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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

CWC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciZFISH:HS07872-MONOMER.
BRENDAi5.2.1.8. 2681.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Alternative name(s):
Antigen NY-CO-10
Serologically defined colon cancer antigen 10
Gene namesi
Name:CWC27
Synonyms:SDCCAG10
ORF Names:UNQ438/PRO871
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10664. CWC27.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10283.
OpenTargetsiENSG00000153015.
PharmGKBiPA35594.

Polymorphism and mutation databases

BioMutaiCWC27.
DMDMi74749411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003136472 – 472Peptidyl-prolyl cis-trans isomerase CWC27 homologAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi201N-linked (GlcNAc...)1 Publication1
Modified residuei346PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6UX04.
MaxQBiQ6UX04.
PaxDbiQ6UX04.
PeptideAtlasiQ6UX04.
PRIDEiQ6UX04.

PTM databases

iPTMnetiQ6UX04.
PhosphoSitePlusiQ6UX04.

Expressioni

Gene expression databases

BgeeiENSG00000153015.
CleanExiHS_SDCCAG10.
ExpressionAtlasiQ6UX04. baseline and differential.
GenevisibleiQ6UX04. HS.

Organism-specific databases

HPAiHPA020344.
HPA024149.
HPA065809.

Interactioni

Protein-protein interaction databases

BioGridi115572. 19 interactors.
IntActiQ6UX04. 6 interactors.
MINTiMINT-4655166.
STRINGi9606.ENSP00000370460.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 19Combined sources6
Beta strandi22 – 29Combined sources8
Turni30 – 32Combined sources3
Helixi34 – 45Combined sources12
Turni46 – 51Combined sources6
Beta strandi56 – 58Combined sources3
Turni59 – 61Combined sources3
Beta strandi62 – 65Combined sources4
Beta strandi70 – 73Combined sources4
Beta strandi95 – 101Combined sources7
Beta strandi113 – 118Combined sources6
Helixi121 – 123Combined sources3
Turni124 – 126Combined sources3
Beta strandi129 – 133Combined sources5
Helixi135 – 137Combined sources3
Helixi138 – 143Combined sources6
Helixi151 – 153Combined sources3
Beta strandi155 – 157Combined sources3
Beta strandi160 – 168Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HQ6X-ray1.75A8-173[»]
4R3EX-ray2.00A1-178[»]
ProteinModelPortaliQ6UX04.
SMRiQ6UX04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UX04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 230Sequence analysisAdd BLAST25
Coiled coili306 – 377Sequence analysisAdd BLAST72

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ6UX04.
KOiK12737.
OMAiSENHYIN.
OrthoDBiEOG091G0BVF.
PhylomeDBiQ6UX04.
TreeFamiTF105935.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGSHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLSEVDID
160 170 180 190 200
DDERPHNPHK IKSCEVLFNP FDDIIPREIK RLKKEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPVVES
260 270 280 290 300
EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA
310 320 330 340 350
GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE
360 370 380 390 400
APPDGAVAEY RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI
410 420 430 440 450
AETPENDIPE TEVEDDEGWM SHVLQFEDKS RKVKDASMQD SDTFEIYDPR
460 470
NPVNKRRREE SKKLMREKKE RR
Length:472
Mass (Da):53,847
Last modified:July 5, 2004 - v1
Checksum:iBB0102157083439D
GO
Isoform 2 (identifier: Q6UX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-391: TLALLNQ → DVTCTS
     392-472: Missing.

Show »
Length:390
Mass (Da):43,989
Checksum:i29010D816F06A71E
GO

Sequence cautioni

The sequence AAC18041 differs from that shown. Reason: Frameshift at position 41.Curated
The sequence AAC18042 differs from that shown. Reason: Frameshift at position 136.Curated
The sequence AAH12117 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 112SQ → TH in AAC18041 (PubMed:9610721).Curated2
Sequence conflicti331K → E in AAC18042 (PubMed:9610721).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037686256P → A.1 PublicationCorresponds to variant rs7735338dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030082385 – 391TLALLNQ → DVTCTS in isoform 2. 1 Publication7
Alternative sequenceiVSP_030083392 – 472Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358569 mRNA. Translation: AAQ88932.1.
CH471137 Genomic DNA. Translation: EAW51365.1.
AF039692 mRNA. Translation: AAC18041.1. Frameshift.
AF039693 mRNA. Translation: AAC18042.1. Frameshift.
BC012117 mRNA. Translation: AAH12117.1. Different initiation.
CCDSiCCDS3982.2. [Q6UX04-1]
RefSeqiNP_001284573.1. NM_001297644.1.
NP_001284574.1. NM_001297645.1.
NP_005860.2. NM_005869.3. [Q6UX04-1]
UniGeneiHs.371372.

Genome annotation databases

EnsembliENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
GeneIDi10283.
KEGGihsa:10283.
UCSCiuc003jtn.2. human. [Q6UX04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358569 mRNA. Translation: AAQ88932.1.
CH471137 Genomic DNA. Translation: EAW51365.1.
AF039692 mRNA. Translation: AAC18041.1. Frameshift.
AF039693 mRNA. Translation: AAC18042.1. Frameshift.
BC012117 mRNA. Translation: AAH12117.1. Different initiation.
CCDSiCCDS3982.2. [Q6UX04-1]
RefSeqiNP_001284573.1. NM_001297644.1.
NP_001284574.1. NM_001297645.1.
NP_005860.2. NM_005869.3. [Q6UX04-1]
UniGeneiHs.371372.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HQ6X-ray1.75A8-173[»]
4R3EX-ray2.00A1-178[»]
ProteinModelPortaliQ6UX04.
SMRiQ6UX04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115572. 19 interactors.
IntActiQ6UX04. 6 interactors.
MINTiMINT-4655166.
STRINGi9606.ENSP00000370460.

PTM databases

iPTMnetiQ6UX04.
PhosphoSitePlusiQ6UX04.

Polymorphism and mutation databases

BioMutaiCWC27.
DMDMi74749411.

Proteomic databases

EPDiQ6UX04.
MaxQBiQ6UX04.
PaxDbiQ6UX04.
PeptideAtlasiQ6UX04.
PRIDEiQ6UX04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
GeneIDi10283.
KEGGihsa:10283.
UCSCiuc003jtn.2. human. [Q6UX04-1]

Organism-specific databases

CTDi10283.
DisGeNETi10283.
GeneCardsiCWC27.
HGNCiHGNC:10664. CWC27.
HPAiHPA020344.
HPA024149.
HPA065809.
neXtProtiNX_Q6UX04.
OpenTargetsiENSG00000153015.
PharmGKBiPA35594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ6UX04.
KOiK12737.
OMAiSENHYIN.
OrthoDBiEOG091G0BVF.
PhylomeDBiQ6UX04.
TreeFamiTF105935.

Enzyme and pathway databases

BioCyciZFISH:HS07872-MONOMER.
BRENDAi5.2.1.8. 2681.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiCWC27. human.
EvolutionaryTraceiQ6UX04.
GenomeRNAii10283.
PROiQ6UX04.

Gene expression databases

BgeeiENSG00000153015.
CleanExiHS_SDCCAG10.
ExpressionAtlasiQ6UX04. baseline and differential.
GenevisibleiQ6UX04. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCWC27_HUMAN
AccessioniPrimary (citable) accession number: Q6UX04
Secondary accession number(s): O60529, O60530, Q96EM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.