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Q6UX04 (CWC27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Short name=PPIase CWC27
EC=5.2.1.8
Alternative name(s):
Antigen NY-CO-10
Serologically defined colon cancer antigen 10
Gene names
Name:CWC27
Synonyms:SDCCAG10
ORF Names:UNQ438/PRO871
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Sequence similarities

Belongs to the cyclophilin-type PPIase family.

Contains 1 PPIase cyclophilin-type domain.

Sequence caution

The sequence AAC18041.1 differs from that shown. Reason: Frameshift at position 41.

The sequence AAC18042.1 differs from that shown. Reason: Frameshift at position 136.

The sequence AAH12117.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Molecular functionIsomerase
Rotamase
   PTMAcetylation
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA splicing, via spliceosome

Inferred by curator PubMed 11991638. Source: UniProtKB

protein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcatalytic step 2 spliceosome

Inferred from direct assay PubMed 11991638. Source: UniProtKB

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UX04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UX04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     385-391: TLALLNQ → DVTCTS
     392-472: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 472471Peptidyl-prolyl cis-trans isomerase CWC27 homolog
PRO_0000313647

Regions

Domain11 – 166156PPIase cyclophilin-type
Coiled coil206 – 23025 Potential
Coiled coil306 – 37772 Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.6
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Ref.5

Natural variations

Alternative sequence385 – 3917TLALLNQ → DVTCTS in isoform 2.
VSP_030082
Alternative sequence392 – 47281Missing in isoform 2.
VSP_030083
Natural variant2561P → A. Ref.1
Corresponds to variant rs7735338 [ dbSNP | Ensembl ].
VAR_037686

Experimental info

Sequence conflict111 – 1122SQ → TH in AAC18041. Ref.1
Sequence conflict3311K → E in AAC18042. Ref.1

Secondary structure

............................... 472
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BB0102157083439D

FASTA47253,847
        10         20         30         40         50         60 
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD NTIFHRVVPG 

        70         80         90        100        110        120 
FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA MANAGSHDNG SQFFFTLGRA 

       130        140        150        160        170        180 
DELNNKHTIF GKVTGDTVYN MLRLSEVDID DDERPHNPHK IKSCEVLFNP FDDIIPREIK 

       190        200        210        220        230        240 
RLKKEKPEEE VKKLKPKGTK NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP 

       250        260        270        280        290        300 
HLSSVPVVES EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA 

       310        320        330        340        350        360 
GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE APPDGAVAEY 

       370        380        390        400        410        420 
RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI AETPENDIPE TEVEDDEGWM 

       430        440        450        460        470 
SHVLQFEDKS RKVKDASMQD SDTFEIYDPR NPVNKRRREE SKKLMREKKE RR 

« Hide

Isoform 2 [UniParc].

Checksum: 29010D816F06A71E
Show »

FASTA39043,989

References

« Hide 'large scale' references
[1]"Characterization of human colon cancer antigens recognized by autologous antibodies."
Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.
Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-256.
Tissue: Colon carcinoma.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[5]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-201.
Tissue: Plasma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358569 mRNA. Translation: AAQ88932.1.
CH471137 Genomic DNA. Translation: EAW51365.1.
AF039692 mRNA. Translation: AAC18041.1. Frameshift.
AF039693 mRNA. Translation: AAC18042.1. Frameshift.
BC012117 mRNA. Translation: AAH12117.1. Different initiation.
RefSeqNP_005860.2. NM_005869.2.
UniGeneHs.371372.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HQ6X-ray1.75A8-173[»]
ProteinModelPortalQ6UX04.
SMRQ6UX04. Positions 8-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115572. 11 interactions.
IntActQ6UX04. 5 interactions.
MINTMINT-4655166.
STRING9606.ENSP00000370460.

PTM databases

PhosphoSiteQ6UX04.

Polymorphism databases

DMDM74749411.

Proteomic databases

PaxDbQ6UX04.
PRIDEQ6UX04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381070; ENSP00000370460; ENSG00000153015. [Q6UX04-1]
GeneID10283.
KEGGhsa:10283.
UCSCuc003jtm.3. human. [Q6UX04-1]
uc010iwt.1. human. [Q6UX04-2]

Organism-specific databases

CTD10283.
GeneCardsGC05P064064.
HGNCHGNC:10664. CWC27.
HPAHPA020344.
HPA024149.
neXtProtNX_Q6UX04.
PharmGKBPA35594.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0652.
HOGENOMHOG000161443.
HOVERGENHBG097993.
InParanoidQ6UX04.
KOK12737.
OMAANMQDED.
OrthoDBEOG7353XC.
PhylomeDBQ6UX04.
TreeFamTF105935.

Gene expression databases

ArrayExpressQ6UX04.
BgeeQ6UX04.
CleanExHS_SDCCAG10.
GenevestigatorQ6UX04.

Family and domain databases

InterProIPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSPR00153. CSAPPISMRASE.
PROSITEPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ6UX04.
GenomeRNAi10283.
NextBio38960.
PROQ6UX04.

Entry information

Entry nameCWC27_HUMAN
AccessionPrimary (citable) accession number: Q6UX04
Secondary accession number(s): O60529, O60530, Q96EM3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM