Q6UWY5 (OLFL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactomedin-like protein 1

Gene names

Name:	OLFML1
ORF Names:	UNQ564/PRO1126

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Ref.6.
Tissue specificity	Mainly expressed in the small intestine, liver, lung and heart. Ref.6
Post-translational modification	Highly N-glycosylated. Ref.6
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Ref.5
	Chain	29 – 402	374	Olfactomedin-like protein 1		PRO_0000020090
Regions
	Domain	140 – 397	258	Olfactomedin-like
	Coiled coil	79 – 133	55	Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Disulfide bond	141 ↔ 324		By similarity
Natural variations
	Natural variant	113	1	E → V. Ref.1 Ref.3 Ref.4 Corresponds to variant rs12805648 [ dbSNP | Ensembl ].		VAR_034362
	Natural variant	259	1	A → T. Corresponds to variant rs12803046 [ dbSNP | Ensembl ].		VAR_034363

Sequences

	Sequence		Length	Mass (Da)
	Q6UWY5 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: FB767C162E8D14D0	FASTA	402	45,951
	10 20 30 40 50 60 MMVALRGASA LLVLFLAAFL PPPQCTQDPA MVHYIYQRFR VLEQGLEKCT QATRAYIQEF 70 80 90 100 110 120 QEFSKNISVM LGRCQTYTSE YKSAVGNLAL RVERAQREID YIQYLREADE CIESEDKTLA 130 140 150 160 170 180 EMLLQEAEEE KKIRTLLNAS CDNMLMGIKS LKIVKKMMDT HGSWMKDAVY NSPKVYLLIG 190 200 210 220 230 240 SRNNTVWEFA NIRAFMEDNT KPAPRKQILT LSWQGTGQVI YKGFLFFHNQ ATSNEIIKYN 250 260 270 280 290 300 LQKRTVEDRM LLPGGVGRAL VYQHSPSTYI DLAVDEHGLW AIHSGPGTHS HLVLTKIEPG 310 320 330 340 350 360 TLGVEHSWDT PCRSQDAEAS FLLCGVLYVV YSTGGQGPHR ITCIYDPLGT ISEEDLPNLF 370 380 390 400 FPKRPRSHSM IHYNPRDKQL YAWNEGNQII YKLQTKRKLP LK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-113.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-113.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-113. Tissue: Pancreas and Placenta.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-43.
[6]	"hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro." Wan B., Zhou Y.B., Zhang X., Zhu H., Huo K., Han Z.G. FEBS Lett. 582:3185-3192(2008) [PubMed: 18708057] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358591 mRNA. Translation: AAQ88954.1. AK298137 mRNA. Translation: BAG60415.1. AC107884 Genomic DNA. No translation available. BC035895 mRNA. Translation: AAH35895.1. BC092488 mRNA. Translation: AAH92488.1.
IPI	IPI00394820.
RefSeq	NP_940876.2. NM_198474.3.
UniGene	Hs.503500.
3D structure databases
ProteinModelPortal	Q6UWY5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UWY5.
PTM databases
PhosphoSite	Q6UWY5.
Polymorphism databases
DMDM	308153468.
Proteomic databases
PRIDE	Q6UWY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329293; ENSP00000332511; ENSG00000183801.
GeneID	283298.
KEGG	hsa:283298.
UCSC	uc001mfi.1. human.
Organism-specific databases
CTD	283298.
GeneCards	GC11P007463.
H-InvDB	HIX0026180.
HGNC	HGNC:24473. OLFML1.
HPA	HPA039735.
neXtProt	NX_Q6UWY5.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17407.
GeneTree	ENSGT00560000077036.
HOGENOM	HBG445753.
HOVERGEN	HBG053368.
InParanoid	Q6UWY5.
OMA	GVLYVVY.
OrthoDB	EOG4SN1NW.
PhylomeDB	Q6UWY5.
Gene expression databases
ArrayExpress	Q6UWY5.
Bgee	Q6UWY5.
CleanEx	HS_OLFML1.
Genevestigator	Q6UWY5.
GermOnline	ENSG00000183801. Homo sapiens.
Family and domain databases
InterPro	IPR003112. Olfac-like. [Graphical view]
Pfam	PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	93790.

Entry information

Entry name

OLFL1_HUMAN

Accession

Primary (citable) accession number: Q6UWY5
Secondary accession number(s): B4DP03, Q569G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.