Arylsulfatase K precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q6UWY0 (ARSK_HUMAN)

Last modified November 24, 2009. Version 52. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Arylsulfatase K
      Short name=ASK
    EC=3.1.6.-
Alternative name(s):
    Telethon sulfatase

Gene names

Name:	ARSK
Synonyms:	TSULF
ORF Names:	UNQ630/PRO1246

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	Secreted Potential.
Post-translational modification	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity By similarity.
Sequence similarities	Belongs to the sulfatase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylsulfatase activity Ref.1 Traceable author statement. Source: HGNC calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

22

Potential

Chain

514

Arylsulfatase K

PRO_0000042219

Sites

Metal binding

1

Calcium By similarity

Metal binding

1

Calcium; via 3-oxoalanine By similarity

Metal binding

1

Calcium By similarity

Metal binding

1

Calcium By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Amino acid modifications

Modified residue

1

3-oxoalanine (Cys) By similarity

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

1

Q → R: dbSNP rs17084927. Ref.4

VAR_052516

Experimental info

Sequence conflict

1

S → P in CAD38634. Ref.6

Sequences

Sequence

Length

Mass (Da)

Tools

Q6UWY0-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5A6D1B0FD8FCF386
Show »

536

61,450

        10         20         30         40         50         60 
MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP GSQVVKLPFI 

        70         80         90        100        110        120 
NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN NFKGLDPNYT TWMDVMERHG 

       130        140        150        160        170        180 
YRTQKFGKLD YTSGHHSISN RVEAWTRDVA FLLRQEGRPM VNLIRNRTKV RVMERDWQNT 

       190        200        210        220        230        240 
DKAVNWLRKE AINYTEPFVI YLGLNLPHPY PSPSSGENFG SSTFHTSLYW LEKVSHDAIK 

       250        260        270        280        290        300 
IPKWSPLSEM HPVDYYSSYT KNCTGRFTKK EIKNIRAFYY AMCAETDAML GEIILALHQL 

       310        320        330        340        350        360 
DLLQKTIVIY SSDHGELAME HRQFYKMSMY EASAHVPLLM MGPGIKAGLQ VSNVVSLVDI 

       370        380        390        400        410        420 
YPTMLDIAGI PLPQNLSGYS LLPLSSETFK NEHKVKNLHP PWILSEFHGC NVNASTYMLR 

       430        440        450        460        470        480 
TNHWKYIAYS DGASILPQLF DLSSDPDELT NVAVKFPEIT YSLDQKLHSI INYPKVSASV 

       490        500        510        520        530 
HQYNKEQFIK WKQSIGQNYS NVIANLRWHQ DWQKEPRKYE NAIDQWLKTH MNPRAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship." Sardiello M., Annunziata I., Roma G., Ballabio A. Hum. Mol. Genet. 14:3203-3217(2005) [PubMed: 16174644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and initial characterization of three novel human sulfatases." Obaya A.J. Gene 372:110-117(2006) [PubMed: 16500042] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-525. Tissue: Trachea.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-536. Tissue: Heart.

Cross-references

Sequence databases
	AY875939 mRNA. Translation: AAW66667.1. AY358596 mRNA. Translation: AAQ88959.1. AK303855 mRNA. Translation: BAG64796.1. BC130329 mRNA. Translation: AAI30330.1. AL832711 mRNA. Translation: CAD38634.1.
IPI	IPI00296524.
RefSeq	NP_937793.1.
UniGene	Hs.585051
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UWY0.
PTM databases
PhosphoSite	Q6UWY0.
Proteomic databases
PRIDE	Q6UWY0.
Genome annotation databases
Ensembl	ENST00000380009; ENSP00000369346; ENSG00000164291; Homo sapiens. [Genome view]
GeneID	153642.
KEGG	hsa:153642.
NMPDR	fig\|9606.3.peg.25524.
UCSC	uc003kld.1. human.
Organism-specific databases
CTD	153642.
GeneCards	GC05P094917.
HGNC	HGNC:25239. ARSK.
MIM	610011. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6UWY0.
OMA	ANLRWHQ
OrthoDB	EOG9JT2S5
Gene expression databases
ArrayExpress	Q6UWY0.
Bgee	Q6UWY0.
CleanEx	HS_ARSK.
Genevestigator	Q6UWY0.
GermOnline	ENSG00000164291. Homo sapiens.
Family and domain databases
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR000917. Sulfatase. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 1 hit.
Pfam	PF00884. Sulfatase. 1 hit. [Graphical view]
PROSITE	PS00523. SULFATASE_1. False negative. PS00149. SULFATASE_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	87151.
SOURCE	Search...

Entry information

Entry name

ARSK_HUMAN

Accession

Primary (citable) accession number: Q6UWY0
Secondary accession number(s): A2BDE3, B4E1I4, Q8N3Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents