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Protein

Arylsulfatase K

Gene

ARSK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40CalciumBy similarity1
Metal bindingi80Calcium; via 3-oxoalanineBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi313CalciumBy similarity1
Metal bindingi314CalciumBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09053-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase K (EC:3.1.6.-)
Short name:
ASK
Alternative name(s):
Telethon sulfatase
Gene namesi
Name:ARSK
Synonyms:TSULF
ORF Names:UNQ630/PRO1246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25239. ARSK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi153642.
OpenTargetsiENSG00000164291.
PharmGKBiPA143485311.

Polymorphism and mutation databases

BioMutaiARSK.
DMDMi74738157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004221923 – 536Arylsulfatase KAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei803-oxoalanine (Cys)By similarity1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Glycosylationi262N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWY0.
MaxQBiQ6UWY0.
PaxDbiQ6UWY0.
PeptideAtlasiQ6UWY0.
PRIDEiQ6UWY0.

PTM databases

iPTMnetiQ6UWY0.
PhosphoSitePlusiQ6UWY0.

Expressioni

Gene expression databases

BgeeiENSG00000164291.
CleanExiHS_ARSK.
ExpressionAtlasiQ6UWY0. baseline and differential.
GenevisibleiQ6UWY0. HS.

Organism-specific databases

HPAiHPA042384.

Interactioni

Protein-protein interaction databases

BioGridi127507. 25 interactors.
STRINGi9606.ENSP00000369346.

Structurei

3D structure databases

ProteinModelPortaliQ6UWY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00730000110906.
HOGENOMiHOG000034080.
HOVERGENiHBG054703.
InParanoidiQ6UWY0.
KOiK12376.
OMAiKMSMYEA.
OrthoDBiEOG091G061W.
PhylomeDBiQ6UWY0.
TreeFamiTF313545.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP
60 70 80 90 100
GSQVVKLPFI NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN
110 120 130 140 150
NFKGLDPNYT TWMDVMERHG YRTQKFGKLD YTSGHHSISN RVEAWTRDVA
160 170 180 190 200
FLLRQEGRPM VNLIRNRTKV RVMERDWQNT DKAVNWLRKE AINYTEPFVI
210 220 230 240 250
YLGLNLPHPY PSPSSGENFG SSTFHTSLYW LEKVSHDAIK IPKWSPLSEM
260 270 280 290 300
HPVDYYSSYT KNCTGRFTKK EIKNIRAFYY AMCAETDAML GEIILALHQL
310 320 330 340 350
DLLQKTIVIY SSDHGELAME HRQFYKMSMY EASAHVPLLM MGPGIKAGLQ
360 370 380 390 400
VSNVVSLVDI YPTMLDIAGI PLPQNLSGYS LLPLSSETFK NEHKVKNLHP
410 420 430 440 450
PWILSEFHGC NVNASTYMLR TNHWKYIAYS DGASILPQLF DLSSDPDELT
460 470 480 490 500
NVAVKFPEIT YSLDQKLHSI INYPKVSASV HQYNKEQFIK WKQSIGQNYS
510 520 530
NVIANLRWHQ DWQKEPRKYE NAIDQWLKTH MNPRAV
Length:536
Mass (Da):61,450
Last modified:July 5, 2004 - v1
Checksum:i5A6D1B0FD8FCF386
GO

Sequence cautioni

The sequence AAH36047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti380S → P in CAD38634 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052516525Q → R.1 PublicationCorresponds to variant rs17084927dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875939 mRNA. Translation: AAW66667.1.
AY358596 mRNA. Translation: AAQ88959.1.
AK303855 mRNA. Translation: BAG64796.1.
BC036047 mRNA. Translation: AAH36047.1. Different initiation.
BC130329 mRNA. Translation: AAI30330.1.
AL832711 mRNA. Translation: CAD38634.1.
CCDSiCCDS4073.1.
RefSeqiNP_937793.1. NM_198150.2.
UniGeneiHs.585051.

Genome annotation databases

EnsembliENST00000380009; ENSP00000369346; ENSG00000164291.
GeneIDi153642.
KEGGihsa:153642.
UCSCiuc003kld.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875939 mRNA. Translation: AAW66667.1.
AY358596 mRNA. Translation: AAQ88959.1.
AK303855 mRNA. Translation: BAG64796.1.
BC036047 mRNA. Translation: AAH36047.1. Different initiation.
BC130329 mRNA. Translation: AAI30330.1.
AL832711 mRNA. Translation: CAD38634.1.
CCDSiCCDS4073.1.
RefSeqiNP_937793.1. NM_198150.2.
UniGeneiHs.585051.

3D structure databases

ProteinModelPortaliQ6UWY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127507. 25 interactors.
STRINGi9606.ENSP00000369346.

PTM databases

iPTMnetiQ6UWY0.
PhosphoSitePlusiQ6UWY0.

Polymorphism and mutation databases

BioMutaiARSK.
DMDMi74738157.

Proteomic databases

EPDiQ6UWY0.
MaxQBiQ6UWY0.
PaxDbiQ6UWY0.
PeptideAtlasiQ6UWY0.
PRIDEiQ6UWY0.

Protocols and materials databases

DNASUi153642.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380009; ENSP00000369346; ENSG00000164291.
GeneIDi153642.
KEGGihsa:153642.
UCSCiuc003kld.4. human.

Organism-specific databases

CTDi153642.
DisGeNETi153642.
GeneCardsiARSK.
HGNCiHGNC:25239. ARSK.
HPAiHPA042384.
MIMi610011. gene.
neXtProtiNX_Q6UWY0.
OpenTargetsiENSG00000164291.
PharmGKBiPA143485311.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3731. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00730000110906.
HOGENOMiHOG000034080.
HOVERGENiHBG054703.
InParanoidiQ6UWY0.
KOiK12376.
OMAiKMSMYEA.
OrthoDBiEOG091G061W.
PhylomeDBiQ6UWY0.
TreeFamiTF313545.

Enzyme and pathway databases

BioCyciZFISH:HS09053-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Miscellaneous databases

GenomeRNAii153642.
PROiQ6UWY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164291.
CleanExiHS_ARSK.
ExpressionAtlasiQ6UWY0. baseline and differential.
GenevisibleiQ6UWY0. HS.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSK_HUMAN
AccessioniPrimary (citable) accession number: Q6UWY0
Secondary accession number(s): A2BDE3
, B4E1I4, Q3ZCW3, Q8N3Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.