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Protein

HHIP-like protein 2

Gene

HHIPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
HHIP-like protein 2
Gene namesi
Name:HHIPL2
Synonyms:HHIP3, KIAA1822L
ORF Names:UNQ841/PRO1779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143512.12
HGNCiHGNC:25842 HHIPL2
neXtProtiNX_Q6UWX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79802
OpenTargetsiENSG00000143512
PharmGKBiPA162390914

Polymorphism and mutation databases

BioMutaiHHIPL2
DMDMi74749406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000031496442 – 724HHIP-like protein 2Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi204 ↔ 546By similarity
Disulfide bondi208 ↔ 553By similarity
Disulfide bondi424 ↔ 442By similarity
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi509 ↔ 609By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UWX4
PaxDbiQ6UWX4
PeptideAtlasiQ6UWX4
PRIDEiQ6UWX4

PTM databases

iPTMnetiQ6UWX4
PhosphoSitePlusiQ6UWX4

Expressioni

Gene expression databases

BgeeiENSG00000143512
CleanExiHS_HHIPL2
GenevisibleiQ6UWX4 HS

Organism-specific databases

HPAiHPA059673

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALOX5P099176EBI-10196655,EBI-79934

Protein-protein interaction databases

BioGridi122899, 1 interactor
IntActiQ6UWX4, 1 interactor
STRINGi9606.ENSP00000342118

Structurei

3D structure databases

ProteinModelPortaliQ6UWX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HHIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE87 Eukaryota
COG2133 LUCA
GeneTreeiENSGT00530000063250
HOGENOMiHOG000244857
HOVERGENiHBG107978
InParanoidiQ6UWX4
OMAiIYKFVDP
OrthoDBiEOG091G01D0
PhylomeDBiQ6UWX4
TreeFamiTF329059

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018143 Folate_rcpt-like
IPR012938 Glc/Sorbosone_DH
IPR011041 Quinoprot_gluc/sorb_DH
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit
PF07995 GSDH, 1 hit
SUPFAMiSSF50952 SSF50952, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP
60 70 80 90 100
PFQPPLHLEF CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY
110 120 130 140 150
IKDILCQECS PYAAHLYDAE NTQTPLRNLP GLCSDYCSAF HSNCHSAISL
160 170 180 190 200
LTNDRGLQES HGRDGTRFCH LLDLPDKDYC FPNVLRNDYL NRHLGMVAQD
210 220 230 240 250
PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV VWVYLPDGSR
260 270 280 290 300
LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK
310 320 330 340 350
VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM
360 370 380 390 400
YIFTGDGGQA GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD
410 420 430 440 450
NPFVSEPGAH PAIYAYGIRN MWRCAVDRGD PITRQGRGRI FCGDVGQNRF
460 470 480 490 500
EEVDLILKGG NYGWRAKEGF ACYDKKLCHN ASLDDVLPIY AYGHAVGKSV
510 520 530 540 550
TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW KKQDLCLGST
560 570 580 590 600
TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP
610 620 630 640 650
SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA
660 670 680 690 700
TLASGPAQGL SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR
710 720
KSLKSHSGRM RPSAEQKRAG RSLP
Length:724
Mass (Da):80,779
Last modified:July 5, 2004 - v1
Checksum:i1202DFFC6D6F44BC
GO

Sequence cautioni

The sequence AAH15201 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH15201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15201 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu.Curated
The sequence AAH16552 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14717 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254P → S in AAH07638 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053986241V → M. Corresponds to variant dbSNP:rs3811466Ensembl.1
Natural variantiVAR_062220391H → D. Corresponds to variant dbSNP:rs3748666Ensembl.1
Natural variantiVAR_062221394R → Q. Corresponds to variant dbSNP:rs3748665Ensembl.1
Natural variantiVAR_062222434R → L. Corresponds to variant dbSNP:rs3748663Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358602 mRNA Translation: AAQ88965.1
AL592148 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93274.1
BC007638 mRNA Translation: AAH07638.1
BC015167 mRNA Translation: AAH15167.1
BC015201 mRNA Translation: AAH15201.1 Sequence problems.
BC016552 mRNA Translation: AAH16552.1 Different initiation.
AK023902 mRNA Translation: BAB14717.1 Different initiation.
CCDSiCCDS1530.2
RefSeqiNP_079022.2, NM_024746.3
UniGeneiHs.665660

Genome annotation databases

EnsembliENST00000343410; ENSP00000342118; ENSG00000143512
GeneIDi79802
KEGGihsa:79802
UCSCiuc001hnh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHIPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWX4
Secondary accession number(s): Q6GU65
, Q96BT4, Q96BU5, Q9H8A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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