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Protein

Transmembrane protein 207

Gene

TMEM207

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 207
Gene namesi
Name:TMEM207
ORF Names:UNQ846/PRO1784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:33705. TMEM207.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi136 – 1372PP → RS: Loss of WWOX-binding. 1 Publication

Organism-specific databases

PharmGKBiPA162406407.

Polymorphism and mutation databases

BioMutaiTMEM207.
DMDMi74738156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 146117Transmembrane protein 207PRO_0000317525Add
BLAST

Proteomic databases

PaxDbiQ6UWW9.

Expressioni

Tissue specificityi

Expressed in some signet-ring cell carcinoma, especially those showing high invasion and metastatic activity (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000198398.
CleanExiHS_TMEM207.
GenevisibleiQ6UWW9. HS.

Organism-specific databases

HPAiHPA014332.

Interactioni

Subunit structurei

Interacts with WWOX.1 Publication

Protein-protein interaction databases

BioGridi126299. 2 interactions.
STRINGi9606.ENSP00000346981.

Structurei

3D structure databases

ProteinModelPortaliQ6UWW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYYW. Eukaryota.
ENOG41118MT. LUCA.
GeneTreeiENSGT00390000006126.
HOGENOMiHOG000154622.
HOVERGENiHBG108581.
InParanoidiQ6UWW9.
OMAiPTVGIHL.
OrthoDBiEOG091G0RF7.
PhylomeDBiQ6UWW9.
TreeFamiTF342774.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRLFSVT SAISTIGILC LPLFQLVLSD LPCEEDEMCV NYNDQHPNGW
60 70 80 90 100
YIWILLLLVL VAALLCGAVV LCLQCWLRRP RIDSHRRTMA VFAVGDLDSI
110 120 130 140
YGTEAAVSPT VGIHLQTQTP DLYPVPAPCF GPLGSPPPYE EIVKTT
Length:146
Mass (Da):16,116
Last modified:July 5, 2004 - v1
Checksum:i1FAB4346037B6DAE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571L → V.
Corresponds to variant rs35161724 [ dbSNP | Ensembl ].
VAR_051436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358607 mRNA. Translation: AAQ88970.1.
CH471052 Genomic DNA. Translation: EAW78105.1.
BC071780 mRNA. Translation: AAH71780.1.
CCDSiCCDS3297.1.
RefSeqiNP_997199.1. NM_207316.2.
UniGeneiHs.335321.

Genome annotation databases

EnsembliENST00000354905; ENSP00000346981; ENSG00000198398.
GeneIDi131920.
KEGGihsa:131920.
UCSCiuc003fsj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358607 mRNA. Translation: AAQ88970.1.
CH471052 Genomic DNA. Translation: EAW78105.1.
BC071780 mRNA. Translation: AAH71780.1.
CCDSiCCDS3297.1.
RefSeqiNP_997199.1. NM_207316.2.
UniGeneiHs.335321.

3D structure databases

ProteinModelPortaliQ6UWW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126299. 2 interactions.
STRINGi9606.ENSP00000346981.

Polymorphism and mutation databases

BioMutaiTMEM207.
DMDMi74738156.

Proteomic databases

PaxDbiQ6UWW9.

Protocols and materials databases

DNASUi131920.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354905; ENSP00000346981; ENSG00000198398.
GeneIDi131920.
KEGGihsa:131920.
UCSCiuc003fsj.4. human.

Organism-specific databases

CTDi131920.
GeneCardsiTMEM207.
HGNCiHGNC:33705. TMEM207.
HPAiHPA014332.
MIMi614786. gene.
neXtProtiNX_Q6UWW9.
PharmGKBiPA162406407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYYW. Eukaryota.
ENOG41118MT. LUCA.
GeneTreeiENSGT00390000006126.
HOGENOMiHOG000154622.
HOVERGENiHBG108581.
InParanoidiQ6UWW9.
OMAiPTVGIHL.
OrthoDBiEOG091G0RF7.
PhylomeDBiQ6UWW9.
TreeFamiTF342774.

Miscellaneous databases

ChiTaRSiTMEM207. human.
GenomeRNAii131920.
PROiQ6UWW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198398.
CleanExiHS_TMEM207.
GenevisibleiQ6UWW9. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM207_HUMAN
AccessioniPrimary (citable) accession number: Q6UWW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.