Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HHIP-like protein 2

Gene

HHIPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: InterPro
  2. quinone binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HHIP-like protein 2
Gene namesi
Name:HHIPL2
Synonyms:HHIP3, KIAA1822L
ORF Names:UNQ841/PRO1779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25842. HHIPL2.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390914.

Polymorphism and mutation databases

BioMutaiHHIPL2.
DMDMi74749406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence AnalysisAdd
BLAST
Chaini42 – 724683HHIP-like protein 2PRO_0000314964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi204 ↔ 546By similarity
Disulfide bondi208 ↔ 553By similarity
Disulfide bondi424 ↔ 442By similarity
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi509 ↔ 609By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UWX4.
PaxDbiQ6UWX4.
PRIDEiQ6UWX4.

PTM databases

PhosphoSiteiQ6UWX4.

Expressioni

Gene expression databases

BgeeiQ6UWX4.
CleanExiHS_HHIPL2.
GenevestigatoriQ6UWX4.

Organism-specific databases

HPAiHPA054029.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALOX5P099173EBI-10196655,EBI-79934

Protein-protein interaction databases

BioGridi122899. 1 interaction.
IntActiQ6UWX4. 1 interaction.
STRINGi9606.ENSP00000342118.

Structurei

3D structure databases

ProteinModelPortaliQ6UWX4.
SMRiQ6UWX4. Positions 207-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HHIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2133.
GeneTreeiENSGT00530000063250.
HOGENOMiHOG000244857.
HOVERGENiHBG107978.
InParanoidiQ6UWX4.
OMAiPAVYAYG.
OrthoDBiEOG7CZK54.
PhylomeDBiQ6UWX4.
TreeFamiTF329059.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP
60 70 80 90 100
PFQPPLHLEF CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY
110 120 130 140 150
IKDILCQECS PYAAHLYDAE NTQTPLRNLP GLCSDYCSAF HSNCHSAISL
160 170 180 190 200
LTNDRGLQES HGRDGTRFCH LLDLPDKDYC FPNVLRNDYL NRHLGMVAQD
210 220 230 240 250
PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV VWVYLPDGSR
260 270 280 290 300
LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK
310 320 330 340 350
VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM
360 370 380 390 400
YIFTGDGGQA GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD
410 420 430 440 450
NPFVSEPGAH PAIYAYGIRN MWRCAVDRGD PITRQGRGRI FCGDVGQNRF
460 470 480 490 500
EEVDLILKGG NYGWRAKEGF ACYDKKLCHN ASLDDVLPIY AYGHAVGKSV
510 520 530 540 550
TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW KKQDLCLGST
560 570 580 590 600
TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP
610 620 630 640 650
SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA
660 670 680 690 700
TLASGPAQGL SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR
710 720
KSLKSHSGRM RPSAEQKRAG RSLP
Length:724
Mass (Da):80,779
Last modified:July 5, 2004 - v1
Checksum:i1202DFFC6D6F44BC
GO

Sequence cautioni

The sequence AAH15201.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH15201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15201.1 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu.Curated
The sequence AAH16552.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14717.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541P → S in AAH07638 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411V → M.
Corresponds to variant rs3811466 [ dbSNP | Ensembl ].
VAR_053986
Natural varianti391 – 3911H → D.
Corresponds to variant rs3748666 [ dbSNP | Ensembl ].
VAR_062220
Natural varianti394 – 3941R → Q.
Corresponds to variant rs3748665 [ dbSNP | Ensembl ].
VAR_062221
Natural varianti434 – 4341R → L.
Corresponds to variant rs3748663 [ dbSNP | Ensembl ].
VAR_062222

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358602 mRNA. Translation: AAQ88965.1.
AL592148 Genomic DNA. Translation: CAI40465.1.
CH471100 Genomic DNA. Translation: EAW93274.1.
BC007638 mRNA. Translation: AAH07638.1.
BC015167 mRNA. Translation: AAH15167.1.
BC015201 mRNA. Translation: AAH15201.1. Sequence problems.
BC016552 mRNA. Translation: AAH16552.1. Different initiation.
AK023902 mRNA. Translation: BAB14717.1. Different initiation.
CCDSiCCDS1530.2.
RefSeqiNP_079022.2. NM_024746.3.
UniGeneiHs.665660.

Genome annotation databases

EnsembliENST00000343410; ENSP00000342118; ENSG00000143512.
GeneIDi79802.
KEGGihsa:79802.
UCSCiuc001hnh.1. human.

Polymorphism and mutation databases

BioMutaiHHIPL2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358602 mRNA. Translation: AAQ88965.1.
AL592148 Genomic DNA. Translation: CAI40465.1.
CH471100 Genomic DNA. Translation: EAW93274.1.
BC007638 mRNA. Translation: AAH07638.1.
BC015167 mRNA. Translation: AAH15167.1.
BC015201 mRNA. Translation: AAH15201.1. Sequence problems.
BC016552 mRNA. Translation: AAH16552.1. Different initiation.
AK023902 mRNA. Translation: BAB14717.1. Different initiation.
CCDSiCCDS1530.2.
RefSeqiNP_079022.2. NM_024746.3.
UniGeneiHs.665660.

3D structure databases

ProteinModelPortaliQ6UWX4.
SMRiQ6UWX4. Positions 207-618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122899. 1 interaction.
IntActiQ6UWX4. 1 interaction.
STRINGi9606.ENSP00000342118.

PTM databases

PhosphoSiteiQ6UWX4.

Polymorphism and mutation databases

BioMutaiHHIPL2.
DMDMi74749406.

Proteomic databases

MaxQBiQ6UWX4.
PaxDbiQ6UWX4.
PRIDEiQ6UWX4.

Protocols and materials databases

DNASUi79802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343410; ENSP00000342118; ENSG00000143512.
GeneIDi79802.
KEGGihsa:79802.
UCSCiuc001hnh.1. human.

Organism-specific databases

CTDi79802.
GeneCardsiGC01M222695.
H-InvDBHIX0001611.
HGNCiHGNC:25842. HHIPL2.
HPAiHPA054029.
neXtProtiNX_Q6UWX4.
PharmGKBiPA162390914.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2133.
GeneTreeiENSGT00530000063250.
HOGENOMiHOG000244857.
HOVERGENiHBG107978.
InParanoidiQ6UWX4.
OMAiPAVYAYG.
OrthoDBiEOG7CZK54.
PhylomeDBiQ6UWX4.
TreeFamiTF329059.

Miscellaneous databases

ChiTaRSiHHIPL2. human.
GenomeRNAii79802.
NextBioi69368.
PROiQ6UWX4.

Gene expression databases

BgeeiQ6UWX4.
CleanExiHS_HHIPL2.
GenevestigatoriQ6UWX4.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Lung and Muscle.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-724.
    Tissue: Thyroid.
  6. "Comparative genomics on HHIP family orthologs."
    Katoh Y., Katoh M.
    Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiHIPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWX4
Secondary accession number(s): Q6GU65
, Q96BT4, Q96BU5, Q9H8A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.