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Protein

Lipocalin-15

Gene

LCN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipocalin-15
Gene namesi
Name:LCN15
ORF Names:UNQ2541/PRO6093
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33777. LCN15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722091.

Polymorphism and mutation databases

BioMutaiLCN15.
DMDMi74749403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 184164Lipocalin-15PRO_0000317518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UWW0.
PRIDEiQ6UWW0.

Expressioni

Gene expression databases

BgeeiQ6UWW0.
GenevisibleiQ6UWW0. HS.

Organism-specific databases

HPAiHPA060584.

Interactioni

Protein-protein interaction databases

BioGridi133279. 9 interactions.
STRINGi9606.ENSP00000313833.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni30 – 334Combined sources
Beta strandi35 – 4410Combined sources
Helixi47 – 526Combined sources
Helixi53 – 553Combined sources
Beta strandi59 – 657Combined sources
Helixi67 – 693Combined sources
Beta strandi71 – 766Combined sources
Beta strandi85 – 928Combined sources
Beta strandi98 – 1014Combined sources
Helixi102 – 1043Combined sources
Beta strandi106 – 1149Combined sources
Beta strandi116 – 12813Combined sources
Beta strandi131 – 14414Combined sources
Helixi147 – 15610Combined sources
Helixi157 – 1604Combined sources
Helixi164 – 1663Combined sources
Beta strandi167 – 1693Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XSTX-ray1.63A19-177[»]
ProteinModelPortaliQ6UWW0.
SMRiQ6UWW0. Positions 20-173.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UWW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWK3. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00620000088005.
HOGENOMiHOG000231660.
InParanoidiQ6UWW0.
OMAiALSTMVQ.
OrthoDBiEOG7DFXDR.
PhylomeDBiQ6UWW0.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL
60 70 80 90 100
GKKDHLSMST RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR
110 120 130 140 150
VPALGYLDVR IVDTDYSSFA VLYIYKELEG ALSTMVQLYS RTQDVSPQAL
160 170 180
KSFQDFYPTL GLPKDMMVML PQSDACNPES KEAP
Length:184
Mass (Da):20,454
Last modified:July 5, 2004 - v1
Checksum:iCEE57C05BD0C8ED8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521S → A.
Corresponds to variant rs2297723 [ dbSNP | Ensembl ].
VAR_059453
Natural varianti164 – 1641K → E.
Corresponds to variant rs2297722 [ dbSNP | Ensembl ].
VAR_059454

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358618 mRNA. Translation: AAQ88981.1.
AL355987 Genomic DNA. Translation: CAM14252.1.
BC093893 mRNA. Translation: AAH93893.1.
BC093895 mRNA. Translation: AAH93895.1.
CCDSiCCDS7006.1.
RefSeqiNP_976222.1. NM_203347.1.
UniGeneiHs.413902.

Genome annotation databases

EnsembliENST00000316144; ENSP00000313833; ENSG00000177984.
GeneIDi389812.
KEGGihsa:389812.
UCSCiuc004cjd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358618 mRNA. Translation: AAQ88981.1.
AL355987 Genomic DNA. Translation: CAM14252.1.
BC093893 mRNA. Translation: AAH93893.1.
BC093895 mRNA. Translation: AAH93895.1.
CCDSiCCDS7006.1.
RefSeqiNP_976222.1. NM_203347.1.
UniGeneiHs.413902.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XSTX-ray1.63A19-177[»]
ProteinModelPortaliQ6UWW0.
SMRiQ6UWW0. Positions 20-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133279. 9 interactions.
STRINGi9606.ENSP00000313833.

Polymorphism and mutation databases

BioMutaiLCN15.
DMDMi74749403.

Proteomic databases

PaxDbiQ6UWW0.
PRIDEiQ6UWW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316144; ENSP00000313833; ENSG00000177984.
GeneIDi389812.
KEGGihsa:389812.
UCSCiuc004cjd.3. human.

Organism-specific databases

CTDi389812.
GeneCardsiLCN15.
HGNCiHGNC:33777. LCN15.
HPAiHPA060584.
neXtProtiNX_Q6UWW0.
PharmGKBiPA164722091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWK3. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00620000088005.
HOGENOMiHOG000231660.
InParanoidiQ6UWW0.
OMAiALSTMVQ.
OrthoDBiEOG7DFXDR.
PhylomeDBiQ6UWW0.
TreeFamiTF336103.

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

EvolutionaryTraceiQ6UWW0.
GenomeRNAii389812.
PROiQ6UWW0.

Gene expression databases

BgeeiQ6UWW0.
GenevisibleiQ6UWW0. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Crystal structure of the human lipocalin 15."
    Structural genomics consortium (SGC)
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 19-177.

Entry informationi

Entry nameiLCN15_HUMAN
AccessioniPrimary (citable) accession number: Q6UWW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.