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Q6UWX4

- HIPL2_HUMAN

UniProt

Q6UWX4 - HIPL2_HUMAN

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Protein
HHIP-like protein 2
Gene
HHIPL2, HHIP3, KIAA1822L, UNQ841/PRO1779
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: InterPro
  2. quinone binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HHIP-like protein 2
Gene namesi
Name:HHIPL2
Synonyms:HHIP3, KIAA1822L
ORF Names:UNQ841/PRO1779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25842. HHIPL2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 Reviewed prediction
Add
BLAST
Chaini42 – 724683HHIP-like protein 2
PRO_0000314964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi204 ↔ 546 By similarity
Disulfide bondi208 ↔ 553 By similarity
Disulfide bondi424 ↔ 442 By similarity
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi509 ↔ 609 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UWX4.
PaxDbiQ6UWX4.
PRIDEiQ6UWX4.

PTM databases

PhosphoSiteiQ6UWX4.

Expressioni

Gene expression databases

BgeeiQ6UWX4.
CleanExiHS_HHIPL2.
GenevestigatoriQ6UWX4.

Organism-specific databases

HPAiHPA054029.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342118.

Structurei

3D structure databases

ProteinModelPortaliQ6UWX4.
SMRiQ6UWX4. Positions 207-618.

Family & Domainsi

Sequence similaritiesi

Belongs to the HHIP family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2133.
HOGENOMiHOG000244857.
HOVERGENiHBG107978.
InParanoidiQ6UWX4.
OMAiPKSERVI.
OrthoDBiEOG7CZK54.
PhylomeDBiQ6UWX4.
TreeFamiTF329059.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWX4-1 [UniParc]FASTAAdd to Basket

« Hide

MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP    50
PFQPPLHLEF CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY 100
IKDILCQECS PYAAHLYDAE NTQTPLRNLP GLCSDYCSAF HSNCHSAISL 150
LTNDRGLQES HGRDGTRFCH LLDLPDKDYC FPNVLRNDYL NRHLGMVAQD 200
PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV VWVYLPDGSR 250
LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK 300
VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM 350
YIFTGDGGQA GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD 400
NPFVSEPGAH PAIYAYGIRN MWRCAVDRGD PITRQGRGRI FCGDVGQNRF 450
EEVDLILKGG NYGWRAKEGF ACYDKKLCHN ASLDDVLPIY AYGHAVGKSV 500
TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW KKQDLCLGST 550
TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP 600
SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA 650
TLASGPAQGL SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR 700
KSLKSHSGRM RPSAEQKRAG RSLP 724
Length:724
Mass (Da):80,779
Last modified:July 5, 2004 - v1
Checksum:i1202DFFC6D6F44BC
GO

Sequence cautioni

The sequence AAH15201.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH15201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH16552.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14717.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH15201.1 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411V → M.
Corresponds to variant rs3811466 [ dbSNP | Ensembl ].
VAR_053986
Natural varianti391 – 3911H → D.
Corresponds to variant rs3748666 [ dbSNP | Ensembl ].
VAR_062220
Natural varianti394 – 3941R → Q.
Corresponds to variant rs3748665 [ dbSNP | Ensembl ].
VAR_062221
Natural varianti434 – 4341R → L.
Corresponds to variant rs3748663 [ dbSNP | Ensembl ].
VAR_062222

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541P → S in AAH07638. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358602 mRNA. Translation: AAQ88965.1.
AL592148 Genomic DNA. Translation: CAI40465.1.
CH471100 Genomic DNA. Translation: EAW93274.1.
BC007638 mRNA. Translation: AAH07638.1.
BC015167 mRNA. Translation: AAH15167.1.
BC015201 mRNA. Translation: AAH15201.1. Sequence problems.
BC016552 mRNA. Translation: AAH16552.1. Different initiation.
AK023902 mRNA. Translation: BAB14717.1. Different initiation.
CCDSiCCDS1530.2.
RefSeqiNP_079022.2. NM_024746.3.
UniGeneiHs.665660.

Genome annotation databases

EnsembliENST00000343410; ENSP00000342118; ENSG00000143512.
GeneIDi79802.
KEGGihsa:79802.
UCSCiuc001hnh.1. human.

Polymorphism databases

DMDMi74749406.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358602 mRNA. Translation: AAQ88965.1 .
AL592148 Genomic DNA. Translation: CAI40465.1 .
CH471100 Genomic DNA. Translation: EAW93274.1 .
BC007638 mRNA. Translation: AAH07638.1 .
BC015167 mRNA. Translation: AAH15167.1 .
BC015201 mRNA. Translation: AAH15201.1 . Sequence problems.
BC016552 mRNA. Translation: AAH16552.1 . Different initiation.
AK023902 mRNA. Translation: BAB14717.1 . Different initiation.
CCDSi CCDS1530.2.
RefSeqi NP_079022.2. NM_024746.3.
UniGenei Hs.665660.

3D structure databases

ProteinModelPortali Q6UWX4.
SMRi Q6UWX4. Positions 207-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000342118.

PTM databases

PhosphoSitei Q6UWX4.

Polymorphism databases

DMDMi 74749406.

Proteomic databases

MaxQBi Q6UWX4.
PaxDbi Q6UWX4.
PRIDEi Q6UWX4.

Protocols and materials databases

DNASUi 79802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343410 ; ENSP00000342118 ; ENSG00000143512 .
GeneIDi 79802.
KEGGi hsa:79802.
UCSCi uc001hnh.1. human.

Organism-specific databases

CTDi 79802.
GeneCardsi GC01M222695.
H-InvDB HIX0001611.
HGNCi HGNC:25842. HHIPL2.
HPAi HPA054029.
neXtProti NX_Q6UWX4.
PharmGKBi PA162390914.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2133.
HOGENOMi HOG000244857.
HOVERGENi HBG107978.
InParanoidi Q6UWX4.
OMAi PKSERVI.
OrthoDBi EOG7CZK54.
PhylomeDBi Q6UWX4.
TreeFami TF329059.

Miscellaneous databases

ChiTaRSi HHIPL2. human.
GenomeRNAii 79802.
NextBioi 69368.
PROi Q6UWX4.

Gene expression databases

Bgeei Q6UWX4.
CleanExi HS_HHIPL2.
Genevestigatori Q6UWX4.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view ]
Pfami PF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view ]
SUPFAMi SSF50952. SSF50952. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Lung and Muscle.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-724.
    Tissue: Thyroid.
  6. "Comparative genomics on HHIP family orthologs."
    Katoh Y., Katoh M.
    Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiHIPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWX4
Secondary accession number(s): Q6GU65
, Q96BT4, Q96BU5, Q9H8A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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