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Q6UWX4

- HIPL2_HUMAN

UniProt

Q6UWX4 - HIPL2_HUMAN

Protein

HHIP-like protein 2

Gene

HHIPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: InterPro
    2. quinone binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HHIP-like protein 2
    Gene namesi
    Name:HHIPL2
    Synonyms:HHIP3, KIAA1822L
    ORF Names:UNQ841/PRO1779
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25842. HHIPL2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390914.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 724683HHIP-like protein 2PRO_0000314964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi204 ↔ 546By similarity
    Disulfide bondi208 ↔ 553By similarity
    Disulfide bondi424 ↔ 442By similarity
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi509 ↔ 609By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ6UWX4.
    PaxDbiQ6UWX4.
    PRIDEiQ6UWX4.

    PTM databases

    PhosphoSiteiQ6UWX4.

    Expressioni

    Gene expression databases

    BgeeiQ6UWX4.
    CleanExiHS_HHIPL2.
    GenevestigatoriQ6UWX4.

    Organism-specific databases

    HPAiHPA054029.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000342118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UWX4.
    SMRiQ6UWX4. Positions 207-618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HHIP family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2133.
    HOGENOMiHOG000244857.
    HOVERGENiHBG107978.
    InParanoidiQ6UWX4.
    OMAiPKSERVI.
    OrthoDBiEOG7CZK54.
    PhylomeDBiQ6UWX4.
    TreeFamiTF329059.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR018143. Folate_rcpt-like.
    IPR012938. Glc/Sorbosone_DH.
    IPR011041. Quinoprot_gluc/sorb_DH.
    [Graphical view]
    PfamiPF03024. Folate_rec. 1 hit.
    PF07995. GSDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF50952. SSF50952. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UWX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP    50
    PFQPPLHLEF CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY 100
    IKDILCQECS PYAAHLYDAE NTQTPLRNLP GLCSDYCSAF HSNCHSAISL 150
    LTNDRGLQES HGRDGTRFCH LLDLPDKDYC FPNVLRNDYL NRHLGMVAQD 200
    PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV VWVYLPDGSR 250
    LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK 300
    VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM 350
    YIFTGDGGQA GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD 400
    NPFVSEPGAH PAIYAYGIRN MWRCAVDRGD PITRQGRGRI FCGDVGQNRF 450
    EEVDLILKGG NYGWRAKEGF ACYDKKLCHN ASLDDVLPIY AYGHAVGKSV 500
    TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW KKQDLCLGST 550
    TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP 600
    SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA 650
    TLASGPAQGL SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR 700
    KSLKSHSGRM RPSAEQKRAG RSLP 724
    Length:724
    Mass (Da):80,779
    Last modified:July 5, 2004 - v1
    Checksum:i1202DFFC6D6F44BC
    GO

    Sequence cautioni

    The sequence AAH15201.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH15201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH16552.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14717.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH15201.1 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti254 – 2541P → S in AAH07638. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti241 – 2411V → M.
    Corresponds to variant rs3811466 [ dbSNP | Ensembl ].
    VAR_053986
    Natural varianti391 – 3911H → D.
    Corresponds to variant rs3748666 [ dbSNP | Ensembl ].
    VAR_062220
    Natural varianti394 – 3941R → Q.
    Corresponds to variant rs3748665 [ dbSNP | Ensembl ].
    VAR_062221
    Natural varianti434 – 4341R → L.
    Corresponds to variant rs3748663 [ dbSNP | Ensembl ].
    VAR_062222

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358602 mRNA. Translation: AAQ88965.1.
    AL592148 Genomic DNA. Translation: CAI40465.1.
    CH471100 Genomic DNA. Translation: EAW93274.1.
    BC007638 mRNA. Translation: AAH07638.1.
    BC015167 mRNA. Translation: AAH15167.1.
    BC015201 mRNA. Translation: AAH15201.1. Sequence problems.
    BC016552 mRNA. Translation: AAH16552.1. Different initiation.
    AK023902 mRNA. Translation: BAB14717.1. Different initiation.
    CCDSiCCDS1530.2.
    RefSeqiNP_079022.2. NM_024746.3.
    UniGeneiHs.665660.

    Genome annotation databases

    EnsembliENST00000343410; ENSP00000342118; ENSG00000143512.
    GeneIDi79802.
    KEGGihsa:79802.
    UCSCiuc001hnh.1. human.

    Polymorphism databases

    DMDMi74749406.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358602 mRNA. Translation: AAQ88965.1 .
    AL592148 Genomic DNA. Translation: CAI40465.1 .
    CH471100 Genomic DNA. Translation: EAW93274.1 .
    BC007638 mRNA. Translation: AAH07638.1 .
    BC015167 mRNA. Translation: AAH15167.1 .
    BC015201 mRNA. Translation: AAH15201.1 . Sequence problems.
    BC016552 mRNA. Translation: AAH16552.1 . Different initiation.
    AK023902 mRNA. Translation: BAB14717.1 . Different initiation.
    CCDSi CCDS1530.2.
    RefSeqi NP_079022.2. NM_024746.3.
    UniGenei Hs.665660.

    3D structure databases

    ProteinModelPortali Q6UWX4.
    SMRi Q6UWX4. Positions 207-618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000342118.

    PTM databases

    PhosphoSitei Q6UWX4.

    Polymorphism databases

    DMDMi 74749406.

    Proteomic databases

    MaxQBi Q6UWX4.
    PaxDbi Q6UWX4.
    PRIDEi Q6UWX4.

    Protocols and materials databases

    DNASUi 79802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343410 ; ENSP00000342118 ; ENSG00000143512 .
    GeneIDi 79802.
    KEGGi hsa:79802.
    UCSCi uc001hnh.1. human.

    Organism-specific databases

    CTDi 79802.
    GeneCardsi GC01M222695.
    H-InvDB HIX0001611.
    HGNCi HGNC:25842. HHIPL2.
    HPAi HPA054029.
    neXtProti NX_Q6UWX4.
    PharmGKBi PA162390914.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2133.
    HOGENOMi HOG000244857.
    HOVERGENi HBG107978.
    InParanoidi Q6UWX4.
    OMAi PKSERVI.
    OrthoDBi EOG7CZK54.
    PhylomeDBi Q6UWX4.
    TreeFami TF329059.

    Miscellaneous databases

    ChiTaRSi HHIPL2. human.
    GenomeRNAii 79802.
    NextBioi 69368.
    PROi Q6UWX4.

    Gene expression databases

    Bgeei Q6UWX4.
    CleanExi HS_HHIPL2.
    Genevestigatori Q6UWX4.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR018143. Folate_rcpt-like.
    IPR012938. Glc/Sorbosone_DH.
    IPR011041. Quinoprot_gluc/sorb_DH.
    [Graphical view ]
    Pfami PF03024. Folate_rec. 1 hit.
    PF07995. GSDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50952. SSF50952. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney, Lung and Muscle.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-724.
      Tissue: Thyroid.
    6. "Comparative genomics on HHIP family orthologs."
      Katoh Y., Katoh M.
      Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.

    Entry informationi

    Entry nameiHIPL2_HUMAN
    AccessioniPrimary (citable) accession number: Q6UWX4
    Secondary accession number(s): Q6GU65
    , Q96BT4, Q96BU5, Q9H8A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3