Q6UX01 (LMBRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LMBR1L

Alternative name(s):
Limb region 1 protein homolog-like
Lipocalin-1-interacting membrane receptor
Short name=Lipocalin-interacting membrane receptor

Gene names

Name:	LMBR1L
Synonyms:	KIAA1174, LIMR
ORF Names:	UNQ458/PRO783

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable LCN1 receptor. May mediate LCN1 endocytosis. Ref.1 Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate. Ref.1
Developmental stage	Expressed in fetal kidney and lung. Ref.1
Sequence similarities	Belongs to the LIMR family.
Sequence caution	The sequence BAA86488.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UX01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UX01-2)

The sequence of this isoform differs from the canonical sequence as follows:
     53-54: Missing.

Isoform 3 (identifier: Q6UX01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     336-355: Missing.

Isoform 4 (identifier: Q6UX01-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MEAPDYEVLS...RFKKPAEFTT → MVNVKALCEP...PETSLMTGEP

Isoform 5 (identifier: Q6UX01-5)

The sequence of this isoform differs from the canonical sequence as follows:
     363-393: LMVSSVVGFYSSPLFRSLRPRWHDTAMTQII → PSGNPSLPLFSKPVSWDSRPSTSWTLSPLGL
     394-489: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Protein LMBR1L		PRO_0000053910
Regions
	Topological domain	1 – 21	21	Extracellular Potential
	Transmembrane	22 – 42	21	Helical; Potential
	Topological domain	43 – 66	24	Cytoplasmic Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Topological domain	88 – 114	27	Extracellular Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Topological domain	176 – 196	21	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Topological domain	218 – 305	88	Cytoplasmic Potential
	Transmembrane	306 – 326	21	Helical; Potential
	Topological domain	327 – 350	24	Extracellular Potential
	Transmembrane	351 – 371	21	Helical; Potential
	Topological domain	372 – 388	17	Cytoplasmic Potential
	Transmembrane	389 – 409	21	Helical; Potential
	Topological domain	410 – 431	22	Extracellular Potential
	Transmembrane	432 – 452	21	Helical; Potential
	Topological domain	453 – 489	37	Cytoplasmic Potential
	Region	1 – 76	76	LCN1-binding
Natural variations
	Alternative sequence	1 – 52	52	MEAPD…AEFTT → MVNVKALCEPEVSNCWMNVI TGTGSVSSPLLVLPQPGPET SLMTGEP in isoform 4.		VSP_016892
	Alternative sequence	53 – 54	2	Missing in isoform 2.		VSP_016893
	Alternative sequence	336 – 355	20	Missing in isoform 3.		VSP_016894
	Alternative sequence	363 – 393	31	LMVSS…MTQII → PSGNPSLPLFSKPVSWDSRP STSWTLSPLGL in isoform 5.		VSP_016895
	Alternative sequence	394 – 489	96	Missing in isoform 5.		VSP_016896
Experimental info
	Sequence conflict	11	1	V → A in BAA91811. Ref.4
	Sequence conflict	120	1	S → P in AAQ88935. Ref.3
	Sequence conflict	157	1	M → T in BAA91646. Ref.4
	Sequence conflict	211	1	V → L in AAH08337. Ref.5
	Sequence conflict	334	1	G → V in BAA91646. Ref.4
	Sequence conflict	361	1	F → L in BAA86488. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 80D169C977F182E2	FASTA	489	55,209
