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Q6UWX4 (HIPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HHIP-like protein 2
Gene names
Name:HHIPL2
Synonyms:HHIP3, KIAA1822L
ORF Names:UNQ841/PRO1779
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length724 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the HHIP family.

Sequence caution

The sequence AAH15201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH15201.1 differs from that shown. Reason: Erroneous termination at position 452. Translated as Glu.

The sequence AAH15201.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH16552.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14717.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential
Chain42 – 724683HHIP-like protein 2
PRO_0000314964

Amino acid modifications

Glycosylation4801N-linked (GlcNAc...) Potential
Disulfide bond204 ↔ 546 By similarity
Disulfide bond208 ↔ 553 By similarity
Disulfide bond424 ↔ 442 By similarity
Disulfide bond509 ↔ 609 By similarity

Natural variations

Natural variant2411V → M.
Corresponds to variant rs3811466 [ dbSNP | Ensembl ].
VAR_053986
Natural variant3911H → D.
Corresponds to variant rs3748666 [ dbSNP | Ensembl ].
VAR_062220
Natural variant3941R → Q.
Corresponds to variant rs3748665 [ dbSNP | Ensembl ].
VAR_062221
Natural variant4341R → L.
Corresponds to variant rs3748663 [ dbSNP | Ensembl ].
VAR_062222

Experimental info

Sequence conflict2541P → S in AAH07638. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q6UWX4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1202DFFC6D6F44BC

FASTA72480,779
        10         20         30         40         50         60 
MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP PFQPPLHLEF 

        70         80         90        100        110        120 
CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY IKDILCQECS PYAAHLYDAE 

       130        140        150        160        170        180 
NTQTPLRNLP GLCSDYCSAF HSNCHSAISL LTNDRGLQES HGRDGTRFCH LLDLPDKDYC 

       190        200        210        220        230        240 
FPNVLRNDYL NRHLGMVAQD PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV 

       250        260        270        280        290        300 
VWVYLPDGSR LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK 

       310        320        330        340        350        360 
VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM YIFTGDGGQA 

       370        380        390        400        410        420 
GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD NPFVSEPGAH PAIYAYGIRN 

       430        440        450        460        470        480 
MWRCAVDRGD PITRQGRGRI FCGDVGQNRF EEVDLILKGG NYGWRAKEGF ACYDKKLCHN 

       490        500        510        520        530        540 
ASLDDVLPIY AYGHAVGKSV TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW 

       550        560        570        580        590        600 
KKQDLCLGST TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP 

       610        620        630        640        650        660 
SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA TLASGPAQGL 

       670        680        690        700        710        720 
SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR KSLKSHSGRM RPSAEQKRAG 


RSLP 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney, Lung and Muscle.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-724.
Tissue: Thyroid.
[6]"Comparative genomics on HHIP family orthologs."
Katoh Y., Katoh M.
Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358602 mRNA. Translation: AAQ88965.1.
AL592148 Genomic DNA. Translation: CAI40465.1.
CH471100 Genomic DNA. Translation: EAW93274.1.
BC007638 mRNA. Translation: AAH07638.1.
BC015167 mRNA. Translation: AAH15167.1.
BC015201 mRNA. Translation: AAH15201.1. Sequence problems.
BC016552 mRNA. Translation: AAH16552.1. Different initiation.
AK023902 mRNA. Translation: BAB14717.1. Different initiation.
CCDSCCDS1530.2.
RefSeqNP_079022.2. NM_024746.3.
UniGeneHs.665660.

3D structure databases

ProteinModelPortalQ6UWX4.
SMRQ6UWX4. Positions 207-618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000342118.

PTM databases

PhosphoSiteQ6UWX4.

Polymorphism databases

DMDM74749406.

Proteomic databases

MaxQBQ6UWX4.
PaxDbQ6UWX4.
PRIDEQ6UWX4.

Protocols and materials databases

DNASU79802.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343410; ENSP00000342118; ENSG00000143512.
GeneID79802.
KEGGhsa:79802.
UCSCuc001hnh.1. human.

Organism-specific databases

CTD79802.
GeneCardsGC01M222695.
H-InvDBHIX0001611.
HGNCHGNC:25842. HHIPL2.
HPAHPA054029.
neXtProtNX_Q6UWX4.
PharmGKBPA162390914.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2133.
HOGENOMHOG000244857.
HOVERGENHBG107978.
InParanoidQ6UWX4.
OMAPKSERVI.
OrthoDBEOG7CZK54.
PhylomeDBQ6UWX4.
TreeFamTF329059.

Gene expression databases

BgeeQ6UWX4.
CleanExHS_HHIPL2.
GenevestigatorQ6UWX4.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR018143. Folate_rcpt-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamPF03024. Folate_rec. 1 hit.
PF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMSSF50952. SSF50952. 1 hit.
ProtoNetSearch...

Other

ChiTaRSHHIPL2. human.
GenomeRNAi79802.
NextBio69368.
PROQ6UWX4.

Entry information

Entry nameHIPL2_HUMAN
AccessionPrimary (citable) accession number: Q6UWX4
Secondary accession number(s): Q6GU65 expand/collapse secondary AC list , Q96BT4, Q96BU5, Q9H8A0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM