Q6UWX4 (HIPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HHIP-like protein 2

Gene names

Name:	HHIPL2
Synonyms:	HHIP3, KIAA1822L
ORF Names:	UNQ841/PRO1779

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the HHIP family.
Sequence caution	The sequence AAH15201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH15201.1 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu. The sequence AAH15201.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH16552.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14717.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 724	683	HHIP-like protein 2		PRO_0000314964
Amino acid modifications
	Glycosylation	480	1	N-linked (GlcNAc...) Potential
	Disulfide bond	204 ↔ 546		By similarity
	Disulfide bond	208 ↔ 553		By similarity
	Disulfide bond	424 ↔ 442		By similarity
	Disulfide bond	509 ↔ 609		By similarity
Natural variations
	Natural variant	241	1	V → M. Corresponds to variant rs3811466 [ dbSNP | Ensembl ].		VAR_053986
	Natural variant	391	1	H → D. Corresponds to variant rs3748666 [ dbSNP | Ensembl ].		VAR_062220
	Natural variant	394	1	R → Q. Corresponds to variant rs3748665 [ dbSNP | Ensembl ].		VAR_062221
	Natural variant	434	1	R → L. Corresponds to variant rs3748663 [ dbSNP | Ensembl ].		VAR_062222
Experimental info
	Sequence conflict	254	1	P → S in AAH07638. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q6UWX4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1202DFFC6D6F44BC	FASTA	724	80,779
	10 20 30 40 50 60 MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP PFQPPLHLEF 70 80 90 100 110 120 CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY IKDILCQECS PYAAHLYDAE 130 140 150 160 170 180 NTQTPLRNLP GLCSDYCSAF HSNCHSAISL LTNDRGLQES HGRDGTRFCH LLDLPDKDYC 190 200 210 220 230 240 FPNVLRNDYL NRHLGMVAQD PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV 250 260 270 280 290 300 VWVYLPDGSR LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK 310 320 330 340 350 360 VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM YIFTGDGGQA 370 380 390 400 410 420 GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD NPFVSEPGAH PAIYAYGIRN 430 440 450 460 470 480 MWRCAVDRGD PITRQGRGRI FCGDVGQNRF EEVDLILKGG NYGWRAKEGF ACYDKKLCHN 490 500 510 520 530 540 ASLDDVLPIY AYGHAVGKSV TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW 550 560 570 580 590 600 KKQDLCLGST TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP 610 620 630 640 650 660 SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA TLASGPAQGL 670 680 690 700 710 720 SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR KSLKSHSGRM RPSAEQKRAG RSLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney, Lung and Muscle.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-724. Tissue: Thyroid.
[6]	"Comparative genomics on HHIP family orthologs." Katoh Y., Katoh M. Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358602 mRNA. Translation: AAQ88965.1. AL592148 Genomic DNA. Translation: CAI40465.1. CH471100 Genomic DNA. Translation: EAW93274.1. BC007638 mRNA. Translation: AAH07638.1. BC015167 mRNA. Translation: AAH15167.1. BC015201 mRNA. Translation: AAH15201.1. Sequence problems. BC016552 mRNA. Translation: AAH16552.1. Different initiation. AK023902 mRNA. Translation: BAB14717.1. Different initiation.
IPI	IPI00015504.
RefSeq	NP_079022.2. NM_024746.3.
UniGene	Hs.665660.
3D structure databases
ProteinModelPortal	Q6UWX4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000342118.
PTM databases
PhosphoSite	Q6UWX4.
Polymorphism databases
DMDM	74749406.
Proteomic databases
PaxDb	Q6UWX4.
PRIDE	Q6UWX4.
Protocols and materials databases
DNASU	79802.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343410; ENSP00000342118; ENSG00000143512.
GeneID	79802.
KEGG	hsa:79802.
UCSC	uc001hnh.1. human.
Organism-specific databases
CTD	79802.
GeneCards	GC01M222695.
H-InvDB	HIX0001611.
HGNC	HGNC:25842. HHIPL2.
HPA	HPA054029.
neXtProt	NX_Q6UWX4.
PharmGKB	PA162390914.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2133.
HOGENOM	HOG000244857.
HOVERGEN	HBG107978.
InParanoid	Q6UWX4.
OMA	IAARYWD.
OrthoDB	EOG4GHZNW.
Gene expression databases
Bgee	Q6UWX4.
CleanEx	HS_HHIPL2.
Genevestigator	Q6UWX4.
Family and domain databases
Gene3D	2.120.10.30. 1 hit.
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR018143. Folate_rcpt-like. IPR012938. Glc/Sorbosone_DH. IPR011041. Quinoprot_gluc/sorb_DH. [Graphical view]
Pfam	PF03024. Folate_rec. 1 hit. PF07995. GSDH. 1 hit. [Graphical view]
SUPFAM	SSF50952. Quino_gluc_DH. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	HHIPL2. human.
GenomeRNAi	79802.
NextBio	69368.

Entry information

Entry name

HIPL2_HUMAN

Accession

Primary (citable) accession number: Q6UWX4
Secondary accession number(s): Q6GU65 , Q96BT4, Q96BU5, Q9H8A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.