	10 20 30 40 50 60 MEAPDYEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTVDDEDATV 70 80 90 100 110 120 NKIALELCTF TLAIALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS 130 140 150 160 170 180 NLSLIFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLML LTLLVLGMVW VASAIVDKNK 190 200 210 220 230 240 ANRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ 250 260 270 280 290 300 LYCSAFEEAA LTRRICNPTS CWLPLDMELL HRQVLALQTQ RVLLEKRRKA SAWQRNLGYP 310 320 330 340 350 360 LAMLCLLVLT GLSVLIVAIH ILELLIDEAA MPRGMQGTSL GQVSFSKLGS FGAVIQVVLI 370 380 390 400 410 420 FYLMVSSVVG FYSSPLFRSL RPRWHDTAMT QIIGNCVCLL VLSSALPVFS RTLGLTRFDL 430 440 450 460 470 480 LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC LVKTFTAAVR AELIRAFGLD RLPLPVSGFP QASRKTQHQ
	Isoform 2 [UniParc]. Checksum: C98C4510D10E9042	FASTA	487	54,995
	10 20 30 40 50 60 MEAPDYEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTDEDATVNK 70 80 90 100 110 120 IALELCTFTL AIALGAVLLL PFSIISNEVL LSLPRNYYIQ WLNGSLIHGL WNLVFLFSNL 130 140 150 160 170 180 SLIFLMPFAY FFTESEGFAG SRKGVLGRVY ETVVMLMLLT LLVLGMVWVA SAIVDKNKAN 190 200 210 220 230 240 RESLYDFWEY YLPYLYSCIS FLGVLLLLVC TPLGLARMFS VTGKLLVKPR LLEDLEEQLY 250 260 270 280 290 300 CSAFEEAALT RRICNPTSCW LPLDMELLHR QVLALQTQRV LLEKRRKASA WQRNLGYPLA 310 320 330 340 350 360 MLCLLVLTGL SVLIVAIHIL ELLIDEAAMP RGMQGTSLGQ VSFSKLGSFG AVIQVVLIFY 370 380 390 400 410 420 LMVSSVVGFY SSPLFRSLRP RWHDTAMTQI IGNCVCLLVL SSALPVFSRT LGLTRFDLLG 430 440 450 460 470 480 DFGRFNWLGN FYIVFLYNAA FAGLTTLCLV KTFTAAVRAE LIRAFGLDRL PLPVSGFPQA SRKTQHQ
	Isoform 3 [UniParc]. Checksum: 49FB3525632D3335	FASTA	469	53,244
	10 20 30 40 50 60 MEAPDYEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTVDDEDATV 70 80 90 100 110 120 NKIALELCTF TLAIALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS 130 140 150 160 170 180 NLSLIFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLML LTLLVLGMVW VASAIVDKNK 190 200 210 220 230 240 ANRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ 250 260 270 280 290 300 LYCSAFEEAA LTRRICNPTS CWLPLDMELL HRQVLALQTQ RVLLEKRRKA SAWQRNLGYP 310 320 330 340 350 360 LAMLCLLVLT GLSVLIVAIH ILELLIDEAA MPRGMQVVLI FYLMVSSVVG FYSSPLFRSL 370 380 390 400 410 420 RPRWHDTAMT QIIGNCVCLL VLSSALPVFS RTLGLTRFDL LGDFGRFNWL GNFYIVFLYN 430 440 450 460 AAFAGLTTLC LVKTFTAAVR AELIRAFGLD RLPLPVSGFP QASRKTQHQ
	Isoform 4 [UniParc]. Checksum: 285F0F2180A084E5	FASTA	484	53,890
	10 20 30 40 50 60 MVNVKALCEP EVSNCWMNVI TGTGSVSSPL LVLPQPGPET SLMTGEPVDD EDATVNKIAL 70 80 90 100 110 120 ELCTFTLAIA LGAVLLLPFS IISNEVLLSL PRNYYIQWLN GSLIHGLWNL VFLFSNLSLI 130 140 150 160 170 180 FLMPFAYFFT ESEGFAGSRK GVLGRVYETV VMLMLLTLLV LGMVWVASAI VDKNKANRES 190 200 210 220 230 240 LYDFWEYYLP YLYSCISFLG VLLLLVCTPL GLARMFSVTG KLLVKPRLLE DLEEQLYCSA 250 260 270 280 290 300 FEEAALTRRI CNPTSCWLPL DMELLHRQVL ALQTQRVLLE KRRKASAWQR NLGYPLAMLC 310 320 330 340 350 360 LLVLTGLSVL IVAIHILELL IDEAAMPRGM QGTSLGQVSF SKLGSFGAVI QVVLIFYLMV 370 380 390 400 410 420 SSVVGFYSSP LFRSLRPRWH DTAMTQIIGN CVCLLVLSSA LPVFSRTLGL TRFDLLGDFG 430 440 450 460 470 480 RFNWLGNFYI VFLYNAAFAG LTTLCLVKTF TAAVRAELIR AFGLDRLPLP VSGFPQASRK TQHQ
	Isoform 5 [UniParc]. Checksum: 3F3D73D213863E3A	FASTA	393	44,358
