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Protein

Lipocalin-15

Gene

LCN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipocalin-15
Gene namesi
Name:LCN15
ORF Names:UNQ2541/PRO6093
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33777. LCN15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177984.
PharmGKBiPA164722091.

Polymorphism and mutation databases

BioMutaiLCN15.
DMDMi74749403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000031751821 – 184Lipocalin-15Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UWW0.
PeptideAtlasiQ6UWW0.
PRIDEiQ6UWW0.

Expressioni

Gene expression databases

BgeeiENSG00000177984.
GenevisibleiQ6UWW0. HS.

Organism-specific databases

HPAiHPA060584.

Interactioni

Protein-protein interaction databases

BioGridi133279. 9 interactors.
IntActiQ6UWW0. 1 interactor.
STRINGi9606.ENSP00000313833.

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni30 – 33Combined sources4
Beta strandi35 – 44Combined sources10
Helixi47 – 52Combined sources6
Helixi53 – 55Combined sources3
Beta strandi59 – 65Combined sources7
Helixi67 – 69Combined sources3
Beta strandi71 – 76Combined sources6
Beta strandi85 – 92Combined sources8
Beta strandi98 – 101Combined sources4
Helixi102 – 104Combined sources3
Beta strandi106 – 114Combined sources9
Beta strandi116 – 128Combined sources13
Beta strandi131 – 144Combined sources14
Helixi147 – 156Combined sources10
Helixi157 – 160Combined sources4
Helixi164 – 166Combined sources3
Beta strandi167 – 169Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XSTX-ray1.63A19-177[»]
ProteinModelPortaliQ6UWW0.
SMRiQ6UWW0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UWW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWK3. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00620000088005.
HOGENOMiHOG000231660.
InParanoidiQ6UWW0.
OMAiALSTMVQ.
OrthoDBiEOG091G0QEI.
PhylomeDBiQ6UWW0.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL
60 70 80 90 100
GKKDHLSMST RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR
110 120 130 140 150
VPALGYLDVR IVDTDYSSFA VLYIYKELEG ALSTMVQLYS RTQDVSPQAL
160 170 180
KSFQDFYPTL GLPKDMMVML PQSDACNPES KEAP
Length:184
Mass (Da):20,454
Last modified:July 5, 2004 - v1
Checksum:iCEE57C05BD0C8ED8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059453152S → A.Corresponds to variant rs2297723dbSNPEnsembl.1
Natural variantiVAR_059454164K → E.Corresponds to variant rs2297722dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358618 mRNA. Translation: AAQ88981.1.
AL355987 Genomic DNA. Translation: CAM14252.1.
BC093893 mRNA. Translation: AAH93893.1.
BC093895 mRNA. Translation: AAH93895.1.
CCDSiCCDS7006.1.
RefSeqiNP_976222.1. NM_203347.1.
UniGeneiHs.413902.

Genome annotation databases

EnsembliENST00000316144; ENSP00000313833; ENSG00000177984.
GeneIDi389812.
KEGGihsa:389812.
UCSCiuc004cjd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358618 mRNA. Translation: AAQ88981.1.
AL355987 Genomic DNA. Translation: CAM14252.1.
BC093893 mRNA. Translation: AAH93893.1.
BC093895 mRNA. Translation: AAH93895.1.
CCDSiCCDS7006.1.
RefSeqiNP_976222.1. NM_203347.1.
UniGeneiHs.413902.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XSTX-ray1.63A19-177[»]
ProteinModelPortaliQ6UWW0.
SMRiQ6UWW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133279. 9 interactors.
IntActiQ6UWW0. 1 interactor.
STRINGi9606.ENSP00000313833.

Polymorphism and mutation databases

BioMutaiLCN15.
DMDMi74749403.

Proteomic databases

PaxDbiQ6UWW0.
PeptideAtlasiQ6UWW0.
PRIDEiQ6UWW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316144; ENSP00000313833; ENSG00000177984.
GeneIDi389812.
KEGGihsa:389812.
UCSCiuc004cjd.3. human.

Organism-specific databases

CTDi389812.
GeneCardsiLCN15.
HGNCiHGNC:33777. LCN15.
HPAiHPA060584.
neXtProtiNX_Q6UWW0.
OpenTargetsiENSG00000177984.
PharmGKBiPA164722091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWK3. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00620000088005.
HOGENOMiHOG000231660.
InParanoidiQ6UWW0.
OMAiALSTMVQ.
OrthoDBiEOG091G0QEI.
PhylomeDBiQ6UWW0.
TreeFamiTF336103.

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

EvolutionaryTraceiQ6UWW0.
GenomeRNAii389812.
PROiQ6UWW0.

Gene expression databases

BgeeiENSG00000177984.
GenevisibleiQ6UWW0. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCN15_HUMAN
AccessioniPrimary (citable) accession number: Q6UWW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.