA. Translation: AAH12117.1. Different initiation.
CCDSiCCDS3982.2. [Q6UX04-1]
RefSeqiNP_001284573.1. NM_001297644.1.
NP_001284574.1. NM_001297645.1.
NP_005860.2. NM_005869.3. [Q6UX04-1]
UniGeneiHs.371372.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HQ6X-ray1.75A8-173[»]
4R3EX-ray2.00A1-178[»]
ProteinModelPortaliQ6UX04.
SMRiQ6UX04. Positions 6-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115572. 12 interactions.
IntActiQ6UX04. 5 interactions.
MINTiMINT-4655166.
STRINGi9606.ENSP00000370460.

PTM databases

PhosphoSiteiQ6UX04.

Polymorphism and mutation databases

BioMutaiCWC27.
DMDMi74749411.

Proteomic databases

MaxQBiQ6UX04.
PaxDbiQ6UX04.
PRIDEiQ6UX04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
GeneIDi10283.
KEGGihsa:10283.
UCSCiuc003jtm.3. human. [Q6UX04-1]
uc010iwt.1. human. [Q6UX04-2]

Organism-specific databases

CTDi10283.
GeneCardsiGC05P064064.
HGNCiHGNC:10664. CWC27.
HPAiHPA020344.
HPA024149.
neXtProtiNX_Q6UX04.
PharmGKBiPA35594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0652.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ6UX04.
KOiK12737.
OMAiFNMLKLE.
OrthoDBiEOG7353XC.
PhylomeDBiQ6UX04.
TreeFamiTF105935.

Enzyme and pathway databases

BRENDAi5.2.1.8. 2681.

Miscellaneous databases

ChiTaRSiCWC27. human.
EvolutionaryTraceiQ6UX04.
GenomeRNAii10283.
NextBioi38960.
PROiQ6UX04.

Gene expression databases

BgeeiQ6UX04.
CleanExiHS_SDCCAG10.
ExpressionAtlasiQ6UX04. baseline and differential.
GenevestigatoriQ6UX04.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human colon cancer antigens recognized by autologous antibodies."
    Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.
    Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-256.
    Tissue: Colon carcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-201.
    Tissue: Plasma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCWC27_HUMAN
AccessioniPrimary (citable) accession number: Q6UX04
Secondary accession number(s): O60529, O60530, Q96EM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.