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Protein

Serine protease 57

Gene

PRSS57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay systemBy similarity
Active sitei122 – 1221Charge relay systemBy similarity
Active sitei218 – 2181Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 57 (EC:3.4.21.-)
Alternative name(s):
Serine protease 1-like protein 1
Gene namesi
Name:PRSS57
Synonyms:PRSSL1
ORF Names:UNQ782/PRO1599
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31397. PRSS57.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742285.

Polymorphism and mutation databases

BioMutaiPRSS57.
DMDMi296452873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 283252Serine protease 57PRO_0000295853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi188 ↔ 202PROSITE-ProRule annotation
Disulfide bondi214 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UWY2.
PaxDbiQ6UWY2.
PeptideAtlasiQ6UWY2.
PRIDEiQ6UWY2.

Expressioni

Gene expression databases

BgeeiQ6UWY2.
CleanExiHS_PRSSL1.
ExpressionAtlasiQ6UWY2. baseline and differential.

Organism-specific databases

HPAiHPA005894.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327386.

Structurei

Secondary structure

1
283
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 536Combined sources
Beta strandi56 – 6510Combined sources
Beta strandi68 – 714Combined sources
Helixi73 – 764Combined sources
Helixi81 – 833Combined sources
Beta strandi84 – 896Combined sources
Beta strandi101 – 1033Combined sources
Beta strandi105 – 1106Combined sources
Turni116 – 1183Combined sources
Beta strandi124 – 1307Combined sources
Beta strandi135 – 1373Combined sources
Beta strandi156 – 1638Combined sources
Beta strandi176 – 1838Combined sources
Helixi185 – 1917Combined sources
Turni192 – 1943Combined sources
Beta strandi200 – 2045Combined sources
Beta strandi206 – 2094Combined sources
Beta strandi221 – 2244Combined sources
Beta strandi227 – 2348Combined sources
Beta strandi247 – 2504Combined sources
Helixi251 – 2544Combined sources
Helixi255 – 26410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q7XX-ray2.55A/B34-283[»]
4Q7YX-ray2.70A34-283[»]
4Q7ZX-ray1.40A34-283[»]
4Q80X-ray3.07A/B34-283[»]
ProteinModelPortaliQ6UWY2.
SMRiQ6UWY2. Positions 34-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 263230Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOVERGENiHBG013304.
InParanoidiQ6UWY2.
OMAiRARWVVS.
OrthoDBiEOG7MKW6Q.
PhylomeDBiQ6UWY2.
TreeFamiTF333630.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGLRGWGR PLLTVATALM LPVKPPAGSW GAQIIGGHEV TPHSRPYMAS
60 70 80 90 100
VRFGGQHHCG GFLLRARWVV SAAHCFSHRD LRTGLVVLGA HVLSTAEPTQ
110 120 130 140 150
QVFGIDALTT HPDYHPMTHA NDICLLRLNG SAVLGPAVGL LRPPGRRARP
160 170 180 190 200
PTAGTRCRVA GWGFVSDFEE LPPGLMEAKV RVLDPDVCNS SWKGHLTLTM
210 220 230 240 250
LCTRSGDSHR RGFCSADSGG PLVCRNRAHG LVSFSGLWCG DPKTPDVYTQ
260 270 280
VSAFVAWIWD VVRRSSPQPG PLPGTTRPPG EAA
Length:283
Mass (Da):30,334
Last modified:May 18, 2010 - v2
Checksum:i62A09B03C20CBDDA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431P → L.2 Publications
Corresponds to variant rs8102982 [ dbSNP | Ensembl ].
VAR_051839

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358594 mRNA. Translation: AAQ88957.1.
AC004156 Genomic DNA. No translation available.
AC112708 Genomic DNA. No translation available.
BC137161 mRNA. Translation: AAI37162.1.
CCDSiCCDS12041.1.
RefSeqiNP_999875.1. NM_214710.4.
UniGeneiHs.245146.

Genome annotation databases

EnsembliENST00000613411; ENSP00000482358; ENSG00000185198.
GeneIDi400668.
KEGGihsa:400668.
UCSCiuc002lpl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358594 mRNA. Translation: AAQ88957.1.
AC004156 Genomic DNA. No translation available.
AC112708 Genomic DNA. No translation available.
BC137161 mRNA. Translation: AAI37162.1.
CCDSiCCDS12041.1.
RefSeqiNP_999875.1. NM_214710.4.
UniGeneiHs.245146.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q7XX-ray2.55A/B34-283[»]
4Q7YX-ray2.70A34-283[»]
4Q7ZX-ray1.40A34-283[»]
4Q80X-ray3.07A/B34-283[»]
ProteinModelPortaliQ6UWY2.
SMRiQ6UWY2. Positions 34-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327386.

Polymorphism and mutation databases

BioMutaiPRSS57.
DMDMi296452873.

Proteomic databases

EPDiQ6UWY2.
PaxDbiQ6UWY2.
PeptideAtlasiQ6UWY2.
PRIDEiQ6UWY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613411; ENSP00000482358; ENSG00000185198.
GeneIDi400668.
KEGGihsa:400668.
UCSCiuc002lpl.2. human.

Organism-specific databases

CTDi400668.
GeneCardsiPRSS57.
HGNCiHGNC:31397. PRSS57.
HPAiHPA005894.
neXtProtiNX_Q6UWY2.
PharmGKBiPA164742285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOVERGENiHBG013304.
InParanoidiQ6UWY2.
OMAiRARWVVS.
OrthoDBiEOG7MKW6Q.
PhylomeDBiQ6UWY2.
TreeFamiTF333630.

Miscellaneous databases

GenomeRNAii400668.
PROiQ6UWY2.

Gene expression databases

BgeeiQ6UWY2.
CleanExiHS_PRSSL1.
ExpressionAtlasiQ6UWY2. baseline and differential.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-143.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-143.
    Tissue: Testis.

Entry informationi

Entry nameiPRS57_HUMAN
AccessioniPrimary (citable) accession number: Q6UWY2
Secondary accession number(s): B2RNW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.