	10 20 30 40 50 60 MEAPDYEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTVDDEDATV 70 80 90 100 110 120 NKIALELCTF TLAIALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS 130 140 150 160 170 180 NLSLIFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLML LTLLVLGMVW VASAIVDKNK 190 200 210 220 230 240 ANRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ 250 260 270 280 290 300 LYCSAFEEAA LTRRICNPTS CWLPLDMELL HRQVLALQTQ RVLLEKRRKA SAWQRNLGYP 310 320 330 340 350 360 LAMLCLLVLT GLSVLIVAIH ILELLIDEAA MPRGMQGTSL GQVSFSKLGS FGAVIQVVLI 370 380 390 FYPSGNPSLP LFSKPVSWDS RPSTSWTLSP LGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display." Wojnar P., Lechner M., Merschak P., Redl B. J. Biol. Chem. 276:20206-20212(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), FUNCTION, TOPOLOGY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE. Tissue: Pituitary.
[2]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Teratocarcinoma.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Kidney and Uterus.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-489 (ISOFORMS 1/2/4). Tissue: Testis.
[7]	"Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells." Wojnar P., Lechner M., Redl B. J. Biol. Chem. 278:16209-16215(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF260728 mRNA. Translation: AAK60600.1. AF351620 Genomic DNA. Translation: AAK63067.1. AB033000 mRNA. Translation: BAA86488.1. Different initiation. AY358572 mRNA. Translation: AAQ88935.1. AK001356 mRNA. Translation: BAA91646.1. AK001651 mRNA. Translation: BAA91811.1. BC008337 mRNA. Translation: AAH08337.1. BC015015 mRNA. Translation: AAH15015.1. BC031550 mRNA. Translation: AAH31550.1. AL137599 mRNA. Translation: CAB70835.1.
IPI	IPI00018238. IPI00186336. IPI00386768. IPI00642776. IPI00657654.
PIR	T46306.
RefSeq	NP_060583.2. NM_018113.2.
UniGene	Hs.272838.
3D structure databases
ProteinModelPortal	Q6UX01.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000267102.
Polymorphism databases
DMDM	85681040.
Proteomic databases
PaxDb	Q6UX01.
PRIDE	Q6UX01.
Protocols and materials databases
DNASU	55716.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000267102; ENSP00000267102; ENSG00000139636. ENST00000395141; ENSP00000378573; ENSG00000139636. ENST00000547382; ENSP00000447329; ENSG00000139636.
GeneID	55716.
KEGG	hsa:55716.
UCSC	uc001rtg.4. human. uc001rth.4. human. uc001rti.4. human. uc009zld.1. human.
Organism-specific databases
CTD	55716.
GeneCards	GC12M049490.
H-InvDB	HIX0010593.
HGNC	HGNC:18268. LMBR1L.
MIM	610007. gene.
neXtProt	NX_Q6UX01.
PharmGKB	PA142671545.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246746.
HOVERGEN	HBG072983.
InParanoid	Q6UX01.
OMA	RVYETFT.
OrthoDB	EOG4XWFXS.
PhylomeDB	Q6UX01.
Gene expression databases
ArrayExpress	Q6UX01.
Bgee	Q6UX01.
CleanEx	HS_LMBR1L.
Genevestigator	Q6UX01.
GermOnline	ENSG00000139636. Homo sapiens.
Family and domain databases
InterPro	IPR008075. Lipcalin_1_rcpt. IPR006876. LMBR1-like_membr_prot. [Graphical view]
Pfam	PF04791. LMBR1. 1 hit. [Graphical view]
PRINTS	PR01692. LIPOCALINIMR.
ProtoNet	Search...
Other
GenomeRNAi	55716.
NextBio	60603.
SOURCE	Search...

Entry information

Entry name

LMBRL_HUMAN

Accession

Primary (citable) accession number: Q6UX01
Secondary accession number(s): Q969J4 , Q96BY8, Q96HN8, Q9NT09, Q9NVE1, Q9NVU9, Q9ULP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.